Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Canadian Journal of Physiology and Pharmacology

• Publication date

  2000-10-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1139/Y00-053PMID 11077984
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vanadium compounds as insulin mimics.

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• Distinct glucose lowering and beta cell protective effects of vanadium and food restriction in streptozotocin-diabetes.

  1999cited by this paper
• Acute and chronic oral administration of bis(maltolato)oxovanadium(IV) in Zucker diabetic fatty (ZDF) rats.

  1999cited by this paper
• Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes.

  1999cited by this paper
• Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats.

  1999cited by this paper
• Independent signal-transduction pathways for vanadate and for insulin in the activation of glycogen synthase and glycogenesis in rat adipocytes.

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• Bis(N,N-dimethylhydroxamido)hydroxooxovanadate inhibition of protein tyrosine phosphatase activity in intact cells: comparison with vanadate.

  1999cited by this paper
• Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene.

  1999cited by this paper
• Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes

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• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
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• Kinetic analysis and comparison of uptake, distribution, and excretion of 48V-labeled compounds in rats.

  1998cited by this paper
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  1998cited by this paper
• Vanadate fully stimulates insulin receptor substrate‐1 associated phosphatidyl inositol 3‐kinase activity in adipocytes from young and old rats

  1998cited by this paper
• Multifunctional actions of vanadium compounds on insulin signaling pathways: Evidence for preferential enhancement of metabolic versus mitogenic effects

  1998cited by this paper
• Vanadyl Sulfate Does Not Enhance Insulin Action in Patients With Type 1 Diabetes

  1998cited by this paper
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  1998cited by this paper
• Vanadate elevates lipogenicity of starved rat adipose tissue: mechanism of action.

  1998cited by this paper
• Tyrosine phosphatase inhibitors, vanadate and pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol 3-kinase and protein kinase C.

  1998cited by this paper
• Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate.

  1997cited by this paper
• Vanadate stimulation of 2-deoxyglucose transport is not mediated by PI 3-kinase in human skeletal muscle.

  1997cited by this paper
• Vanadate Activates Membranous Nonreceptor Protein Tyrosine Kinase in Rat Adipocytes

  1997cited by this paper
• Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

  1997cited by this paper
• Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance

  1997cited by this paper
• Partial preservation of pancreatic β-cells by vanadian: Evidence for long-term amelioration of diabetes

  1997cited by this paper
• Vanadium compounds biological actions and potential as pharmacological agents.

  1997cited by this paper
• Antilipolytic Actions of Vanadate and Insulin in Rat Adipocytes Mediated by Distinctly Different Mechanisms.

  1997cited by this paper
• Effects of oral vanadyl treatment on diabetes-induced alterations in the heart GLUT-4 transporter.

  1997cited by this paper
• Partial preservation of pancreatic beta-cells by vanadium: evidence for long-term amelioration of diabetes.

  1997cited by this paper
• Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate*

  1997cited by this paper
• Effect of vanadate on glucose transporter (GLUT4) intrinsic activity in skeletal muscle plasma membrane giant vesicles.

  1996cited by this paper
• Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects.

  1996cited by this paper
• Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: is glucose 6-phosphate the signalling metabolite?

  1996cited by this paper
• Effects of low and high dose administration of bis(maltolato)oxovanadium(IV) on fa/fa Zucker rats.

  1996cited by this paper
• Oral Vanadyl Sulfate Improves Insulin Sensitivity in NIDDM but Not in Obese Nondiabetic Subjects

  1996cited by this paper
• Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus.

  1996cited by this paper
• Effects of peroxovanadate and vanadate on insulin binding, degradation and sensitivity in rat adipocytes.

  1996cited by this paper
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  1996cited by this paper
• Evidence for the distinct vanadyl(+4)-dependent activating system for manifesting insulin-like effects.

  1996cited by this paper
• Phlorizin or Vanadate Treatment Reverses Impaired Expression of Albumin and Hepatocyte Nuclear Factor 1 in Diabetic Rats

  1996cited by this paper
• Regulation of gene expression by insulin.

  1996cited by this paper
• Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research.

  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Decrease in protein tyrosine phosphatase activities in vanadate-treated obese Zucker (fa/fa) rat liver

  1995cited by this paper
• Improved glucose tolerance by acute vanadate but not by selenate exposure in genetically obese rats (fa/fa).

  1995cited by this paper
• Glucose transporter gene expression: regulation of transcription and mRNA stability.

  1995cited by this paper
• Okadaic Acid, Vanadate, and Phenylarsine Oxide Stimulate 2-Deoxyglucose Transport in Insulin-Resistant Human Skeletal Muscle

  1995cited by this paper
• Skeletal Muscle Mitogen-Activated Protein Kinases and Ribosomal S6 Kinases: Suppression in Chronic Diabetic Rats and Reversal by Vanadium

  1995cited by this paper
• Concentration-dependent glucose-lowering effects of oral vanadyl are maintained following treatment withdrawal in streptozotocin-diabetic rats.

  1995cited by this paper
• Comparison of the glucose-lowering properties of vanadyl sulfate and bis(maltolato)oxovanadium(IV) following acute and chronic administration.

  1995cited by this paper
• In vivo andin vitro studies of vanadate in human and rodent diabetes mellitus

  1995cited by this paper
• Evidence for selective effects of vanadium on adipose cell metabolism involving actions on cAMP-dependent protein kinase

  1995cited by this paper
• Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.

