Chronic stress induced remodeling of the prefrontal cortex: structural re-organization of microglia and the inhibitory effect of minocycline.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cerebral Cortex

• Publication date

  2013-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/cercor/bhs151PMID 22710611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cerebral Cortex

  2017cited by this paper
• Microglia

  2013cited by this paper
• Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation.

  2012cited by this paper
• Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.

  2012cited by this paper
• Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex.

  2012cited by this paper
• Physiology of microglia.

  2011cited by this paper
• β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

  2011cited by this paper
• Role of microglia in CNS inflammation

  2011cited by this paper
• Repeated social defeat selectively increases δFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex.

  2011cited by this paper
• Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

  2010cited by this paper
• Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions.

  2010influential reference
• Microglial Interactions with Synapses Are Modulated by Visual Experience

  2010cited by this paper
• Changing Face of Microglia

  2010cited by this paper
• P2Y12 receptor‐mediated integrin‐β1 activation regulates microglial process extension induced by ATP

  2010cited by this paper
• Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific.

  2009cited by this paper
• Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling

  2009cited by this paper
• Differential microglial activation between acute stress and lipopolysaccharide treatment.

  2009cited by this paper
• Adhesion to fibronectin regulates interleukin-1 beta expression in microglial cells.

  2009influential reference
• Microglia: biology and pathology

  2009cited by this paper
• Immune and behavioral consequences of microglial reactivity in the aged brain.

  2009cited by this paper
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

  2008cited by this paper
• The molecular neurobiology of depression

  2008cited by this paper
• Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

  2008cited by this paper
• GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro.

  2008cited by this paper
• Diverse

  2008cited by this paper
• Spatial arrangement of microglia in the mouse hippocampus: A stereological study in comparison with astrocytes

  2007cited by this paper
• Actin-binding Proteins Coronin-1a and IBA-1 are Effective Microglial Markers for Immunohistochemistry

  2007cited by this paper
• Activin as an anti-inflammatory cytokine produced by microglia.

  2007cited by this paper
• Minocycline decreases in vitro microglial motility, β1‐integrin, and Kv1.3 channel expression

  2007cited by this paper
• Differential laminar effects of amphetamine on prefrontal parvalbumin interneurons.

  2007cited by this paper
• Diverse microglial responses after intrahippocampal administration of lipopolysaccharide

  2006cited by this paper
• Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex.

  2006cited by this paper
• Motor neuronal and glial apoptosis in the adult facial nucleus after intracranial nerve transection.

  2006cited by this paper
• Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers

  2005cited by this paper
• CD163 Identifies a Unique Population of Ramified Microglia in HIV Encephalitis (HIVE)

  2004cited by this paper
• Facial nerve axotomy in aged and young adult rats: analysis of the glial response.

  2003cited by this paper
• Intracellular signaling in M‐CSF‐induced microglia activation: Role of Iba1

  2002cited by this paper
• Use of fractal theory in neuroscience: methods, advantages, and potential problems.

  2001cited by this paper
• Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

  2001cited by this paper
• Dynamics of microglial activation: A confocal time‐lapse analysis in hippocampal slices

  2001cited by this paper
• Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture.

  2001cited by this paper
• The neurobiology of stress: from serendipity to clinical relevance.

  2000cited by this paper
• A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.

  1999cited by this paper
• Reactive microgliosis.

  1999cited by this paper
• The microglia/macrophage response in the neonatal rat facial nucleus following axotomy.

  1998cited by this paper
• Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells

  1998cited by this paper
• Ramification of microglia, monocytes and macrophages in vitro: influences of various epithelial and mesenchymal cells and their conditioned media*

  1997cited by this paper
• Microglia: a sensor for pathological events in the CNS.

  1996cited by this paper
• Microglial response to degeneration of serotonergic axon terminals

  1994cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Cytology & cellular pathology of the nervous system

  1965cited by this paper
• The measurable parameters of the cerebral cortex and their significance in its organization.

  1956cited by this paper

• Inflammation modifies breathing phenotype in mice with epilepsy

  2026cites this paper
• Region-specific features of early glial activation and Aquaporin-4 dysregulation in conditional mouse models of TDP-43 proteinopathies

  2026cites this paper
• Striatal injection of aminochrome in Wistar rats induces early-stage behavioral changes of Parkinson's disease and dopaminergic degeneration in the caudal and medial regions of the nigra pars compacta.

