Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Clinical Cancer Research

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-13-3229PMID 26133775PMCID PMC4494107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Myc induced replicative stress response: How to cope with it and exploit it.

  2015cited by this paper
• PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

  2015cited by this paper
• Improving the efficacy of chemoradiation with targeted agents.

  2014cited by this paper
• A Novel ATM Kinase Inhibitor Effectively Radiosensitizes Glioblastoma in Mice

  2014cited by this paper
• DNA single-strand break repair.

  2014cited by this paper
• A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

  2014influential reference
• Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

  2014cited by this paper
• Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer

  2014cited by this paper
• DNA DSB repair pathway choice: an orchestrated handover mechanism.

  2014influential reference
• ATM signalling and cancer

  2014cited by this paper
• DNA-Damage Foci to Detect and Characterize DNA Repair Alterations in Children Treated for Pediatric Malignancies

  2014cited by this paper
• ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency.

  2014cited by this paper
• Functional Ex Vivo Assay to Select Homologous Recombination–Deficient Breast Tumors for PARP Inhibitor Treatment

  2014cited by this paper
• From breaking bad to worse: exploiting homologous DNA repair deficiency in cancer.

  2014cited by this paper
• RPA inhibition increases replication stress and suppresses tumor growth.

  2014cited by this paper
• Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.

  2014cited by this paper
• Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM-Defective Tumors

  2013cited by this paper
• ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation

  2013cited by this paper
• DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy

  2013cited by this paper
• Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.

  2013cited by this paper
• Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

  2013cited by this paper
• Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

  2013cited by this paper
• Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

  2012cited by this paper
• Radiation therapy to convert the tumor into an in situ vaccine.

  2012cited by this paper
• Functional, Genetic, and Epigenetic Aspects of Base and Nucleotide Excision Repair in Colorectal Carcinomas

  2012cited by this paper
• RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells

  2012influential reference
• Synthetic Lethal Interactions between EGFR and PARP Inhibition in Human Triple Negative Breast Cancer Cells

  2012cited by this paper
• Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation

  2012cited by this paper
• An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression.

  2012cited by this paper
• PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition.

  2012cited by this paper
• The role of homologous recombination in radiation-induced double-strand break repair.

  2011cited by this paper
• Targeting hypoxia in cancer therapy

  2011cited by this paper
• Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft

  2011cited by this paper
• Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1

  2011cited by this paper
• Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

  2011cited by this paper
• MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-Defective Human Tumor Cells

  2011cited by this paper
• Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

  2011cited by this paper
• Factors determining DNA double‐strand break repair pathway choice in G2 phase

  2011cited by this paper
• ATR: a master conductor of cellular responses to DNA replication stress.

  2011cited by this paper
• Novel Irreversible Small Molecule Inhibitors of Replication Protein A Display Single-Agent Activity and Synergize with Cisplatin

  2011cited by this paper
• Abstract 2657: Radiosensitization of pancreatic cancer cells by combined inhibition of Chk1 and PARP1 using AZD7762 and olaparib

  2011cited by this paper
• In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762

  2010cited by this paper
• Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets.

  2010cited by this paper
• Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.

  2010cited by this paper
• Membrane receptor signaling and control of DNA repair after exposure to ionizing radiation Membranrezeptorsignale und Kontrolle der DNA-Reparatur nach ionisierender Strahlung

  2010cited by this paper
• Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair

  2010cited by this paper
• The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

  2010cited by this paper
• Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

  2010cited by this paper
• Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.

  2010cited by this paper
• DNA Repair and Cell Cycle Regulation After Ionizing Irradiation

  2009cited by this paper
• Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

  2009cited by this paper
• Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies

  2009cited by this paper
• Exploring the role of cancer stem cells in radioresistance

  2008cited by this paper
• The Mre11 Complex Mediates the S-Phase Checkpoint through an Interaction with Replication Protein A

  2007cited by this paper
• A Stronger DNA Damage-Induced G2 Checkpoint Due to Over-Activated CHK1 in the Absence of PARP-1

  2006cited by this paper
• Is There a Link Between DNA Polymerase Beta and Cancer?

