Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Histochemistry and Cell Biology

• Publication date

  2001-08-17

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/s004180100317PMID 11685557
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
• Albuminuria in patients with type 1 diabetes is directly linked to changes in the lysosome-mediated degradation of albumin during renal passage.

  2000cited by this paper
• Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.

  2000cited by this paper
• Megalin knockout mice as an animal model of low molecular weight proteinuria.

  1999cited by this paper
• Initial Ultrastructural Changes in Pore Size and Anionic Sites of the Glomerular Basement Membrane in Streptozotocin-Induced Diabetic Rats and Their Prevention by Insulin Treatment

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  1999cited by this paper
• Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions.

  1999cited by this paper
• Ultrastructural and functional changes of the proximal tubular epithelial cells in the renal cortex from spontaneously diabetic KKAy mice.

  1999cited by this paper
• Megalin-mediated endocytosis in renal proximal tubule.

  1998cited by this paper
• Monoclonal antibody P-31 recognizes a novel intermediate filament-associated protein (p250) in rat podocytes.

  1998cited by this paper
• Predictors of Renal Morphological Changes in the Early Stage of Microalbuminuria in Adolescents With IDDM

  1997cited by this paper
• Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney.

  1997influential reference
• Megalin/gp330 mediates uptake of albumin in renal proximal tubule.

  1996cited by this paper
• Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney.

  1994cited by this paper
• Tubular cell protein degradation in early diabetic renal hypertrophy.

  1994cited by this paper
• Glomerular filtration and tubular reabsorption of albumin in preproteinuric and proteinuric diabetic rats.

  1993cited by this paper
• Correlation between MitochondriaI Enlargement in RenaI Proximal Tubules and Microalbuminuria in Rats with Early Streptozotocin‐induced Diabetes

  1992cited by this paper
• Mitochondrial Enlargement and Basement Membrane Thickening of Renal Proximal Tubules, Possible Initiators of Microalbuminuria in Non‐Insulin‐Dependent Diabetics (NIDDM)

  1992cited by this paper
• Correlation between mitochondrial enlargement in renal proximal tubules and microalbuminuria in rats with early streptozotocin-induced diabetes.

  1992cited by this paper
• Renal hypertrophy in streptozotocin diabetic rats: role of proteolytic lysosomal enzymes.

  1992cited by this paper
• Intrarenal handling of proteins in rats using fractional micropuncture technique.

  1992cited by this paper
• Lipid peroxidation in isolated rat nephron segments.

  1992cited by this paper
• Urinary excretion of glycated albumin in insulin-dependent diabetic patients with micro- and macroalbuminuria.

  1992cited by this paper
• Glycation of Albumin, Not Glomerular Basement Membrane, Alters Permeability in an In Vitro Model

  1992cited by this paper
• Effects of Manidipine Hydrochloride on the Renal Microcirculation in Spontaneously Hypertensive Rats

  1992cited by this paper
• Pathophysiology of proteinuria in diabetic glomerular disease

  1990cited by this paper
• Urinary excretion of brush-border antigen and plasma proteins in early stages of diabetic nephropathy.

  1990influential reference
• Effects of very mild versus overt diabetes on vascular haemodynamics and barrier function in rats

  1989cited by this paper
• Renal tubular proteinuria and microalbuminuria in diabetic patients.

  1989influential reference
• Effect of glycation of albumin on its renal clearance in normal and diabetic rats.

  1988cited by this paper
• Glomerular size and charge selectivity in insulin-dependent diabetes mellitus.

  1988influential reference
• Electrical charge of serum and urinary albumin in normal and diabetic humans.

  1985cited by this paper
• Tubular lesions in streptozotocin-diabetic rats

  1984cited by this paper
• Glomerular permeability to neutral and anionic dextrans in experimental diabetes.

  1982cited by this paper
• Glomerular selective permeability to macromolecular neutral dextrans in experimental diabetes

  1981cited by this paper

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• Association of high vibration perception threshold with reduced renal function in patients with type 2 diabetes

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• Renal handling of albumin in rats with early stage diabetes: A theoretical analysis

  2024cites this paper
• AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and dedifferentiation induced by lipotoxicity

  2024cites this paper
• The angiotensin II/type 1 angiotensin II receptor pathway is implicated in the dysfunction of albumin endocytosis in renal proximal tubule epithelial cells induced by high glucose levels.

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• Emerging roles of proximal tubular endocytosis in renal fibrosis

  2023cites this paper
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• Inhibition of SGLT2 co-transporter by dapagliflozin ameliorates tubular proteinuria and tubule-interstitial injury at the early stage of diabetic kidney disease.

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• N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine.

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• Megalin and Vitamin D Metabolism—Implications in Non-Renal Tissues and Kidney Disease

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  2022cites this paper
• Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes.

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• Surface megalin expression is a target to the inhibitory effect of bradykinin on the renal albumin endocytosis.

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  2020cites this paper
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  2017cites this paper
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• Mechanism of increased clearance of glycated albumin by proximal tubule cells.

  2016cites this paper
• Transforming growth factor-β1 and diabetic nephropathy.

  2016cites this paper
• Tubular Mechanisms in Proteinuria

  2016cites this paper
• The impact of acute kidney injury in diabetes mellitus

  2016influential citation
• Megalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease.

  2016cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
• Proteinuria and progression of glomerular diseases

  2013cites this paper
• Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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