Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Chemico-Biological Interactions

• Publication date

  2018-01-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.cbi.2017.10.019PMID 29054324
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model.

  2017cited by this paper
• Supplementation with Herbal Extracts to Promote Behavioral and Neuroprotective Effects in Experimental Models of Parkinson's Disease: A Systematic Review

  2017cited by this paper
• Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.

  2017cited by this paper
• Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.

  2017cited by this paper
• Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair

  2017cited by this paper
• D‐Ala2‐GIP‐glu‐PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

  2017cited by this paper
• Effects of L‐DOPA/benserazide co‐treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration

  2017cited by this paper
• Involvement of BDNF/TrkB signaling in the effect of diphenyl diselenide on motor function in a Parkinson's disease rat model

  2017cited by this paper
• Plant flavonoids in cancer chemoprevention: role in genome stability.

  2017cited by this paper
• Differential pattern of motor impairments in neurotoxic, environmental and inflammation-driven rat models of Parkinson's disease.

  2016cited by this paper
• Chrysin promotes attenuation of depressive-like behavior and hippocampal dysfunction resulting from olfactory bulbectomy in mice.

  2016cited by this paper
• Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

  2016cited by this paper
• Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies.

  2016cited by this paper
• Neuroprotective and Therapeutic Strategies against Parkinson’s Disease: Recent Perspectives

  2016cited by this paper
• Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

  2016cited by this paper
• Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence.

  2016cited by this paper
• Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson’s Disease

  2016cited by this paper
• Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.

  2016cited by this paper
• Neurochemical factors associated with the antidepressant-like effect of flavonoid chrysin in chronically stressed mice.

  2016cited by this paper
• Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

  2016cited by this paper
• Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin.

  2015cited by this paper
• Advances in Neurotrophic Factor and Cell-Based Therapies for Parkinson's Disease: A Mini-Review

  2015cited by this paper
• Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain.

  2015cited by this paper
• The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease.

  2015cited by this paper
• Oxidative stress and Parkinson's disease: New hopes in treatment with herbal antioxidants.

  2015cited by this paper
• Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

  2015cited by this paper
• Overnight S100B in Parkinson's Disease: A glimpse into sleep-related neuroinflammation.

  2015cited by this paper
• Neuroprotective effects of chrysin: From chemistry to medicine.

  2015cited by this paper
• CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice.

  2014cited by this paper
• Neurogenesis in the striatum of the adult human brain.

  2014cited by this paper
• Cerebrospinal fluid inflammatory markers in Parkinson's disease--associations with depression, fatigue, and cognitive impairment.

  2013cited by this paper
• The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

  2013cited by this paper
• Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

  2013cited by this paper
• Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats.

  2012cited by this paper
• Animal models of Parkinson’s disease

  2012cited by this paper
• Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease.

  2012cited by this paper
• IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

  2012cited by this paper
• Protective effect of chrysin on carbon tetrachloride (CCl4)—induced tissue injury in male Wistar rats

  2011cited by this paper
• IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

  2011cited by this paper
• Tyrosine hydroxylase and regulation of dopamine synthesis.

  2011cited by this paper
• Systemic administration of neuregulin‐1β1 protects dopaminergic neurons in a mouse model of Parkinson’s disease

  2011cited by this paper
• Hepatoprotective effect of chrysin on prooxidant‐antioxidant status during ethanol‐induced toxicity in female albino rats

  2009cited by this paper
• Evaluation of Estrogen Neuroprotective Effect on Nigrostriatal Dopaminergic Neurons Following 6-Hydroxydopamine Injection into the Substantia Nigra Pars Compacta or the Medial Forebrain Bundle

  2008cited by this paper
• Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism.

  2008cited by this paper
• Design-based stereology in neuroscience.

  2005cited by this paper
• Organization of midbrain dopamine systems and the pathophysiology of Parkinson's disease.

  2003cited by this paper
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• The smooth fractionator

  2002cited by this paper
• Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor.

  2000cited by this paper
• Increased Survival of Dopaminergic Neurons in Striatal Grafts of Fetal Ventral Mesencephalic Cells Exposed to Neurotrophin-3 or Glial Cell Line-Derived Neurotrophic Factor

  2000cited by this paper
• Topographic guidance labels in a sensory projection to the forebrain.

