Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature

• Publication date

  2004-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature02328PMID 14961024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1987cited by this paper
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  2010cites this paper
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  2010cites this paper
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