The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Cancer Chemotherapy and Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s002800050817PMID 9744771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• p53 tumour suppressor

  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996influential reference
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  1996cited by this paper
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