Rate‐Dependent Class III Antiarrhythmic Action, Negative Chronotropy, and Positive Inotropy of a Novel Ik Blocking Drug, UK‐68,798: Potent in Guinea Pig but no Effect in Rat Myocardium

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Journal of Cardiovascular Pharmacology

• Publication date

  1990-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/00005344-199009000-00008PMID 1700210
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of the duration of the action potential on contraction in the mammalian heart muscle

  2004cited by this paper
• Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

  1990cited by this paper
• Class III antiarrhythmic action linked with positive inotropy: acute electrophysiological and inotropic effects of amiodarone in vitro.

  1990cited by this paper
• Cardiodepressive effects of antiarrhythmic drugs.

  1989cited by this paper
• Interaction of potassium channel openers and blockers in canine atrial muscle

  1989cited by this paper
• Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations?

  1989cited by this paper
• Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo.

  1989cited by this paper
• Calcium mobilization and cardiac inotropic mechanisms.

  1988cited by this paper
• Class III antiarrhythmic action linked with positive inotropy: effects of the d- and l-isomer of sotalol on isolated rat atria at threshold and suprathreshold stimulation.

  1988cited by this paper
• Quinidine delays IK activation in guinea pig ventricular myocytes.

  1988cited by this paper
• QTU Prolongation and Polymorphic Ventricular Tachyarrhythmias Due to Bradycardia‐Dependent Early: Afterdepolarizations Afterdepolarizations and Ventricular Arrhythmias

  1988cited by this paper
• Cellular electrophysiological effects of d‐and dl‐sotalol in guinea‐pig sinoatrial node, atrium and ventricle and human atrium: differential tissue sensitivity

  1987cited by this paper
• Electrical activity and contraction in cells isolated from rat and guinea‐pig ventricular muscle: a comparative study.

  1987cited by this paper
• Excitation-contraction coupling in myocardium: implications of calcium release and Na+-Ca2+ exchange.

  1987cited by this paper
• Calcium‐activated inward current and contraction in rat and guinea‐pig ventricular myocytes.

  1987cited by this paper
• Effect of Antiarrhythmic Drugs on the Cycle Length-Dependent Action Potential Duration in Dog Purkinje and Ventricular Muscle Fibers

  1986cited by this paper
• Electrophysiologic and antiarrhythmic effects of sotalol in patients with life-threatening ventricular tachyarrhythmias.

  1985cited by this paper
• Action Potential Prolongation and Induction of Abnormal Automaticity by Low Quinidine Concentrations in Canine Purkinje Fibers Relationship to Potassium and Cycle Length

  1985cited by this paper
• Electrophysiological Effects of Amiodarone on Isolated Rabbit Heart Muscles

  1985cited by this paper
• Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers.

  1985cited by this paper
• Ventricular arrhythmias in severe heart failure: incidence, significance, and effectiveness of antiarrhythmic therapy.

  1985cited by this paper
• A Comparison of Calcium Currents in Rat and Guinea Pig Single Ventricular Cells

  1984cited by this paper
• Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.

  1984cited by this paper
• Early Outward Current in Rat Single Ventricular Cells

  1984cited by this paper
• Clinical Pharmacokinetics and Efficacy of Amiodarone for Refractory Tachyarrhythmias

  1983cited by this paper
• The influence of the rate of electrical stimulation on the effects of the Anemonia sulcata Toxin ATX II in guinea pig papillary muscle.

  1982cited by this paper
• Effect of tetraethylammonium chloride on action potential in cardiac Purkinje fibers.

  1981cited by this paper
• Effects of 4-aminopyridine on contractile response and action potential of rabbit papillary muscle.

  1981cited by this paper
• In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide.

  1981cited by this paper
• A study of the factors responsible for rate‐dependent shortening of the action potential in mammalian ventricular muscle.

  1978cited by this paper
• Interspecies variation in myocardial physiology: the anomalous rat

  1978cited by this paper
• Relationship between internal calcium and outward current in mammalian ventricular muscle; a mechanism for the control of the action potential duration?

  1976cited by this paper
• Electrophysiological and Beta‐Receptor Blocking Effects of MJ 1999 on Dog and Rabbit Cardiac Tissue

  1970cited by this paper
• The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle

  1970cited by this paper
• Temporal Relation Between Long-Lasting Aftercontractions and Action Potentials in Cat Papillary Muscles

  1968cited by this paper

• Antiarrhythmic drugs to prevent sudden cardiac death: Is there a way forward?

  2026cites this paper
• The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review.

  2024cites this paper
• Facilitation of hERG Activation by Its Blocker: A Mechanism to Reduce Drug-Induced Proarrhythmic Risk

  2023cites this paper
• Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes

  2023cites this paper
• New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models

  2023cites this paper
• Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs

  2022cites this paper
• Species dependent differences in the inhibition of various potassium currents and in their effects on repolarization in cardiac ventricular muscle.

