Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

Among all the diverse actions of insulin, one of the most critical and intensively studied is its regulation of glucose homeostasis. In the postabsorptive state, insulin action in muscle and adipose tissue results in increased glucose uptake from the circulation, thereby maintaining plasma euglycemia and preventing hyperglycemia (1–3). Defects in this pathway result in insulin resistance, a condition in which excessive concentrations of insulin are required to reduce blood glucose levels and often precede the development of frank Type II diabetes (3, 4). Although it has been appreciated for almost two decades that this major action of insulin results from a redistribution of glucose transporter proteins from intracellular storage sites to the plasma membrane (5, 6), the cellular mechanisms responsible for these trafficking events and the defects associated with insulin resistance have remained largely enigmatic.

• Publication year

  1999

• Venue

  Journal of Biological Chemistry

• Publication date

  1999-01-29

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.274.5.2593PMID 9915783
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Signaling Mechanisms That Regulate Glucose Transport*

  1999cited by this paper
• GLUT4 Gene Regulation and Manipulation*

  1999cited by this paper
• Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

  1998cited by this paper
• Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways

  1998cited by this paper
• Expression of a Dominant Interfering Dynamin Mutant in 3T3L1 Adipocytes Inhibits GLUT4 Endocytosis without Affecting Insulin Signaling*

  1998cited by this paper
• Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

  1998cited by this paper
• Inhibition of Insulin-induced GLUT4 Translocation by Munc18c through Interaction with Syntaxin4 in 3T3-L1 Adipocytes*

  1998cited by this paper
• Syndet, an Adipocyte Target SNARE Involved in the Insulin-induced Translocation of GLUT4 to the Cell Surface*

  1998cited by this paper
• Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes*

  1998cited by this paper
• Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

  1998cited by this paper
• Vesicle-associated Membrane Protein 2 Plays a Specific Role in the Insulin-dependent Trafficking of the Facilitative Glucose Transporter GLUT4 in 3T3-L1 Adipocytes*

  1998cited by this paper
• Perturbation of Dynamin II with an Amphiphysin SH3 Domain Increases GLUT4 Glucose Transporters at the Plasma Membrane in 3T3-L1 Adipocytes

  1998cited by this paper
• Dynamin associates with Src-Homology Collagen (Shc) and becomes tyrosine phosphorylated in response to insulin.

  1998cited by this paper
• Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

  1998cited by this paper
• Endocytosis of the Glucose Transporter GLUT4 Is Mediated by the GTPase Dynamin*

  1998cited by this paper
• Guanosine 5′-O-(3-Thiotriphosphate) (GTPγS) Stimulation of GLUT4 Translocation is Tyrosine Kinase-dependent*

  1998cited by this paper
• Domain structure and intramolecular regulation of dynamin GTPase

  1997cited by this paper
• Ca2+ and the regulation of neurotransmitter secretion.

  1997cited by this paper
• Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway*

  1997cited by this paper
• A Synthetic Peptide Corresponding to the GLUT4 C-terminal Cytoplasmic Domain Causes Insulin-like Glucose Transport Stimulation and GLUT4 Recruitment in Rat Adipocytes*

  1997cited by this paper
• Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber. Differential protein composition and sensitivity to insulin.

  1997cited by this paper
• Clathrin-coated vesicle formation and protein sorting: an integrated process.

  1997cited by this paper
• Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport.

  1997cited by this paper
• Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes

  1997cited by this paper
• Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytes.

  1997cited by this paper
• Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

  1997cited by this paper
• Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

  1997cited by this paper
• The Amino Terminus of Insulin-responsive Aminopeptidase Causes Glut4 Translocation in 3T3-L1 Adipocytes*

  1997cited by this paper
• Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.

  1997cited by this paper
• Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.

  1997cited by this paper
• Characterization of Munc-18c and Syntaxin-4 in 3T3-L1 Adipocytes

  1997cited by this paper
• Synaptic vesicle endocytosis.

  1997cited by this paper
• The dynamins: redundant or distinct functions for an expanding family of related GTPases?

