Hepatoprotective effect of chrysin on prooxidant‐antioxidant status during ethanol‐induced toxicity in female albino rats

No abstract is available for this paper.

• Publication year

  2009

• Venue

  The Journal of pharmacy and pharmacology

• Publication date

  2009-06-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1211/jpp.61.06.0015PMID 19505373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Selenium: biochemical role as a component of glutathione peroxidase.

  2009influential reference
• Antioxidant effect of 2‐hydroxy‐4‐methoxy benzoic acid on ethanol‐induced hepatotoxicity in rats

  2007cited by this paper
• Effect of 2‐hydroxy 4‐methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment

  2007cited by this paper
• Liver disease

  2005cited by this paper
• Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives.

  2005cited by this paper
• Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?

  2004cited by this paper
• Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress.

  2004cited by this paper
• Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury.

  2003cited by this paper
• Synthesis and anticancer effect of chrysin derivatives.

  2003cited by this paper
• Flavonoids in health and disease.

  2003cited by this paper
• Role of leptin on alcohol-induced oxidative stress in Swiss mice.

  2003cited by this paper
• Effects of Chronic Chrysin Treatment in Spontaneously Hypertensive Rats

  2002cited by this paper
• Liver disease in alcohol abusers: clinical perspective.

  2002cited by this paper
• C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.

  2001cited by this paper
• Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria.

  2000cited by this paper
• A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro.

  2000cited by this paper
• Modeling Alcohol’s Effects on Organs in Animal Models

  2000cited by this paper
• Effect of coenzyme Q(10) and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals.

  2000cited by this paper
• Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients.

  2000cited by this paper
• Effect of coenzyme Q10 and α‐tocopherol content of mitochondria on the production of superoxide anion radicals

  2000cited by this paper
• Role of Kupffer cells and gut‐derived endotoxins in alcoholic liver injury1

  2000cited by this paper
• Dose- and time-dependent effects of ethanol on plasma antioxidant system in rat.

  1999cited by this paper
• Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice.

  1999cited by this paper
• Inhibition of 17β-Estradiol Formation by Isoflavonoids and Flavonoids in Cultured JEG-3 Cells: Search for Aromatase-Targeting Dietary Compounds

  1999cited by this paper
• Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

  1999cited by this paper
• Synthesis and hypoglycemic effect of chrysin derivatives.

  1999cited by this paper
• Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

  1998cited by this paper
• Effects of phytoestrogens on DNA synthesis in MCF-7 cells in the presence of estradiol or growth factors.

  1998cited by this paper
• Dose and time dependent effects of ethanol on plasma antioxidant system in rats

  1998cited by this paper
• Chrysin and other leaf exudate flavonoids in the genus Pelargonium.

  1997cited by this paper
• Nutrient Requirements and Interactions Interactions between Vitamin C and Vitamin E Are Observed in Tissues of Inherently Scorbutic Rats

  1997cited by this paper
• Endotoxin-induced reduction of social investigation by mice: interaction with amphetamine and anti-inflammatory drugs

  1997cited by this paper
• Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.

  1997cited by this paper
• Guide for the Care and Use of Laboratory Animals

  1996cited by this paper
• Inhibition of HIV Activation in Latently Infected Cells by Flavonoid Compounds

  1996cited by this paper
• Inhibition by antioxidants of nitric oxide synthase expression in murine macrophages: role of nuclear factor kB and interferon regulatory factor 1

  1996cited by this paper
• The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

  1995cited by this paper
• Inactivation of Cu,Zn-superoxide dismutase by free radicals derived from ethanol metabolism: a gamma radiolysis study.

  1995cited by this paper
• Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats.

  1995cited by this paper
• Subacute toxicity of urea herbicide, isoproturon, in male rats.

  1995cited by this paper
• Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study.

  1995cited by this paper
• Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea.

  1994cited by this paper
• Alcohol and antioxidant systems.

  1994cited by this paper
• Effect of alcohol consumption on blood antioxidant nutrients and oxidative stress indicators.

  1994cited by this paper
• Role of lipid peroxides, glutathione and antiperoxidative enzymes in alcohol and drug toxicity.

  1993cited by this paper
• Implication of free radical mechanisms in ethanol-induced cellular injury.

  1992cited by this paper
• Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes

  1992cited by this paper
• Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein.

  1992cited by this paper
• Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals.

  1990cited by this paper
• Biochemical and molecular basis of alcohol-induced injury to liver and other tissues.

  1988cited by this paper
• Effect of chronic ethanol treatment under partial catalase inhibition on the activity of enzymes related to peroxide metabolism in rat liver and heart.

  1988cited by this paper
• Histologic Spectrum of Alcoholic Liver Disease

  1986cited by this paper
• A modified spectrophotometric assay of superoxide dismutase.

  1984cited by this paper
• The effect of chronic alcohol feeding on lipid peroxidation in microsomes: lack of relationship to hydroxyl radical generation.

  1984cited by this paper
• 'Mucosal' mast cells.

  1984cited by this paper
• Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells.

  1984cited by this paper
• A MODIFIED SPECTROPHOTOMETRIC ASSAY OF SOD

  1984influential reference
• Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats.

