Survival at Extreme Altitude: Protective Effect of Increased Hemoglobin-Oxygen Affinity

No abstract is available for this paper.

• Publication year

  1974

• Venue

  Science

• Publication date

  1974-02-22

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1126/science.183.4126.743PMID 4821240
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Red cell metabolism. A. Defects not causing hemolytic disease. B. Environmental modification.

  1972cited by this paper
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  1969cited by this paper
• Red-cell 2,3-diphosphoglycerate levels in subjects with chronic hypoxemia.

  1969cited by this paper
• Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels.

  1968cited by this paper
• Improved oxygen release: an adaptation of mature red cells to hypoxia.

  1968cited by this paper
• The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human.

  1968cited by this paper

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  2024cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2017cites this paper
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  2013cites this paper
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  2011cites this paper
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  2010cites this paper
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  2007cites this paper
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  1999cites this paper
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  1999cites this paper
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  1991cites this paper
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  1990cites this paper
• [Mechanisms of adaptation of the oxyphoric function of hemoglobin in mammals].

  1990cites this paper
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  1990cites this paper
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  1990cites this paper
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  1989cites this paper
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  1988cites this paper
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  1987cites this paper
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  1987cites this paper
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  1986cites this paper
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  1986cites this paper
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