  1998cited by this paper
• The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism.

  1998cited by this paper
• Total number of neurons in the neostriatal, pallidal, subthalamic, and substantia nigral nuclei of the rat basal ganglia: A stereological study using the cavalieri and optical disector methods

  1996cited by this paper
• Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements.

  1995cited by this paper
• Relation between motor asymmetry and direction of rotational behaviour under amphetamine and apomorphine in rats with unilateral degeneration of the nigrostriatal dopamine system.

  1990cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Comprehensive Analysis of Autophagy-Related Gene Profiles and Immune Characteristics in Parkinson's Disease.

  2026cites this paper
• Neurofilament light chain protein exposure contributes to protein aggregation, microgliosis, astrogliosis and neuroinflammation via p38/MK2/NF-κB/CREB1/Nrf2/HO-1 signalling leading to Parkinson's disease.

  2026cites this paper
• Chrysin's Anti-Inflammatory Action in the Central Nervous System: A Scoping Review and an Evidence-gap mapping of its Mechanisms.

  2025cites this paper
• Natural Products from Chinese Medicine Targeting NF-κB Signaling: Emerging Therapeutic Avenues for Neurodegenerative Diseases

  2025cites this paper
• Flavonoids and phenolic compounds: a promising avenue for neurodegenerative disease therapy

  2025cites this paper
• Neurochemical Analysis of the Effect of the Combination of Ladasten with Fabomotizole on the Dopaminergic System of the Mouse Brain in 6-Hydroxydophamine Model of Parkinsonian Syndrome

  2025cites this paper
• Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review.

  2025cites this paper
• Phytochemicals against the 6-hydroxydopamine-induced Parkinson’s Phytochemicals against the 6-hydroxydopamine-induced Parkinson’s disease in rodents: a systematic review

  2025cites this paper
• Artemether exerts neuroprotective effect in Parkinson's disease through the PI3K/Akt/GSK-3β signaling pathway.

  2025cites this paper
• Role of Flavonoids in Protecting Against Neurodegenerative Diseases—Possible Mechanisms of Action

  2025cites this paper
• Sinapic acid attenuates PERK-dependent ER stress signaling and resolves α-synuclein pathology in rotenone-induced Parkinson's disease rat model.

  2025cites this paper
• Antiparkinsonian Effect of Ladasten on a 6-Hydroxydopamine-Induced Parkinsonian Syndrome Model in Mice

  2025cites this paper
• Carveol, a natural monoterpene from essential oils prevents neuronal impairments associated with murine Parkinson's disease model in rats

  2025cites this paper
• Nature’s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson’s Disease

  2025cites this paper
• Nuclear Factor Kappa B: A Nobel Therapeutic Target of Flavonoids Against Parkinson's Disease.

  2024cites this paper
• What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson’s Disease?

  2024cites this paper
• Unlocking the neuroprotective potential of Ziziphora clinopodioides flavonoids in combating neurodegenerative diseases and other brain injuries.

  2024cites this paper
• Lipid-based nanoparticles for drug delivery in Parkinson’s disease

  2024cites this paper
• Exploring the therapeutic potential of Chinese herbs on comorbid type 2 diabetes mellitus and Parkinson's disease: A mechanistic study.

  2024cites this paper
• Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease

  2024cites this paper
• Validating the Nutraceutical and Neuroprotective Pharmacodynamics of Flavones.

  2024cites this paper
• Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders.

