Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Annals of Internal Medicine

• Publication date

  1998-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.7326/0003-4819-128-3-199802010-00002PMID 9454525
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of Troglitazone: A new hypoglycemic agent in patients with NIDDM poorly controlled by diet therapy

  1996cited by this paper
• Erratum to: Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.

  1996cited by this paper
• Mechanism of free fatty acid-induced insulin resistance in humans.

  1996cited by this paper
• Suppression of hepatic gluconeogenesis in long-term Troglitazone treated diabetic KK and C57BL/KsJ-db/db mice.

  1995cited by this paper
• Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BL KsJ-db db mice

  1995cited by this paper
• Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and beta-oxidation in fructose-fed rats.

  1995cited by this paper
• Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.

  1995cited by this paper
• Troglitazone Prevents Glucose-Induced Insulin Resistance of Insulin Receptor in Rat-1 Fibroblasts

  1994cited by this paper
• Relationship Between Hepatic Glucose Production and Fasting Plasma Glucose Concentration in Patients With NIDDM

  1994cited by this paper
• Metabolic Effects of Troglitazone on Fructose-Induced Insulin Resistance in the Rat

  1994influential reference
• Role of insulin resistance in the pathophysiology of non-insulin dependent diabetes mellitus.

  1993cited by this paper
• Radioactive and Stable Isotope Tracers in Biomedicine

  1993cited by this paper
• Thiazolidinediones (AD-4833 and CS-045) improve hepatic insulin resistance in streptozotocin-induced diabetic rats.

  1993cited by this paper
• Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis

  1992cited by this paper
• Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects

  1992cited by this paper
• Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: a balanced overview

  1992cited by this paper
• Characterization of CS-045, a new oral antidiabetic agent, II. Effects on glycemic control and pancreatic islet structure at a late stage of the diabetic syndrome in C57BL/KsJ-db/db mice.

  1991cited by this paper
• The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats.

  1991cited by this paper
• Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.

  1991cited by this paper
• In vitro studies on the action of CS-045, a new antidiabetic agent.

  1990cited by this paper
• On the determination of basal glucose production rate in patients with Type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion

  1990cited by this paper
• Acarbose: A Preliminary Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential

  1988cited by this paper
• Effect of time on measurement of hepatic glucose production.

  1988cited by this paper
• Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

  1988cited by this paper
• Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

  1987cited by this paper
• Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.

  1984cited by this paper
• Effect of fatty acids on glucose production and utilization in man.

  1983cited by this paper
• Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus

  1982cited by this paper
• Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

  1981cited by this paper
• Glucose clamp technique: a method for quantifying insulin secretion and resistance.

  1979cited by this paper
• Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group.

  1979cited by this paper
• The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.

  1963cited by this paper

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