Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Blood

• Publication date

  2005-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2004-10-4112PMID 15827126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Calpain-1 Regulates Bax and Subsequent Smac-dependent Caspase-3 Activation in Neutrophil Apoptosis*

  2004cited by this paper
• Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils

  2004cited by this paper
• Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils

  2003cited by this paper
• Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.

  2003cited by this paper
• Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils.

  2003cited by this paper
• Neutrophil apoptosis pathways and their modifications in inflammation

  2003cited by this paper
• Macrophage migration inhibitory factor delays apoptosis in neutrophils by inhibiting the mitochondria‐dependent death pathway

  2003cited by this paper
• SHP-1: a regulator of neutrophil apoptosis.

  2003cited by this paper
• Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes.

  2003cited by this paper
• Granulocyte colony-stimulating factor inhibits the mitochondria-dependent activation of caspase-3 in neutrophils.

  2002cited by this paper
• Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

  2002cited by this paper
• Siglecs, sialic acids and innate immunity.

  2001cited by this paper
• Critical Role for Caspases 3 and 8 in Neutrophil But Not Eosinophil Apoptosis

  2001cited by this paper
• The autophagosomal–lysosomal compartment in programmed cell death

  2001cited by this paper
• Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells

  2001cited by this paper
• Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways1

  2000cited by this paper
• Role of reactive oxygen species (ROS) in apoptosis induction

  2000cited by this paper
• Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.

  2000cited by this paper
• Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs

  2000cited by this paper
• Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

  2000cited by this paper
• Siglec-9, a Novel Sialic Acid Binding Member of the Immunoglobulin Superfamily Expressed Broadly on Human Blood Leukocytes*

  2000cited by this paper
• Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.

  1999cited by this paper
• Ligation of Fc gamma RII (CD32) pivotally regulates survival of human eosinophils.

  1999cited by this paper
• Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation.

  1999cited by this paper
• Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1.

  1999cited by this paper
• SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome).

  1999cited by this paper
• Identification and Molecular Cloning of P75/Airm1, a Novel Member of the Sialoadhesin Family That Functions as an Inhibitory Receptor in Human Natural Killer Cells

  1999cited by this paper
• Spontaneous Neutrophil Apoptosis Involves Caspase 3-mediated Activation of Protein Kinase C-δ*

  1999cited by this paper
• Caspase-mediated proteolysis and activation of protein kinase Cdelta plays a central role in neutrophil apoptosis.

  1999cited by this paper
• Role for tyrosine phosphorylation and Lyn tyrosine kinase in fas receptor-mediated apoptosis in eosinophils.

  1998cited by this paper
• Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

  1998cited by this paper
• SHP-1 Associates with Both Platelet-derived Growth Factor Receptor and the p85 Subunit of Phosphatidylinositol 3-Kinase*

  1998cited by this paper
• Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

  1998cited by this paper
• Fas-ligand: privilege and peril.

  1997cited by this paper
• Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis.

  1997cited by this paper
• Regulation of Src Homology 2-containing Tyrosine Phosphatase 1 during Activation of Human Neutrophils

  1997cited by this paper
• Expression and function of the Fas receptor on human blood and tissue eosinophils

  1996cited by this paper
• Role of cytokines in rheumatoid arthritis.

  1996cited by this paper
• Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils

  1996cited by this paper
• Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin‐like domains.

  1994cited by this paper
• Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils.

  1994cited by this paper
• Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

  1994cited by this paper
• Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

  1993cited by this paper
• Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death.

  1992cited by this paper
• Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products.

  1992cited by this paper
• Neutrophil apoptosis and clearance from neonatal lungs.

  1991cited by this paper
• The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion

  1990cited by this paper

• Adjuvant comprising nano-aluminum hydroxide pickering emulsion with polysialic acid for enhanced vaccination.

  2026cites this paper
• Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

  2025cites this paper
• Sialylated glycoproteins binds to Siglec-9 in a cis manner on platelets to suppress platelet activation.