  2004cited by this paper
• Cell-cycle checkpoints and cancer

  2004cited by this paper
• EGFR Autocrine Signaling in a Compliant Interstitial Space: Mechanotransduction from the Outside In

  2004cited by this paper
• The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

  2002cited by this paper

• TrpC5 silencing reduces cell invasion and migration and enhances radiosensitivity in papillary thyroid carcinoma cells.

  2026cites this paper
• ZIP10 drives radioresistance and malignant progression in lung adenocarcinoma by inhibiting the Hippo pathway via a Zinc-LATS axis.

  2026cites this paper
• Theranostic and Radionuclide-based Treatment Approaches for Radioiodine-refractory Thyroid Cancer: From Biology to Clinical Application.

  2026cites this paper
• Functional Profiling of DNA Repair Pathways in Lung Cancer Patients Uncovers Radiotherapy-Induced and Cancer-Associated Alterations in Oxidative Lesion Repair.

  2026cites this paper
• Naringin Mitigates Synergistic Brain Aging Model Induced by D‐Galactose and Gamma Radiation via Targeting Oxidative Stress, Inflammation and Senescence

  2026cites this paper
• Orthogonally targeted tumor radiosensitization using cell penetrating peptide-ATM inhibitor conjugates to stimulate anti-tumor immune responses

  2026cites this paper
• [Mechanistic research progress on radiotherapy resistance of cancer stem cells].

  2025cites this paper
• ROBO1 enhanced esophageal carcinoma cell radioresistance through accelerating G3BP2-mediated eIF3A degradation

  2025cites this paper
• AMP-activated protein kinase mediates adaptation of glioblastoma cells to conditions of the tumor microenvironment

  2025cites this paper
• Combined MEK and PARP inhibition enhances radiation response in rectal cancer

  2025cites this paper
• Glutathione-associated redox regulation alleviates radio-resistance of canine cancer stem-like cells with low proteasome activity

  2025cites this paper
• Overcoming Radioresistance in Prostate Cancer by Targeting DNA Damage Repair.

  2025cites this paper
• Ultrasmall Gold Nanoparticles Boost Radiotherapy and Protect against Radiation Damage

  2025cites this paper
• Double minutes: exploring the formation and oncogenic roles in cancer progression

  2025cites this paper
• Our Experience and Literature Update Regarding Concomitant Radiotherapy with CDK4/6 Inhibitors and Hormonal Therapy in Metastatic Breast Cancer

  2025cites this paper
• Milciclib-mediated CDK2 inhibition to boost radiotherapy sensitivity in colorectal cancer

  2025cites this paper
• Co-delivery of CO/H2 gases for synergistic radiosensitization and intestinal protection in peritoneal metastases therapy.

  2025cites this paper
• Cancer Immunotherapy in Combination with Radiotherapy and/or Chemotherapy: Mechanisms and Clinical Therapy

  2025cites this paper
• Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells

  2025cites this paper
• Dual‐Functional Hafnium Oxide Nanoplatform Combining High‐Z Radiosensitization With Bcl‐2 Gene Silencing for Enhanced Cancer Radiotherapy

  2025cites this paper
• miRISC inhibition causes mitotic defects and synergizes with genotoxic agents in cancers

  2025cites this paper
• DNA repair and the contribution to chemotherapy resistance

  2025cites this paper
• A Metformin-Based Multifunctional Nanoplatform as a DNA Damage Amplifier for Maximized Radio-Immunotherapy to Overcome Radiotherapy Resistance.

  2025cites this paper
• Circular SNX25 encoded radioresistance augmenter facilitates DNA damage repair in hepatocellular carcinoma by targeting BAG6-GET4 interaction

  2025cites this paper
• Comparative analysis of melatonin’s protective role against flattening filter and flattening filter-free X-ray induced nephropathy: focus on apoptosis and SIRT1 modulation

  2025cites this paper
• Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer

  2025cites this paper
• Concurrent Amplification of Ferroptosis and Immune System Activation Via Nanomedicine‐Mediated Radiosensitization for Triple‐Negative Breast Cancer Therapy

  2024cites this paper
• Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres

  2024cites this paper
• Melanoma Cells from Different Patients Differ in Their Sensitivity to Alpha Radiation-Mediated Killing, Sensitivity Which Correlates with Cell Nuclei Area and Double Strand Breaks

  2024cites this paper
• Global Proteomics Indicates Subcellular-Specific Anti-Ferroptotic Responses to Ionizing Radiation

  2024cites this paper
• ATR inhibition increases reliance on PARP-mediated DNA repair revealing an improved therapeutic strategy for cervical cancer.