  1997cited by this paper
• SNAREs and regulated vesicle exocytosis.

  1997cited by this paper
• Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

  1997cited by this paper
• Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes

  1996cited by this paper
• The Carboxyl Terminus of GLUT4 Contains a Serine-Leucine-Leucine Sequence That Functions as a Potent Internalization Motif in Chinese Hamster Ovary Cells*

  1996cited by this paper
• Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes

  1996cited by this paper
• Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle

  1996cited by this paper
• The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin- sensitive cells

  1996cited by this paper
• Structure, function, and regulation of the mammalian facilitative glucose transporter gene family.

  1996cited by this paper
• Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation*

  1996cited by this paper
• Compartmentalization of protein traffic in insulin-sensitive cells.

  1996cited by this paper
• Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells.

  1996cited by this paper
• Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport.

  1996cited by this paper
• Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.

  1996cited by this paper
• Gq-coupled Receptors Transmit the Signal for GLUT4 Translocation via an Insulin-independent Pathway*

  1996cited by this paper
• A Synthetic Peptide Corresponding to the Rab4 Hypervariable Carboxyl-terminal Domain Inhibits Insulin Action on Glucose Transport in Rat Adipocytes (*)

  1996cited by this paper
• Synaptic vesicle biogenesis, docking, and fusion: a molecular description.

  1996cited by this paper
• Molecular actions of insulin on glucose transport.

  1995cited by this paper
• Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues (*)

  1995cited by this paper
• Insulin-sensitive targeting of the GLUT4 glucose transporter in L6 myoblasts is conferred by its COOH-terminal cytoplasmic tail

  1995cited by this paper
• The Effects of Wortmannin on Rat Skeletal Muscle

  1995cited by this paper
• Dissection of GLUT4 recycling pathway into exocytosis and endocytosis in rat adipocytes. Evidence that GTP-binding proteins are involved in both processes

  1995cited by this paper
• Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles (*)

  1995cited by this paper
• Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes

  1995cited by this paper
• Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment

  1995cited by this paper
• A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal [published erratum appears in J Cell Biol 1994 Sep;126(6):1625]

  1994cited by this paper
• Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures

  1994cited by this paper
• A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal [published erratum appears in J Cell Biol 1994 Sep;126(6):1625]

  1994cited by this paper
• n-Sec1: a neural-specific syntaxin-binding protein.

  1994cited by this paper
• Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin‐responsive cells

  1994cited by this paper
• gp160, a tissue-specific marker for insulin-activated glucose transport.

  1994cited by this paper
• A complex of GRB2‐dynamin binds to tyrosine‐phosphorylated insulin receptor substrate‐1 after insulin treatment.

  1994cited by this paper
• Insulin and okadaic acid induce Rab4 redistribution in adipocytes.

  1993cited by this paper
• Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.

  1993cited by this paper
• Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

  1993cited by this paper
• Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

  1993cited by this paper
• Insulin action on the internalization of the GLUT4 glucose transporter in isolated rat adipocytes.

  1993cited by this paper
• Glucose transporter recycling in rat adipose cells. Effects of potassium depletion.

  1993cited by this paper
• Exofacial epitope-tagged glucose transporter chimeras reveal COOH- terminal sequences governing cellular localization

  1993cited by this paper
• Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts

  1992cited by this paper
• Fructose transporter in human spermatozoa and small intestine is GLUT5.

  1992cited by this paper
• Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices

  1992cited by this paper
• Immunocytochemical and biochemical studies of GLUT4 in rat skeletal muscle.

  1992cited by this paper
• Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.

  1992cited by this paper
• Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.

  1991cited by this paper
• Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

  1991cited by this paper
• Immunoelectron microscopic demonstration of insulin-stimulated translocation of glucose transporters to the plasma membrane of isolated rat adipocytes and masking of the carboxyl-terminal epitope of intracellular GLUT4.

  1991cited by this paper
• Insulin and nonhydrolyzable GTP analogs induce translocation of GLUT 4 to the plasma membrane in alpha-toxin-permeabilized rat adipose cells.