  2025cites this paper
• Glial Plasticity and Metabolic Stability After Knockdown of Astrocytic Cx43 in the Dorsal Vagal Complex

  2025cites this paper
• Non-obese genetic type 2 diabetes causes brain and behavioral hallmarks of chronic stress

  2025cites this paper
• 3-dimensional morphological analysis of microglia in the sheep brain.

  2025cites this paper
• A comparison of microglial morphological complexity in adult mouse brain samples using 2-dimensional and 3-dimensional image analysis tools

  2025cites this paper
• From Stress to Substance Use Disorders: The Expanding Role of Microglia–Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens

  2025cites this paper
• The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms

  2025cites this paper
• Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress

  2025cites this paper
• Cryptococcus exploits delayed microglial activation, and microglial osteopontin/Spp1 impairs peripheral host control.

  2025cites this paper
• Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment

  2025cites this paper
• Early life ACE2 inhibition leads to long term anxiety-like behaviour in rats by disrupting the amygdala.

  2025cites this paper
• The impact and mechanisms of YL-IPA08, a potent ligand for the translocator protein (18 kDa) on protection against LPS-induced depression and cognitive dysfunction in rodents

  2025cites this paper
• Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s disease

  2025cites this paper
• Growth hormone reduces retinal inflammation and preserves microglial morphology after optic nerve crush in male rats

  2025cites this paper
• The Role of Microglia in the Pathophysiology of Post-Traumatic Stress Disorder

  2025cites this paper
• Zebrafish models: Charting promising platform and illuminating the depths of depression.

  2025cites this paper
• Quercetin ameliorates chronic restraint stress- and LPS-induced anxiety-like behaviors by modulating neuroinflammation in the lateral hypothalamus

  2025cites this paper
• Early-life adversities compromise behavioral development in male and female mice heterozygous for CNTNAP2

  2025cites this paper
• Early life stress alters microglia in ventral hippocampus and dorsal CA2 associated with anxiety-like behavior in adolescent male rats

  2025cites this paper
• Chronic activation of a negative engram induces behavioral and cellular abnormalities

  2024cites this paper
• Ultrastructural features of psychological stress resilience in the brain: a microglial perspective

  2024cites this paper
• Microglia morphology in the developing primate amygdala and effects of early life stress

  2024cites this paper
• Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits

  2024cites this paper
• Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression

  2024cites this paper
• Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives

  2024cites this paper
• Effects of social dominance and acute social stress on morphology of microglia and structural integrity of the medial prefrontal cortex.

  2024cites this paper
• Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions.

  2024cites this paper
• Box-Counting Fractal Analysis: A Primer for the Clinician.

  2024cites this paper
• Post-weaning social isolation alters sociability in a sex-specific manner

  2024cites this paper
• Stress and Microglia: A Double-edged Relationship.

  2024cites this paper
• Post-weaning social isolation alters sociability in a sex-specific manner

  2024cites this paper
• Inflammation subsequent to mild iron excess differentially alters regional brain iron metabolism, oxidation and neuroinflammation status in mice

  2024cites this paper
• PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation

  2024cites this paper
• Associations of the immune system in aggression traits and the role of microglia as mediators.

  2024cites this paper
• Developmental and adult stress: effects of steroids and neurosteroids

  2024cites this paper
• Chronic activation of astrocytic Gq GPCR signaling has causal effects on visual LTP formation: implications for neurodegenerative diseases

  2024cites this paper
• Running exercise decreases microglial activation in the medial prefrontal cortex in an animal model of depression.

  2024cites this paper
• Alleviative effect of scopolamine‑induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from Boesenbergia rotunda (L.)

  2024influential citation
• Phloretin alleviates sleep deprivation-induced cognitive impairment by reducing inflammation through PPARγ/NF-κB signaling pathway.

  2024cites this paper
• Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus

  2024cites this paper
• Inflammation and Mental Health Disorders: Immunomodulation as a Potential Therapy for Psychiatric Conditions.

  2023cites this paper
• Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases

  2023cites this paper
• impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus

  2023cites this paper
• Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge.

  2023cites this paper
• The role of leukotriene inhibition using a 5-lipoxygenase (5-LO) inhibitor in a joint contracture model

  2023cites this paper
• Early-life stress contributes to depression-like behaviors in a two-hit mouse model.

  2023cites this paper
• A consideration of the increased risk of schizophrenia due to prenatal maternal stress, and the possible role of microglia.

