Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease

Curcumin is a spice derived nutraceutical which gained tremendous attention because of its profound medicinal values. It alters a number of molecular pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF‐κB), signal transducer and activator of transcription 3 (STAT3), nuclear factor erythroid 2-related factor 2 (Nrf2) and cyclooxygenases-2 (COX‐2), which make it potential therapeutic choice in treating multiple disorders. It also possesses the potential to prevent protein aggregation and thus protect against degeneration of neurons in neurodegenerative disorders including Huntington’s disease (HD). HD is an autosomal dominant disorder linked with altered gene expression which leads to an increase in the size of cytosine, adenine and guanine (CAG) trinucleotide repeats, aids in protein aggregation throughout the brain and thus damages neurons. Upstream regulation of oxidative stress and inflammatory cascade are two important factors that drive HD progression. Available therapies just suppress the severity of symptoms with a number of side effects. Curcumin targets multiple mechanisms in treating or preventing HD including antioxidant and anti-inflammatory potential, metal ion chelation, transcriptional alterations and upregulating activity of molecular chaperons, heat shock proteins (HSPs). Having a favorable safety profile, curcumin can be an alternative therapeutic choice in treating neurodegenerative disorders like HD. This review will focus on mechanistic aspects of curcumin in treating or preventing HD and its potential to arrest disease progression and will open new dimensions for safe and effective therapeutic agents in diminishing HD.

• Publication year

  2020

• Venue

  Current Neuropharmacology

• Publication date

  2020-05-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.2174/1570159X18666200522201123PMID 32442088PMCID 8686321
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recent advances in the therapeutic development for Huntington disease.

  2019cited by this paper
• The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies.

  2019influential reference
• A role for autophagy in Huntington's disease.

  2019cited by this paper
• An active cognitive lifestyle as a potential neuroprotective factor in Huntington's disease

  2019cited by this paper
• Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.

  2019cited by this paper
• Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review

  2019cited by this paper
• Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

  2019influential reference
• Assessing the Antioxidant Properties of Larrea tridentata Extract as a Potential Molecular Therapy against Oxidative Stress

  2018cited by this paper
• Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases.

  2018cited by this paper
• Activation of Heat Shock Protein Induced by Curcumin to Prevent Huntington Disease- an Analytical Approach in the Context of Protein Vibration

  2018cited by this paper
• Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.

  2018cited by this paper
• Biological and clinical manifestations of juvenile Huntington's disease: a retrospective analysis.

  2018cited by this paper
• A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

  2018cited by this paper
• Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing

  2018cited by this paper
• Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation

  2018cited by this paper
• Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

  2018cited by this paper
• Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

  2018cited by this paper
• Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42

  2017cited by this paper
• Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

  2017cited by this paper
• Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

  2017cited by this paper
• Epidemiology of Huntington disease.

  2017cited by this paper
• High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation

  2017influential reference
• Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats

  2016cited by this paper
• Curcumin modulates cell death and is protective in Huntington’s disease model

  2016cited by this paper
• Huntington disease: a single-gene degenerative disorder of the striatum

  2016influential reference
• Neurodegenerative diseases: From available treatments to prospective herbal therapy.

  2016cited by this paper
• The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review

  2016cited by this paper
• The global prevalence of Huntington's disease: a systematic review and discussion.

  2016cited by this paper
• The Prevalence of Huntington's Disease

  2016cited by this paper
• Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

  2015cited by this paper
• Huntington’s Disease: Relationship Between Phenotype and Genotype

  2015cited by this paper
• Metal complexes of curcumin--synthetic strategies, structures and medicinal applications.

  2015cited by this paper
• Potential anticancer properties and mechanisms of action of curcumin.

  2015cited by this paper
• Curcumin Increases HSP70 Expression in Primary Rat Cortical Neuronal Apoptosis Induced by gp120 V3 Loop Peptide

  2015influential reference
• Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism

  2015influential reference
• Curcumin Nanoparticles Attenuate Neurochemical and Neurobehavioral Deficits in Experimental Model of Huntington’s Disease

  2014cited by this paper
• Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression

  2014cited by this paper
• Curcumin, a component of golden spice: from bedside to bench and back.

  2014cited by this paper
• Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.

  2014influential reference
• Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway.

  2014influential reference
• Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

  2014cited by this paper
• Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

  2014influential reference
• Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

  2014cited by this paper
• Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats.

  2014influential reference
• RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.

  2013influential reference
• Expanded Polyglutamine-containing N-terminal Huntingtin Fragments Are Entirely Degraded by Mammalian Proteasomes*

  2013cited by this paper
• Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

  2013cited by this paper
• Dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibition.

  2013cited by this paper
• Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice

  2013influential reference
• Curcumin and neurodegenerative diseases

  2013cited by this paper
• PAK in Alzheimer disease, Huntington disease and X-linked mental retardation

  2012cited by this paper
• Antioxidant and antibacterial activities of oleoresins isolated from nine Curcuma species

  2012cited by this paper
• Curcumin Prevents Formation of Polyglutamine Aggregates by Inhibiting Vps36, a Component of the ESCRT-II Complex

  2012influential reference
• Curcumin and neurodegenerative diseases: a perspective

  2012cited by this paper
• Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.

  2012cited by this paper
• Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

  2012cited by this paper
• Gambogic acid, a natural product inhibitor of Hsp90.

  2011cited by this paper
• Neuroprotective actions of flavonoids.

  2011cited by this paper
• The targets of curcumin.

