Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients

Kl. West,Dk. Sivakolundu,Gb. Maruthy,Zuppichini,Peiying Liu,B. Thomas,Js. Spence,Hanzhang Lu,D. Okuda,Bart Rypma

Published 2020 in NeuroImage: Clinical

ABSTRACT

Highlights • Lower global oxygen metabolism (CMRO2) in MS patients compared to healthy controls.• CMRO2 predicts increased fatigue and reduced cognitive performance in MS patients.• MS patients with higher CMRO2 have reduced FA in normal-appearing white-matter.• CMRO2 may reflect ongoing MS-related autoimmune activity.

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