  2024cites this paper
• An unmet need for pharmacology: Treatments for radiation-induced gastrointestinal mucositis.

  2024cites this paper
• Targeting DNA damage repair mechanism by using RAD50-silencing siRNA nanoparticles to enhance radiotherapy in triple negative breast cancer

  2024influential citation
• BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

  2024cites this paper
• Innovative insights: ITLN1 modulates renal injury in response to radiation.

  2024cites this paper
• Integrating evolutionarily conserved mechanism of response to radiation for exploring novel Caenorhabditis elegans radiation-responsive genes for estimation of radiation dose associated with spaceflight.

  2024cites this paper
• Epigenetics as a determinant of radiation response in cancer.

  2024cites this paper
• Mechanisms and therapeutic target of anti-tumour treatment-related Ferroptosis: How to improve cancer therapy?

  2024cites this paper
• Transcription factor NF-E2-related factor 2 plays a critical role in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) by regulating ferroptosis

  2024cites this paper
• Design and synthesis of new nicotinamide derivatives generated via Suzuki Miyaura coupling as potential anticancer hits targeting pancreatic cancer cell line MIA PaCa-2

  2024cites this paper
• PTEN Depletion Increases Radiosensitivity in Response to Ataxia Telangiectasia-Related-3 (ATR) Inhibition in Non-Small Cell Lung Cancer (NSCLC)

  2024cites this paper
• Growth hormone and radiation therapy: friend, foe, or both?

  2024cites this paper
• A Multistep In Silico Approach Identifies Potential Glioblastoma Drug Candidates via Inclusive Molecular Targeting of Glioblastoma Stem Cells

  2024cites this paper
• Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

  2024cites this paper
• Aqueous Extracts of Ocimum gratissimum Sensitize Hepatocellular Carcinoma Cells to Cisplatin through BRCA1 Inhibition

  2024cites this paper
• Severe Combined Immunodeficiency from a Homozygous DNA Ligase 1 Mutant with Reduced Catalytic Activity but Increased Ligation Fidelity

  2024cites this paper
• Targets for improving prostate tumor response to radiotherapy.

  2024cites this paper
• A Nucleophilicity‐Engineered DNA Ligation Blockade Nanoradiosensitizer Induces Irreversible DNA Damage to Overcome Cancer Radioresistance

  2024cites this paper
• Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide

  2023cites this paper
• Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization

  2023cites this paper
• Synergistic lethality between auranofin-induced oxidative DNA damage and ATR inhibition in cancer cells.

  2023cites this paper
• Low-dose radiation-induced cell death in doxorubicin-sensitive leukemic K562 and resistant leukemic K562/Dox cancer cells associated with ferroptosis induction

  2023cites this paper
• The AEG-1-USP10-PARP1 axis confers radioresistance in esophageal squamous cell carcinoma via facilitating homologous recombination-dependent DNA damage repair.

  2023cites this paper
• Pathogenesis and therapy of radiation enteritis with gut microbiota

  2023cites this paper
• Evaluation of BMP-2 as a differentiating and radiosensitizing agent for colorectal cancer stem cells.