  2025cites this paper
• Association of SIGLEC9 Expression with Cytokine Expression, Tumor Grading, KRAS, NRAS, BRAF, PIK3CA, AKT Gene Mutations, and MSI Status in Colorectal Cancer

  2024cites this paper
• Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophils

  2024influential citation
• Sialic acid in the regulation of blood cell production, differentiation and turnover

  2024cites this paper
• Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection

  2024cites this paper
• Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection

  2024cites this paper
• The secretome as a biomarker and functional agent in heart failure

  2023cites this paper
• Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs

  2023cites this paper
• Neutrophil extracellular traps (NET): not only antimicrobial but also modulators of innate and adaptive immunities in inflammatory autoimmune diseases

  2023cites this paper
• Roles of the Siglec family in bone and bone homeostasis.

  2023cites this paper
• Siglec-9 is an inhibitory receptor on human mast cells in vitro.

  2023cites this paper
• Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

  2023cites this paper
• C-type lectin (CTL) and sialic acid-binding lectin (SABL) from Venerupis philippinarum: Function on PAMP binding and opsonic activities in immune responses.

  2023cites this paper
• Remotely monitored Baduanjin exercise in moderate-to-severe chronic obstructive pulmonary disease patients (BROCADE): A study protocol

  2022cites this paper
• Microbes and the fate of neutrophils

  2022cites this paper
• Bronchial asthma from glycomics` point of view

  2022cites this paper
• Wogonin attenuates neutrophilic inflammation and airway smooth muscle proliferation through inducing caspase-dependent apoptosis and inhibiting MAPK/Akt signaling in allergic airways.

  2022cites this paper
• Targeting Myeloid Checkpoint Molecules in Combination With Antibody Therapy: A Novel Anti-Cancer Strategy With IgA Antibodies?

  2022cites this paper
• Glycans in Inflammation

  2022cites this paper
• Development of Effective Siglec-9 Antibodies Against Cancer

  2022cites this paper
• Human sialoglycan ligands for immune inhibitory Siglecs.

  2022cites this paper
• A Putative Serine Protease is Required to Initiate the RIPK3-MLKL—Mediated Necroptotic Death Pathway in Neutrophils

  2021cites this paper
• Targetable pathogenic mechanisms in nasal polyposis

  2021cites this paper
• Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments

  2021cites this paper
• Low molecular weight polysialic acid prevents lipopolysaccharide‐induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice

  2021cites this paper
• Siglecs Modulate Activities of Immune Cells Through Positive and Negative Regulation of ROS Generation

  2021influential citation
• Sialic acid-binding immunoglobulin-like lectin 9 as a potential therapeutic target for chronic obstructive pulmonary disease

  2021influential citation
• CD300a contributes to the resolution of articular inflammation triggered by MSU crystals by controlling neutrophil apoptosis

  2021cites this paper
• Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases

  2021cites this paper
• Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19

  2021cites this paper
• Carbohydrates in allergy: from disease to novel immunotherapies.

  2021cites this paper
• Siglecs as Therapeutic Targets in Cancer

  2021cites this paper
• Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation

  2021cites this paper
• Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity

  2021cites this paper
• Siglec Ligands

  2021cites this paper
• Siglec Signaling in the Tumor Microenvironment

  2021cites this paper
• A novel C-type lectin activates the complement cascade in the primitive oyster Crassostrea gigas

  2021cites this paper
• Synthetic Siglec-9 agonists inhibit neutrophil activation associated with COVID-19

  2020cites this paper
• Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils

  2020cites this paper
• IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators

  2020cites this paper
• RIPK3–MLKL–Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α

  2020cites this paper
• Linking glucocorticoid-induced osteoporosis to osteoimmunology

  2020cites this paper
• Modulation of immune cell reactivity with cis-binding Siglec agonists

  2020cites this paper
• Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG).

  2020cites this paper
• Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells

  2019cites this paper
• Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase‐derived reactive oxygen species in aging

  2019cites this paper
• Immune recognition, antimicrobial and opsonic activities mediated by a sialic acid binding lectin from Ruditapes philippinarum.

  2019cites this paper
• Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.

  2019cites this paper
• The sialoglycan-Siglec glyco-immune checkpoint – a target for improving innate and adaptive anti-cancer immunity

  2019cites this paper
• Intravenous immunoglobulin replacement treatment reduces in vivo elastase secretion in patients with common variable immune disorders.

  2019cites this paper
• Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers.

  2019cites this paper
• Siglec-9 regulates an effector memory CD8 + T-cell subset that congregates in the melanoma tumor microenvironment

  2019cites this paper
• Allergy and Atopic Diseases: An Update on Experimental Evidence

  2019cites this paper
• Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses

  2019cites this paper
• Immunosuppressive Siglec-E ligands on mouse aorta are up-regulated by LPS via NF-κB pathway.

