When signaling kinases meet histones and histone modifiers in the nucleus.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecules and Cells

• Publication date

  2011-05-06

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molcel.2011.03.022PMID 21549306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

  2011cited by this paper
• Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs

  2010cited by this paper
• PKC and the control of localized signal dynamics

  2010cited by this paper
• Cooperative epigenetic modulation by cancer amplicon genes.

  2010cited by this paper
• Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

  2010cited by this paper
• Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

  2010influential reference
• Phosphotyrosine signaling: evolving a new cellular communication system.

  2010cited by this paper
• Covalent histone modifications — miswritten, misinterpreted and mis-erased in human cancers

  2010cited by this paper
• Chromatin remodelling during development

  2010cited by this paper
• RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer.

  2010influential reference
• S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

  2010cited by this paper
• Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

  2010influential reference
• Haspin: a newly discovered regulator of mitotic chromosome behavior

  2010cited by this paper
• Phosphorylation of SU(VAR)3–9 by the Chromosomal Kinase JIL-1

  2010cited by this paper
• Chk-ing in and Chk-ing out: kinase compartmentalization comes to checkpoint control.

  2010cited by this paper
• AMP-activated protein kinase and its downstream transcriptional pathways

  2010cited by this paper
• Inducible gene expression: diverse regulatory mechanisms

  2010cited by this paper
• Abstract 309: RSK2 mediates NF-κB activity through the phosphorylation of IκBα in the TNF-R1 pathway

  2010cited by this paper
• Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

  2010influential reference
• Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage

  2010cited by this paper
• Histone variants — ancient wrap artists of the epigenome

  2010cited by this paper
• Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.

  2010cited by this paper
• Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.

  2010cited by this paper
• Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.

  2010cited by this paper
• New functions for an old variant: no substitute for histone H3.3.

  2010influential reference
• Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases.

  2010cited by this paper
• Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.

  2009cited by this paper
• Phosphorylation of Histone H3 Thr-45 Is Linked to Apoptosis*♦

  2009influential reference
• WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase

  2009cited by this paper
• Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis.

  2009cited by this paper
• The versatile role of MSKs in transcriptional regulation.

  2009cited by this paper
• JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

  2009cited by this paper
• JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

  2009influential reference
• The role of histone H2A and H2B post-translational modifications in transcription: a genomic perspective.

  2009cited by this paper
• Mitotic drivers—inhibitors of the Aurora B Kinase

  2009cited by this paper
• Tyrosine Dephosphorylation of H2AX Modulates Apoptosis and Survival Decisions

  2009influential reference
• Histones: annotating chromatin.

  2009cited by this paper
• Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

  2009cited by this paper
• Histone H3 phosphorylation: Universal code or lineage specific dialects?

  2009cited by this paper
• H3 phosphorylation: dual role in mitosis and interphase.

  2009cited by this paper
• Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.

  2009cited by this paper
• TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.

  2008cited by this paper
• WSTF regulates the function of H2A.X via a novel tyrosine kinase activity

  2008cited by this paper
• Lysine acetylation: codified crosstalk with other posttranslational modifications.

  2008cited by this paper
• Tyrosine Phosphorylation of the Nuclear Receptor Coactivator AIB1/SRC-3 Is Enhanced by Abl Kinase and Is Required for Its Activity in Cancer Cells

  2008cited by this paper
• Is there a code embedded in proteins that is based on post-translational modifications?

  2008cited by this paper
• Biosignaling of mammalian Ste20-related kinases.

  2008cited by this paper
• Histone ubiquitination: triggering gene activity.

  2008cited by this paper
• Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

  2008influential reference
• Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

  2008influential reference
• The Aurora kinase family in cell division and cancer.

  2008cited by this paper
• Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover.

  2008cited by this paper
• Crosstalk among Histone Modifications.

  2008cited by this paper
• Chromatin modifications and their function.

  2007cited by this paper
• SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

  2007cited by this paper
• Regulation of histone methylation by demethylimination and demethylation

  2007cited by this paper
• The complex language of chromatin regulation during transcription

  2007cited by this paper
• How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

  2007cited by this paper
• PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation

  2007cited by this paper
• Covalent modifications of histones during development and disease pathogenesis

  2007cited by this paper
• Mitotic Histone H3 Phosphorylation by Vaccinia-Related Kinase 1 in Mammalian Cells

  2007cited by this paper
• Multivalent engagement of chromatin modifications by linked binding modules

  2007cited by this paper
• Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.

  2007influential reference
• Phosphorylation of CBP by IKKα Promotes Cell Growth by Switching the Binding Preference of CBP from p53 to NF-κB

  2007influential reference
• Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.

  2006cited by this paper
• Activated Signal Transduction Kinases Frequently Occupy Target Genes

  2006cited by this paper
• A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

  2006cited by this paper
• MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

  2006cited by this paper
• Inaugural Article: Histone H3 variants and their potential role in indexing mammalian genomes: The "H3 barcode hypothesis"

  2006cited by this paper
• Histone variants meet their match

  2005cited by this paper
• Phosphorylation of Ser28 in Histone H3 Mediated by Mixed Lineage Kinase-like Mitogen-activated Protein Triple Kinase α*

  2005cited by this paper
• The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

  2005cited by this paper
• The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila

  2005cited by this paper
• Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes.