  1983cited by this paper
• Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat

  1981cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• Chemicals, drugs, and lipid peroxidation.

  1976cited by this paper
• Purification and characterization of the flavoenzyme glutathione reductase from rat liver.

  1975influential reference
• Energy wastage in rats given drugs that induce microsomal enzymes.

  1975cited by this paper
• Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.

  1974influential reference
• Colorimetric assay of catalase.

  1972influential reference
• Patterns of 35S-thiamine hydrochloride absorption in the malnourished alcoholic patient.

  1970cited by this paper
• Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration.

  1968cited by this paper
• Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver.

  1967cited by this paper
• Peroxisomes (microbodies and related particles).

  1966cited by this paper
• Quantitative estimation of peroxidative degeneration of rat liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning.

  1966cited by this paper
• Tissue sulfhydryl groups.

  1959influential reference
• PLASMA TOCOPHEROL IN MAN AT VARIOUS TIMES AFTER INGESTING FREE OR ACETYLATED TOCOPHEROL

  1951influential reference
• Protein measurement with the Folin phenol reagent.

  1951influential reference

• Natural compounds as immune checkpoint inhibitors in melanoma: a systematic review.

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  2025cites this paper
• Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review

  2025cites this paper
• Hepatoprotective potential of Chrysin in a rat model of isoniazid- and rifampicin-induced hepatic injury: suppression of matrix metalloproteinase and transforming growth factor β

  2025cites this paper
• The Role of Oxidative Stress in Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies

  2024cites this paper
• Bioactive Flavonoids Partitioning in a Deep Eutectic Solvent/Surfactant Aqueous Biphasic System: Efficiency and Thermodynamics

  2024cites this paper
• Cinnamon nanoemulsion mitigates acetamiprid-induced hepatic and renal toxicity in rats: biochemical, histopathological, immunohistochemical, and molecular docking analysis

  2024cites this paper
• Development and Evaluation of Liquid Formulations of Chrysin and Budesonide for Asthma and COPD; Evaluation of the Formulations’ Genotoxicity and Anti-Inflammatory Activity

  2024cites this paper
• Effects of Flavonoids on Alcoholic Liver Disease: A Review

  2024cites this paper
• Biochemical and Histological Studies on the Protective Effects of Curcumin against Acetamiprid-Induced Hepato-Renal Toxicity

  2023cites this paper
• The Flavonoid Chrysin Protects against Testicular Apoptosis Induced by Torsion/Detorsion in Adult Rats

  2023cites this paper
• Neuroprotective impacts of chrysin against clonazepam induced cognitive deficits in male rats

  2023cites this paper
• The protective effects of baicalin and chrysin against emamectin benzoate-induced toxicity in Wistar albino rats

  2023cites this paper
• Neuroprotective Role of Chrysin Against Bupivacaine Induced Apoptosis and Oxidative Stress in SH-SY5Y Cell Line

  2023cites this paper
• BETAINE SUPPLEMENTATION PROTECTS RATS AGAINST ALCOHOL-INDUCED HEPATIC AND DUODENAL INJURY: AN HISTOPATHOLOGICAL STUDY

  2023cites this paper
• A Review on the Role of Phytoconstituents Chrysin on the Protective Effect on Liver and Kidney.

  2023cites this paper
• Protective effects of Folic acid against reproductive, hematological, hepatic, and renal toxicity induced by Acetamiprid in male Albino rats.

  2022cites this paper
• Hepatoprotective cocrystal of ethionamide: A new attempt to refurbish old drug through crystal engineering

  2022cites this paper
• Effect of intoxication by gavage with pyrethroid and neonicotinoid insecticides on the liver in adult male rats of the Wistar strain

  2022cites this paper
• Ameliorative Effects of Propolis and Royal Jelly against CCl4‐Induced Hepatotoxicity and Nephrotoxicity in Wistar Rats

  2022cites this paper
• Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin

  2022cites this paper
• Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation

  2022cites this paper
• Ameliorative Potential of Bambara Nuts against Acute Ethanol- Induced Oxidative Stress in Wistar Rats

  2021cites this paper
• Specific Target Organ Toxicity (STOT) After Acute Exposure of Dinotefuan And Its Attenuation With Vitamin C Supplementation

  2021cites this paper
• The Effect of Chrysin on Oxidative Stress in the Ovarian Tissue of Aspirin Administered Rats

  2021cites this paper
• Protective effects of three propolis-abundant flavonoids against ethanol-induced injuries in HepG2 cells involving the inhibition of ERK1/2-AHR-CYP1A1 signaling pathways

  2020cites this paper
• The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage in rats.

  2020cites this paper
• Chrysin, an Important Active Ingredient of Honey: Beneficial Pharmacological Activities and Molecular Mechanism of Action

  2020cites this paper
• HEPATOPROTECTIVE EFFECT OF N-MIRACLE (POLYHERBAL FORMULATION) AGAINST ETHANOL INDUCED TOXICITY IN MALE ALBINO RATS

  2020cites this paper
• Possible ameliorative effects of hydromethanol extract of Thymus vulgaris on cadmium induced hepatorenal toxicity in rats

  2020cites this paper
• Chrysin loaded lipid-core nanocapsules ameliorates neurobehavioral alterations induced by β-amyloid1-42 in aged female mice.

