CNS energy metabolism as related to function.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Brain research. Brain research reviews

• Publication date

  2000-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0165-0173(00)00038-2PMID 11086186
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of constant and flickering light on retinal metabolism in rabbits.

  2009cited by this paper
• Electrophysiological consequences of retinal hypoxia

  2007cited by this paper
• Developmental changes of carbonic anhydrase in the retina of the mouse: a histochemical study

  2005cited by this paper
• Extracellular–Intracellular Distribution of Glucose and Lactate in the Rat Brain Assessed Noninvasively by Diffusion-Weighted 1H Nuclear Magnetic Resonance Spectroscopy In Vivo

  2000cited by this paper
• An Increase in Lactate Output by Brain Tissue Serves to Meet the Energy Needs of Glutamate-Activated Neurons

  1999cited by this paper
• Small‐Conductance Calcium‐Activated Potassium Channels

  1999cited by this paper
• Increased hypoxic stress decreases AMP hydrolysis in rabbit heart.

  1999cited by this paper
• Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging.

  1999cited by this paper
• The metabolic cost of neural information

  1998cited by this paper
• Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites.

  1998cited by this paper
• Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain.

  1998cited by this paper
• Kinesin and dynein superfamily proteins and the mechanism of organelle transport.

  1998cited by this paper
• Neurochemical organization of the macaque retina: effect of TTX on levels and gene expression of cytochrome oxidase and nitric oxide synthase and on the immunoreactivity of Na+ K+ ATPase and NMDA receptor subunit I.

  1998cited by this paper
• ATP-sensitive K+ channel activation provides transient protection to the anoxic turtle brain.

  1998cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998cited by this paper
• Activation-Induced Resetting of Cerebral Oxygen and Glucose Uptake in the Rat

  1998cited by this paper
• ATP-sensitive K+ channel activation provides transient protection to the anoxic turtle brain.

  1998cited by this paper
• Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.

  1998cited by this paper
• Glucose metabolism in cat outer retina. Effects of light and hyperoxia.

  1997cited by this paper
• Evidence for uncoupling of oxygen and glucose utilization during neuronal activation in rat striatum.

  1997cited by this paper
• Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release.

  1997cited by this paper
• Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells.

  1997cited by this paper
• Factors that reverse the persistent depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro.

  1997cited by this paper
• Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

  1997cited by this paper
• What makes brain neurons run?

  1997cited by this paper
• Comparison of Lactate Transport in Astroglial Cells and Monocarboxylate Transporter 1 (MCT 1) Expressing Xenopus laevis Oocytes

  1997cited by this paper
• Neuroscience: What Makes Brain Neurons Run?

  1997cited by this paper
• The Effect of Intravenous Lactate on Cerebral Function During Hypoglycaemia

  1997cited by this paper
• Energetic demands of the Na+/K+ ATPase in mammalian astrocytes

  1997cited by this paper
• Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation

  1997cited by this paper
• Rapid Changes in Local Extracellular Rat Brain Glucose Observed with an In Vivo Glucose Sensor

  1997cited by this paper
• Metabolic and energetic properties of isolated nerve ending particles (synaptosomes).

  1996cited by this paper
• The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.

  1996cited by this paper
• Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

  1996cited by this paper
• Limitation of glycolysis by hexokinase in rat brain synaptosomes during intense ion pumping.

  1996cited by this paper
• RECENT INSIGHTS INTO THE REGULATION OF CEREBRAL CIRCULATION

  1996cited by this paper
• Downregulation of cellular metabolism during environmental stress: mechanisms and implications.

  1996cited by this paper
• Regulation of GABA Level in Rat Brain Synaptosomes: Fluxes Through Enzymes of the GABA Shunt and Effects of Glutamate, Calcium, and Ketone Bodies

  1996cited by this paper
• Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR.

  1996cited by this paper
• Astrocyte glucose metabolism under normal and pathological conditions in vitro.

