Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of the American Medical Association (JAMA)

• Publication date

  2015-02-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1001/jama.2015.12PMID 25647203PMCID PMC4374744
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Surgical Research

  2017cited by this paper
• Detailed description of all deaths in both the shock and traumatic brain injury hypertonic saline trials of the Resuscitation Outcomes Consortium.

  2015cited by this paper
• Changing patterns of in-hospital deaths following implementation of damage control resuscitation practices in US forward military treatment facilities

  2015cited by this paper
• Increasing Trauma Deaths in the United States

  2014cited by this paper
• How I treat patients with massive hemorrhage.

  2014cited by this paper
• Changing patterns of in-hospital deaths following implementation of damage control resuscitation practices in US forward military treatment facilities.

  2014cited by this paper
• Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial: design, rationale and implementation.

  2014cited by this paper
• Temporal trends of postinjury multiple-organ failure: Still resource intensive, morbid, and lethal

  2014cited by this paper
• Management of bleeding and coagulopathy following major trauma: an updated European guideline

  2013cited by this paper
• Resuscitate early with plasma and platelets or balance blood products gradually: Findings from the PROMMTT study

  2013cited by this paper
• An emergency department thawed plasma protocol for severely injured patients.

  2013cited by this paper
• STILL RESOURCE-INTENSIVE , MORBID AND LETHAL

  2013cited by this paper
• 1:1:1 – Warranted or wasteful? Even where appropriate, high ratio transfusion protocols are costly: early transition to individualized care benefits patients and transfusion services

  2013cited by this paper
• Application of the Berlin definition in PROMMTT patients: The impact of resuscitation on the incidence of hypoxemia

  2013cited by this paper
• Seven deadly sins in trauma outcomes research: An epidemiologic post mortem for major causes of bias

  2013cited by this paper
• Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results–guided transfusion in patients with severe trauma: a randomized feasibility trial

  2013cited by this paper
• Redefining massive transfusion when every second counts

  2013cited by this paper
• Low hemorrhage‐related mortality in trauma patients in a Level I trauma center employing transfusion packages and early thromboelastography‐directed hemostatic resuscitation with plasma and platelets

  2013cited by this paper
• Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding: A Randomized, Plasma-Controlled, Phase IIIb Study

  2013cited by this paper
• Optimal trauma resuscitation with plasma as the primary resuscitative fluid: the surgeon's perspective.

  2013cited by this paper
• The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.

  2013cited by this paper
• Transfusion strategies and development of acute respiratory distress syndrome in combat casualty care

  2013cited by this paper
• Changes in massive transfusion over time: An early shift in the right direction?

  2012cited by this paper
• Prevalence of Survivor Bias in Observational Studies on Fresh Frozen Plasma: Erythrocyte Ratios in Trauma Requiring Massive Transfusion

  2012cited by this paper
• Challenges to Effective Research in Acute Trauma Resuscitation: Consent and Endpoints

  2011cited by this paper
• Damage Control Resuscitation Is Associated With a Reduction in Resuscitation Volumes and Improvement in Survival in 390 Damage Control Laparotomy Patients

  2011cited by this paper
• Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States

  2011cited by this paper
• Effect of Blood Products Transfusion on the Development of Postinjury Multiple Organ Failure

  2011cited by this paper
• Clinical review: Canadian National Advisory Committee on Blood and Blood Products - Massive Transfusion Consensus Conference 2011: report of the panel

  2011cited by this paper
• Increased platelet:RBC ratios are associated with improved survival after massive transfusion.

  2011cited by this paper
• Out-of-hospital Hypertonic Resuscitation After Traumatic Hypovolemic Shock: A Randomized, Placebo Controlled Trial

  2011cited by this paper
• Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage.

  2010cited by this paper
• Evidence‐based practice guidelines for plasma transfusion

  2010cited by this paper
• Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients

  2010cited by this paper
• Effect of blood products transfusion on the development of postinjury multiple organ failure.

  2010cited by this paper
• Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial.

  2009cited by this paper
• The relationship of blood product ratio to mortality: survival benefit or survival bias?

  2009cited by this paper
• Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)?

  2009cited by this paper
• Scientific and logistical challenges in designing the CONTROL trial: recombinant factor VIIa in severe trauma patients with refractory bleeding

  2009cited by this paper
• Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.

  2009cited by this paper
• An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients.

  2009cited by this paper
• Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: a before and after study

  2008cited by this paper
• Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

  2008cited by this paper
• An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.

  2008cited by this paper
• Review of current blood transfusions strategies in a mature level I trauma center: were we wrong for the last 60 years?

