Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson’s Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Molecular Neurobiology

• Publication date

  2020-05-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12035-020-01940-3PMID 32458386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.

  2020cited by this paper
• Parkinson's disease: From bench to bedside.

  2020cited by this paper
• Classic animal models of Parkinson's disease: a historical perspective.

  2019cited by this paper
• Neuroregeneration in Parkinson’s Disease: From Proteins to Small Molecules

  2019cited by this paper
• Chrysin protects against behavioral, cognitive and neurochemical alterations in a 6-hydroxydopamine model of Parkinson's disease.

  2019cited by this paper
• Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer's disease, Parkinson's disease.

  2019cited by this paper
• Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

  2019cited by this paper
• Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins.

  2018cited by this paper
• Cellular phenotypes as inflammatory mediators in Parkinson's disease: Interventional targets and role of natural products.

  2018cited by this paper
• Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.

  2018cited by this paper
• Depression and Anxiety in Parkinson’s Disease

  2018cited by this paper
• The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model.

  2017cited by this paper
• El modelo de 6-hidroxidopamina y la fisiopatología parkinsoniana: nuevos hallazgos en un viejo modelo

  2017cited by this paper
• Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson’s Disease-Lessons from Transgenic Mice

  2016cited by this paper
• Naringin treatment induces neuroprotective effects in a mouse model of Parkinson's disease in vivo, but not enough to restore the lesioned dopaminergic system.

  2016cited by this paper
• Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity.

  2016cited by this paper
• Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy

  2016cited by this paper
• ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress.

  2016cited by this paper
• Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

  2016cited by this paper
• Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

  2015cited by this paper
• Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

  2015cited by this paper
• Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.

  2015cited by this paper
• Parkinson's disease

  2015cited by this paper
• Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

  2015cited by this paper
• Modulation of neurotrophic signaling pathways by polyphenols

  2015cited by this paper
• Tyrosine hydroxylase expression and activity in nigrostriatal dopaminergic neurons of MPTP-treated mice at the presymptomatic and symptomatic stages of parkinsonism.

  2014cited by this paper
• Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels.

  2014cited by this paper
• Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice.

  2014cited by this paper
• Knocking Out DJ-1 Attenuates Astrocytes Neuroprotection Against 6-Hydroxydopamine Toxicity

  2013cited by this paper
• Therapeutic prospects for Parkinson disease

  2013cited by this paper
• Animal models of Parkinson’s disease

  2012cited by this paper
• Neuroinflammation in Parkinson's disease.

  2012cited by this paper
• Systemic administration of neuregulin‐1β1 protects dopaminergic neurons in a mouse model of Parkinson’s disease

  2011cited by this paper
• Factors associated with depression in Parkinson's disease.

  2011cited by this paper
• Repairing the parkinsonian brain with neurotrophic factors.

  2011cited by this paper
• Parkinson's disease: genetics and pathogenesis.

  2011cited by this paper
• The impact of non‐motor symptoms on health‐related quality of life of patients with Parkinson's disease

  2011cited by this paper
• Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?

  2010cited by this paper
• Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction

  2010cited by this paper
• Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine.

  2010cited by this paper
• Parkinson's disease (vol 373, pg 2055, 2009)

  2009cited by this paper
• Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment.

  2009cited by this paper
• What is Parkinson's disease?

  2006cited by this paper
• Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population

  2006cited by this paper
• Light/dark cycle manipulation influences mice behaviour in the elevated plus maze.

  2006cited by this paper
• Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

  2005cited by this paper
• Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol.

  2005cited by this paper
• Neuroinflammation: a potential therapeutic target

  2005cited by this paper
• Design-based stereology in neuroscience.

  2005cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.

  2003cited by this paper
• The smooth fractionator

  2002cited by this paper
• Chemistry and pharmacology of the citrus bioflavonoid hesperidin

  2001cited by this paper
• Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor.

  2000cited by this paper
• Increased Survival of Dopaminergic Neurons in Striatal Grafts of Fetal Ventral Mesencephalic Cells Exposed to Neurotrophin-3 or Glial Cell Line-Derived Neurotrophic Factor

  2000cited by this paper
• Tyrosine hydroxylase and Parkinson's disease

  1998cited by this paper
• Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: A stereological study using the cavalieri and optical disector methods

  1996cited by this paper
• 6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death.

