Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Developmental Biology

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ydbio.2009.07.016PMID 19631203
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CGH-1 and the control of maternal mRNAs.

  2009cited by this paper
• Re‐programming of translation following cell stress allows IRES‐mediated translation to predominate

  2008cited by this paper
• Messenger RNA regulation: to translate or to degrade

  2008cited by this paper
• Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic Translation Initiation Factor 3 To Stimulate Translation

  2008cited by this paper
• The dynamics of mammalian P body transport, assembly, and disassembly in vivo.

  2008cited by this paper
• C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.

  2008influential reference
• Translationally repressed mRNA transiently cycles through stress granules during stress.

  2008cited by this paper
• Regulation of mRNA Translation during cellular division

  2008cited by this paper
• A Drosophila orthologue of larp protein family is required for multiple processes in male meiosis.

  2007influential reference
• The ARE-associated factor AUF1 binds poly(A) in vitro in competition with PABP.

  2006cited by this paper
• Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen.

  2006cited by this paper
• Aberrant termination triggers nonsense-mediated mRNA decay.

  2006cited by this paper
• Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors

  2005cited by this paper
• The ε-Subunit of Mitochondrial ATP Synthase Is Required for Normal Spindle Orientation During the Drosophila Embryonic Divisions

  2005cited by this paper
• The DAZL family proteins are PABP‐binding proteins that regulate translation in germ cells

  2005cited by this paper
• Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

  2005cited by this paper
• Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.

  2005cited by this paper
• CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.

  2005cited by this paper
• Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression

  2004cited by this paper
• Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome

  2004cited by this paper
• Genome-wide survey of protein kinases required for cell cycle progression

  2004cited by this paper
• Translational control by MAPK signaling in long-term synaptic plasticity and memory.

  2004cited by this paper
• The DrosDel Collection

  2004cited by this paper
• The enzymes and control of eukaryotic mRNA turnover

  2004cited by this paper
• The roles of cytoplasmic poly(A)-binding proteins in regulating gene expression: a developmental perspective.

  2004cited by this paper
• RNAi in Drosophila Cell Cultures

  2004cited by this paper
• RNAi in transgenic animal models

  2004cited by this paper
• Translational repression by a novel partner of human poly(A) binding protein, Paip2.

  2001cited by this paper
• Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution.

  2001cited by this paper
• dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions

  2000cited by this paper
• Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions

  2000cited by this paper
• Translational control of gene expression

  2000cited by this paper
• 2 The Pathway and Mechanism of Initiation of Protein Synthesis

  2000cited by this paper
• Recognition of polyadenylate RNA by the poly(A)-binding protein.

  1999cited by this paper
• A newly identified N‐terminal amino acid sequence of human eIF4G binds poly(A)‐binding protein and functions in poly(A)‐dependent translation

  1998cited by this paper
• Circularization of mRNA by eukaryotic translation initiation factors.

  1998cited by this paper
• Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

  1998cited by this paper
• Negative Control of the Poly(A)-binding Protein mRNA Translation Is Mediated by the Adenine-rich Region of Its 5′-Untranslated Region*

  1998cited by this paper
• A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation.

  1998cited by this paper
• The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.

  1998cited by this paper
• P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F.

  1997cited by this paper
• A maternal requirement for glutamine synthetase I for the mitotic cycles of syncytial Drosophila embryos.

  1996cited by this paper
• Chromatin and microtubule organization during premeiotic, meiotic and early postmeiotic stages of Drosophila melanogaster spermatogenesis.

  1994cited by this paper
• La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth

  1994cited by this paper
• The Cell cycle : a practical approach

  1993influential reference
• The Drosophila cdc25 homolog twine is required for meiosis.

  1992cited by this paper
• twine, a cdc25 homolog that functions in the male and female germline of Drosophila.

  1992cited by this paper
• A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability

  1987cited by this paper
• Genetics

  1977cited by this paper

• Conserved Functions of LARP1 Proteins in Eukaryotes

  2025influential citation
• Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster

  2025cites this paper
• Larp1 supports brain growth and spatial memory via post-transcriptional control of the translation machinery

  2025cites this paper
• LARP1 acts as a key mediator in preventing angiotensin II-induced cardiac dysfunction and fibrosis

  2025cites this paper
• Insights into key kinase regulatory network of LARP1 based on co-occurring phosphorylation events.