  2008cited by this paper
• Early Aggressive Use of Fresh Frozen Plasma Does Not Improve Outcome in Critically Injured Trauma Patients

  2008cited by this paper
• Damage control resuscitation: directly addressing the early coagulopathy of trauma.

  2007cited by this paper
• Massive blood transfusion and outcome in 1062 polytrauma patients: a prospective study based on the Trauma Registry of the German Trauma Society

  2007cited by this paper
• The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.

  2007cited by this paper
• Practice Guidelines for Perioperative Blood Transfusion and Adjuvant Therapies: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies

  2006cited by this paper
• Practice guidelines for perioperative blood transfusion and adjuvant therapies: An updated report by the American Society of Anesthesiologists Task Force on perioperative blood transfusion and adjuvant therapies

  2006cited by this paper
• Are we giving enough coagulation factors during major trauma resuscitation?

  2005cited by this paper
• Regulatory perspectives on clinical trials for trauma, transfusion, and hemostasis

  2005cited by this paper
• Survival Analysis: Techniques for Censored and Truncated Data

  2004cited by this paper
• A graphical sensitivity analysis for clinical trials with non‐ignorable missing binary outcome

  2002cited by this paper
• Death in the operating room: an analysis of a multi-center experience.

  1995cited by this paper
• Death in the operating room : an analysis of a multi-center experience

  1994cited by this paper
• Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non-zero risk difference or non-unity relative risk.

  1990cited by this paper
• The appropriateness of analysis of variance and multiple-comparison procedures.

  1983cited by this paper
• The appropriateness of analysis of variance and multiple-comparison procedures.

  1983cited by this paper
• A multiple testing procedure for clinical trials.

  1979cited by this paper
• The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.

  1974cited by this paper
• On the combination of independent two-sample tests of wilcoxon : Corrected version

  1959cited by this paper

• Outcomes in austere trauma care: An analysis of patients transferred from scene compared to inter-hospital transfers.

  2026cites this paper
• Human Factors in Trauma Resuscitation (People, Environment, Communication & Professionalism); A Narrative Review

  2026cites this paper
• Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study

  2026cites this paper
• Hemostatic resuscitation: blood product replacement during cesarean delivery.

  2026cites this paper
• Pro-Con Debate: Formulaic Approach Using Fixed Ratios of Blood Components Versus Targeted Therapy Approach Guided By Viscoelastic Hemostatic Assays for Resuscitation in Traumatic Major Hemorrhage.

  2026cites this paper
• Analysis of RHD variant alleles in serologically D-negative Thai patients: Prevalence and novel discoveries.

  2026cites this paper
• Post Traumatic Acute Respiratory Distress Syndrome in the Emergency and Critical Care Units of the Douala General Hospital Cameroon

  2026cites this paper
• ALM Resuscitation Without Transfusion Improves Platelet Function and Survival After Liver Injury and Uncontrolled Hemorrhage

  2026cites this paper
• Platelet function in major trauma: A 5-day trajectory analysis by injury pattern.

  2026cites this paper
• Narrative review of strategies for blood product shelf-life extension.

  2026cites this paper
• The evolving landscape of platelet therapy: risks, innovations, and clinical judgment

  2026cites this paper
• Management of Acute Hemorrhage and Damage-Control Resuscitation: Critical Care Concepts for Vascular Interventional Radiologists

  2026cites this paper
• Resuscitating children in hemorrhagic shock: Lessons learned from combat.

  2026cites this paper
• Stratifying Early Risk of Death From Hemorrhage in the Era of Whole Blood.

  2026cites this paper
• Prehospital blood transfusion coalition core competencies for emergency medical services personnel

  2026cites this paper
• Hemostatic resuscitation in patients with trauma-induced coagulopathy: a narrative review

  2026cites this paper
• Real-time, artificial intelligence-guided intraoperative resuscitation and fluid management in trauma anesthesia.

  2026cites this paper
• Who Needs Most? Multicenter Subanalysis of Blood Transfusion Profiles in the German Patient Blood Management Network Registry

  2026cites this paper
• Early transfusion strategies in haemorrhagic shock

  2026cites this paper
• Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma.

  2026cites this paper
• Rethinking the hemorrhagic shock chain of survival: The role, importance, and impact of prehospital blood administration.

  2026cites this paper
• Unique Pattern of Coagulopathy Among Patients With Severe Traumatic Brain Injury: A Principal Component Analysis of Hemorrhagic Shock Trials.