  1995cited by this paper
• Biochemistry of Parkinson's disease with special reference to the dopaminergic systems

  1994cited by this paper
• Anhedonia in Schizophrenic, Depressed, or Alcohol-Dependent Patients - Neurobiological Correlates

  1994cited by this paper
• Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

  1994cited by this paper
• The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

  1988cited by this paper
• Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.

  1985cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.

  1971cited by this paper
• 6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

  1968cited by this paper

• Neurofilament light chain protein exposure contributes to protein aggregation, microgliosis, astrogliosis and neuroinflammation via p38/MK2/NF-κB/CREB1/Nrf2/HO-1 signalling leading to Parkinson's disease.

  2026cites this paper
• Non-motor Symptom Replication in Neurotoxic Mouse Models of Parkinson’s Disease: A Review and Guide

  2026cites this paper
• Circadian feeding promotion by Ninjin’yoeito counteracts frailty in aged mice

  2026cites this paper
• Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways, therapeutic targets, and translational insights.

  2026cites this paper
• Hesperidin reverses behavioral deficits and neurochemical disruptions in a single prolonged stress-induced PTSD rat model: targeting monoaminergic and GABAergic systems

  2025cites this paper
• The regulatory mechanisms of active ingredients in traditional Chinese medicine for inflammation in Parkinson disease: A review

  2025cites this paper
• Potential new drug sources for the treatment of Parkinson’s disease: flavonoid O-glycosides

  2025cites this paper
• Neuroactive Phytochemicals as Multi-Target Modulators of Mental Health and Cognitive Function: An Integrative Review

  2025cites this paper
• Further characterisation of the intrastriatal 6-OHDA Parkinson's disease model with non-motor symptom replication and widespread catecholamine dysfunction in male mice.

  2025cites this paper
• Understanding the Pre-Clinical Stages of Parkinson’s Disease: Where Are We in Clinical and Research Settings?

  2025cites this paper
• The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways

  2025cites this paper
• Investigation of neuroprotective effects of newly synthesized benzimidazolium salt against neurotoxicity in differentiated SH-SY5Y neuronal cells.

  2025cites this paper
• An updated and comprehensive review of the health benefits and pharmacological activities of hesperidin.

  2025cites this paper
• Hesperidin in Chronic Fatigue Syndrome: An Integrated Analysis of Traditional Pharmacology and Machine Learning–Based Therapeutic Predictions

  2025cites this paper
• Comparison of ultrasound-assisted extraction and modified QuEChERS technique for extraction of hesperidin from lemon peel (Citrus limon L.) as determined by HPLC

  2025cites this paper
• Multidimensional mechanisms of anxiety and depression in Parkinson's Disease: integrating neuroimaging, neurocircuits, and molecular pathways.

  2025cites this paper
• Leveraging animal models to understand non-motor symptoms of Parkinson's disease.

  2025cites this paper
• A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters

  2025cites this paper
• Integrated UHPLC-Q-TOF-MS Technology and Network Pharmacology Exploring the Pharmacodynamic Material Basis and Mechanism of Zhi-Zi-Hou-Po Granule for Treatment of Depression-Anxiety Comorbidity.

  2025cites this paper
• A classic traditional chinese medicine formula for depression: mechanistic insights from phytochemical constituents and multitarget pathways.

  2025cites this paper
• Harnessing hesperidin for brain metabolism: epigenetic signatures, cellular homeostasis, synaptic function, and neuroprotection in age-related diseases and neurodegenerative diseases

  2025cites this paper
• Phytomedicine Nanoformulations for Parkinson's disease

  2024cites this paper
• Behavioral effects of 6-hydroxydopamine-induced damage to nigro-striatal pathway and Locus coeruleus as a rodent model of Parkinson's disease.

  2024cites this paper
• Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro‐inflammatory functions after traumatic brain injury

  2024cites this paper
• Antioxidant responses driven by Hesperetin and Hesperidin Counteract Parkinson's Disease-like Phenotypes in Drosophila melanogaster.

  2024cites this paper
• Recent understanding of the mechanisms of the biological activities of hesperidin and hesperetin and their therapeutic effects on diseases

  2024cites this paper
• The avBNSTGABA-VTA and avBNSTGABA-DRN pathways are respectively involved in the regulation of anxiety-like behaviors in parkinsonian rats.

  2024cites this paper
• Lateral habenula 5-HT1B receptors are involved in regulation of anxiety-like behaviors in parkinsonian rats.

  2024cites this paper
• Experimental Parkinson Models and Green Chemistry Approach.

