Estimating the number of protein folds.

A number of fundamental questions in structural biology concern the diversity of protein architectures (or folds). Here, we address two of them, the size of the universe of folds, and the distribution of sequence families among them, using an analysis based on a new and rigorous statistical sampling method. In particular we show that the number of known non-transmembrane protein folds is approximately one half of the total that exist, and that certain superfolds should exist, which accommodate dozens of non-homologous sequence families.

• Publication year

  1998

• Venue

  Journal of Molecular Biology

• Publication date

  1998-12-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/JMBI.1998.2282PMID 9878351
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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