  2011cited by this paper
• Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo.

  2011cited by this paper
• Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction.

  2010cited by this paper
• Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders.

  2010cited by this paper
• Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death

  2010cited by this paper
• Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism.

  2010influential reference
• Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry.

  2010cited by this paper
• Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

  2009cited by this paper
• Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties.

  2009cited by this paper
• Antioxidant and iron-binding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate.

  2008cited by this paper
• Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

  2008cited by this paper
• ROCK, PAK, and Toll of synapses in Alzheimer's disease.

  2008cited by this paper
• Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.

  2007cited by this paper
• Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response

  2007cited by this paper
• Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity.

  2007cited by this paper
• Neuroprotective effects of curcumin.

  2007cited by this paper
• Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.

  2007cited by this paper
• Curry consumption and cognitive function in the elderly.

  2006cited by this paper
• Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.

  2006cited by this paper
• Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract

  2006cited by this paper
• Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

  2006cited by this paper
• Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid.

  2005cited by this paper
• The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice.

  2004cited by this paper
• Evaluation of the nitric oxide radical scavenging activity of manganese complexes of curcumin and its derivative.

  2004influential reference
• Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

  2004cited by this paper
• Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases

  2004cited by this paper
• Calpain Is a Major Cell Death Effector in Selective Striatal Degeneration Induced In Vivo by 3-Nitropropionate: Implications for Huntington's Disease

  2003cited by this paper
• Chaperones increase association of tau protein with microtubules

  2003cited by this paper
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

  2002cited by this paper
• Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology.

  2001cited by this paper
• Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.

  2001cited by this paper
• The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

  2001cited by this paper
• Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.

  2001cited by this paper
• Loss of normal huntingtin function: new developments in Huntington's disease research.

  2001cited by this paper
• Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease.

  2000cited by this paper
• Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.

  2000cited by this paper
• Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

  2000cited by this paper
• Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat.

  2000cited by this paper
• [Population genetic study of Huntington's disease--prevalence and founder's effect in the San-in area, western Japan].

  1999cited by this paper
• Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA

  1998cited by this paper
• The prevalence of Huntington's disease

  1990cited by this paper

• Nose to Brain Delivery of Curcumin Loaded Therapeutic Nanostructures for Neurodegenerative Diseases.

  2026cites this paper
• Nano-conjugation of small molecule modulators of protein aggregation: Enhancing the therapeutic precision.

  2025cites this paper
• Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways

  2025cites this paper
• The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

  2025cites this paper
• Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders

  2025cites this paper
• Lipid-based nanostructures in targeted management of neurological disorders: a comprehensive review.

  2025cites this paper
• Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics

  2025cites this paper
• Pharmacology of natural bioactive compounds used for management of Huntington Diseases: An overview

  2024cites this paper
• Unraveling mitochondrial dysfunction: comprehensive perspectives on its impact on neurodegenerative diseases

  2024cites this paper
• Neuroprotective Effects of Curcumin in Neurodegenerative Diseases

  2024cites this paper
• Investigating Holistic Natural Strategies for The Management of Huntington's Disease

  2024cites this paper
• Curcumin protects mice with myasthenia gravis by regulating the gut microbiota, short-chain fatty acids, and the Th17/Treg balance

  2024cites this paper
• A review of traditional Chinese medicine Curcumae Rhizoma for treatment of glioma.

  2023cites this paper
• Multiple mechanisms of curcumin targeting spinal cord injury.

  2023cites this paper
• Non-Enzymatic Antioxidants against Alzheimer’s Disease: Prevention, Diagnosis and Therapy

  2023cites this paper
• Potential roles and molecular mechanisms of bioactive ingredients in Curcumae Rhizoma against breast cancer.

  2023cites this paper
• The Emerging Role of Curcumin in Inducing Neuronal Trans-differentiation of Mesenchymal Stem Cells: a Review

  2023cites this paper
• Antiradical and Antioxidant Activity of Compounds Containing 1,3-Dicarbonyl Moiety: An Overview

  2023cites this paper
• Nrf2 as a Potential Therapeutic Target for Treatment of Huntington’s Disease

  2023cites this paper
• Recent progress and applications of small molecule inhibitors of Keap1-Nrf2 axis for neurodegenerative diseases.

  2023cites this paper
• Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives.

  2023cites this paper
• Neuroprotective effect of curcumin against experimental autoimmune encephalomyelitis-induced cognitive and physical impairments in mice: an insight into the role of the AMPK/SIRT1 pathway

  2023cites this paper
• Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

  2023cites this paper
• Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

  2022cites this paper
• Nrf2 Pathway in Huntington’s Disease (HD): What Is Its Role?

  2022cites this paper
• Mitochondria in Huntington’s disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies

  2022cites this paper
• Role of Nrf2 in Aging, Alzheimer's and Other Neurodegenerative Diseases.

  2022cites this paper
• Curcumin Interacts with α-Synuclein Condensates To Inhibit Amyloid Aggregation under Phase Separation

  2022cites this paper
• Effect of Curcumin on Oral Lichen Planus: A Single Blind Randomized Controlled Clinical Trial

  2022cites this paper
• Curcumin as a Holistic Treatment for Tau Pathology

  2022cites this paper
• Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease

  2022cites this paper
• The pharmacological basis of the curcumin nutraceutical uses: an update

  2021cites this paper
• Curcumin–cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects

  2021cites this paper
• Epigenetic regulation by polyphenols in diabetes and related complications

  2020cites this paper