Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular Genetics and Metabolism

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.ymgme.2009.05.011PMID 19560954
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease

  2009cited by this paper
• Serum homocysteine in Indian adolescents

  2009cited by this paper
• Homocysteine increases the risk associated with hyperlipidaemia

  2009cited by this paper
• Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.

  2008cited by this paper
• Murine models of hyperhomocysteinemia and their vascular phenotypes.

  2008cited by this paper
• Hypertriglyceridemia and cardiovascular risk reduction.

  2007cited by this paper
• Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.

  2007cited by this paper
• Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.

  2007cited by this paper
• Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice.

  2007cited by this paper
• Inhibition of Fibroblast Growth Factor Receptor Signaling Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice

  2006cited by this paper
• Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview

  2006cited by this paper
• Elevated Homocysteine Reduces Apolipoprotein A-I Expression in Hyperhomocysteinemic Mice and in Males With Coronary Artery Disease

  2006influential reference
• Abnormal Lipid Metabolism in Cystathionine β-Synthase-deficient Mice, an Animal Model for Hyperhomocysteinemia*

  2004cited by this paper
• Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice

  2004cited by this paper
• Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.

  2003cited by this paper
• Homocysteine‐betaine interactions in a murine model of 5,10‐methylenetetrahydrofolate reductase deficiency

  2003cited by this paper
• Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation.

  2003cited by this paper
• Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.

  2001cited by this paper
• Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance.

  2001cited by this paper
• Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

  2001influential reference
• Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E‐related disorders in humans

  2001cited by this paper
• C3H apoE(-/-) mice have less atherosclerosis than C57BL apoE(-/-) mice despite having a more atherogenic serum lipid profile.

  2000cited by this paper
• Genetic background determines the extent of atherosclerosis in ApoE-deficient mice.

  1999cited by this paper
• Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia*

  1998cited by this paper
• Hyperhomocysteinemia induced by folic acid deficiency and methionine load--applications of a modified HPLC method.

  1996cited by this paper
• Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men.

  1996cited by this paper
• Protection Against Atherogenesis in Mice Mediated by Human Apolipoprotein A-IV

  1996cited by this paper
• Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans.

  1995cited by this paper
• Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

  1995cited by this paper
• A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

  1995cited by this paper
• ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

  1994cited by this paper
• Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.

  1992cited by this paper
• Variation in susceptibility to atherosclerosis among inbred strains of mice.

  1985cited by this paper
• Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia.

  1983cited by this paper

• Research Progress on MTHFR, MTRR Gene Polymorphisms and Blood Lipid Levels

  2026cites this paper
• Association study between genetic polymorphisms in MTHFR and stroke susceptibility in Egyptian population: a case–control study

  2024cites this paper
• Severe hyperhomocysteinemia due to MTHFR deficiency caused by a new mutation: A case report and literature review

  2024cites this paper
• Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish.

  2023cites this paper
• Mild methylenetetrahydrofolate reductase deficiency accelerates liver triacylglycerol and uric acid accumulation in fructose-fed mice.

  2022cites this paper
• Hyperhomocysteinemia: Metabolic Role and Animal Studies with a Focus on Cognitive Performance and Decline—A Review

  2021cites this paper
• The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ

  2020cites this paper
• Correlation of homocysteine and lipid profile parameters with ischemic heart disease

  2020cites this paper
• Exploring Mechanisms of Persistent Cognitive Deficits in Mice with Transient Hyperhomocysteinemia

  2019cites this paper
• Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion

  2019cites this paper
• Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

  2018cites this paper
• Genetic Diversity, Epigenetic Reprogramming and Environmental Factors: Leading Directions in the Study of the Complex Human Diseases

  2017cites this paper
• Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury

  2017cites this paper
• Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population

  2017cites this paper
• Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID).

  2016cites this paper
• Supplementation with Watermelon Extract Reduces Total Cholesterol and LDL Cholesterol in Adults with Dyslipidemia under the Influence of the MTHFR C677T Polymorphism

  2016cites this paper
• Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

  2016cites this paper
• Adipose tissue-liver axis in alcoholic liver disease.

  2016cites this paper
• Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

  2015influential citation
• Adipose Tissue Dysfunction and Alcoholic Liver Disease

  2015cites this paper
• MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.

  2015cites this paper
• La programmation foetale de la carence en donneurs de méthyles entraîne une stéato-hépatite chez les rats soumis à un régime hyper-énergétique au cours de la vie adulte

  2015cites this paper
• Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.

  2013cites this paper
• Etude des mécanismes contribuant aux effets des variations de l'apport en précurseurs de méthyles sur le protéome cardiaque

  2012cites this paper
• Combined methylmalonic acidemia and homocystinuria, cblC type. II. Complications, pathophysiology, and outcomes

  2012cites this paper
• Effets sur le métabolisme énergétique mitochondrial myocardique et hépatique de la carence en donneurs de méthyles au cours de la gestation et de l'allaitement chez le raton

  2012cites this paper
• Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10.

  2012cites this paper
• Association Between Polymorphisms in MTHFR and APOA5 and Metabolic Syndrome in the Greek Population

  2011cites this paper
• O Papel dos Polimorfismos Genéticos na Doença Cardíaca Isquémica.

  2011cites this paper
• Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

  2011cites this paper
• Genetics Primer for the General Cardiologist Epigenetic Modifications Basic Mechanisms and Role in Cardiovascular Disease

  2011cites this paper
• Determinants of Hyperhomocysteinemia After Gastric Bypass Surgery in Obese Subjects

  2011cites this paper
• Experimental models of vascular dementia and vascular cognitive impairment: a systematic review

  2010cites this paper
• Hiperhomocisteinemia. Panorama actual y contribución del ratón a su estudio

  2010cites this paper