RNA targets of wild-type and mutant FET family proteins

FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed similar binding profiles, whereas FUS mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization.

• Publication year

  2011

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2011-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nsmb.2163PMID 22081015PMCID 3230689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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