  1991cited by this paper
• Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type

  1991cited by this paper
• Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

  1980cited by this paper
• Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

  1980cited by this paper

• Co-Exposure to Bisphenol A and a High-Fat Diet Induces Insulin Resistance via Suppression of Insulin Signaling Molecule Expression and GLUT4 Translocation.

  2026cites this paper
• Discovery of New Nanomolar Selective IRAP Inhibitors

  2025cites this paper
• COMMD10 Regulates Endosomal Recycling of Epithelial Sodium Channel (ENaC)

  2024cites this paper
• Conditional Deletion of β-Catenin in the Mediobasal Hypothalamus Impairs Adaptive Energy Expenditure in Response to High-Fat Diet and Exacerbates Diet-Induced Obesity

  2024cites this paper
• Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway

  2024cites this paper
• Effect of sorghum intake on postprandial blood glucose levels: A randomized, double-blind, crossover study

  2024cites this paper
• Potential molecular mechanism of exercise reversing insulin resistance and improving neurodegenerative diseases

  2024cites this paper
• GLUT4 as A Protein Target for T2DM Therapy with Natural Compounds

  2023cites this paper
• Relationship between obesity, insulin resistance and cell membrane properties

  2023cites this paper
• Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus

  2023cites this paper
• Changing lanes: seasonal differences in cellular metabolism of adipocytes in grizzly bears (Ursus arctos horribilis)

  2022cites this paper
• The Mechanisms of the Potential Probiotic Lactiplantibacillus plantarum against Cardiovascular Disease and the Recent Developments in its Fermented Foods

  2022cites this paper
• β-Cells retain a pool of insulin-containing secretory vesicles regulated by adherens junctions and the cadherin-binding protein p120 catenin

  2022cites this paper
• Tumeric Ethanol Extract Up-regulated the Lipolysis by Activation of Lipase Related Pathway in HepG2 Cells

  2021cites this paper
• Intranasal insulin and orexins to treat age-related cognitive decline.

  2021cites this paper
• Endometrial Glucose Transporters in Health and Disease

  2021cites this paper
• Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases.

  2021cites this paper
• Computational, chemical profiling and biochemical evaluation of antidiabetic potential of Parkia biglobosa stem bark extract in type 2 model of rats

  2021cites this paper
• Functional Characterization of Facilitative Glucose Transporter 4 With a Delay Responding to Plasma Glucose Level in Blunt Snout Bream (Megalobrama amblycephala)

  2020cites this paper
• The mother relationship between insulin resistance and non-alcoholic steatohepatitis: Glucosinolates hydrolysis products as a promising insulin resistance-modulator and fatty liver-preventer.

  2020cites this paper
• Goldfish adipocytes are pancreatic beta cell‐like, glucose‐responsive insulin‐producing cells

  2020cites this paper
• The Effect Of Butyrate Feeding On Skeletal Muscle And Adipose Tissue Glucose Uptake

  2020cites this paper
• Role of linagliptin in preventing the pathological progression of hepatic fibrosis in high fat diet and streptozotocin-induced diabetic obese rats.

  2020cites this paper
• Effect of resveratrol on SNARE proteins expression and insulin resistance in skeletal muscle of diabetic rats

  2019cites this paper
• Comparative study of testosterone and vitamin D analogue, elocalcitol, on insulin-controlled signal transduction pathway regulation in human skeletal muscle cells

  2019cites this paper
• Identification of novel targets for the treatment of type 2 diabetes

  2019cites this paper
• Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear

  2019cites this paper
• Diabetes mellitus and oxidative stress a Co relative and therapeutic approach

  2019cites this paper
• Molecular characterization and expression analysis of glucose transporter 4 from Trachinotus ovatus, Rachycentron canadums and Oreochromis niloticus in response to different dietary carbohydrate-to-lipid ratios

  2019cites this paper
• Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

  2019cites this paper
• Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer’s Disease in Rats

  2019cites this paper
• Polymorphisms near EXOC 4 and LRGUK on chromosome 7 q 32 are associated with Type 2 Diabetes and fasting glucose ; The NHLBI Family Heart Study

  2019cites this paper
• GLUT4 Storage Vesicles: Specialized Organelles for Regulated Trafficking

  2019cites this paper
• Glucose and white adipose tissue metabolism. Effects of site and sex on the fate of glucose

  2018cites this paper
• Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling.