  2024cites this paper
• Intranasal AdipoRon Mitigated Anxiety and Depression-Like Behaviors in 6-OHDA-Induced Parkinson ’s Disease Rat Model: Going Beyond Motor Symptoms

  2024cites this paper
• Crosstalk between gut–brain axis: unveiling the mysteries of gut ROS in progression of Parkinson’s disease

  2024cites this paper
• Effectiveness of Flavonoid-Rich Diet in Alleviating Symptoms of Neurodegenerative Diseases

  2024influential citation
• Therapeutic potential of berries in age-related neurological disorders

  2024cites this paper
• NF-κB in biology and targeted therapy: new insights and translational implications

  2024cites this paper
• Characterization of graded 6-Hydroxydopamine unilateral lesion in medial forebrain bundle of mice

  2024cites this paper
• Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

  2024cites this paper
• Data-Driven Approaches Used for Compound Library Design for the Treatment of Parkinson’s Disease

  2023cites this paper
• Possible mechanisms involved in the neuroprotective effects of chrysin against mild traumatic brain injury-induced spatial cognitive decline: An in vivo study in a rat model.

  2023cites this paper
• Investigation of the protective effect of anzer propolis in cerebral ischemia-reperfusion injury.

  2023cites this paper
• Therapeutic potential of GDNF in neuroinflammation: Targeted delivery approaches for precision treatment in neurological diseases

  2023cites this paper
• Phytopharmaceuticals in Neurodegenerative Disorders

  2023cites this paper
• Parkinson’s Disease: Exploring Different Animal Model Systems

  2023cites this paper
• Analysis of phenolic compounds in Parkinson’s disease: a bibliometric assessment of the 100 most cited papers

  2023cites this paper
• Marine Macroalgae Polyphenols as Potential Neuroprotective Antioxidants in Neurodegenerative Diseases

  2023cites this paper
• Mitochondrial Complex I as a Pathologic and Therapeutic Target for Parkinson's Disease.

  2023cites this paper
• Biotransformation, metabolic response, and toxicity of UV-234 and UV-326 in larval zebrafish (Danio rerio).

  2023cites this paper
• Neuroprotective impacts of chrysin against clonazepam induced cognitive deficits in male rats

  2023cites this paper
• A critical analysis on the concentrations of phenolic compounds tested using in vitro and in vivo Parkinson’s disease models

  2023influential citation
• Honey on brain health: A promising brain booster

  2023cites this paper
• The effects of gallic acid and vagotomy on motor function, intestinal transit, brain electrophysiology and oxidative stress alterations in a rat model of Parkinson's disease induced by rotenone.

  2023cites this paper
• The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine-Induced Parkinson's Disease in Zebrafish: The Current Applications and Perspectives.

  2022cites this paper
• The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism

  2022cites this paper
• A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders.

  2022cites this paper
• Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

  2022influential citation
• The Protective Effect of a Unique Mix of Polyphenols and Micronutrients against Neurodegeneration Induced by an In Vitro Model of Parkinson’s Disease

  2022cites this paper
• Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

  2022cites this paper
• Possible mechanisms involved in the protective effects of chrysin against lead-induced cognitive decline: An in vivo study in a rat model.

  2022cites this paper
• Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease.

  2022cites this paper
• Evaluation of betulinic acid effects on pain, memory, anxiety, catalepsy, and oxidative stress in animal model of Parkinson’s disease

  2022cites this paper
• Chrysin supplementation mitigated neurobehavioral changes in a animal model of Parkinson’s disease: Influence on TH+ neurons

  2022cites this paper
• The Impact of Chrysin on The Folliculogenesis and Ovarian Apoptosis in Ischemia-Reperfusion Injury in The Rat Model

  2022cites this paper
• Molecular understanding of the translational models and the therapeutic potential natural products of Parkinson's disease.

  2022cites this paper
• Chrysin attenuates sodium arsenite-induced nephrotoxicity in rats by suppressing oxidative stress and inflammation.

  2021cites this paper
• Polyphenols and neurodegenerative diseases: focus on neuronal regeneration

  2021cites this paper
• Advancements in delivery of herbal drugs for cognitive disorders

  2021cites this paper
• Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson's Disease Rat Model.

  2021cites this paper
• IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease.

