Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity

Mitchell R. Dyer,William E Plautz,M. Ragni,Wyeth Alexander,Shannon Haldeman,J. Sperry,F. Guyette,B. Zuckerbraun,M. Rollins-Raval,J. Raval,M. Neal

Published 2020 in Transfusion

ABSTRACT

Increases in plasma von Willebrand Factor (VWF) levels, accompanied by decreases in the metalloprotease ADAMTS13, have been demonstrated soon after traumatic injury while downstream effects remain unclear.

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