Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Mini-Reviews in Medical Chemistry

• Publication date

  2015-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2174/1389557515666150414152933PMID 25873069
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Flavonoids from the leaves of Carya cathayensis Sarg. inhibit vascular endothelial growth factor-induced angiogenesis.

  2014cited by this paper
• Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don

  2013cited by this paper
• Rutin exerts antitumor effects on nude mice bearing SW480 tumor.

  2013cited by this paper
• (−)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α

  2013cited by this paper
• Inhibitory Effect of Baicalin and Baicalein on Ovarian Cancer Cells

  2013cited by this paper
• Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors.

  2013cited by this paper
• Nova Science Publishers

  2013cited by this paper
• Anticancer Properties of Phytochemicals Present in Medicinal Plants of North America

  2013cited by this paper
• EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin

  2012cited by this paper
• Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways

  2012cited by this paper
• Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1.

  2012cited by this paper
• Liquiritigenin Inhibits Tumor Growth and Vascularization in a Mouse Model of Hela Cells

  2012cited by this paper
• Novel anti-angiogenic effects of formononetin in human colon cancer cells and tumor xenograft.

  2012cited by this paper
• The molecular mechanism of luteolin-induced apoptosis is potentially related to inhibition of angiogenesis in human pancreatic carcinoma cells.

  2012cited by this paper
• Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways

  2012cited by this paper
• Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.

  2011cited by this paper
• Dietary Flavonoids as Cancer Prevention Agents

  2011cited by this paper
• (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer.

  2011cited by this paper
• Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells.

  2011cited by this paper
• The Biflavonoid Amentoflavone Inhibits Neovascularization Preventing the Activity of Proangiogenic Vascular Endothelial Growth Factors*

  2011cited by this paper
• Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway.

  2011cited by this paper
• Scutellarin promotes in vitro angiogenesis in human umbilical vein endothelial cells.

  2010cited by this paper
• The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions.

  2010cited by this paper
• Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo.

  2010cited by this paper
• The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.

  2010cited by this paper
• Flavonoids inhibit hypoxia-induced vascular endothelial growth factor expression by a HIF-1 independent mechanism.

  2010influential reference
• Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells

  2009cited by this paper
• Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells.

  2009cited by this paper
• Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.

  2009cited by this paper
• Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression.

  2009cited by this paper
• Baicalein suppresses hypoxia-induced HIF-1alpha protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells.

  2008cited by this paper
• Grape Seed Extract Inhibits Angiogenesis via Suppression of the Vascular Endothelial Growth Factor Receptor Signaling Pathway

  2008cited by this paper
• Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.

  2008cited by this paper
• Inhibition of HIF‐1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3‐M cells

  2008cited by this paper
• Flavonoids induce HIF-1α but impair its nuclear accumulation and activity

  2008cited by this paper
• Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity.

  2008cited by this paper
• Apigenin and cancer chemoprevention: progress, potential and promise (review).

  2007cited by this paper
• Chrysin inhibits expression of hypoxia-inducible factor-1α through reducing hypoxia-inducible factor-1α stability and inhibiting its protein synthesis

  2007cited by this paper
• Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.

  2007cited by this paper
• The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron.

  2007cited by this paper
• The flavonoid quercetin induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation by depleting intracellular iron

  2007cited by this paper
• Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells.

  2006cited by this paper
• Hypoxia-Inducible Factor-1 (HIF-1)

  2006cited by this paper
• Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells.

  2006cited by this paper
• Inhibitory effect of isoflavones on prostate cancer cells and PTEN gene.

  2006cited by this paper
• Delphinidin and cyanidin inhibit PDGFAB‐induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK

  2006cited by this paper
• Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression.

  2006cited by this paper
• Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation.

  2006cited by this paper
• Cytotoxicity of flavonoids toward cultured normal human cells.

  2005cited by this paper
• Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways

  2005cited by this paper
• Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts.

  2004cited by this paper
• Selective Cytotoxicity of a Red Grape Wine Flavonoid Fraction Against MCF-7 Cells

  2004cited by this paper
• The role of hypoxia-induced factors in tumor progression.

  2004cited by this paper
• Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate.

  2004cited by this paper
• Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells

  2004cited by this paper
• Flavonoids: Promising anticancer agents

  2003cited by this paper
• Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids.

  2003cited by this paper
• Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation.

  2002cited by this paper
• Role of angiogenesis in tumor growth and metastasis.

  2002cited by this paper
• EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells

  2001cited by this paper
• Measurement of food flavonoids by high-performance liquid chromatography: A review.

  2000cited by this paper
• Oncotic pressure in solid tumors is elevated.

  2000cited by this paper
• The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells

  1999cited by this paper
• Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

  1995cited by this paper
• [Origin of cancer cells].

  1956cited by this paper
• On the origin of cancer cells.

  1956cited by this paper
• THE METABOLISM OF TUMORS IN THE BODY

  1927cited by this paper

• Phloridzin Docosahexaenoate, an Omega-3 Fatty Acid Ester of a Flavonoid Precursor, Inhibits Angiogenesis by Suppressing Endothelial Cell Proliferation, Migration, and Differentiation

  2024cites this paper
• Evaluation of the Possible Pathways Involved in the Protective Effects of Quercetin, Naringenin, and Rutin at the Gene, Protein and miRNA Levels Using In-Silico Multidimensional Data Analysis

  2023cites this paper
• Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer

  2023cites this paper
• Mechanism of Antiangiogenic and Antioxidant Activity of Newly Synthesized CAMBA in Ehrlich Ascites Carcinoma-Bearing Mice

  2021cites this paper
• Discovery of a Potential Multi-Target Anti-Tumor Agent via Structural Modification on Flavonoid

  2021cites this paper
• Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.

  2020cites this paper
• Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds.

  2020cites this paper
• Flavonoids as potential therapeutic agents for the management of diabetic neuropathy.

  2020cites this paper
• Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review.

  2020cites this paper
• A Review on the Pharmacokinetic Properties of Naringin and Its Therapeutic Efficacies in Respiratory Diseases.

  2019cites this paper
• An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects

  2019cites this paper
• The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective.

  2018cites this paper
• MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1.

  2018cites this paper
• Juglone down-regulates the Akt-HIF-1α and VEGF signaling pathways and inhibits angiogenesis in MIA Paca-2 pancreatic cancer in vitro

  2018cites this paper
• Apigenin in the regulation of cholesterol metabolism and protection of blood vessels

  2017cites this paper
• SYNERGISTIC ACTIVITY OF PLANT BASED BIOACTIVES IN COMBATING CANCER: AN OVERVIEW.

  2017cites this paper
• Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301

  2016cites this paper
• VEGF mimic peptides: Potential applications in central nervous system therapeutics

  2016cites this paper
• Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy in rats by reduction of blood pressure and inhibition of myocardial hypoxia inducible factor-1alpha expression

  2016cites this paper
• Inhibition of AGS Cancer Cell Proliferation following siRNA-Mediated Downregulation of VEGFR2

  2016cites this paper
• The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin

  2016cites this paper
• Phytochemicals in Ischemic Stroke

  2016cites this paper
• Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells.

  2016cites this paper
• The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs Ningning

  2015cites this paper
• The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs

  2015cites this paper
• The critical role of quercetin in autophagy and apoptosis in HeLa cells

  2015cites this paper
• The modulation of carbonyl reductase 1 by polyphenols

  2015cites this paper