  2018cites this paper
• Consequences of tyrosine phosphorylation of Syntaxin4 and Munc18c on GLUT4 trafficking

  2018influential citation
• Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats.

  2018cites this paper
• Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1

  2018cites this paper
• The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity

  2018cites this paper
• THE ROLE OF PROGESTERONE RECEPTOR MEMBRANE COMPONENT 1 IN RECEPTOR TRAFFICKING AND DISEASE

  2017cites this paper
• β-Adrenergic Signalling Through mTOR

  2017cites this paper
• Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears

  2017cites this paper
• Membrane lipid alterations in the metabolic syndrome and the role of dietary oils.

  2017cites this paper
• Peptide hydroxamate derivatives as regulators for insulin receptor signaling and its degradation by zinc metalloprotease in diabetic rats

  2016influential citation
• An investigation of antioxidant and antidiabetic effect of aqueous leaf extracts of Mucuna pruriens

  2016cites this paper
• Chapter 40 – Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History

  2016cites this paper
• Effects of Chromium-Loaded Chitosan Nanoparticles on Glucose Transporter 4, Relevant mRNA, and Proteins of Phosphatidylinositol 3-Kinase, Akt2-Kinase, and AMP-Activated Protein Kinase of Skeletal Muscles in Finishing Pigs

  2016cites this paper
• A method for assessing real time rates of dissolution and absorption of carbohydrate and other food matrices in human subjects.

  2016cites this paper
• insulin-resistant mice Normal Akt/PKB with reduced PI3K activation in

  2016cites this paper
• The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial.

  2016cites this paper
• Relationship Between College Students’ Knowledge of the Risk Factors for Type 2 Diabetes and Health Behaviors

  2016cites this paper
• Anthocyanin Extraction from Purple Sweet Potato Cultivar Antin-3 (Ipomoea batatas L.) using Maceration, Microwave Assisted Extraction, Ultrasonic Assisted Extraction and Their Application as Anti-Hyperglycemic Agents in Alloxan-Induced Wistar Rats

  2016cites this paper
• Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake.

  2015cites this paper
• Effets bénéfiques d'un supplément riche en polyphénols de fraises et de canneberges sur la sensibilité à l'insuline et le profil de risque cardiométabolique chez des hommes et des femmes résistants à l'insuline

  2015cites this paper
• Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance.

  2015cites this paper
• The impact of calcium on the interactions between epigallocatechin-3-gallate and B-lactoglobulin and their effects on the metabolic response of mice

  2015cites this paper
• Effects of Eight Weeks Aerobic Exercise on Plasma Levels of Orexin A, Leptin, Glucose, Insulin, and Insulin Resistance in Males with Type 2 Diabetes

  2015cites this paper
• Évaluation de l’effet antidiabétique de plantes médicinales de la forêt boréale et identification des principes actifs de deux espèces prometteuses

  2015cites this paper
• Development and evaluation of a novel insulin analogue

  2015cites this paper
• Diabetes Mellitus-Types and Prevalence: A Mini Review

  2015cites this paper
• Doxorrubicina causa intolerância à glicose mediada pela inibição da sinalização da AMPk no músculo esquelético

  2015cites this paper
• Alterations in insulin-signaling and coagulation pathways in platelets during hyperglycemia-hyperinsulinemia in healthy non-diabetic subject.

  2014cites this paper
• Structural and Functional Evolution of Glucose Transporter 4 (GLUT4): A Look at GLUT4 in Fish

  2014cites this paper
• 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells.