  2019cites this paper
• Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment

  2019cites this paper
• Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran

  2019cites this paper
• Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses

  2019cites this paper
• Cell Injury and Necrosis

  2018cites this paper
• Targeting Neutrophils in Severe Asthma via Siglec-9

  2018cites this paper
• Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

  2018cites this paper
• Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis

  2018cites this paper
• Differential antibacterial control by neutrophil subsets.

  2018cites this paper
• Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication

  2018cites this paper
• Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways

  2018cites this paper
• Enhanced neutrophil autophagy and increased concentrations of IL‐6, IL‐8, IL‐10 and MCP‐1 in rheumatoid arthritis

  2018cites this paper
• Sialic acid‐binding lectins (SABLs) from Solen grandis function as PRRs ensuring immune recognition and bacterial clearance

  2018cites this paper
• Investigating the mechanism of bone marrow failure observed in patients with acute myeloid leukaemia

  2018cites this paper
• Viewing Siglecs through the lens of tumor immunology

  2017cites this paper
• STUDY OF INNATE IMMUNITY AND THE EFFECT OF IVIG INFUSIONS IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY AND X-LINKED AGAMMAGLOBULINEMIA PhD COURSE IN IMMUNOLOGICAL, HAEMATOLOGICAL AND RHEUMATOLOGICAL SCIENCES CLINICAL IMMUNOLOGY XXIX CYCLE

  2017cites this paper
• Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer.

  2017cites this paper
• Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations

  2017cites this paper
• Role of granule proteases in the life and death of neutrophils.

  2017cites this paper
• Increased expression of Siglec-9 in chronic obstructive pulmonary disease

  2017cites this paper
• IVIG regulates the survival of human but not mouse neutrophils

  2017cites this paper
• Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties

  2017cites this paper
• A novel siglec (CgSiglec-1) from the Pacific oyster (Crassostrea gigas) with broad recognition spectrum and inhibitory activity to apoptosis, phagocytosis and cytokine release.

  2016cites this paper
• Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

  2016cites this paper
• Multivalent Interactions of Human Primary Amine Oxidase with the V and C22 Domains of Sialic Acid-Binding Immunoglobulin-Like Lectin-9 Regulate Its Binding and Amine Oxidase Activity

  2016cites this paper
• DESIGN AND SYNTHESIS OF LIGANDS AND ANTAGONISTS OF SIGLECS AS IMMUNE RESPONSE MODIFIERS

  2016cites this paper
• Intravenous immunoglobulin replacement treatment does not alter polymorphonuclear leukocytes function and surface receptors expression in patients with common variable immunodeficiency.

  2016cites this paper
• Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming

  2016cites this paper
• Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

  2016cites this paper
• Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

  2016cites this paper
• Glycobiology simplified: diverse roles of glycan recognition in inflammation

  2016cites this paper
• The Fab Fragment of a Human Anti-Siglec-9 Monoclonal Antibody Suppresses LPS-Induced Inflammatory Responses in Human Macrophages

  2016cites this paper
• The immunosuppressive network in patients with glioma; focus on the role of myeloid derived suppressor cells

  2016cites this paper
• Siglec‐7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell‐Mediated Activities

  2016cites this paper
• Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells.

  2015cites this paper
• The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

  2015cites this paper
• Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation.

  2015cites this paper
• The Expanding Role of Therapeutic Antibodies

  2015cites this paper
• Intravenous immunoglobulin replacement induces an in vivo reduction of inflammatory monocytes and retains the monocyte ability to respond to bacterial stimulation in patients with common variable immunodeficiencies.

  2015cites this paper
• Unconventional apoptosis of polymorphonuclear neutrophils (PMN): staurosporine delays exposure of phosphatidylserine and prevents phagocytosis by MΦ‐2 macrophages of PMN

  2015cites this paper
• Enhanced lentiviral vector production in 293FT cells expressing Siglec-9

  2015cites this paper
• Sialoside Arrays: New Synthetic Strategies and Applications.

  2015cites this paper
• Neutrophil extracellular trap formation is associated with autophagy‐related signalling in ANCA‐associated vasculitis

  2015cites this paper
• Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense

  2014cites this paper