  2025cites this paper
• RNMT-dependent RNA cap methylation in health and disease

  2025cites this paper
• Polyadenylate-binding proteins are essential for the molting development of locusts

  2025cites this paper
• LncRNA‐ATB Contributes to Severe Preeclampsia by Modulating the p53/MDM2 Pathway via PABPC1

  2025cites this paper
• Epigenomic Changes in Ostrinia Moths Under Elevated Pupal and Adult Temperature

  2025cites this paper
• Autonomous function of Antennapedia (Antp) in adult muscle precursors directly connects Hox genes to adult muscle development.

  2025cites this paper
• Mitochondrial Differentiation during Spermatogenesis: Lessons from Drosophila melanogaster

  2024cites this paper
• Greatwall-Endos-PP2A/B55Twins network regulates translation and stability of maternal transcripts in the Drosophila oocyte-to-embryo transition

  2024cites this paper
• The LARP1 homolog Slr1p controls the stability and expression of proto-5'TOP mRNAs in fission yeast.

  2023cites this paper
• Light-induced trapping of endogenous proteins reveals spatiotemporal roles of microtubule and kinesin-1 in dendrite patterning of Drosophila sensory neurons

  2023cites this paper
• Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex

  2023cites this paper
• Construction of hub transcription factor–microRNAs–messenger RNA regulatory network in recurrent implantation failure

  2023cites this paper
• Translating across kingdoms: TOR promotes protein synthesis through conserved and divergent pathways in plants.

  2022cites this paper
• Identification of Candidate Genes Regulating Carcass Depth and Hind Leg Circumference in Simmental Beef Cattle Using Illumina Bovine Beadchip and Next-Generation Sequencing Analyses

  2022cites this paper
• Characteristics of miRNAs Present in Bovine Sperm and Associations With Differences in Fertility

  2022cites this paper
• Tubulin post-translational modifications in meiosis.

  2021cites this paper
• mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

  2021cites this paper
• A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis

  2021cites this paper
• LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization

  2021cites this paper
• Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

  2021cites this paper
• LARP1 isoform expression in human cancer cell lines

  2020cites this paper
• Genetic pressure in animal breeding is sparking the interest to select for elite boars

  2020cites this paper
• A systems biology framework integrating GWAS and RNA-seq to shed light on the molecular basis of sperm quality in swine

  2020cites this paper
• XIST: A Meaningful Long Noncoding RNA in NSCLC Process.

  2020cites this paper
• RECOMBINANT PHAGES FOR SPODOPTERA FRUGIPERDA CONTROL: NEW PERSPECTIVES TO TACKLE AN ECONOMIC PROBLEM

  2020cites this paper
• TOP mRNPs: Molecular Mechanisms and Principles of Regulation

  2020cites this paper
• Controversies around the function of LARP1

  2020cites this paper
• Post-transcriptional gene regulation regulates germline stem cell to oocyte transition during Drosophila oogenesis.

  2020cites this paper
• Investigating the gene expression profiles of cells in seven embryonic stages with machine learning algorithms.

  2020cites this paper
• Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells.

  2020influential citation
• PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations.

  2019cites this paper
• Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation

  2019cites this paper
• La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates

  2019cites this paper
• La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

  2018cites this paper
• Trans‐acting translational regulatory RNA binding proteins

  2018cites this paper
• Human La Function in Expression of Coding Transcripts

  2018cites this paper
• Human La binds mRNAs through contacts to the poly(A) tail

  2018cites this paper
• Correlation of LARP1 and E-cadherin expression with prognosis of intrahepatic cholangiocarcinoma.

  2018cites this paper
• A concert of RNA-binding proteins coordinates mitochondrial function

  2018cites this paper
• Overexpression of Larp4B downregulates dMyc and reduces cell and organ sizes in Drosophila.

  2018cites this paper
• Poly(A)-binding proteins are required for translational regulation in vertebrate oocytes and early embryos.