  2021cites this paper
• Unraveling the Mechanisms Underlying Irregularities in Inspiratory Rhythm Generation in a Mouse Model of Parkinson's Disease

  2021cites this paper
• Does Anzer Propolis Have a Protective Effect on Rabbit Spinal Cord Ischemia/Reperfusion Injury?*

  2021cites this paper
• Do Naturally Occurring Antioxidants Protect Against Neurodegeneration of the Dopaminergic System? A Systematic Revision in Animal Models of Parkinson's Disease

  2021cites this paper
• Honey Ameliorate Negative Effects in Neurodegenerative Diseases: An Evidence-Based Review

  2021cites this paper
• Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative Stress in Parkinson’s Disease

  2021cites this paper
• Natural Phytochemicals as Novel Therapeutic Strategies to Prevent and Treat Parkinson's Disease: Current Knowledge and Future Perspectives

  2021influential citation
• ROLE OF CHRYSIN IN NEUROLOGICAL DISORDERS

  2021cites this paper
• Towards a Better Understanding of Nutritional and Therapeutic Effects of Honey and Their Applications in Apitherapy

  2021cites this paper
• Protective effect of Chrysin as Antioxidant, Anti-inflammatory and Anti apoptotic agent in Transient global cerebral Ischemia - Reperfusion injury among diabetic rats

  2021cites this paper
• The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota.

  2021cites this paper
• Genetic Imaging of Neuroinflammation in Parkinson’s Disease: Recent Advancements

  2021cites this paper
• Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD.

  2021cites this paper
• Sunflower Honey Produced in Turkey Scavenges Singlet Oxygen and Inhibits Lipid Peroxidation via Antiradical Activity

  2021cites this paper
• The protective effect of chrysin against oxidative stress and organ toxicity in rats exposed to propetamphos

  2021cites this paper
• Chrysin restores memory deficit in hypothyroidism mice: Behavioral, neurochemical and computational approaches involving the neurotrophinergic system.

  2021cites this paper
• Neuroprotective Potential of Chrysin: Mechanistic Insights and Therapeutic Potential for Neurological Disorders

  2021cites this paper
• Protective Effects of Chrysin against the Neurotoxicity Induced by Aluminium: In Vitro and In Vivo Studies.

  2021cites this paper
• Antioxidative role of Traditional Chinese Medicine in Parkinson's disease.

  2021cites this paper
• Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders

  2021cites this paper
• Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

  2020cites this paper
• New heteroleptic Cu(II) complexes of chrysin with 2,2ꞌ–bipyridine and substituted 1,10–phenanthrolines: Synthesis, characterization, thermal stability and antioxidant activity

  2020cites this paper
• Neuroprotective Effects of Honey: A Mechanistic View

  2020cites this paper
• Chrysin, an Important Active Ingredient of Honey: Beneficial Pharmacological Activities and Molecular Mechanism of Action

  2020cites this paper
• Mechanisms involved in the possible protective effect of chrysin against sodium arsenite-induced liver toxicity in rats.

  2020cites this paper
• The Effect of Chrysin-Loaded Phytosomes on Insulin Resistance and Blood Sugar Control in Type 2 Diabetic db/db Mice

  2020cites this paper
• Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly

  2020influential citation
• Molecular Mechanism-Based Therapeutic Properties of Hmechanism-based therapeutic properties of honey.

  2020cites this paper
• Deferred Administration of Afobazole Induces Sigma1R-Dependent Restoration of Striatal Dopamine Content in a Mouse Model of Parkinson’s Disease

  2020cites this paper
• Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation

  2020cites this paper
• Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis

  2020cites this paper
• Emerging role of S100B protein implication in Parkinson’s disease pathogenesis

  2020cites this paper
• Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

  2020cites this paper
• Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model.

  2020cites this paper
• Neuroprotective effects of prenylated flavanones isolated from Dalea species, in vitro and in silico studies.

  2020cites this paper
• Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

  2020cites this paper
• Tissue and Stem Cell Sourced Extracellular Vesicle Communications with Microglia

  2020cites this paper
• Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids

  2020cites this paper
• Analysis of Quinone Reductase 2 Implication in Mechanism of Antiparkinsonian Action of Afobazole

  2020cites this paper
• Propolis as a Potential Disease-Modifying Strategy in Parkinson’s disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model

  2020cites this paper
• Bioactive Molecules from Indian Medicinal Plants as Possible Candidates for the Management of Neurodegenerative Disorders

  2020cites this paper