  1996cited by this paper
• Cellular Mechanisms of Brain Energy Metabolism. Relevance to Functional Brain Imaging and to Neurodegenerative Disorders a

  1996cited by this paper
• Differential glutamatergic innervation in cytochrome oxidase‐rich and ‐poor regions of the macaque striate cortex: Quantitative EM analysis of neurons and neuropil

  1996cited by this paper
• Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping

  1996cited by this paper
• Localization and ontogeny of GLUT3 expression in the rat retina.

  1996cited by this paper
• Dephosphorylation of 2-deoxyglucose 6-phosphate and 2-deoxyglucose export from cultured astrocytes.

  1996cited by this paper
• Suppression of Creatine Kinase-catalyzed Phosphotransfer Results in Increased Phosphoryl Transfer by Adenylate Kinase in Intact Skeletal Muscle*

  1996cited by this paper
• Flux coupling in a neuronal glutamate transporter

  1996cited by this paper
• Ca2+ release from intracellular stores induced by afferent stimulation of CA3 pyramidal neurons in hippocampal slices.

  1996cited by this paper
• Selective Distribution of Lactate Dehydrogenase Isoenzymes in Neurons and Astrocytes of Human Brain

  1996cited by this paper
• Neural activity and the levels of high energy phosphates during deprivation of oxygen and/or glucose in hippocampal slices of immature and adult rats

  1995cited by this paper
• Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina

  1995cited by this paper
• Adenosine pre- and postsynaptic modulation of glutamate-dependent calcium activity in hypothalamic neurons.

  1995cited by this paper
• Aging, energy, and oxidative stress in neurodegenerative diseases

  1995cited by this paper
• Adenylate Kinase-catalyzed Phosphoryl Transfer Couples ATP Utilization with Its Generation by Glycolysis in Intact Muscle (*)

  1995cited by this paper
• Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR

  1995cited by this paper
• Lactate Metabolism and Its Effects on Glucose Metabolism in an Excised Neural Tissue

  1995cited by this paper
• Hippocampal CA1 lacunosum-moleculare interneurons: comparison of effects of anoxia on excitatory and inhibitory postsynaptic currents.

  1995cited by this paper
• Protection against CNS Ischemia by Temporary Interruption of Function-Related Processes of Neurons

  1995cited by this paper
• Metabolic compartmentation and substrate channelling in muscle cells

  1994cited by this paper
• Glucose Can Fuel Glutamate Uptake in Ischemic Brain

  1994cited by this paper
• Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices.

  1994cited by this paper
• Ions and energy in mammalian brain.

  1994cited by this paper
• Functional Alterations in Alzheimer's Disease: Selective Loss of Mitochondrial-encoded Cytochrome Oxidase mRNA in the Hippocampal Formation

  1994cited by this paper
• Glucose metabolism in photoreceptor outer segments. Its role in phototransduction and in NADPH-requiring reactions.

  1994cited by this paper
• Protection by lactate of cerebral function during hypoglycaemia.

  1994cited by this paper
• Molecular and cellular physiology of intracellular calcium stores.

  1994cited by this paper
• Glucose transporter proteins in brain

  1994cited by this paper
• Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

  1994cited by this paper
• Transport of lactate and other monocarboxylates across mammalian plasma membranes.

  1993cited by this paper
• Nuclear magnetic resonance imaging and spectroscopy of human brain function.

  1993cited by this paper
• Physiological Stimulation Increases Nonoxidative Glucose Metabolism in the Brain of the Freely Moving Rat

  1993cited by this paper
• Transport ofl-lactate by cultured rat brain astrocytes

  1993cited by this paper
• Uptake of L-lactate by cultured rat brain neurons.

  1993cited by this paper
• Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose.

  1993cited by this paper
• The glutamatergic nerve terminal.

  1993cited by this paper
• Glycogen in astrocytes: possible function as lactate supply for neighboring cells.