  2026cites this paper
• Emergency scenarios simulations in the obstetrics maternity ward-“training together, treating together”

  2026cites this paper
• Tactical transfusion-Importance and logistics of integrating prehospital blood in tactical EMS operations.

  2026cites this paper
• Fluid and Transfusion Strategies in Obstetric Hemorrhage: An Evidence-Based Review

  2026cites this paper
• FFP:RBC Ratio, Surgery Category, and 30-Day Survival in Intraoperative MT Meeting Concurrent Volume and Rate Criteria: An Exploratory Study

  2026cites this paper
• Microvesicles in stored human whole blood increase thrombin generation via phosphatidylserine.

  2026cites this paper
• End-tidal carbon dioxide monitoring to predict hypovolaemic shock and the subsequent need for blood transfusions in adult pre-hospital trauma patients: a systematic review

  2026cites this paper
• Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma.

  2026cites this paper
• Nationwide pediatric prehospital blood product use after motor vehicle crashes 2020-2023.

  2026cites this paper
• Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model

  2026cites this paper
• What Would Mother Say? Whole Blood and RhD Alloimmunization in Trauma Resuscitation.

  2026cites this paper
• Does damage control surgery for abdominal trauma have a real impact on survival benefit in major trauma patients? A systematic review of literature with meta-analysis

  2025cites this paper
• Prioritizing circulation over airway in trauma patients with exsanguinating injuries: What you need to know

  2025cites this paper
• Timing of trauma deaths due to uncontrolled bleeding have not changed in three decades: A multicenter study of patients in hemorrhagic shock.

  2025cites this paper
• Improving the Compliance of Massive Hemorrhage Protocols Through Education Is Associated with Patient Survival

  2025cites this paper
• Myter og fakta om plasmatransfusjon

  2025cites this paper
• Nonoperative management of liver and spleen injuries in pediatric trauma patients

  2025cites this paper
• Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations

  2025cites this paper
• Comparison of machine learning and human prediction to identify trauma patients in need of hemorrhage control resuscitation (ShockMatrix study): a prospective observational study

  2025cites this paper
• The Transfusion Timing of Plasma and Red Blood Cells in a 1 : 1 Ratio Is Related with Survival and Functional Outcomes in Multiple Trauma Patients with Severe Traumatic Brain Injury

  2025cites this paper
• Intent Vs Execution: Failure To Achieve Balanced Resuscitation In Bleeding Trauma Patients.

  2025cites this paper
• Prioritizing circulation over airway to improve survival in trauma patients with exsanguinating injuries: a world society of emergency surgery-panamerican trauma consensus statement

  2025cites this paper
• Is Whole Blood Really Better?

  2025cites this paper
• Comment on Jeon et al. Predictive Limitations of the Geriatric Trauma Outcome Score: A Retrospective Analysis of Mortality in Elderly Patients with Multiple Traumas and Severe Traumatic Brain Injury. Diagnostics 2025, 15, 586

  2025cites this paper
• Attenuated interferon-γ following injury is associated with chronic critical illness.

  2025cites this paper
• Evidence Based Reviews in Surgery: a critical appraisal of whole blood resuscitation in injured patients

  2025cites this paper
• Normotensive trauma patients with renal injuries: Hidden candidates for massive transfusion

  2025cites this paper
• Perioperative Blood Management

  2025cites this paper
• Principles and Practice in Pediatric Vascular Trauma: Part 1: Scope of Problem, Team Structure, Multidisciplinary Dynamics, and Solutions.

  2025cites this paper
• From bedside to data and back to bedside: why do we need better data to perform trauma phenotyping and improve trauma care?

  2025cites this paper
• A national analysis of whole blood versus component therapy in pediatric trauma resuscitations.

  2025cites this paper
• Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury.

  2025cites this paper
• Trauma-Induced Coagulopathy: A Review of Specific Molecular Mechanisms

  2025cites this paper
• Change in resuscitation influenced development and severity of inflammatory complications in severely injured

  2025cites this paper
• Inhospital coagulation management and fluid replacement therapy in patients with multiple and/or severe injuries – a systematic review and clinical practice guideline update

  2025influential citation
• Resuscitating massive transfusion knowledge: An update for the pharmacist.

  2025cites this paper
• Whole blood use in patients with traumatic brain injury and hemorrhagic shock is not associated with decreased mortality.

  2025cites this paper
• Mise au point sur la stratégie transfusionnelle en préhospitalier chez les polytraumatisés

  2025cites this paper
• How do we improve massive transfusion protocol adherence among anesthesia providers?

