Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Blood

• Publication date

  1999-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V93.6.2013.406K25_2013_2024PMID 10068674
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Effects of

  2000cited by this paper
• Fyn, Yes, and Syk Phosphorylation Sites in c-Cbl Map to the Same Tyrosine Residues That Become Phosphorylated in Activated T Cells*

  1998cited by this paper
• The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70*

  1997cited by this paper
• The Cbl family of signal transduction molecules.

  1997cited by this paper
• PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

  1997cited by this paper
• Inhibitory Tyrosine Protein Kinase p50 csk Is Associated with Protein-tyrosine Phosphatase PTP-PEST in Hemopoietic and Non-hemopoietic Cells*

  1997cited by this paper
• The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase.

  1997cited by this paper
• Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.

  1997cited by this paper
• Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain.

  1996cited by this paper
• Two Splice Variants of a Tyrosine Phosphatase Differ in Substrate Specificity, DNA Binding, and Subcellular Location*

  1996cited by this paper
• Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G (*)

  1996cited by this paper
• CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

  1996cited by this paper
• From form to function: signaling by protein tyrosine phosphatases.

  1996cited by this paper
• Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.

  1996cited by this paper
• Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.

  1996cited by this paper
• Form and function in protein dephosphorylation.

  1996cited by this paper
• Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors (*)

  1996cited by this paper
• Patient-based assessment: tools for monitoring and improving healthcare outcomes.

  1996cited by this paper
• Protein tyrosine phosphatases as adhesion receptors.

  1995cited by this paper
• Alternative Splicing Generates Four Different Forms of a Non-Transmembrane Protein Tyrosine Phosphatase mRNA

  1995cited by this paper
• Modular binding domains in signal transduction proteins.

  1995cited by this paper
• Protein modules and signalling networks

  1995cited by this paper
• Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase.

  1995cited by this paper
• Deletion of the PEST-like Region of Photosystem Two Modifies the QB-binding Pocket but Does Not Prevent Rapid Turnover of D1 (*)

  1995cited by this paper
• Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.

  1995cited by this paper
• RNA splicing regulates the activity of a SH2 domain-containing protein tyrosine phosphatase.

  1994cited by this paper
• Nuclear localization of the PEP protein tyrosine phosphatase

  1994cited by this paper
• Cytogenetic findings and results of combined immunophenotyping and karyotyping in Hodgkin's disease.

  1994cited by this paper
• The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

  1994cited by this paper
• Digitized and differentially shaded human chromosome ideograms for genomic applications.

  1994cited by this paper
• Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

  1993cited by this paper
• Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene.

  1993cited by this paper
• Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

  1993cited by this paper
• Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice.

  1993cited by this paper
• Modes of DAPI banding and simultaneous in situ hybridization

  1993cited by this paper
• Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.

  1993cited by this paper
• Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.

  1993cited by this paper
• Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila.

  1993cited by this paper
• Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences

  1992cited by this paper
• Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridization.

  1992cited by this paper
• Age‐associated changes in mitogen‐induced protein phosphorylation in murine T lymphocytes

  1992cited by this paper
• Cloning and expression of an inducible lymphoid‐specific, protein tyrosine phosphatase (HePTPase)

  1992cited by this paper
• Great expectations: protein tyrosine phosphatases in cell regulation.

  1992cited by this paper
• Cancer susceptibility in ataxia-telangiectasia.

  1992cited by this paper
• The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children.

  1992cited by this paper
• 1002 protein phosphatases?

  1992cited by this paper
• Chromosome rearrangements in fumigant appliers: possible relationship to non-Hodgkin's lymphoma risk.

  1992cited by this paper
• The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence.

  1992cited by this paper
• Differential kinetics of engraftment and induction of CD10 on human pre-B leukemia cell lines in immune deficient scid mice.

  1992cited by this paper
• The C terminus of mouse ornithine decarboxylase confers rapid degradation on dihydrofolate reductase. Support for the pest hypothesis.

  1991cited by this paper
• A Tyr/Ser protein phosphatase encoded by vaccinia virus

  1991cited by this paper
• Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.

  1991cited by this paper
• Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes.

  1991cited by this paper
• Reassignment of the human CSF1 gene to chromosome 1p13-p21.

  1991cited by this paper
• Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

  1991cited by this paper
• Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.

  1991cited by this paper
• High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones.

  1990cited by this paper
• Structural diversity and evolution of human receptor‐like protein tyrosine phosphatases.

  1990cited by this paper
• The effects of leukemia inhibitory factor (LIF) on the blast stem cells of acute myeloblastic leukemia.

  1990cited by this paper
• Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase.

  1990cited by this paper
• cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.

  1989cited by this paper
• The leukocyte common antigen family.

  1989cited by this paper
• SUP-HD1: a new Hodgkin's disease-derived cell line with lymphoid features produces interferon-gamma.