  1993cited by this paper
• Glycolysis and recovery of pottasium ion homeostasis and synaptic transmission in hippocampal slices after anoxia or stimulated pottasium release

  1993cited by this paper
• Time course and mechanisms of contractile dysfunction during acute myocardial ischemia.

  1993cited by this paper
• Energy requirements of glutamatergic pathways in rabbit retina

  1992cited by this paper
• Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis.

  1992cited by this paper
• Energy requirements of CNS cells as related to their function and to their vulnerability to ischemia: a commentary based on studies on retina.

  1992cited by this paper
• Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography.

  1992cited by this paper
• Astrocyte glutamate uptake during chemical hypoxia in vitro.

  1992cited by this paper
• Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism.

  1992cited by this paper
• Energy metabolism of rabbit retina as related to function: high cost of Na+ transport

  1992cited by this paper
• Glycolysis, Oxidative Metabolism, and Brain Potassium Ion Clearance

  1992cited by this paper
• Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization.

  1992cited by this paper
• Studies on pH Regulatory Mechanisms in Cultured Astrocytes of DBA and C57 Mice

  1992cited by this paper
• Effects of intravenous acetazolamide on retinal pH in the cat.

  1992cited by this paper
• The nature of fuel provision for the Na+,K(+)‐ATPase in porcine vascular smooth muscle.

  1992cited by this paper
• Diseases of the mitochondrial DNA.

  1992cited by this paper
• Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

  1992cited by this paper
• Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1H and 31P Magnetic Resonance Spectroscopy

  1992cited by this paper
• Foundations of vectorial metabolism and osmochemistry

  1991cited by this paper
• Specialized vascularization of the primate visual cortex

  1991cited by this paper
• Kinetics and compartmentation of energy metabolism in intact skeletal muscle determined from 18O labeling of metabolite phosphoryls.

  1991cited by this paper
• Coupled in vivo activity of creatine phosphokinase and the membrane-bound (Na+,K+)-ATPase in the resting and stimulated electric organ of the electric fish Narcine brasiliensis.

  1991cited by this paper
• Ischemic Thresholds of Cerebral Protein Synthesis and Energy State following Middle Cerebral Artery Occlusion in Rat

  1991cited by this paper
• Protection of Ischaemic Synaptosomes from Calcium Overload by Addition of Exogenous Lactate

  1991cited by this paper
• Relations between intracellular ions and energy metabolism: a study with monensin in synaptosomes, neurons, and C6 glioma cells

  1991cited by this paper

• High spatial resolution 23Na-MRI for ischemic brain injury detection

  2026cites this paper
• Absolute quantification of tricarboxylic acid (TCA) cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism

  2026cites this paper
• Comprehensive Analysis of Immune-Related Mitochondrial Genes in Ischemic Stroke Through Integrated Bioinformatics and Validation.

  2026cites this paper
• Species-specific blood–brain barrier permeability in amphibians

  2025cites this paper
• Disruption of the Pum2 axis Aggravates neuronal damage following cerebral Ischemia-Reperfusion in mice.

  2025cites this paper
• Structural and causal links between retinal vascular geometry and neural layer thickness.

  2025cites this paper
• Fat traffic control: S-acylation in axonal transport

  2025cites this paper
• Platelet Extracellular Vesicles as Natural Delivery Vehicles for Mitochondrial Dysfunction Therapy?

  2025cites this paper
• Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke

  2025cites this paper
• The Neurocognitive efficiency score: Derivation, validation, and application of a novel combination of concurrent electrophysiological and behavioral data

  2025cites this paper
• Absolute quantification of TCA cycle intermediates in mouse ocular tissues reveals distinct tissue- and sex-specific mitochondrial metabolism

  2025cites this paper
• Giant unilamellar vesicles as a model system for studying ion transport

  2025cites this paper
• A quinolinyl resveratrol derivative alleviates acute ischemic stroke injury by promoting mitophagy for neuroprotection via targeting CK2α'.