  1995cited by this paper
• Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.

  1995cited by this paper
• p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors.

  1995cited by this paper
• Activation of mesangial cells by the phosphatase inhibitor vanadate. Potential implications for diabetic nephropathy.

  1995cited by this paper
• Vanadium activates or inhibits receptor and non-receptor protein tyrosine kinases in cell-free experiments, depending on its oxidation state. Possible role of endogenous vanadium in controlling cellular protein tyrosine kinase activity.

  1994cited by this paper
• Toxicity studies on one-year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulphate.

  1994cited by this paper
• PI 3-kinase activation is required for insulin stimulation of glucose transport into L6 myotubes.

  1994cited by this paper
• Distinct protein tyrosine phosphorylation during mitogenesis induced in quiescent sv40‐transformed 3T3 T cells by insulin or vanadate

  1994cited by this paper
• Activation of mitogen activated protein (MAP) kinases by vanadate is independent of insulin receptor autophosphorylation

  1994cited by this paper
• Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate

  1994cited by this paper
• Vanadate Augments Insulin-Stimulated Insulin Receptor Kinase Activity and Prolongs Insulin Action In Rat Adipocytes: Evidence for Transduction of Amplitude of Signaling into Duration of Response

  1994cited by this paper
• Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.

  1994cited by this paper
• Peroxovanadate but not vanadate exerts insulin-like effects in human adipocytes

  1993cited by this paper
• In vivo antidiabetic actions of naglivan, an organic vanadyl compound in streptozotocin-induced diabetes.

  1993cited by this paper
• Mechanism of pervanadate stimulation and potentiation of insulin-activated glucose transport in rat adipocytes: dissociation from vanadate effect.

  1993cited by this paper
• Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.

  1993cited by this paper
• Vanadate treatment restores the expression of genes for key enzymes in the glucose and ketone bodies metabolism in the liver of diabetic rats.

  1993cited by this paper
• Noninsulin-like action of sodium orthovanadate in the isolated perfused liver of fed, non-diabetic rats

  1993cited by this paper
• Vanadate treatment of diabetic rats reverses the impaired expression of genes involved in hepatic glucose metabolism: effects on glycolytic and gluconeogenic enzymes, and on glucose transporter GLUT2.

  1993cited by this paper
• Effects of high sucrose diet on insulin-like effects of vanadate in diabetic rats

  1993cited by this paper
• Long-term effectiveness of oral vanadyl sulphate in streptozotocin-diabetic rats

  1993cited by this paper
• Phlorizin treatment of diabetic rats partially reverses the abnormal expression of genes involved in hepatic glucose metabolism

  1993cited by this paper
• Vanadate increases cell surface insulin binding and improves insulin sensitivity in both normal and insulin-resistant rat adipocytes

  1992cited by this paper
• Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes.

  1992cited by this paper
• Vanadate stimulates D-glucose transport into sarcolemmal vesicles from rat skeletal muscles.

  1992cited by this paper
• Mechanisms of Hyperglycemia-Induced Insulin Resistance in Whole Body and Skeletal Muscle of Type I Diabetic Patients

  1992cited by this paper
• A cytosolic protein tyrosine kinase in rat adipocytes

  1992cited by this paper
• The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells.

  1992cited by this paper
• Vanadate stimulates system A amino acid transport activity in skeletal muscle. Evidence for the involvement of intracellular pH as a mediator of vanadate action.

  1992cited by this paper
• Oral administration of vanadate to diabetic rats restores liver 6-phosphofructo-2-kinase content and mRNA

  1992cited by this paper
• Vanadate potentiates the glycogenic action of insulin‐like growth factors on isolated diaphragm

  1992cited by this paper
• Inhibition of increasing effect of vanadate on glycogen content and lipoprotein lipase activity in fat pads by 5-N,N-hexamethylene amiloride.

  1992cited by this paper
• Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

  1992cited by this paper
• Oral vanadate decreases muscle insulin resistance in obese fa/fa rats

  1992cited by this paper
• Vanadate treatment markedly increases glucose utilization in muscle of insulin-resistant fa/fa rats without modifying glucose transporter expression.

  1992cited by this paper
• Effect of streptozotocin-induced diabetes on GLUT-4 phosphorylation in rat adipocytes.

  1992cited by this paper
• Vanadate induces the recruitment of glut-4 glucose transporter to the plasma membrane of rat adipocytes

  1992cited by this paper
• Vanadate inhibits glucose output from isolated perfused rat liver

  1991cited by this paper
• Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

  1991cited by this paper
• Long-term effects of vanadate treatment on glycogen metabolizing and lipogenic enzymes of liver in genetically diabetic (db/db) mice.

  1991cited by this paper
• Antidiabetic Action of Vanadyl in Rats Independent of in Vivo Insulin-Receptor Kinase Activity

  1991cited by this paper
• Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus.

  1991cited by this paper
• Effects of vanadate on 6‐phosphofructo 2‐kinase activity and fructose 2,6‐bisphosphate levels in cultured rat hepatocytes

  1990cited by this paper
• Insulinlike Effects of Vanadate on Hepatic Glycogen Metabolism in Nondiabetic and Streptozocin-Induced Diabetic Rats

  1990cited by this paper
• Vanadate augments insulin binding and prolongs insulin action in rat adipocytes.

  1990cited by this paper

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