  1989cited by this paper
• Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

  1989cited by this paper
• A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

  1989cited by this paper
• Purification of the major protein-tyrosine-phosphatases of human placenta.

  1988cited by this paper
• The approaching era of the tumor suppressor genes.

  1987cited by this paper
• Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

  1986cited by this paper
• Asylum: US cancer researcher in Moscow

  1986cited by this paper
• Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis.

  1986cited by this paper
• Prediction of protein antigenic determinants from amino acid sequences.

  1981cited by this paper

• The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

  2025cites this paper
• 1H, 13C and 15N backbone resonance assignment of the catalytic domain of human PTPN22

  2025cites this paper
• Phosphatase PTPN22 functions as an adaptor in the mTORC2 complex

  2025cites this paper
• The Association between PTPN22 SNPs and susceptibility to type 1 diabetes: An updated meta-analysis

  2025cites this paper
• The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

  2025cites this paper
• PTPN22 and the pathogenesis of ulcerative colitis: Insights into T cell differentiation and the JAK/STAT signaling pathway.

  2024cites this paper
• LYP regulates SLP76 and other adaptor proteins in T cells

  2024cites this paper
• Association of endometriosis with Sjögren's syndrome: Genetic insights (Review)

  2024cites this paper
• A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

  2024cites this paper
• A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

  2024cites this paper
• The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis.

  2024cites this paper
• Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

  2024cites this paper
• Regulation of T Cell Signaling and Immune Responses by PTPN22

  2024cites this paper
• The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study

  2023cites this paper
• The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression

  2023cites this paper
• Discovery of benzofuran-2-carboxylic acid derivatives as lymphoid tyrosine phosphatase (LYP) inhibitors for cancer immunotherapy.

  2023cites this paper
• Analysis of PTPN22 −1123 G>C, +788 G>A and +1858 C>T Polymorphisms in Patients with Primary Sjögren’s Syndrome

  2023cites this paper
• Molecular Mechanisms in Autoimmune Thyroid Disease

  2023cites this paper
• UBASH3A Interacts with PTPN22 to Regulate IL2 Expression and Risk for Type 1 Diabetes

  2023influential citation
• SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

  2022cites this paper
• Association between PTPN22 C1858T polymorphism and juvenile idiopathic arthritis: A meta‐analysis update with trial sequential analysis

  2022cites this paper
• PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

  2022cites this paper
• Three key genes expression profiling in Egyptian rheumatoid arthritis patients.

  2022cites this paper
• Meta-Analysis of the Genetic Association between PTPN22 and CTLA-4 Variants and Risk of Uveitis

  2022cites this paper
• Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy

  2022cites this paper
• Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes

  2022cites this paper
• PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy

  2022cites this paper
• TACG_A_319065 331..339

  2021cites this paper
• Phosphatases in toll-like receptors signaling: the unfairly-forgotten

  2021cites this paper
• The Protein Tyrosine Phosphatase Non-receptor Type N22 (PTPN22) Gene Functional Polymorphism (1858T) is not Associated with Rheumatoid Arthritis in Kuwaiti Patients

  2021cites this paper
• Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt

  2021cites this paper
• The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review.

  2021cites this paper
• circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis

  2021cites this paper
• Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis

  2021cites this paper
• Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity

  2021cites this paper
• Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4+ T Cell Activation

  2021cites this paper
• Graves’ Disease: Pathophysiology, Genetics and Management

  2021cites this paper
• Influence of PTPN22 Allotypes on Innate and Adaptive Immune Function in Health and Disease

  2021cites this paper
• Protein tyrosine phosphatase nonreceptor type 22 gene polymorphism in alopecia areata: Does it have an association with disease severity?

  2020cites this paper
• Gene expression and Levels of Plasma Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22)in Pulmonary Tuberculosis Patients and their Household Contacts in Makassar, Indonesia

  2020cites this paper
• The Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Gene Polymorphism and Susceptibility to Autoimmune Diseases

  2020cites this paper
• Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

  2020cites this paper
• DNA hypermethylation of PTPN22 gene promoter in children and adolescents with Hashimoto thyroiditis

  2020cites this paper
• The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked

  2020cites this paper
• Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy

  2020cites this paper
• Risk Factors for Small Adult Height in Childhood Cancer Survivors.

  2020cites this paper
• PTPN22 +788 G>A (R263Q) Polymorphism is Associated with mRNA Expression but it is not a Susceptibility Marker for Rheumatoid Arthritis Patients from Western Mexico

  2019cites this paper
• Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells

  2019cites this paper
• The Contribution of PTPN22 to Rheumatic Disease

  2019cites this paper
• Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.

  2019cites this paper
• Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.

  2019cites this paper
• Role of C1858T polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian children and adolescents with type 1 diabetes.