  2005cited by this paper
• Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity

  2005influential reference
• MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2

  2005cited by this paper
• Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3

  2005influential reference
• Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation.

  2004cited by this paper
• MAP kinases as structural adaptors and enzymatic activators in transcription complexes

  2004cited by this paper
• A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

  2003cited by this paper
• Binary switches and modification cassettes in histone biology and beyond

  2003influential reference
• CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.

  2003cited by this paper
• A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.

  2003cited by this paper
• Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.

  2003cited by this paper
• Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

  2003influential reference
• Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

  2003cited by this paper
• Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.

  2003cited by this paper
• Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV.

  2002cited by this paper
• Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

  2002cited by this paper
• Aurora-B associated protein phosphatases as negative regulators of kinase activation

  2002cited by this paper
• Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

  2002cited by this paper
• MAP Kinases Mediate UVB-induced Phosphorylation of Histone H3 at Serine 28*

  2001influential reference
• Translating the Histone Code

  2001cited by this paper
• Histone H3 phosphorylation and cell division

  2001cited by this paper
• The Ste20 group kinases as regulators of MAP kinase cascades.

  2001cited by this paper
• The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila.

  2001cited by this paper
• ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks*

  2001cited by this paper
• Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro.

  2000cited by this paper
• Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

  2000cited by this paper
• Phosphorylation of histone H3 correlates with transcriptionally active loci.

  2000cited by this paper

• Unraveling the impact of crizotinib to promote megakaryopoiesis for alleviating thrombocytopenia in myelodysplastic neoplasms

  2025cites this paper
• H2AK119ub dynamics control hair follicle stem cell quiescence

  2025cites this paper
• H3T11 phosphorylation by CKII is required for heterochromatin formation in Neurospora

  2024cites this paper
• ROBUST APPROACH FOR PRODUCTION OF THE HUMAN ONCOLOGY TARGET AURORA KINASE B IN COMPLEX WITH ITS BINDING PARTNER INCENP.

  2024cites this paper
• Mycobacterium tuberculosis elevates SLIT2 expression within the host and contributes to oxidative stress responses during infection.

  2023cites this paper
• Overcoming translational barriers in H3K27-altered diffuse midline glioma: Increasing the drug-tumor residence time

  2023cites this paper
• Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

  2023cites this paper
• Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer therapy.

  2023cites this paper
• Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

  2023cites this paper
• Mycobacterium tuberculosis infection elevates SLIT2 expression to modulate oxidative stress responses in macrophages

  2022cites this paper
• The role of histone modifications: from neurodevelopment to neurodiseases

  2022cites this paper
• Epigenetic regulation of autophagy in gastrointestinal cancers.

  2022cites this paper
• Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy

  2022cites this paper
• AURKB, in concert with REST, acts as an oxygen-sensitive epigenetic regulator of the hypoxic induction of MDM2

  2022cites this paper
• Histone H4 acetylation is dysregulated in active seminiferous tubules adjacent to testicular tumours.

  2022cites this paper
• Impact of Histone Modifications and Their Therapeutic Targeting in Hematological Malignancies

  2022cites this paper
• Dissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis

  2022cites this paper
• The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage.

  2022cites this paper
• Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way

  2021cites this paper
• Dissecting the roles of Haspin and VRK1 in Histone H3 threonine-3 phosphorylation during mitosis

  2021cites this paper
• Cell shape‐based chemical screening reveals an epigenetic network mediated by focal adhesions

  2021cites this paper
• Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss

  2021cites this paper
• Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.

  2020cites this paper
• Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes

  2020cites this paper
• Histone modifications in oral squamous cell carcinoma and oral potentially malignant disorders.

  2020cites this paper
• Approaches for the study of epigenetic modifications in the inner ear and related tissues

  2019cites this paper
• Epigenetic Biomarkers in Toxicology

  2019cites this paper
• Epigenetic therapies in patients with solid tumors: Focus on monotherapy with deoxyribonucleic acid methyltransferase inhibitors and histone deacetylase inhibitors

  2019cites this paper
• SOX9 is controlled by the BRD4 inhibitor JQ1 via multiple regulation mechanisms.

  2019cites this paper
• Peptide Microarrays for Epigenetic Targets

  2019cites this paper
• JNK Signaling Pathway Involvement in Spinal Cord Neuron Development and Death

  2019cites this paper
• K-RasG12V/T35S -ERK1/2 pathway regulates H2BS14ph through Mst1 to facilitate the advancement of breast cancer cells.

  2019influential citation
• CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation

  2019cites this paper
• Histone acetylation in refractory sudden sensorineural hearing loss patients after intratympanic methylprednisolone perfusion

  2019cites this paper
• 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages

  2019cites this paper
• Vanadocene dichloride inhibits cell proliferation by targeting Aurora B.

