The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Advances in Enzyme Regulation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.advenzreg.2009.10.027PMID 19896967
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• The Warburg Effect returns to the cancer stage.

  2009cited by this paper
• IDH1 and IDH2 mutations in gliomas.

  2009cited by this paper
• Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

  2009cited by this paper
• The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths*

  2009cited by this paper
• Metabolic enzymes as oncogenes or tumor suppressors.

  2009cited by this paper
• IDH1 and IDH2 mutations in gliomas.

  2009cited by this paper
• The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

  2008cited by this paper
• Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

  2008cited by this paper
• Aerobic glycolysis in cancers: Implications for the usability of oxygen‐responsive genes and fluorodeoxyglucose‐PET as markers of tissue hypoxia

  2008cited by this paper
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

  2008cited by this paper
• Kidney cancer: now available in a new flavor.

  2008cited by this paper
• Hypoxia, HIF1 and glucose metabolism in the solid tumour

  2008cited by this paper
• A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

  2007cited by this paper
• Energy metabolism in tumor cells

  2007cited by this paper
• Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

  2007influential reference
• Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

  2007cited by this paper
• HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.

  2007cited by this paper
• Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.

  2006cited by this paper
• Energy Deregulation: Licensing Tumors to Grow

  2006cited by this paper
• HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

  2006cited by this paper
• The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism*

  2006cited by this paper
• HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

  2006cited by this paper
• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

  2005cited by this paper
• Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

  2005cited by this paper
• Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

  2005cited by this paper
• Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.

  2005cited by this paper
• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

  2005cited by this paper
• Pyruvate kinase type M2 and its role in tumor growth and spreading.

  2005cited by this paper
• Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

  2005cited by this paper
• Cancer Metabolic Phenotype

  2005cited by this paper
• l-glutamine: a major substrate for tumor cells in vivo?

  2004cited by this paper
• Why do cancers have high aerobic glycolysis?

  2004cited by this paper
• Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology.

  2004cited by this paper
• Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays

  2004cited by this paper
• Akt and Hypoxia-Inducible Factor-1 Independently Enhance Tumor Growth and Angiogenesis

  2004cited by this paper
• Cancer metabolism: facts, fantasy, and fiction.

  2004influential reference
• Understanding the tumor metabolic phenotype in the genomic era.

  2003cited by this paper
• Hexokinase II: the integration of energy metabolism and control of apoptosis.

  2003cited by this paper
• Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells.

  2002cited by this paper
• Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.

  2001cited by this paper
• Activation of the HIF pathway in cancer.

  2001cited by this paper
• Why are cancers acidic? A carrier-mediated diffusion model for H+ transport in the interstitial fluid.

  2001cited by this paper
• Cooperation and Competition in the Evolution of ATP-Producing Pathways

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology.

  2001cited by this paper
• Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

  2000cited by this paper
• Hypoxia and the regulation of gene expression.

  1998cited by this paper
• Understanding the Control of Metabolism

  1996cited by this paper
• Substrate balances across colonic carcinomas in humans.

  1995influential reference
• Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

  1995cited by this paper
• Cancer in the 21st century.

  1994cited by this paper
• Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

  1994cited by this paper
• Application of metabolic-control logic to fuel utilization and its significance in tumor cells.

  1991cited by this paper
• Are transplanted tumours suitable as models for studies on vasculature?

  1991cited by this paper
• Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

  1989cited by this paper
• Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene.

  1988cited by this paper
• Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats.

  1988cited by this paper
• Principles of Biochemistry

  1984cited by this paper
• The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia.

  1980cited by this paper
• Cellular Energy Metabolism and its Regulation

  1977cited by this paper
• Enzymology of cancer cells (first of two parts).

  1977cited by this paper
• Enzymology of cancer cells (second of two parts).

  1977cited by this paper
• Metabolism of hepatomas of different growth rates in situ and during ischemia.

  1971influential reference
• Metabolism of renal tumors in situ and during ischemia.

  1970cited by this paper
• Carbohydrate metabolism in cancer cells and the molecular correlation concept

  1968cited by this paper
• Studies on the development, biochemistry, and biology of experimental hepatomas.