  2024cites this paper
• Hesperidin Mikroemülsiyonunun Bazı Standart (ATCC) Gram Negatif Bakterilere Karşı Antimikrobiyal Etkinliğinin Tespiti

  2024cites this paper
• Intranasal AdipoRon Mitigated Anxiety and Depression-Like Behaviors in 6-OHDA-Induced Parkinson ’s Disease Rat Model: Going Beyond Motor Symptoms

  2024influential citation
• Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease

  2024cites this paper
• Role of different oils and cooking materials on chemical compounds and antioxidant properties of garlic

  2024cites this paper
• The Impact of Hesperidin on Cognitive Deficit and Neurobehavioural Disorders: A Systematic Review and Meta-Analysis of Preclinical Individual Studies

  2024cites this paper
• Therapeutics Effects of the Genus Citrus in Anxiety Disorder

  2024cites this paper
• Inhibition of neuroinflammation by GIBH-130 (AD-16) reduces neurodegeneration, motor deficits, and proinflammatory cytokines in a hemiparkinsonian model

  2024cites this paper
• Luteolin Exhibits Anxiolytic and Antidepressant Potential in Parkinson’s Disease Rat: Antioxidant and Anti-Inflammatory Effects

  2024cites this paper
• Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model

  2023cites this paper
• Neuroprotective Potential of Hesperidin as Therapeutic Agent in the Treatment of Brain Disorders: Preclinical Evidence-based Review.

  2023cites this paper
• Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action

  2023influential citation
• The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect.

  2023cites this paper
• Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies

  2023cites this paper
• The α1 and γ2 subunit-containing GABAA receptor-mediated inhibitory transmission in the anteroventral bed nucleus of stria terminalis is involved in the regulation of anxiety in rats with substantia nigra lesions.

  2023cites this paper
• Hesperidin plays beneficial roles in disorders associated with the central nervous system: a review

  2023cites this paper
• Pomegranate (Punica granatum L.) and its phytochemicals as anxiolytic; an underreported effect with therapeutic potential: a systematic review.

  2023cites this paper
• Polyphenols as novel interventions for depression: exploring the efficacy, mechanisms of action, and implications for future research.

  2023cites this paper
• Mood disturbances in Parkinson's disease: From prodromal origins to application of animal models.

  2023cites this paper
• Hesperidin: A Potential Therapeutic agent against COVID-19.

  2022cites this paper
• Chrysin supplementation mitigated neurobehavioral changes in a animal model of Parkinson’s disease: Influence on TH+ neurons

  2022cites this paper
• Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression.

  2022cites this paper
• The potential applications of traditional Chinese medicine in Parkinson's disease: A new opportunity.

  2022cites this paper
• Improvement of non-motor and motor behavioral alterations associated with Parkinson-like disease in Drosophila melanogaster: comparative effects of treatments with hesperidin and L-dopa.

  2022cites this paper
• The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-Induced Parkinson's Disease in Zebrafish: The Current Applications and Perspectives.

  2022cites this paper
• Changes in the Neuronal Architecture of the Hippocampus in a 6-Hydroxydopamine-Lesioned Rat Model of Parkinson Disease

  2022cites this paper
• TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice.

  2021cites this paper
• The density of calretinin striatal interneurons is decreased in 6-OHDA-lesioned mice

  2021cites this paper
• Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease

  2021cites this paper
• Citrus Polyphenols in Brain Health and Disease: Current Perspectives

  2021influential citation
• Reappraisal of Dietary Phytochemicals for Coronavirus Infection: Focus on Hesperidin and Quercetin

  2021cites this paper
• Potential of an aqueous extract of Lippia multiflora Moldenke (Verbenaceae) in the treatment of anxiety disorders: Possible involvement of serotoninergic transmission

  2021cites this paper
• Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

  2021cites this paper
• Neuropsychiatric and Cognitive Deficits in Parkinson’s Disease and Their Modeling in Rodents

  2021cites this paper
• Compound Dihuang Granule Protects against 6-OHDA Induced Toxicity in Parkinson’s Disease Rats by Suppressing the Phosphorylation of MAPK/ERK1/2

  2021cites this paper
• Compound Dihuang Granule Attenuates the Da Neuron Loss and Motor Deficits in 6-OHDA  Induced Parkinson’s Disease Rats

  2020cites this paper
• World Journal of Psychiatry

  year unknowncites this paper