  2023cites this paper
• Persistence of Hyper-Ramified Microglia in Porcine Cortical Gray Matter after Mild Traumatic Brain Injury

  2023cites this paper
• Interplay between microglia and environmental risk factors in Alzheimer's disease

  2023cites this paper
• Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss

  2023influential citation
• Cigarette smoke-induced pulmonary impairment is associated with social recognition memory impairments and alterations in microglial profiles within the suprachiasmatic nucleus of the hypothalamus.

  2023cites this paper
• Chronic Stress Beginning in Adolescence Decreases Spatial Memory Following an Acute Inflammatory Challenge in Adulthood.

  2023cites this paper
• Regional variances depict a unique glial-specific inflammatory response following closed-head injury

  2023cites this paper
• Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice

  2023cites this paper
• Quantitative analysis of microglia morphological changes in the hypothalamus of chronically stressed rats.

  2023cites this paper
• Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder.

  2023cites this paper
• Control of complex behavior by astrocytes and microglia.

  2022cites this paper
• Met/HGFR triggers detrimental reactive microglia in TBI.

  2022cites this paper
• Activación de la microglía en el hipocampo asociada con lesión del nervio facial

  2022cites this paper
• Peripheral sympathectomy alters neuroin ammatory responses and microglial activity in response to sleep fragmentation in female mice

  2022cites this paper
• The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

  2022cites this paper
• The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

  2022cites this paper
• Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice.

  2022cites this paper
• Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them

  2022cites this paper
• The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes

  2022cites this paper
• Microglia-specific transcriptional repression of interferon-regulated genes after prolonged stress in mice

  2022cites this paper
• Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia.

  2022cites this paper
• High-Fat Diet Exacerbates Autistic-Like Restricted Repetitive Behaviors and Social Abnormalities in CC2D1A Conditional Knockout Mice

  2022cites this paper
• Sex-specific differences in alcohol-induced pain sensitization.

  2022cites this paper
• Extracellular Vesicles and the Stress System

  2022cites this paper
• Microglia morphophysiological diversity and its implications for the CNS

  2022cites this paper
• Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

  2022cites this paper
• Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.

  2022cites this paper
• Peripheral Sympathectomy Alters Neuroinflammatory and Microglial Responses to Sleep Fragmentation in Female Mice.

  2022cites this paper
• The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD

  2022cites this paper
• Identification of hyper‐ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience

  2022cites this paper
• Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders.

  2022cites this paper
• The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism

  2022influential citation
• Different Methods for Evaluating Microglial Activation Using Anti-Ionized Calcium-Binding Adaptor Protein-1 Immunohistochemistry in the Cuprizone Model

  2022cites this paper
• Microglia react to partner loss in a sex- and brain site-specific manner in prairie voles.

  2021cites this paper
• Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model

  2021influential citation
• Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex

  2021cites this paper
• Long-term sensitization of rat spinal neurons induced by adolescent psychophysical stress is further enhanced by a mild-nociceptive lumbar input

  2021cites this paper
• Effects of Remote Immune Activation on Performance in the 5-Choice Serial Reaction Time Task Following Mild Traumatic Brain Injury in Adolescence

  2021cites this paper
• Inflammation increases the development of depression behaviors in male rats after spinal cord injury

  2021cites this paper
• The Role of Nutrition in Space Exploration: Implications for Sensorimotor, Cognition, Behavior and the Cerebral Changes due to the Exposure to Radiation, Altered Gravity, and Isolation/Confinement Hazards of Spaceflight.

  2021cites this paper
• Cell Adhesion Factors in the Orbitofrontal Cortex Control Cue-Induced Reinstatement of Cocaine Seeking and Amygdala-Dependent Goal Seeking

  2021cites this paper
• Social Isolation Induces Neuroinflammation And Microglia Overactivation, While Dihydromyricetin Prevents And Improves Them

  2021cites this paper
• Brain immune cells characterization in UCMS exposed P2X7 Knock-Out mouse.

  2021cites this paper
• Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry

  2021cites this paper
• Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation

  2021cites this paper
• Interactions of neuroimmune signaling and glutamate plasticity in addiction

  2021cites this paper
• Adenosine A2A receptor modulates microglia-mediated synaptic pruning of the retinogeniculate pathway during postnatal development.

  2021cites this paper
• Sex and region-specific effects of variable stress on microglia morphology

  2021cites this paper
• The role of microglia in neuropsychiatric disorders and suicide

  2021cites this paper
• Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse

  2021cites this paper
• Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.

  2021cites this paper
• Microglial Metamorphosis in Three Dimensions in Virus Limbic Encephalitis: An Unbiased Pictorial Representation Based on a Stereological Sampling Approach of Surveillant and Reactive Microglia

  2021cites this paper