  2019cites this paper
• The use of recombinant human growth hormone in patients with Mucopolysaccharidoses and growth hormone deficiency: a case series

  2019cites this paper
• EOMES‐positive CD4+ T cells are increased in PTPN22 (1858T) risk allele carriers

  2018cites this paper
• Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

  2018cites this paper
• T Lymphocytes and Autoimmunity.

  2018cites this paper
• The potential of PTPN22 as a therapeutic target for rheumatoid arthritis

  2018cites this paper
• Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs

  2018cites this paper
• Association of PTPN22 gene polymorphism with non-segmental vitiligo in South Indian Tamils

  2018cites this paper
• The long noncoding RNA MALAT‐1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR‐338‐3p in myasthenia gravis

  2018cites this paper
• The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) R620W Functional Polymorphism in Psoriasis

  2018cites this paper
• Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis.

  2018cites this paper
• The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease

  2018cites this paper
• GENE EXPRESSION PROFILING IN AUTOIMMUNE DISEASES-A STORY OF UPS AND DOWNS THESIS FOR DOCTORAL DEGREE ( Ph . D . ) By

  2018cites this paper
• Association of PTPN22 Haplotypes (−1123G>C/+1858C>T) with Rheumatoid Arthritis in Western Mexican Population

  2017cites this paper
• A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats.

  2017cites this paper
• The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura.

  2017cites this paper
• Expression, purification, and characterization of a novel acid phosphatase that displays protein tyrosine phosphatases activity from Metarhizium anisopliae strain CQMa102

  2017cites this paper
• TRAF3 as a regulator of T lymphocyte activation

  2017cites this paper
• Association of PTPN22 Gene Polymorphisms with Susceptibility to Juvenile Idiopathic Arthritis in Iranian Population

  2017cites this paper
• C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?

  2017cites this paper
• Citrullination and Neutrophil Extracellular Traps

  2017cites this paper
• Dynamics of LFA-1 in T lymphocytes

  2017cites this paper
• Treatment of Chronic Mucocutaneous Candidiasis, an Unsolved Issue. CaseReport and Literature Review

  2017cites this paper
• Multiple sclerosis genetics: Results from meta‐analyses of candidate‐gene association studies

  2017cites this paper
• New Substituted 1‐Aryl‐4,4,6‐Trimethyl‐3,4‐Dihydropyrimidine‐2‐(1H)Thiones; A Metal‐Free and Solvent‐Free Synthesis, Characterization, and Lymphoid Tyrosine Phosphatase Inhibition Studies

  2017cites this paper
• Modulation of VEGF receptor 2 signaling by protein phosphatases.

  2017cites this paper
• Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis

  2017cites this paper
• CTLA-4, ICOS, PD1 and PTPN22 Gene Polymorphisms and Susceptibility to Autoimmune Hepatitis Type 1

  2017cites this paper
• NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome

  2017cites this paper
• Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis

  2017cites this paper
• Immunologic response to vaccine challenge in pregnant PTPN22 R620W carriers and non-carriers

  2017cites this paper
• NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese

  2017cites this paper
• Current immunogenetic predisposition to tuberculosis in the Moroccan population

  2017cites this paper
• Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene single nucleotide polymorphisms and its interaction with T2DM on pulmonary tuberculosis in Chinese Uygur population

  2017cites this paper
• RÔLE DE POLYMORPHISMES NUCLÉOTIDIQUES DANS LES GÈNESDE L’INTERLEUKINE-4 ET SON RÉCEPTEUR ET DU CORÉCEPTEURCD40, ET DES ALLÈLES HLA-DR, DANS LA PROGRESSION DE LAPOLYARTHRITE INFLAMMATOIRE D’INSTALLATION RÉCENTE

  2017cites this paper
• Assessment of biochemical parameters and characterization of TNFα -308G/A and PTPN22 +1858C/T gene polymorphisms in the risk of obesity in adolescents.

  2016cites this paper
• Targeting B-cell receptor signaling in leukemia and lymphoma: how and why?

  2016cites this paper
• Rheumatoid arthritis: What have we learned about the causing factors?

  2016influential citation
• Non-transmembrane PTPs in Cancer

  2016cites this paper
• Protein Tyrosine Phosphatases in Cancer

  2016cites this paper
• Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years: TBI is what really matters

  2016cites this paper
• Diabetes and Health Care: An Overview

  2016cites this paper
• The +1858 C/T Polymorphism in the PTPN22 Gene Is Associated with Cystic Fibrosis Patients in Northeast Mexico.

  2016cites this paper
• The SOD1 transgene expressed in erythroid cells alleviates fatal phenotype in congenic NZB/NZW-F1 mice

  2016cites this paper
• Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population

  2016cites this paper
• The Role of PTPN22 Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

  2015cites this paper
• Genomic profiling and gene-gene interaction in rheumatoid arthritis

  2015cites this paper
• Immunogenetics of systemic lupus erythematosus: A comprehensive review.

  2015cites this paper
• Phosphatase regulation of macrophage activation.

  2015cites this paper