  2023cites this paper
• The role of lipid metabolism in cancer radioresistance

  2023cites this paper
• Renal Clearable BiOI Nanodots with M1 Macrophage Membrane Coating for Enhanced Radiotherapy of Hepatocellular Carcinoma

  2023cites this paper
• Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews

  2023cites this paper
• Low‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives

  2023cites this paper
• Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance

  2023cites this paper
• Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death

  2023cites this paper
• Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate

  2023cites this paper
• Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

  2023cites this paper
• Detecting significantly recurrent genomic connections from simple and complex rearrangements in the cancer genome

  2023cites this paper
• Current Application of Nanoparticle Drug Delivery Systems to the Treatment of Anaplastic Thyroid Carcinomas

  2023cites this paper
• Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

  2023cites this paper
• Cellular Responses to Widespread DNA Replication Stress

  2023cites this paper
• Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells

  2023cites this paper
• Targeting phosphomevalonate kinase enhances radiosensitivity via ubiquitination of the replication protein A1 in lung cancer cells

  2023cites this paper
• MOLECULAR MECHANISMS UNDERLYING CANCER CELL RADIORESISTANCE

  2022cites this paper
• Radiotherapy transiently reduces the sensitivity of cancer cells to lymphocyte cytotoxicity

  2022cites this paper
• Role of autophagy in tumor response to radiation: Implications for improving radiotherapy

  2022cites this paper
• Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells

  2022cites this paper
• Stem Cells: Therapeutic implications in chemotherapy and radiotherapy resistance in Cancer Therapy.

  2022cites this paper
• Knockdown of Annexin A2 Enhances Radiosensitivity by Increasing G2/M-Phase Arrest, Apoptosis and Activating the p38 MAPK-HSP27 Pathway in Nasopharyngeal Carcinoma

  2022cites this paper
• Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)

  2022cites this paper
• The State of Preclinical Modeling for Early Phase Cancer Trials Using Molecularly Targeted Agents with Radiation

  2022cites this paper
• Pixantrone confers radiosensitization in KRAS mutated cancer cells by suppression of radiation-induced prosurvival pathways.

  2022cites this paper
• Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer

  2022cites this paper
• The role and mechanism of long non‐coding RNAs in homologous recombination repair of radiation‐induced DNA damage

  2022cites this paper
• Aspirin Restores Radiosensitivity in Cervical Cancer Cells by Inducing Mitotic Catastrophe through Downregulating G2/M Effectors

  2022cites this paper
• Epigenetic regulation of radioresistance: insights from preclinical and clinical studies

  2022cites this paper
• Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons

  2022cites this paper
• Mechanisms of radioresistance and the underlying signaling pathways in colorectal cancer cells

  2022influential citation
• ATAD2 suppression enhances the combinatorial effect of gemcitabine and radiation in pancreatic cancer cells.

  2022cites this paper
• Radiotherapy-induced metabolic hallmarks in the tumor microenvironment.

  2022cites this paper
• Resveratrol Enhances the Radiosensitivity by Inducing DNA Damage and Antitumor Immunity in a Glioblastoma Rat Model under 3 T MRI Monitoring

  2022cites this paper
• Targeted Therapy of HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy between CDK4/6, PI3K and Sometimes FGFR Inhibitors, but Rarely between PARP and WEE1 Inhibitors

  2022cites this paper
• Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer

  2022cites this paper
• Inhibition of NADPH Oxidase-ROS Signal using Hyaluronic Acid Nanoparticles for Overcoming Radioresistance in Cancer Therapy.

  2022cites this paper
• The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance

  2022cites this paper
• Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer

  2022cites this paper
• Advances in the study of HSP70 inhibitors to enhance the sensitivity of tumor cells to radiotherapy

  2022cites this paper
• ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

  2022cites this paper
• The radiosensitizing effect of β-Thujaplicin, a tropolone derivative inducing S-phase cell cycle arrest, in head and neck squamous cell carcinoma-derived cell lines

  2022cites this paper
• Sappanone A Aggrandises Ionising Radiation-induced Damage in Oral Epithelial Cells.

  2022cites this paper
• Decitabine Sensitizes the Radioresistant Lung Adenocarcinoma to Pemetrexed Through Upregulation of Folate Receptor Alpha

  2021cites this paper
• The role of p53/p21/p16 in DNA damage signaling and DNA repair

  2021cites this paper
• ceRNA Networks: The Backbone Role in Neoadjuvant Chemoradiotherapy Resistance/Sensitivity of Locally Advanced Rectal Cancer

  2021cites this paper
• Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms

  2021cites this paper