  2020cites this paper
• Antidotal or protective effects of honey and chrysin, its major polyphenols, against natural and chemical toxicities

  2019cites this paper
• Hepatoprotective Effect of Parkia biglobosa on Acute Ethanol-induced Oxidative Stress in Wistar Rats

  2019cites this paper
• Alterations in the Transcriptional Profile of the Liver Tissue and the Therapeutic Effects of Propolis Extracts in Alcohol-induced Steatosis in Rats.

  2019cites this paper
• A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents.

  2019cites this paper
• The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice.

  2019cites this paper
• Chrysin, but not flavone backbone, decreases anxiety-like behavior in animal screens

  2019cites this paper
• Chrysin, but not the flavone backbone, decreases anxiety-like behavior in animal tests

  2019cites this paper
• Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes.

  2019cites this paper
• In vitro and in vivo antioxidant activities of the flavonoid-rich extract from Flos populus.

  2019cites this paper
• Understanding the digestibility and nutritional functions of rice starch subjected to heat-moisture treatment

  2018cites this paper
• Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats.

  2018cites this paper
• Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action.

  2018cites this paper
• Chrysin regulates NAD(P)H:quinoneoxidoreductase 1 and inflammatory mediators in rats exposed to smoking and thioacetamide

  2018cites this paper
• Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins.

  2018cites this paper
• Evaluation of skeletal muscle relaxant activity of quercetin and chrysin in Albino rats using rota-rod apparatus and actophotometer

  2017cites this paper
• The Effect of Chrysin on Liver Damage Induced By Subchronic Toxicity of Formaldehyde in Rats

  2017cites this paper
• Ameliorative Effect of Thymus Oil on Paracetamol Induced Hepato-Renal Toxicity: A Biochemical, Antioxidant and Histopathological Studies

  2017cites this paper
• Protective effects of tannic acid on acute doxorubicin-induced cardiotoxicity: Involvement of suppression in oxidative stress, inflammation, and apoptosis.

  2017cites this paper
• Protective Effects of Chrysin Against Drugs and Toxic Agents

  2017cites this paper
• Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach

  2017cites this paper
• Protective effect of 5, 7-dihydroxyflavone on brain of rats exposed to acrylamide or γ-radiation.

  2017cites this paper
• Chrysin cocrystals: Characterization and evaluation

  2017cites this paper
• Restorative effects of Chrysin pretreatment on oxidant–antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol‐induced hepatotoxicity in rats: An experimental and biochemical study

  2017cites this paper
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  2017influential citation
• Pulmonary , gastrointestinal and urogenital pharmacology In vivo cellular and molecular gastroprotective mechanisms of chrysin ; Emphasis on oxidative stress , in fl ammation and angiogenesis

  2017cites this paper
• Recent Advances in Role of Propolis as Natural Additive in Poultry Nutrition

  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• Forest biorefinery: Potential of poplar phytochemicals as value-added co-products.

  2015cites this paper
• The Potential for Plant Derivatives against Acrylamide Neurotoxicity

  2015cites this paper
• In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy.

  2015cites this paper
• The influence of propolis as supplement diet on broiler meat growth performance, carcass body weight, chemical composition and lipid oxidation stability.

  2015cites this paper
• Systemic exposure of Paracetamol (acetaminophen) was enhanced by quercetin and chrysin co-administration in Wistar rats and in vitro model: risk of liver toxicity

  2015cites this paper
• Flavonoid Chrysin prevents age-related cognitive decline via attenuation of oxidative stress and modulation of BDNF levels in aged mouse brain.

  2015cites this paper
• Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity.

  2015cites this paper
• Probing the origins of anticancer activity of chrysin derivatives

  2015cites this paper
• Rutin ameliorates methotrexate induced hepatic injury in rats.

  2015cites this paper
• Localization and interaction of hydroxyflavones with lipid bilayer model membranes: a study using DSC and multinuclear NMR.

  2014cites this paper
• Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.

  2014cites this paper
• Hematological, Biochemical and Histological alterations induced by oral administration of Thiamethoxam and Acetamiprid in male rats

  2014cites this paper
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  2014cites this paper
• INTERACTION OF CHRYSIN AND SOME NOVEL FLAVONES WITH DPPC MODEL MEMBRANE:STUDY BASED ON MD SIMULATION, DSC AND NMR

  2014cites this paper
• Physiological, biochemical and histological alterations induced by administration of imidacloprid in female albino rats.

  2014cites this paper
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  2014cites this paper
• Hepatoprotective Effects of Solanum nigrum Linn Fruits Against Cadmium Chloride Toxicity in Albino Rats

  2014cites this paper
• Biological Activity of Modified Chrysin

  2014cites this paper
• Effect of Solanum nigrum Linn against Lambda CyhalothrinInduced Toxicity in Rats

  2013cites this paper
• Effects of quercetin and chrysin on 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin induced hepatotoxicity in rats

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Propolis protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity in rat hepatocytes.

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper