Gene expression, cell determination, differentiation, and regeneration

Abstract This chapter focuses on determination and differentiation of skeletal muscle as a paradigm for how tissues differentiate in development and regeneration. Classical embryological concepts that emerged from descriptive embryology are explained and cast in genetic and molecular biological terms. An understanding of the mechanistic basis of embryonic commitment to a unique developmental pathway, and the subsequent realization of the adult phenotypes, is essential for understanding embryonic, fetal, and adult cell behavior; and how stem cells might be manipulated for therapeutic purposes. The importance of satellite, or stem cells, in skeletal muscle formation and regeneration of skeletal muscle and the role of transcription factors, microRNAs, and tissue environment play in these processes are illustrated. The challenge of regeneration of anatomic muscles to repair damage from disease, aging, and trauma is a central problem in tissue engineering and requires an understanding of fundamental mechanisms in skeletal muscle determination and differentiation.

• Publication year

  2020

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/b978-0-12-818422-6.00010-1
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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