  2017cites this paper
• LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

  2017cites this paper
• LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

  2017influential citation
• Into the Wild: Parallel Transcriptomics of the Tsetse-Wigglesworthia Mutualism within Kenyan Populations

  2017cites this paper
• Ancient and modern: hints of a core post‐transcriptional network driving chemotherapy resistance in ovarian cancer

  2017cites this paper
• The La and related RNA‐binding proteins (LARPs): structures, functions, and evolving perspectives

  2017cites this paper
• High fat diet has sexually dimorphic effects on body composition, adiposity and glucose homeostasis in Poly(A)- binding protein 4 (Pabp4) knockout mice

  2017cites this paper
• The role of the pAbp gene encoding the cytoplasmic poly(A)-binding protein in spermatogenesis of Drosophila melanogaster

  2017cites this paper
• Caractérisation fonctionnelle de la protéine ECT2 comme lecteur de la modification N6-méthyladénosine des ARN messagers chez la plante Arabidopsis thaliana

  2017cites this paper
• Investigation of RNA binding proteins regulated by mTOR

  2017cites this paper
• The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives

  2017cites this paper
• La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

  2017cites this paper
• Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target

  2016cites this paper
• Evolution of TOR and Translation Control

  2016cites this paper
• Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

  2016cites this paper
• Inhibition of ANXA7 GTPase activity by a small molecule promotes HMBOX1 translation of vascular endothelial cells in vitro and in vivo.

  2016cites this paper
• Regulation of PABP1 function by differential post-translational modification

  2016cites this paper
• The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication

  2016cites this paper
• Evolution of the Protein Synthesis Machinery and Its Regulation

  2016cites this paper
• Characterising novel mitotic microtubule associated proteins in the early Drosophila embryo

  2015cites this paper
• The race to decipher the top secrets of TOP mRNAs.

  2015cites this paper
• LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation

  2015cites this paper
• La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)*

  2015cites this paper
• A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells

  2015cites this paper
• The role of LARP1 in translation and beyond

  2015cites this paper
• A 3′UTR-Associated RNA, FLJ11812 Maintains Stemness of Human Embryonic Stem Cells by Targeting miR-4459

  2015cites this paper
• The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

  2015cites this paper
• The La-Related Proteins, a Family with Connections to Cancer

  2015cites this paper
• LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression

  2014cites this paper
• Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5′TOP mRNA translation

  2014cites this paper
• STUDIES OF PROTEIN FUNCTION BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY

  2014cites this paper
• Exploring the role of nuclear phosphatases and their associated protein in cell growth and development

  2014cites this paper
• Poly(A)-binding proteins are required for diverse biological processes in metazoans

  2014cites this paper
• LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA

  2013cites this paper
• The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins.

  2013cites this paper
• RNA protein interactions governing expression of the most abundant protein in human body, type I collagen

  2013cites this paper
• XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress.

  2013cites this paper
• LARP1 predict the prognosis for early-stage and AFP-normal hepatocellular carcinoma

  2013cites this paper
• Poly(A)-binding proteins: Structure, domain organization, and activity regulation

  2013cites this paper
• Analysis of the uncharacterized La-related protein, Slr1p from Schizosaccharomyces pombe

  2013influential citation
• La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast.

  2012cites this paper
• PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

  2012cites this paper
• Overexpression of a LAM domain containing RNA-binding protein LARP1c induces precocious leaf senescence in Arabidopsis

  2012cites this paper
• Regulation der eukaryotischen Translation durch RNA-bindende Faktoren : Strukturelle und funktionelle Charakterisierung des La-verwandten Proteins 4B (LARP4B)

  2012cites this paper
• Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.

  2011cites this paper
• Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development

  2011cites this paper
• Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?

  2011cites this paper
• The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.

  2011influential citation
• Regulation der eukaryotischen Translation durch RNA- bindende Faktoren: Strukturelle und funktionelle Charakterisierung des La-verwandten Proteins 4B (LARP4B)

  2011cites this paper
• Yeast LA-related proteins and the LA-motif

  2011cites this paper
• A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin

  2011cites this paper
• A stimulatory role for the La-related protein 4B in translation.

  2010influential citation
• The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration

  2010cites this paper
• The RNA binding protein Larp 1 regulates cell division , apoptosis and cell migration

  2010cites this paper
• LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline

  2010cites this paper
• Conserved and divergent features of the structure and function of La and La-related proteins (LARPs).

  2010cites this paper