  2024cites this paper
• Brain energy metabolism as an underlying basis of slow and fast cognitive phenotypes in honeybees

  2024cites this paper
• Metabolic Adaptation in Epilepsy: From Acute Response to Chronic Impairment

  2024cites this paper
• Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry.

  2024cites this paper
• Creatine supplementation research fails to support the theoretical basis for an effect on cognition: Evidence from a systematic review.

  2024cites this paper
• Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats

  2024cites this paper
• Prediction of future input explains lateral connectivity in primary visual cortex

  2024cites this paper
• Rich-club organization of whole-brain spatio-temporal multilayer functional connectivity networks

  2024cites this paper
• Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets

  2024influential citation
• Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

  2024cites this paper
• Na+/K+-ATPase: ion pump, signal transducer, or cytoprotective protein, and novel biological functions

  2024cites this paper
• Eye on the horizon: The metabolic landscape of the RPE in aging and disease

  2024cites this paper
• Unveiling the role of local metabolic constraints on the structure and activity of spiking neural networks

  2024cites this paper
• The effect of metabolism on cognitive performance varies with task complexity in common minnows, Phoxinus phoxinus

  2024cites this paper
• 20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase.

  2024cites this paper
• Single-Cell Transcriptome Reveals Cell Type–Specific Molecular Pathology in a 2VO Cerebral Ischemic Mouse Model

  2024cites this paper
• Oxidative stress involvement in the molecular pathogenesis and progression of multiple sclerosis: a literature review

  2024cites this paper
• Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells

  2024cites this paper
• Parechovirus-3 infection disrupts immunometabolism and leads to glutamate excitotoxicity in neural organoids

  2024cites this paper
• Functional Neuroplasticity of Adults with Partial or Complete Denture Rehabilitation with or without Implants: Evidence from fMRI Studies

  2023cites this paper
• Glutamate-Evoked Ca2+ Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na+/K+-ATPase and Na+/Ca2+-Exchanger

  2023cites this paper
• Metabolic energetics underlying attractors in neural models

  2023cites this paper
• The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury.

  2023cites this paper
• Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics

  2023cites this paper
• Watching the human retina breath in real time and the slowing of mitochondrial respiration with age

  2023cites this paper
• Thermodynamic limitations on brain oxygen metabolism: physiological implications

  2023cites this paper
• TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex

  2023cites this paper
• Co-Integrated Neuromorphic Devices for Bio-Inspired Compliance Control

  2023cites this paper
• Pathophysiology of ion channels in amyotrophic lateral sclerosis

  2023cites this paper
• Dynamic analysis of epileptic seizures caused by energy failure after ischemic stroke

  2023cites this paper
• Disorders of Endogenous and Exogenous Antioxidants in Neurological Diseases

  2023cites this paper
• The accumulated oxygen deficit as an indicator of the ischemic retinal insult.

  2023cites this paper
• Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis

  2023cites this paper
• G Protein-Coupled Receptor 40 Agonist LY2922470 Alleviates Ischemic-Stroke-Induced Acute Brain Injury and Functional Alterations in Mice

  2023cites this paper
• Blood and Brain Metabolites after Cerebral Ischemia

  2023cites this paper
• Metabolic energy consumption and information transmission of a two-compartment neuron model and its cortical network

  2023cites this paper
• Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion

  2023cites this paper
• Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency

  2023cites this paper
• Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules

  2022cites this paper
• Cis-p-tau plays crucial role in lysolecithin-induced demyelination and subsequent axonopathy in mouse optic chiasm.

  2022cites this paper
• Essential metals in health and disease.

  2022cites this paper
• Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy

  2022cites this paper
• Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways

  2022cites this paper
• Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs

  2022cites this paper
• A mathematical model of GLUT1 modulation in rods and RPE and its differential impact in cell metabolism

  2022cites this paper
• Sex differences in seasonal brain plasticity and the neuroendocrine regulation of vocal behavior in songbirds.

