MAP2K4/MKK4 Expression in Pancreatic Cancer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Clinical Cancer Research

• Publication date

  2004-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-04-0885PMID 15623633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transcriptional regulation by the MAP kinase signaling cascades.

  2003cited by this paper
• Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma.

  2002cited by this paper
• Mutation rate of MAP2K4/MKK4 in breast carcinoma

  2002cited by this paper
• Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct.

  2001cited by this paper
• Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17.

  1999cited by this paper
• Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.

  1998cited by this paper
• Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

  1997cited by this paper
• Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.

  1997cited by this paper
• Mammalian Mitogen-activated Protein Kinase Pathways Are Regulated through Formation of Specific Kinase-Activator Complexes*

  1996cited by this paper
• Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

  1995cited by this paper
• Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

  1995cited by this paper
• Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

  1994cited by this paper
• Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

  1994cited by this paper
• Statistical aspects of the analysis of data from retrospective studies of disease.

  1959cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper
• Regression Models and Life-Tables

  year unknowncited by this paper

• Identification of the Carcinogenic Process from Lobular Endocervical Glandular Hyperplasia to Gastric-Type Adenocarcinoma of the Uterine Cervix via Whole-Exome Sequencing.

  2026cites this paper
• In silico screening and in vitro biological evaluation reveal Queuine as a promising MAP4K4 inhibitor for treating pancreatic cancer

  2025cites this paper
• Drivers of Pancreatic Cancer: Beyond the Big 4

  2025cites this paper
• Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data

  2023cites this paper
• In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

  2023cites this paper
• The Role of Maspin Expression as Diagnostic Tissue Marker in Pancreaticoduodenal Malignant Tumors and Benign Lesions

  2022cites this paper
• Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634

  2022cites this paper
• Stress-activated kinases as therapeutic targets in pancreatic cancer

  2021cites this paper
• Pancreatic cancer.

  2021cites this paper
• A new prognosis prediction model combining TNM stage with MAP2K4 and JNK in postoperative pancreatic cancer patients.

  2020cites this paper
• New Insights Into the Complex Mutational Landscape of Sézary Syndrome

  2020cites this paper
• Genetic Alterations of Periampullary and Pancreatic Ductal Adenocarcinoma: An Overview

  2018cites this paper
• Chapter 2 Molecular Genetics of Pancreatic Cancer

  2018cites this paper
• Cancer Genetics at a Glance: The Comprehensive Insights

  2017cites this paper
• Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy.

  2017cites this paper
• MicroRNA‐802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4

  2017cites this paper
• Metastasis suppressor proteins in cutaneous squamous cell carcinoma.

  2016cites this paper
• [Coexpression of MAP2K4 and vimentin proteins in human endometrial carcinoma and its clinicopathological significance].

  2016cites this paper
• Altered expression of mir-222 and mir-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression

  2016cites this paper
• The genomic and metabolomic profiling of pancreas cancer

  2015cites this paper
• MicroRNA-27a Promotes Proliferation, Migration and Invasion by Targeting MAP2K4 in Human Osteosarcoma Cells

  2014cites this paper
• Tumor and Stem Cell Biology Impaired JNK Signaling Cooperates with KrasG 12 D Expression to Accelerate Pancreatic Ductal Adenocarcinoma

  2014cites this paper
• Genetic determinants and potential therapeutic targets for pancreatic adenocarcinoma

  2014cites this paper
• LPS Induced miR-181a Promotes Pancreatic Cancer Cell Migration via Targeting PTEN and MAP2K4

  2014cites this paper
• Map2k4δ - identification and functional characterization of a novel Map2k4 splice variant.

  2014cites this paper
• Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis.

  2014cites this paper
• Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

  2014cites this paper
• Pancreatic cancer genomics: insights and opportunities for clinical translation

  2013cites this paper
• Genomic Alterations in Sporadic Pancreatic Cancer

  2013cites this paper
• Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer.

