MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neuroscience

• Publication date

  2015-08-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuroscience.2015.04.067PMID 25956258
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  2000cited by this paper
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  1998cited by this paper
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