  2022cites this paper
• Molecular and Electrophysiological Role of Diabetes-Associated Circulating Inflammatory Factors in Cardiac Arrhythmia Remodeling in a Metabolic-Induced Model of Type 2 Diabetic Rat

  2021cites this paper
• Dofetilide

  2020cites this paper
• Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

  2019cites this paper
• Cardiac Na+/Ca2+ exchange stimulators among cardioprotective drugs

  2019cites this paper
• Facilitation of hERG channels by blockers: a mechanism predicted to reduce lethal cardiac arrhythmias

  2018cites this paper
• Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias

  2017cites this paper
• Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

  2017cites this paper
• The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat

  2017cites this paper
• Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

  2017cites this paper
• Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

  2017cites this paper
• Anti-Arrhythmic Activity

  2016cites this paper
• Potassium Channel Blockade Enhances Atrial Fibrillation–Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

  2015cites this paper
• Changes in Diet Quality Scores and Risk of Cardiovascular Disease Among US Men and Women

  2015cites this paper
• Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds.

  2013cites this paper
• Preservation of cardiomyocytes from the adult heart.

  2013cites this paper
• In Vivo Preclinical Evaluation of a Promising Antiarrhythmic Agent, EGIS‐7229

  2013cites this paper
• New Approaches to Atrial Fibrillation Management

  2012cites this paper
• Dofetilide

  2012cites this paper
• Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models

  2012cites this paper
• Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes

  2011cites this paper
• BeKm-1, a Peptide Inhibitor of Human ether-a-go-go-Related Gene Potassium Currents, Prolongs QTc Intervals in Isolated Rabbit Heart

  2011cites this paper
• Multiscale Modeling of Myocardial Electrical Activity: From Cell to Organ

  2011cites this paper
• Reduced Antiarrhythmic Efficacy of Verapamil in Isolated Rat Hearts in the Presence of Elevated Extracellular Calcium

  2011cites this paper
• Effects of the Antiarrhythmic Drug Dofetilide on Transmural Dispersion of Repolarization in Ventriculum. A Computer Modeling Study

  2011cites this paper
• ROLE OF THE HERG- CHANNEL IN ARRHYTHMIA AND TERATOGENICITY. STUDIES IN ANIMAL MODELS AND THE HUMAN EMBRYONIC HEART

  2010cites this paper
• Antiarrhythmic therapy in atrial fibrillation.

  2010cites this paper
• Dofetilide as Activator of Na/Ca Exchange: New Perspectives on an ‘Old’ Drug

  2009cites this paper
• Dofetilide Enhances the Contractility of Rat Ventricular Myocytes via Augmentation of Na+–Ca2+ Exchange

  2009cites this paper
• Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model

  2008cites this paper
• EGIS-7229: A New Potent Antiarrhythmic Candidate with Combined Mode of Action

  2007cites this paper
• Preclinical Cardiac Safety Assessment of Drugs

  2007cites this paper
• Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization.

  2007cites this paper
• CALCIUM ANTAGONIST PROPERTY OF CPU228, A DOFETILIDE DERIVATIVE, CONTRIBUTES TO ITS LOW INCIDENCE OF TORSADES DE POINTES IN RABBITS

  2007cites this paper
• Pharmacology of SCH00013: a novel Ca2+ sensitizer.

  2006cites this paper
• Class III effects of dofetilide and arrhythmias are modulated by [K+]o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium.

  2006cites this paper
• Pharmacological treatment of atrial fibrillation: mechanisms of action and efficacy of class III drugs.

  2006cites this paper
• Phase 2 ventricular arrhythmias in acute myocardial infarction: a neglected target for therapeutic antiarrhythmic drug development and for safety pharmacology evaluation

  2005cites this paper
• Cardiac Rapidly Activating Delayed Rectifier K' Channel

  2005cites this paper
• Rate-Dependent Prolongation of Cardiac Action

  2005cites this paper
• Intrapericardial delivery enhances cardiac effects of sotalol and atenolol.

  2004cites this paper
• A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.

  2004cites this paper
• Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide

  2004cites this paper
• Dofetilide Effects on the Inhibition by Trains of Subthreshold Conditioning Stimuli

  2004cites this paper
• Tamoxifen inhibits Na+ and K+ currents in rat ventricular myocytes.

  2003cites this paper
• Effects of the antiarrhythmic drug dofetilide on myocardial electrical activity: a computer modelling study

  2003cites this paper
• Intrapericardial Delivery Enhances Cardiac Effects of Sotalol and Atenolol

  2003cites this paper
• A rapidly-activating delayed rectifier K + current , IKr , regulates pacemaker activity in adult mouse sinoatrial node cells Short title : IKr regulates mouse cardiac pacemaker activity

  2003cites this paper
• Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.

  2003cites this paper
• Modulation of intracellular Ca(2+) concentration by tedisamil, a class III antiarrhythmic agent, in isolated heart preparation.

