Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis

A study of the consequences of removing one copy of Mad2 in diploid budding yeast shows that MAD2 haploinsufficiency is due to subunit imbalance in the Mad1–Mad2 complex and that a normal Mad2:Mad1 ratio is essential for cells to respond to a loss of tension on mitotic chromosomes but is dispensable for a response to unattached chromosomes.

• Publication year

  2011

• Venue

  Molecular Biology of the Cell

• Publication date

  2011-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E09-01-0029PMID 21593209PMCID 3135471
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2003cited by this paper
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