Brain concentrations of tricyclic antidepressants: Single-dose kinetics and relationship to plasma concentrations in chronically dosed rats

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Psychopharmacology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1007/BF00470582PMID 6815692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Concentrations of amitriptyline and its metabolites in urine, blood and tissue in fatal amitriptyline poisoning.

  2009cited by this paper
• Fatal amitriptytine poisoning. Determination of the drug in forensic-chemical material.

  2009cited by this paper
• Suicid mit Opipramol (Insidon®)

  2004cited by this paper
• A liquid chromatographic method for quantitating amitriptyline in brain tissue

  2004cited by this paper
• Clinical and biochemical results of a fatal case of desipramine intoxication

  2004cited by this paper
• Role of the central adrenergic system in mediating amitriptyline-induced alteration in the mammalian blood-brain barrier in vivo.

  1982cited by this paper
• Poisoning with tricyclic antidepressant drugs.

  1977cited by this paper
• Amitriptyline plasma levels and therapeutic response

  1976cited by this paper
• Irreversible protein binding of 14C-imipramine in rats in vivo

  1976cited by this paper
• Poisoning by tricyclic antidepressant drugs: general and pharmacokinetic considerations.

  1975cited by this paper
• Correlation between desipramine levels and (—)‐noradrenaline uptake and chronotropic effect in isolated atria of rats

  1973cited by this paper
• Use of specific gravity in the measurement of cerebral edema.

  1971cited by this paper
• Species differences in the plasma protein binding of desipramine

  1968cited by this paper
• [Suicide with opipramol (Insidon)].

  1967cited by this paper
• A Fatal Case of Poisoning with Amitriptyline

  1963cited by this paper

• Association between Plasma Metabolic Profiles of the Antidepressant Escitalopram and Clinical Response in Subjects with Depression

  2023cites this paper
• G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression

  2023cites this paper
• Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment

  2023cites this paper
• Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII

  2023cites this paper
• Suivi thérapeutique pharmacologique des antidépresseurs imipraminiques

  2023cites this paper
• G protein-biased LPAR1 agonism promotes prototypic antidepressant effects

  2022cites this paper
• How an Understanding of the Function of the Locus Coeruleus Led to Use of Dexmedetomidine to Treat Agitation in Bipolar Disorder: Example of Rational Development of Psychiatric Medications

  2022cites this paper
• KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism

  2022cites this paper
• Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling of Diazepam: Unbound Interstitial Brain Concentrations Correspond to Clinical End Points

  2022cites this paper
• Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging

  2021cites this paper
• Therapeutic Drug Monitoring in Neuropsychiatric Disorders

  2019cites this paper
• Antidepressant amitriptyline‐induced matrix metalloproteinase‐9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line‐derived neurotrophic factor mRNA expression in rat astroglial cells

  2019cites this paper
• Is There a Role of Autophagy in Depression and Antidepressant Action?

  2019cites this paper
• Supratherapeutic Psychotropic Drug Levels in the Emergency Department and Their Association with Delirium Duration: A Preliminary Study

  2019cites this paper
• A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy

  2018cites this paper
• Tricyclic Antidepressants Modulate Stressed Mitochondria in Glioblastoma Multiforme Cells

  2018cites this paper
• Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017

  2018cites this paper
• Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017

  2017cites this paper
• LPA1 Mediates Antidepressant-Induced ERK1/2 Signaling and Protection from Oxidative Stress in Glial Cells

  2016cites this paper
• Measuring citalopram in blood and central nervous system: revealing a distribution pattern that differs from other antidepressants

  2016cites this paper
• The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells.

  2016cites this paper
• Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.

  2016cites this paper
• Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants*

  2016cites this paper
• Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal‐regulated kinase‐dependent early growth response 1 production in rat primary cultured astrocytes

  2015cites this paper
• Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gαi/o Activation in Astroglial Cells*

  2015cites this paper
• Tricyclic antidepressants and mecamylamine bind to different sites in the human α 4 β 2 nicotinic receptor ion channel

  2015cites this paper
• Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.

  2015cites this paper
• Amitriptyline up‐regulates connexin43‐gap junction in rat cultured cortical astrocytes via activation of the p38 and c‐Fos/AP‐1 signalling pathway

  2014cites this paper
• Time-dependent effects of hydrophobic amine-containing drugs on lysosome structure and biogenesis in cultured human fibroblasts.

  2014cites this paper
• AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011.

  2014cites this paper
• Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study.

  2014cites this paper
• Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons

  2013cites this paper
• An Open Source Based High Content Screening Method for Cell Biology Laboratories Investigating Cell Spreading and Adhesion

  2013cites this paper
• Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds.

  2013cites this paper
• The value of drug and metabolite concentration in blood as a biomarker of psychopharmacological therapy

  2013cites this paper
• Early Improvement and Serum Concentrations of Citalopram to Predict Antidepressant Drug Response of Patients with Major Depression

  2013cites this paper
• Effects of gender and age on serum concentrations of antidepressants under naturalistic conditions

  2013cites this paper
• Effects of gender and age on serum concentrations of antidepressants under naturalistic conditions

  2013cites this paper
• Therapeutic drug monitoring for antidepressant drug treatment.