  1965cited by this paper
• Metabolism of Tumours

  1940cited by this paper
• Cancer Metabolic Phenotype Exploiting the Cancer Metabolome in Drug Discovery

  year unknowncited by this paper

• Navigating Tumor Microenvironment with TME-Responsive Nanocarriers: Strategies for Targeted Drug Delivery in Solid Tumors

  2025cites this paper
• Targeting autophagy and metabolism for ewing sarcoma

  2025cites this paper
• Circadian disruption in hepatocellular carcinoma: Current findings and future directions of molecular mechanisms.

  2025cites this paper
• The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer

  2025cites this paper
• Effect of heat-reinforcing needling on hypoxia-inducible factor 1α and glycolysis activity in rabbits with cold syndrome of rheumatoid arthritis.

  2024cites this paper
• Vascular endothelial growth factor A inhibition remodels the transcriptional signature of lipid metabolism in psoriasis non‐lesional skin in 12 h ex vivo culture

  2024cites this paper
• Targeting mitochondrial bioenergetics by combination treatment with imatinib and dichloroacetate in human erythroleukemic K-562 and colorectal HCT-116 cancer cells

  2024cites this paper
• Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers

  2023cites this paper
• NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling

  2023cites this paper
• The emerging regulatory roles of non-coding RNAs associated with Glucose metabolism in Breast Cancer.

  2023cites this paper
• Small extracellular vesicle-mediated metabolic reprogramming: from tumors to pre-metastatic niche formation

  2023influential citation
• Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives

  2022cites this paper
• A positive feedback circuit comprising p21 and HIF‐1α aggravates hypoxia‐induced radioresistance of glioblastoma by promoting Glut1/LDHA‐mediated glycolysis

  2022cites this paper
• The multiple roles of LDH in cancer

  2022cites this paper
• Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis

  2021cites this paper
• Deoxypodophyllotoxin Inhibits Non-Small Cell Lung Cancer Cell Growth by Reducing HIF-1α-Mediated Glycolysis

  2021cites this paper
• Tip of the Iceberg: Roles of CircRNAs in Cancer Glycolysis

  2021cites this paper
• HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells

  2021cites this paper
• Epithelial and Immune Cell Responses to Helicobacter pylori That Shape the Gastric Tumor Microenvironment

  2021cites this paper
• The Heterogeneity Metabolism of Renal Cell Carcinomas.

  2021cites this paper
• Biophysical characterization of melanoma cell phenotype markers during metastatic progression

  2021cites this paper
• How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH

  2020cites this paper
• Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents

  2020cites this paper
• Voluntary Diving Exercise Improves Hippocampus-dependent Learning in Rats

  2020cites this paper
• Metabolism and immunity in breast cancer

  2020cites this paper
• Role of glucose metabolism in the differential antileukemic effect of melatonin on wild‑type and FLT3‑ITD mutant cells.

  2020cites this paper
• Mitochondrial metabolism is inhibited by the HIF1α‐MYC‐PGC‐1β axis in BRAF V600E thyroid cancer

  2019cites this paper
• Mitochondrial metabolism is inhibited by the HIF1 a -MYC-PGC-1 b axis in BRAF V600E thyroid cancer

  2019cites this paper
• Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α.

  2019cites this paper
• Circadian clock gene NPAS2 promotes reprogramming of glucose metabolism in hepatocellular carcinoma cells.

  2019cites this paper
• CircRNAs in cancer metabolism: a review

  2019cites this paper
• Extracellular acidity and increased exosome release as key phenotypes of malignant tumors

  2019cites this paper
• Interaction of Mitochondrial and Epigenetic Regulation in Hepatocellular Carcinoma

  2018cites this paper
• The Metabolism of Renal Cell Carcinomas and Liver Cancer.

  2018cites this paper
• Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

  2018cites this paper
• Therapeutic strategies against cancer stem cells in human colorectal cancer

  2017cites this paper
• Melatonin, mitochondria, and the cancer cell

  2017cites this paper
• Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)

  2016cites this paper
• Characterizing Brain Tumors by MRS

  2016cites this paper
• The lncRNA MALAT1, acting through HIF-1α stabilization, enhances arsenite-induced glycolysis in human hepatic L-02 cells.

  2016cites this paper
• Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer

  2016cites this paper
• Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells

  2015cites this paper
• Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation

  2015cites this paper
• Regulation of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids.