  2018cites this paper
• Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome

  2018cites this paper
• Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope

  2018cites this paper
• PIM 1 KINASE IN ENDOTHELIAL CELL PROLIFERATION AND ADHESION

  2018cites this paper
• Fetal nucleic acids in maternal plasma: from biology to clinical translation.

  2018cites this paper
• LSD 1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells

  2018cites this paper
• Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms

  2018cites this paper
• Arsenite‐induced histone H3 modification and its effects on EGR1 and FOS expression in HeLa cells

  2018influential citation
• Deposited in DRO : 25 January 2017 Version of attached le : Published Version Peer-review status of attached

  2018cites this paper
• Chapter 7 Epigenome , Cancer Prevention and Flavonoids and Curcumin

  2018cites this paper
• Targeting of epigenetic regulators in neuroblastoma

  2018cites this paper
• Investigation of Alcohol-Induced Changes in Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics

  2018cites this paper
• MSK1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression

  2018cites this paper
• Post-transcriptional regulation of protein abundance and function

  2018cites this paper
• Epigenetic Control of Autophagy: Nuclear Events Gain More Attention.

  2017cites this paper
• DNA double‐strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H2O2 appear to increase chromatin bridges and resultant cytokinesis failure

  2017cites this paper
• Repo-Man / PP 1 regulates heterochromatin formation 1 in interphase

  2017cites this paper
• Repo-Man/PP1 regulates heterochromatin formation in interphase

  2017cites this paper
• Understanding the biochemical alterations in cancer cells chronically treated with PI3K/mTOR inhibitors

  2017cites this paper
• Cross Talk Between Bacteria and the Host Epigenetic Machinery

  2017cites this paper
• Signaling coupled epigenomic regulation of gene expression

  2017cites this paper
• Persistent phosphorylation at specific H3 serine residues involved in chemical carcinogen‐induced cell transformation

  2017cites this paper
• Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition

  2017cites this paper
• Cytosolic acetyl-CoA promotes histone H3 lysine 27 acetylation in Arabidopsis

  2017cites this paper
• Papel de la cromatina en la formación de R-loops

  2017cites this paper
• AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3.

  2017cites this paper
• Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone–mediated activation of gonadotropin α-subunit expression

  2017cites this paper
• Epigenetic Regulation of Bone Remodeling and Its Impacts in Osteoporosis

  2016cites this paper
• The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development

  2016cites this paper
• Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes*

  2016cites this paper
• The quest for an effective and safe personalized cell therapy using epigenetic tools

  2016cites this paper
• Repo-Man / PP 1 regulates heterochromatin formation in interphase 1 2

  2016cites this paper
• S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis.

  2016cites this paper
• Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape

  2016cites this paper
• Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription.

  2016cites this paper
• DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics

  2016cites this paper
• University of Dundee The Chromatin Modifier MSK 1 / 2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development

  2016cites this paper
• Regulation of histone H3 phosphorylation at serine 10 in PTTH-stimulated prothoracic glands of the silkworm, Bombyx mori.

  2015cites this paper
• Epigenetics of the failing heart

  2015cites this paper
• Protein kinase C in the immune system: from signalling to chromatin regulation

  2015cites this paper
• Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

  2015influential citation
• Posttranslational Modifications of Baculovirus Protamine-Like Protein P6.9 and the Significance of Its Hyperphosphorylation for Viral Very Late Gene Hyperexpression

  2015cites this paper
• Epigenetics and cancer metabolism.

  2015cites this paper
• Interplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in Leukemia

  2015cites this paper
• Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells

  2015cites this paper
• Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy

  2015cites this paper
• Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer

  2015cites this paper
• Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

  2015cites this paper
• Monitoring Cellular Phosphorylation Signaling Pathways into Chromatin and Down to the Gene Level*

  2015cites this paper
• Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?

  2015cites this paper
• Chapter 17 – Nasopharyngeal Cancer

  2015cites this paper
• Histone H2B-R95A mutant identifies the pheromone pathway that signals cell cycle arrest during rapamycin response

  2015cites this paper
• Epigenetic Regulation of Neurogenesis By Citron Kinase

  2015cites this paper
• Peptide Microarrays for Profiling of Epigenetic Targets

  2015cites this paper
• HACking centrochromatin: on the relationship between centromeres and repressive chromatin

  2015cites this paper
• Molecular mechanisms and outcomes of arsenic-induced histone acetylation and microRNA regulation in cellular transformation

  2015cites this paper
• Mass spectrometric analysis of signal dependent protein modifications

  2015cites this paper
• The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.

  2014cites this paper
• Epigenetics in the hematologic malignancies

  2014cites this paper
• Influence of bacteria on epigenetic gene control

  2014cites this paper
• Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress

  2014cites this paper
• Sensing cellular states—signaling to chromatin pathways targeting Polycomb and Trithorax group function

  2014cites this paper
• Epigenetic mechanisms underlying cardiac degeneration and regeneration.

  2014cites this paper
• Elongating under Stress Eulàlia de Nadal and Francesc Posas

  2014cites this paper
• Stable Isotope Labeling of Phosphoproteins for Large-scale Phosphorylation Rate Determination*

  2014cites this paper