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Human stereoEEG recordings reveal network dynamics of decision-making in a rule-switching task

Marije ter Wal,A. Platonov,P. Cardellicchio,V. Pelliccia,G. LoRusso,I. Sartori,P. Avanzini,G. Orban,P. Tiesinga

Published 2020 in Nature Communications

ABSTRACT

The processing steps that lead up to a decision, i.e., the transformation of sensory evidence into motor output, are not fully understood. Here, we combine stereoEEG recordings from the human cortex, with single-lead and time-resolved decoding, using a wide range of temporal frequencies, to characterize decision processing during a rule-switching task. Our data reveal the contribution of rostral inferior parietal lobule (IPL) regions, in particular PFt, and the parietal opercular regions in decision processing and demonstrate that the network representing the decision is common to both task rules. We reconstruct the sequence in which regions engage in decision processing on single trials, thereby providing a detailed picture of the network dynamics involved in decision-making. The reconstructed timeline suggests that the supramarginal gyrus in IPL links decision regions in prefrontal cortex with premotor regions, where the motor plan for the response is elaborated. How sensory evidence is transformed into motor output is not fully understood. Here, the authors use stereoEEG recordings during a rule-switching task to reveal network dynamics of decision-making.

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