  2012cites this paper
• Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

  2012cites this paper
• Neuropsychopharmaka verändern den intrazellulären pH-Wert von zentralen Neuronen

  2011cites this paper
• Therapeutic Drug Monitoring for Drugs Used in the Treatment of Substance-Related Disorders: Literature Review Using a Therapeutic Drug Monitoring Appropriateness Rating Scale

  2011cites this paper
• AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

  2011cites this paper
• idade d ade de C to de Bi

  2011cites this paper
• The Antidepressant Desipramine Is an Arrestin-biased Ligand at the α2A-Adrenergic Receptor Driving Receptor Down-regulation in Vitro and in Vivo*

  2011cites this paper
• Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

  2011cites this paper
• Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters

  2011cites this paper
• The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors.

  2010cites this paper
• Different interaction between tricyclic antidepressants and mecamylamine with the human alpha3beta4 nicotinic acetylcholine receptor ion channel.

  2010cites this paper
• Direct Agonist Activity of Tricyclic Antidepressants at Distinct Opioid Receptor Subtypes

  2010cites this paper
• Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel.

  2010cites this paper
• Modulatory effects of neuropsychopharmaca on intracellular pH of hippocampal neurones in vitro

  2010influential citation
• Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration

  2010cites this paper
• Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after acute intraperitoneal injection in mice

  2010cites this paper
• Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.

  2009cites this paper
• Therapeutisches Drug Monitoring bei antidepressiver Pharmakotherapie

  2009cites this paper
• Clomipramine and Glucocorticoid Receptor Function

  2009cites this paper
• Reply: ‘Clomipramine and Glucocorticoid Receptor Function’

  2009cites this paper
• Amitriptyline inhibits the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes

  2009cites this paper
• „Therapeutic drug monitoring“ in Epileptologie und Psychiatrie

  2008cites this paper
• Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?

  2008cites this paper
• Drugs and brain death diagnostics: determination of drugs capable of inducing EEG zero line

  2008cites this paper
• Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors.

  2007cites this paper
• The Antidepressant Desipramine Requires the ABCB1 (Mdr1)-Type p-Glycoprotein to Upregulate the Glucocorticoid Receptor in Mice

  2007influential citation
• Inhibition of Astroglial Inwardly Rectifying Kir4.1 Channels by a Tricyclic Antidepressant, Nortriptyline

  2007cites this paper
• Anti-inflammatory properties of desipramine and fluoxetine

  2007cites this paper
• "Therapeutic drug monitoring" in Epileptologie und Psychiatrie

  2007cites this paper
• Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells

  2007influential citation
• Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor.

  2006cites this paper
• Facilitation of spontaneous glutamate release by antidepressant drugs in rat locus coeruleus.

  2005cites this paper
• General Principles of Pharmacokinetics

  2004cites this paper
• Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by Various Antidepressant Drugs

  2004cites this paper
• Cerebral and blood pharmacokinetics of imipramine and its active metabolites in the pregnant rat

  2004cites this paper
• Therapeutic Drug Monitoringof TncyclicAntidepressants

  2004cites this paper
• Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies

  2004cites this paper
• Regulation of the Human Corticotropin-Releasing-Hormone Gene Promoter Activity by Antidepressant Drugs in Neuro-2A and AtT-20 Cells

  2004influential citation
• Ethanol effects on brain concentrations of amitriptyline and the relationship to psychomotor function

  2004cites this paper
• Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters

  2003cites this paper
• Predictors of Therapeutic Effects in Amitriptyline Treatment

  2003cites this paper
• Antidepressants Differentially Influence the Transcriptional Activity of the Glucocorticoid Receptor in vitro

  2003cites this paper
• The Antidepressant Clomipramine Regulates Cortisol Intracellular Concentrations and Glucocorticoid Receptor Expression in Fibroblasts and Rat Primary Neurones

  2003cites this paper
• Differential blockade of neuronal voltage-gated Na(+) and K(+) channels by antidepressant drugs.

  2002cites this paper
• Psychopharmaka: Pharmakogenetik und Therapeutisches Drug-Monitoring/Psychoactive Drugs: Pharmacogenetics and Therapeutic Drug Monitoring

  2002cites this paper
• Therapeutisches Drug Monitoring unter dem Aspekt des Qualitätsmanagements

  2002cites this paper
• Modulation by cationic amphiphilic drugs of serine base-exchange, phosholipase d and intracellular calcium homeostasis in glioma C6 cells.

  2002cites this paper
• Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters

  2001cites this paper
• Pharmacogenetics: a new diagnostic tool in the management of antidepressive drug therapy.

  2001cites this paper
• Antidepressant drugs inhibit glucocorticoid receptor‐mediated gene transcription – a possible mechanism

  2000cites this paper
• Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.

  2000cites this paper
• Therapeutic drug monitoring of antidepressants: cost implications and relevance to clinical practice.

  1999cites this paper
• Acute application of the tricyclic antidepressant desipramine presynaptically stimulates the exocytosis of glutamate in the hippocampus.

  1999cites this paper
• Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs?

  1995cites this paper
• Imipramine stimulates phospholipase C activity in rat brain.

  1994cites this paper
• Human brain fluoxetine concentrations.

  1993cites this paper
• Therapeutic drug monitoring. Principles and practice.

  1993cites this paper
• Amitriptyline inhibits neurite outgrowth in chick cerebral neurons: a possible mechanism.

  1993cites this paper
• Cyclobenzaprine-induced delirium in two octogenarians.

  1993cites this paper
• High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent. Application in mice.

  1992cites this paper
• Amitriptyline‐Mediated Inhibition of Neurite Outgrowth from Chick Embryonic Cerebral Explants Involves a Reduction in Adenylate Cyclase Activity

  1991cites this paper
• Therapeutic drug monitoring for antidepressants: efficacy, safety, and cost effectiveness.

  1991cites this paper