Molecular machinery involved in the insulin-regulated fusion of GLUT4-containing vesicles with the plasma membrane

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular Membrane Biology

• Publication date

  2001-01-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1080/09687680110082400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• New perspectives into the molecular pathogenesis and treatment of type 2 diabetes.

  2001cited by this paper
• Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy.

  2001cited by this paper
• VAMP3 Null Mice Display Normal Constitutive, Insulin- and Exercise-Regulated Vesicle Trafficking

  2001cited by this paper
• Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.

  2001cited by this paper
• Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle*

  2001cited by this paper
• Insulin-mediated GLUT4 Translocation Is Dependent on the Microtubule Network*

  2001cited by this paper
• Direct Interaction of Rab4 with Syntaxin 4*

  2001cited by this paper
• SNAREs are concentrated in cholesterol‐dependent clusters that define docking and fusion sites for exocytosis

  2001cited by this paper
• SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis

  2001cited by this paper
• Pantophysin Is a Phosphoprotein Component of Adipocyte Transport Vesicles and Associates with GLUT4-containing Vesicles*

  2000cited by this paper
• VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts.

  2000cited by this paper
• Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes.

  2000cited by this paper
• Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes.

  2000cited by this paper
• Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes*

  2000cited by this paper
• A Functional Role for VAP‐33 in Insulin‐Stimulated GLUT4 Traffic

  2000cited by this paper
• Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake.

  2000cited by this paper
• The APS adapter protein couples the insulin receptor to the phosphorylation of c‐Cbl and facilitates ligand‐stimulated ubiquitination of the insulin receptor

  2000cited by this paper
• Role of SNAP23 in Insulin-induced Translocation of GLUT4 in 3T3-L1 Adipocytes

  2000cited by this paper
• Discrimination of GLUT4 vesicle trafficking from fusion using a temperature‐sensitive Munc18c mutant

  2000cited by this paper
• Quantification of SNARE protein levels in 3T3-L1 adipocytes: implications for insulin-stimulated glucose transport.

  2000cited by this paper
• Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

  2000cited by this paper
• Effects of insulin on intracellular GLUT4 vesicles in adipocytes: evidence for a secretory mode of regulation.

  2000cited by this paper
• Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells.

  2000influential reference
• Cellugyrin Is a Marker for a Distinct Population of Intracellular Glut4-containing Vesicles*

  2000cited by this paper
• Nsec1 Binds a Closed Conformation of Syntaxin1a

  2000cited by this paper
• Structural analysis of the neuronal SNARE protein syntaxin-1A.

  2000cited by this paper
• CAP defines a second signalling pathway required for insulin-stimulated glucose transport

  2000influential reference
• Munc18c Function Is Required for Insulin-Stimulated Plasma Membrane Fusion of GLUT4 and Insulin-Responsive Amino Peptidase Storage Vesicles

  2000cited by this paper
• Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo.

  1999cited by this paper
• The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting.

  1999cited by this paper
• Membrane fusion and exocytosis.

  1999cited by this paper
• Sec34p, a Protein Required for Vesicle Tethering to the Yeast Golgi Apparatus, Is in a Complex with Sec35p

  1999cited by this paper
• A conformational switch in syntaxin during exocytosis: role of munc18

  1999cited by this paper
• Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

  1999cited by this paper
• Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes.

  1999cited by this paper
• Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane.

  1998cited by this paper
• Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

  1998cited by this paper
• SNAREpins: minimal machinery for membrane fusion.

  1998cited by this paper
• Rab GTPases, Directors of Vesicle Docking*

  1998cited by this paper
• Analysis of GLUT4 Distribution in Whole Skeletal Muscle Fibers: Identification of Distinct Storage Compartments That Are Recruited by Insulin and Muscle Contractions

  1998cited by this paper
• Syndet, an Adipocyte Target SNARE Involved in the Insulin-induced Translocation of GLUT4 to the Cell Surface*

  1998cited by this paper
• Vesicle-associated Membrane Protein 2 Plays a Specific Role in the Insulin-dependent Trafficking of the Facilitative Glucose Transporter GLUT4 in 3T3-L1 Adipocytes*

  1998cited by this paper
• Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate*

  1998cited by this paper
• Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.

  1998cited by this paper
• Initial docking of ER‐derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins

  1998cited by this paper
• The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.

  1998cited by this paper
• Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes*

  1998cited by this paper
• Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

  1998cited by this paper
• Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

  1998cited by this paper
• Inhibition of Insulin-induced GLUT4 Translocation by Munc18c through Interaction with Syntaxin4 in 3T3-L1 Adipocytes*

  1998cited by this paper
• Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytes.

  1997cited by this paper
• Structural organization of the synaptic exocytosis core complex.

  1997influential reference
• Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment.

  1997cited by this paper
• Structural Changes Are Associated with Soluble N-Ethylmaleimide-sensitive Fusion Protein Attachment Protein Receptor Complex Formation*

  1997cited by this paper
• Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes.

  1997cited by this paper
• Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes.

  1997cited by this paper
• Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

  1997cited by this paper
• Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes

  1997cited by this paper
• t-SNARE activation through transient interaction with a rab-like guanosine triphosphatase.

  1997cited by this paper
• Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes

  1997cited by this paper
• Two Naturally Occurring Insulin Receptor Tyrosine Kinase Domain Mutants Provide Evidence That Phosphoinositide 3-Kinase Activation Alone Is Not Sufficient for the Mediation of Insulin’s Metabolic and Mitogenic Effects*

  1997cited by this paper
• Insulin-stimulated Tyrosine Phosphorylation of Caveolin Is Specific for the Differentiated Adipocyte Phenotype in 3T3-L1 Cells*

  1997cited by this paper
• Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

  1997cited by this paper
• Insulin Stimulates Guanine Nucleotide Exchange on Rab4 via a Wortmannin-sensitive Signaling Pathway in Rat Adipocytes*

  1997cited by this paper
• Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.

  1996cited by this paper
• Structure, function, and regulation of the mammalian facilitative glucose transporter gene family.

  1996cited by this paper
• Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.

  1996cited by this paper
• Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes

  1996cited by this paper
• A Synthetic Peptide Corresponding to the Rab4 Hypervariable Carboxyl-terminal Domain Inhibits Insulin Action on Glucose Transport in Rat Adipocytes (*)

  1996cited by this paper
• Compartmentalization of protein traffic in insulin-sensitive cells.

  1996cited by this paper
• Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues (*)

  1995cited by this paper
• Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro.

  1995cited by this paper
• rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin

  1995cited by this paper
• A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

  1995cited by this paper
• Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation.

  1995cited by this paper
• Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission.

  1994cited by this paper
• rop, a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1/Munc-18 proteins, is a negative regulator of neurotransmitter release in vivo.

  1994cited by this paper
• Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures

  1994cited by this paper
• Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

  1993cited by this paper
• Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle.

  1993cited by this paper
• Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

  1993cited by this paper
• A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion.

  1993cited by this paper
• Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

  1993cited by this paper
• Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.

  1992cited by this paper
• The unc‐18 Gene Encodes a Novel Protein Affecting the Kinetics of Acetylcholine Metabolism in the Nematode Caenorhabditis elegans

  1992cited by this paper
• Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

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• Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

  1989cited by this paper
• A synaptic vesicle membrane protein is conserved from mammals to Drosophila.

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• Characterization of Insulin

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• Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells.

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• Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes.

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• Separation of Insulin Signaling into Distinct GLUT4 Translocation and Activation Steps

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