  2015cites this paper
• Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

  2015cites this paper
• Nifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma

  2015cites this paper
• Effect of Dietary ω-3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and Warburg Phenotypes in Cancer

  2015cites this paper
• In vitro expansion of U87-MG human glioblastoma cells under hypoxic conditions affects glucose metabolism and subsequent in vivo growth

  2015cites this paper
• Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma

  2015cites this paper
• Tumor Initiating Cells and Chemoresistance: Which Is the Best Strategy to Target Colon Cancer Stem Cells?

  2014cites this paper
• Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

  2014cites this paper
• Molecular mechanisms and physiology of disease

  2014cites this paper
• Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

  2014cites this paper
• The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism

  2014cites this paper
• Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate

  2014cites this paper
• Cancer systems biology : is the devil in the glycolytic detail?

  2014cites this paper
• Assessing efficacy and molecular mechanisms of curcumin in targeting cancer stem-like cells in colorectal cancer

  2014cites this paper
• Role of stromal fibroblasts in prostate carcinoma progression and metabolic reprogramming of cancer cells

  2014cites this paper
• Molecular aspects of the Warburg effect

  2014cites this paper
• Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect.

  2014cites this paper
• The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells.

  2014cites this paper
• Hypoxia stimulates 18F-fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase.

  2013cites this paper
• The Role of Thioredoxin Interacting Protein (TxNIP) in the Development of Diabetic Nephropathy

  2013cites this paper
• Nucleotide excision repair diseases: molecular biology underlying the clinical heterogeneity

  2013cites this paper
• The mitochondrial ADP/ATP carrier (SLC25 family): pathological implications of its dysfunction.

  2013cites this paper
• Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells.

  2013cites this paper
• Microenvironment and tumor cell plasticity: an easy way out.

  2013cites this paper
• Linking metabolism and epigenetic regulation in development of hepatocellular carcinoma

  2013cites this paper
• Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

  2013cites this paper
• Colon cancer stem cells: controversies and perspectives.

  2013cites this paper
• Microvessel Density But Not Neoangiogenesis Is Associated with 18F-FDG Uptake in Human Atherosclerotic Carotid Plaques

  2012cites this paper
• Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy

  2012cites this paper
• XILOGLUCANA DE SEMENTES DE Copaifera langsdorffii (COPAÍBA) E SEU COMPLEXO COM OXOVANÁDIO (IV/V): EFEITOS SOBRE CÉLULAS DE MELANOMA MURINO B16F10 IN VITRO

  2012cites this paper
• Title Emerging glycolysis targeting and drug discovery from chinesemedicine in cancer therapy

  2012cites this paper
• Tumor perfusie door middel van First-Pass F-18 FDG PET beelden

  2012cites this paper
• Oxygen Glucose Deprivation in Rat Hippocampal Slice Cultures Results in Alterations in Carnitine Homeostasis and Mitochondrial Dysfunction

  2012cites this paper
• The Valley of Death in anticancer drug development: a reassessment.

  2012cites this paper
• Pseudohypoxia, Mitochondrial Mutations, the Warburg Effect, and Cancer.

  2012cites this paper
• Understanding Cancer Metabolism Through Global Metabolomics

  2012cites this paper
• Magnetic Resonance Spectroscopy of Cancer Metabolism and Response to Therapy

  2012cites this paper
• Mitochondria in cancer: at the crossroads of life and death

  2011cites this paper
• Metabolism and Brain Cancer

  2011cites this paper
• Chaperone-Mediated Autophagy Is Required for Tumor Growth

  2011cites this paper
• Molecular mechanisms of genomic imprinting and clinical implications for cancer

  2011cites this paper
• Hypoxia‐mediated biological control

  2011cites this paper
• Correlation between TBARS levels and glycolytic enzymes: the importance to the initial evaluation of clinical outcome of colorectal cancer patients.

  2011cites this paper
• Xeroderma pigmentosum: clues to understanding cancer initiation

  2010cites this paper
• Fatty Acid Uptake and Lipid Storage Induced by HIF-1 α Contribute Fatty Acid Uptake and Lipid Storage Induced by HIF-1 Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation to Cell Growth and Survival after Hypoxia-Reoxygenation

  year unknowncites this paper