  2014cites this paper
• Insulin Resistance Associated Genes and miRNAs

  2014cites this paper
• Insulin‐Sensitizing and Beneficial Lipid‐Metabolic Effects of the Water‐Soluble Melanin Complex Extracted from Inonotus obliquus

  2014cites this paper
• Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

  2014cites this paper
• Exercise prescription for improving inflammatory and glucose regulatory outcomes in inactive Indigenous Australian and Caucasian men

  2014cites this paper
• Beyond the ITC White Paper: emerging sciences in drug transporters and opportunities for drug development.

  2014cites this paper
• In Vitro and In Vivo Enhancement of Adipogenesis by Italian Ryegrass (Lolium multiflorum) in 3T3-L1 Cells and Mice

  2014cites this paper
• A molecular bridge: connecting type 2 diabetes and Alzheimer's disease.

  2014cites this paper
• A nutrient network regulating cellular cholesterol and glucose metabolism

  2014cites this paper
• The regenerative and anti-inflammatory capability of Prosopis Glandulosa

  2014cites this paper
• Positive regulations of adipogenesis by Italian ryegrass [Lolium multiflorum] in 3T3-L1 cells

  2014cites this paper
• JCB_201403080 1..10

  2014cites this paper
• Trafficking of ABCB-type Auxin Transporters

  2014cites this paper
• Diabetes and its Complications and SGLT-2 Inhibitors: A Novel Therapy for Type 2 Diabetes Mellitus

  2014cites this paper
• Membrane transporters and the diseases corresponding to functional defects

  2013cites this paper
• Anti-Hyperglycemic Effect of Single Administered Gardeniae Fructus in Streptozotocin-Induced Diabetic Mice by Improving Insulin Resistance and Enhancing Glucose Uptake in Skeletal Muscle

  2013cites this paper
• Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium

  2013cites this paper
• 6. Diabetes Drugs

  2013cites this paper
• SDF7, a group of Scoparia dulcis Linn. derived flavonoid compounds, stimulates glucose uptake and regulates adipocytokines in 3T3-F442a adipocytes.

  2013cites this paper
• Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.

  2013cites this paper
• Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

  2013cites this paper
• Insulin signalling to the kidney in health and disease.

  2013cites this paper
• C2C12 CELL LINE IS A GOOD MODEL TO EXPLORE THE EFFECTS OF HERBAL EXTRACTS ON GLUT4 EXPRESSION AND TRANSLOCATION

  2012cites this paper
• Altered temporal changes in Ser312-phosphofetuin-A concentrations in response to a glucose challenge in a mouse model of diet-induced obesity and insulin resistance

  2012cites this paper
• Anti-Obesity Effect of Ethyl Acetate Extracts from Agrimonia pilosa Ledeb. in 3T3-L1 preadipocytes

  2012cites this paper
• Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis.

  2012cites this paper
• Leukocyte O-GlcNAcylation : a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus?

  2012cites this paper
• In vitro anti-hyperglycemia properties of the aqueous stem bark extract from Strychnos henningsii (Gilg)

  2012cites this paper
• Mechanisms of Insulin Action

  2012cites this paper
• El GLUT4: efectos de la actividad física y aspectos nutricionales en los mecanismos de captación de glucosa y sus aplicaciones en la diabetes tipo 2

  2012cites this paper
• Mechanism of Lipid Induced Insulin Resistance: An Overview

  2012cites this paper
• Adipocyte Growth and Factors Influencing Adipocyte Life Cycle

  2012cites this paper
• Protein arginine methyltransferase 1 regulates hepatic glucose production in a FoxO1‐dependent manner

  2012cites this paper
• Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury.

  2012cites this paper
• Molecular Basis of Insulin Resistance and Its Relation to Metabolic Syndrome

  2012cites this paper
• Adipose Tissue Biology

  2012cites this paper
• Effects of Combination of Thiazolidinediones with Melatonin in Dexamethasone-induced Insulin Resistance in Mice

  2011cites this paper