  2025cites this paper
• Does the 1:1:1 Transfusion Ratio Mortality Benefit Hold True in Ultra-massive Transfusion? A Study From the Product (Patient Related Outcomes During Ultra-massive transfusion multi-Center Trial) Consortium

  2025cites this paper
• Factors affecting critical care outcomes in the emergency department.

  2025cites this paper
• Transfusion ratios and survival in severe blunt trauma patients receiving massive transfusion

  2025cites this paper
• Can heroic roadside care save lives?

  2025cites this paper
• Blood transfusion strategies for major bleeding in trauma.

  2025cites this paper
• Rotem Guided Bleeding Management

  2025cites this paper
• [Explanation and interpretation of blood transfusion provisions for critically ill and severely bleeding pediatric patients in the national health standard "Guideline for pediatric transfusion"].

  2025cites this paper
• Prehospital whole blood use in civilian trauma care: A review of current evidence and practices.

  2025cites this paper
• The role of factor V in trauma-induced coagulopathy: an observational and experimental study

  2025cites this paper
• Is Mechanism a Biological Variable?: A Secondary Analysis of the PROPPR Trial

  2025cites this paper
• Potential military applications for a new freeze‐dried plasma

  2025cites this paper
• Comparative analysis of cold‐stored platelets using Golden Hour transport boxes: Function and quality

  2025cites this paper
• From shortages to solutions: Liquid plasma as a practical alternative to whole blood for prehospital trauma resuscitation

  2025cites this paper
• Initial management of patients with burns and combined injuries for acute care surgeons: What you need to know.

  2025cites this paper
• A narrative review: Resuscitation of older adults with hemorrhagic shock

  2025cites this paper
• Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH: comment.

  2025cites this paper
• Comparison of fluid resuscitation strategies in hemorrhagic shock: Crystalloid vs Blood products

  2025influential citation
• Nationwide trends in prehospital blood product use after injury 2020–2023

  2025cites this paper
• Rethinking Platelet and Plasma Transfusion Strategies for Neonates: Evidence, Guidelines, and Unanswered Questions

  2025cites this paper
• Whole Blood Requirements in Civilian Trauma Resuscitation: Implications for Blood Inventory Program.

  2025cites this paper
• Nationwide estimates of potential lives saved with prehospital blood transfusions

  2025cites this paper
• Emulating Target Trials to Study Perioperative and Critical Care Interventions with Observational Data: Promise and Limitations

  2025cites this paper
• Rethinking Balanced Resuscitation in Trauma

  2025cites this paper
• Analysis of time to death for children with life‐threatening hemorrhage from traumatic, surgical, and medical etiologies

  2025cites this paper
• Prehospital Trauma Compendium: Transfusion of Blood Products in Trauma - A position statement and resource document of NAEMSP.

  2025cites this paper
• A full response chain surge capacity test of a small rural hospital, prehospital resources and collaborating organisations

  2025cites this paper
• Massive transfusion policy in the Netherlands, a nationwide survey

  2025cites this paper
• State of the Evidence for Prehospital Plasma Infusion for Patients With Suspected Traumatic Hemorrhage: A Rapid Review by the Prehospital Evidence-Based Practice Program.

  2025cites this paper
• Pragmatic O-Positive Whole-blood RandoMizaTion in male trauma Patients (POWeR-MTP)

  2025cites this paper
• A Sprayable Hydrogel Based on Biomimetic Polypeptide‐Modified Lipid Nanoparticles for Treating Non‐Compressible Hemorrhaging

  2025cites this paper
• Blood Product Utilization in Thromboelastography-Aided Transfusion in Gastrointestinal Bleeding: A Single-Center Experience

  2025cites this paper
• Trauma Pneumonectomy: Has Survival Improved Over Two Decades?

  2025cites this paper
• Evidence-Based Perioperative Management of Placenta Accreta Spectrum Disorder

  2025influential citation
• Dried blood products: Current and potential uses in trauma

  2025cites this paper
• Assessing the need for blood transfusion in patients with haemorrhage transported by air ambulance in Northern Ontario.

  2025cites this paper
• Acute traumatic coagulopathy: what you should know, what is debated and what should come next.

  2025cites this paper
• Association between whole blood versus balanced component therapy and survival in isolated severe traumatic brain injury

  2025cites this paper
• Blood product administration in the prehospital setting: a multisociety consensus statement

  2025cites this paper
• A Retrospective Study of Ultramassive Transfusion in Trauma Patients: Is There a Value After Which Additional Transfusions Are Futile?

  2025cites this paper
• Understanding metabolic remodeling in shock through metabolomics lenses.

  2025cites this paper