  2013cites this paper
• Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer

  2013cites this paper
• Biological and Prognostic Relevance of Mitogen-Activated Protein Kinases in Pancreatic Adenocarcinoma

  2012cites this paper
• A sandwich assay for quantitative detection of transcription factors in cell lysate.

  2012cites this paper
• Genomics screens for metastasis genes

  2012cites this paper
• MKK4 acts as a potential tumor suppressor in ovarian cancer

  2011cites this paper
• Functional and Clinicopathological Analysis of Loss of MKK4 Expression in Endometrial Cancer

  2011cites this paper
• A lateral flow biosensor for rapid detection of DNA-binding protein c-jun.

  2011cites this paper
• Molecular Characteristics of Pancreatic Ductal Adenocarcinoma

  2011influential citation
• Loss of MKK4 expression in ovarian cancer: A potential role for the epithelial to mesenchymal transition

  2011cites this paper
• The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7.

  2011cites this paper
• Building on the foundation of daring hypotheses: Using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization

  2011cites this paper
• Metastasis suppressor genes at the interface between the environment and tumor cell growth.

  2011cites this paper
• Harnessing transposons for cancer gene discovery

  2010cites this paper
• The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer.

  2010cites this paper
• The functional relevance of MKK4 and MKK7 splice variants in neural cells

  2010cites this paper
• The pathology and genetics of metastatic pancreatic cancer.

  2009cites this paper
• Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.

  2009cites this paper
• Genetic and molecular alterations in rhabdomyosarcoma: mRNA overexpression of MCL1 and MAP2K4 genes.

  2009cites this paper
• A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma

  2009cites this paper
• Interactions et coopérations cellulaires dans le processus métastatique

  2008cites this paper
• Molecular Genetics of Pancreatic Cancer

  2008cites this paper
• Original Article Gene Expression Profiles Associated with Advanced Pancreatic Cancer

  2008cites this paper
• Gene expression profiles associated with advanced pancreatic cancer.

  2008cites this paper
• Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts.

  2008cites this paper
• Absence of E-Cadherin Expression Distinguishes Noncohesive from Cohesive Pancreatic Cancer

  2008cites this paper
• Pancreatic Carcinogenesis

  2008cites this paper
• Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines

  2008cites this paper
• New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells.

  2008cites this paper
• Role of mitogen-activated protein kinase kinase 4 in cancer

  2007cites this paper
• Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.

  2007cites this paper
• The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.

  2007cites this paper
• A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions

  2007cites this paper
• Up‐regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia

  2007cites this paper
• Palliative management of gastric cancer.

  2007cites this paper
• Award Number: DAMD17-01-1-0700 TITLE: Evaluation of the role of the metastasis-suppressor gene MKK4/SEK1 in transgenic models of prostate cancer

  2007cites this paper
• Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-κB Activation and NF-κB-Regulated Antiapoptotic Gene Products1

  2007cites this paper
• Claudin-4, Mitogen-Activated Protein Kinase Kinase 4, and Stratifin Are Markers of Gastric Adenocarcinoma Precursor Lesions

  2006cites this paper
• Efeito da nicotina injetável e da fumaça do cigarro em um modelo experimental de lesões intra-epiteliais e de adenocarcinoma pancreático induzidos por 7,12-dimetilbenzantraceno (DMBA) em camundongos

  2006influential citation
• Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors.

  2006cites this paper
• MKK4 status predicts survival after resection of gastric adenocarcinoma.

  2006cites this paper
• Profiling of DNA copy number in sarcomas by array comparative genomic hybridisation and identification of candidate cancer genes

  2006cites this paper
• UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA: CIRURGIA

  2006cites this paper
• Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy

  2005cites this paper
• Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7.

  2005cites this paper
• Molecular and Cellular Pathobiology the Mitogen-activated Protein Kinase Kinase 4 Has a Pro-oncogenic Role in Skin Cancer

  year unknowncites this paper