  2022cites this paper
• Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases

  2022cites this paper
• The Energy Homeostasis Principle: A Naturalistic Approach to Explain the Emergence of Behavior

  2022cites this paper
• The Na+/K+ pump dominates control of glycolysis in hippocampal dentate granule cells

  2022influential citation
• Retinal glia

  2022cites this paper
• References

  2022cites this paper
• Mitochondrial heterogeneity and homeostasis through the lens of a neuron

  2022cites this paper
• Early-adolescent antibiotic exposure results in mitochondrial and behavioral deficits in adult male mice

  2021cites this paper
• HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies

  2021cites this paper
• A Metabolic Landscape for Maintaining Retina Integrity and Function

  2021cites this paper
• Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion

  2021cites this paper
• Abnormal Brain Bioenergetics in First-Episode Psychosis

  2021cites this paper
• Adaptive responses to neurodegenerative stress in glaucoma.

  2021cites this paper
• Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination

  2021cites this paper
• Effects of lactate and carbon monoxide interactions on neuroprotection and neuropreservation

  2021cites this paper
• Social context shapes cognitive abilities: associative memories are modulated by fight outcome and social isolation in the crab Neohelice granulata

  2021cites this paper
• Impaired mitochondrial bioenergetics in psychiatric disorders

  2021cites this paper
• A rare but treatable inborn error of metabolism: Arginine glycine amidinotransferase (AGAT) deficiency

  2021cites this paper
• FAM3A Ameliorates Brain Impairment Induced by Hypoxia–Ischemia in Neonatal Rat

  2021cites this paper
• Brain power

  2021cites this paper
• CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?

  2021cites this paper
• Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.

  2021cites this paper
• The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body

  2021cites this paper
• Predicting signaling pathways regulating demyelination in a rat model of lithium-pilocarpine-induced acute epilepsy: A proteomics study.

  2021cites this paper
• Green oxygen power plants in the brain rescue neuronal activity

  2021cites this paper
• Energy Homeostasis Principle: A Naturalistic Approach to Explain the Emergence of Behavior

  2021cites this paper
• Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

  2021cites this paper
• Hypoxic and osmotic expression of Kir2.1 potassium channels in retinal pigment epithelial cells: Contribution to vascular endothelial growth factor expression.

  2021cites this paper
• The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

  2021cites this paper
• ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response

  2021cites this paper
• Vanishing basal ganglia in ATP1A3‐related polymicrogyria

  2021cites this paper
• The Active and Passive Components of Neuronal Excitation and its Glial Support

  2021cites this paper
• The Energy as a Determinant Factor in the Ethiopathogeny of Chromosomal Abnormalities. The Unsuspected Bioenergetic Role of Melanin

  2020cites this paper
• Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder.

  2020cites this paper
• Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients

  2020cites this paper
• Locomotor activity patterns in three spider species suggest relaxed selection on endogenous circadian period and novel features of chronotype

  2020cites this paper
• Microelectrode electrode array studies of spinal motor neurons

  2020cites this paper
• Characterization of Carbonic Anhydrase In Vivo Using Magnetic Resonance Spectroscopy

  2020cites this paper
• Metabolic Regulation of Glial Phenotypes: Implications in Neuron–Glia Interactions and Neurological Disorders

  2020cites this paper
• Energy supply per neuron is constrained by capillary density in the mouse brain

  2020cites this paper
• Dopamine Release Neuroenergetics in Mouse Striatal Slices

  2020cites this paper
• Computational animal welfare: towards cognitive architecture models of animal sentience, emotion and wellbeing

  2020cites this paper
• Universal Glia to Neurone Lactate Transfer in the Nervous System: Physiological Functions and Pathological Consequences

  2020cites this paper