  2003cites this paper
• Clinical Experience with Dofetilide in the Treatment of Patients with Atrial Fibrillation

  2003cites this paper
• Tamoxifen inhibits sodium and potassium currents in rat ventricular myocytes

  2003cites this paper
• Does QT Widening in the Langendorff-perfused Rat Heart Represent the Effect of Repolarization Delay or Conduction Slowing?

  2003cites this paper
• Increasing I(Ks) corrects abnormal repolarization in rabbit models of acquired LQT2 and ventricular hypertrophy.

  2002cites this paper
• Role of the 293b-sensitive, slowly activating delayed rectifier potassium current, i(Ks), in pacemaker activity of rabbit isolated sino-atrial node cells.

  2002cites this paper
• Rate-Dependent Effects of Dofetilide on Epicardial Monophasic Action Potentials in Isolated Rabbit Heart with Atrial Pacing*

  2002influential citation
• Development of Drugs That Alter Ventricular Repolarization

  2002cites this paper
• Effects of dofetilide on cardiovascular tissues from normo‐ and hypertensive rats

  2002cites this paper
• Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey.

  2001cites this paper
• Dofetilide: is the treatment worse than the disease?

  2001cites this paper
• Dofetilide: a new class III antiarrhythmic agent.

  2001cites this paper
• Pause-dependent polymorphic ventricular tachycardia during long-term treatment with dofetilide: a placebo-controlled, implantable cardioverter-defibrillator-based evaluation.

  2001cites this paper
• Effects of EGIS-7229 (S 21407), a Novel Class III Antiarrhythmic Drug, on Myocardial Refractoriness to Electrical Stimulation In Vivo and In Vitro

  2001cites this paper
• Density and Kinetics of IKr and IKs in Guinea Pig and Rabbit Ventricular Myocytes Explain Different Efficacy of IKs Blockade at High Heart Rate in Guinea Pig and Rabbit: Implications for Arrhythmogenesis in Humans

  2001cites this paper
• Effects of mitoxantrone on excitation-contraction coupling in guinea pig ventricular myocytes.

  2000cites this paper
• Cardiovascular drugs. Dofetilide.

  2000cites this paper
• Dofetilide: A Class III-Specific Antiarrhythmic Agent

  2000cites this paper
• Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter.

  2000cites this paper
• Dofetilide: a new pure class III antiarrhythmic agent.

  2000cites this paper
• Positive atrial inotropic effect of dofetilide after cardioversion of atrial fibrillation or flutter.

  2000cites this paper
• Cardiovascular Drugs

  2000cites this paper
• Dofetilide, a New Class III Antiarrhythmic Agent

  2000influential citation
• Acute effects of mitoxantrone on the electromechanical properties of ventricular myocardium

  2000cites this paper
• Effects of mitoxantrone on action potential and membrane currents in isolated cardiac myocytes

  1999cites this paper
• Dofetilideof its Use in Atrial Fibrillation and Atrial Flutter

  1999cites this paper
• Repercussions of pharmacologic reduction in ionic currents on action potential configuration in rabbit Purkinje fibers: Are they indicative of proarrhythmic potential?

  1999cites this paper
• The class III effect of azimilide is not associated with reverse use-dependence in open-chest dogs.

  1999cites this paper
• Investigation on SCH00013, a Novel Cardiotonic Agent with Ca++ Sensitizing Action

  1999cites this paper
• Effects of a class III antiarrhythmic drug, dofetilide, on the in situ canine heart assessed by the simultaneous monitoring of hemodynamic and electrophysiological parameters.

  1999cites this paper
• Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers.

  1999cites this paper
• Carvedilol blocks the repolarizing K+ currents and the L-type Ca2+ current in rabbit ventricular myocytes.

  1999cites this paper
• QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development.

  1999cites this paper
• Investigation on SCH00013, a Novel Cardiotonic Agent with Ca++ Sensitizing Action

  1999cites this paper
• Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide.

  1998cites this paper
• Effects of the chromanol 293 B , a selective blocker of the slow , component of the delayed rectifier K q current , on repolarization in human and guinea pig ventricular myocytes

  1998cites this paper
• Electrophysiological Effects of MS-551 , a New Class III Agent : Comparison with dl-Sotalol in Dogs 1

  1998cites this paper
• Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes.

  1998cites this paper
• Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation.

  1998cites this paper
• Electrophysiologic effects of intravenous MS-551, a novel class III antiarrhythmic agent, on human atrium and ventricle.

  1998cites this paper
• Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids.

  1998cites this paper
• Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids.

  1998cites this paper
• KCB-328: a novel class III antiarrhythmic agent with little reverse frequency dependence in isolated guinea pig myocardium.

  1998cites this paper
• Cardiac cell volume: crystal clear or murky waters? A comparison with other cell types.

  1998cites this paper
• Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.

  1998cites this paper