Up‐regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Pathology

• Publication date

  2007-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/path.2194PMID 17577251
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PRAK is essential for ras-induced senescence and tumor suppression.

  2007cited by this paper
• The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma.

  2006cited by this paper
• Claudin-4, Mitogen-Activated Protein Kinase Kinase 4, and Stratifin Are Markers of Gastric Adenocarcinoma Precursor Lesions

  2006cited by this paper
• Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

  2006cited by this paper
• The p38 transduction pathway in prostatic neoplasia

  2006cited by this paper
• Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy

  2006cited by this paper
• Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase

  2006cited by this paper
• Homozygous deletion of MKK4 in ovarian serous carcinoma

  2006cited by this paper
• MKK4 status predicts survival after resection of gastric adenocarcinoma.

  2006cited by this paper
• Critical role of the c-JunNH2-terminal kinase and p38 mitogen-activated protein kinase pathways on sodium butyrate-induced apoptosis in DU145 human prostate cancer cells

  2006cited by this paper
• Interleukin‐6 and oncostatin M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen‐activated protein kinase and phosphatidylinositol 3‐kinase

  2005cited by this paper
• Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.

  2005cited by this paper
• Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7.

  2005cited by this paper
• MAP2K4/MKK4 Expression in Pancreatic Cancer

  2004cited by this paper
• Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth

  2004cited by this paper
• Enhanced Redundancy in Akt and Mitogen-activated Protein Kinase-induced Survival of Malignant versus Normal Prostate Epithelial Cells

  2004cited by this paper
• Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cells

  2004cited by this paper
• Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.

  2003cited by this paper
• Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer

  2003cited by this paper
• Role of JNK in Tumor Development

  2003cited by this paper
• Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.

  2003cited by this paper
• Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway*

  2003cited by this paper
• Activation of pro-apoptotic p38-MAPK pathway in the prostate cancer cell line M12 expressing a truncated IGF-IR.

  2003cited by this paper
• Negative Feedback Regulation of MKK6 mRNA Stability by p38α Mitogen-Activated Protein Kinase

  2003cited by this paper
• Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma.

  2002cited by this paper
• Regulation of proliferation/apoptosis equilibrium by mitogen-activated protein kinases in normal, hyperplastic, and carcinomatous human prostate.

  2002cited by this paper
• Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis

  2002cited by this paper
• Mutation rate of MAP2K4/MKK4 in breast carcinoma

  2002cited by this paper
• Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.

  2001cited by this paper
• Human gastric cancer kinase profile and prognostic significance of MKK4 kinase.

  2000cited by this paper
• Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17.

  1999cited by this paper
• Control of cell cycle progression by c-Jun is p53 dependent.

  1999cited by this paper
• Mitogen-activated protein kinases and apoptosis in PIN

  1998cited by this paper
• Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.

  1998cited by this paper
• Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases.

  1998cited by this paper
• Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.

  1997cited by this paper
• Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.

  1997cited by this paper
• Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*)

  1996cited by this paper
• Prostate cancer in a transgenic mouse.

  1995cited by this paper
• Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

  1995cited by this paper
• On the design of synthetic case-control studies.

  1986cited by this paper

• Pharmacological inhibition of the MAP2K7 kinase in human disease

  2024cites this paper
• QTL Mapping-Based Identification of Visceral White-Nodules Disease Resistance Genes in Larimichthys polyactis

  2024cites this paper
• LncRNA PTTG3P promotes tumorigenesis and metastasis of NSCLC by binding with ILF3 to maintain mRNA stability and form a positive feedback loop with E2F1

  2023cites this paper
• Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome

  2022cites this paper
• Molecular Mechanisms of Antiproliferative and Apoptosis Activity by 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)1,4-Pentadiene-3-one (MS13) on Human Non-Small Cell Lung Cancer Cells

  2021cites this paper
• Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia

  2021cites this paper
• CircRNA LRIG3 knockdown inhibits hepatocellular carcinoma progression by regulating miR-223-3p and MAPK/ERK pathway

  2021cites this paper
• CircRNA LRIG3 knockdown inhibits the progression of hepatocellular carcinoma by regulating miR-223-3p/MAP2K6 axis and inactivating MAPK/ERK pathway

  2020cites this paper
• Integrin α2β1 inhibition attenuates prostate cancer cell proliferation by cell cycle arrest, promoting apoptosis and reducing epithelial–mesenchymal transition

  2020cites this paper
• Catalytic domain plasticity of MKK7 reveals structural mechanisms of allosteric activation and new targeting opportunities

  2020cites this paper
• Down-Regulation of DDR1 Induces Apoptosis and Inhibits EMT through Phosphorylation of Pyk2/MKK7 in DU-145 and Lncap-FGC Prostate Cancer Cell Lines.

  2020cites this paper
• Inhibition of didscoidin domain receptor 1 reduces epithelial–mesenchymal transition and induce cell‐cycle arrest and apoptosis in prostate cancer cell lines

  2019cites this paper
• Modeling MEK4 Kinase Inhibitors Through Perturbed Electrostatic Potential (ESP) Charges.

  2019cites this paper
• Synthesis and Biological Evaluation of 3‐Arylindazoles as Selective MEK4 Inhibitors

  2019cites this paper
• Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.

  2019cites this paper
• Role of MAP2K6 in sensitivity to radiotherapy of human nasopharyngeal carcinoma CNE cells

  2018cites this paper
• Loss-of-function uORF mutations in human malignancies

  2018cites this paper
• Truncation and Motif Based Pan-Cancer Analysis Highlights Novel Tumor Suppressing Kinases

  2018cites this paper
• Quantitative proteome analysis identifies MAP2K6 as potential regulator of LIFR-induced radioresistance in nasopharyngeal carcinoma cells.

  2018cites this paper
• Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma.

  2018cites this paper
• MicroRNA‑136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen‑activated protein kinase kinase 4.

  2018cites this paper
• Submitted to International Journal of Oncology Involvement of the glutamine RF-amide peptide (QRFP) and its cognate receptor GPR103 in prostate cancer

  2018cites this paper
• Involvement of the glutamine RF-amide peptide and its cognate receptor GPR103 in prostate cancer

  2018cites this paper
• Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

  2018cites this paper
• A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family.

  2017cites this paper
• INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 IN BREAST TUMORIGENESIS.

  2017cites this paper
• Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers

  2016cites this paper
• Kinase modulation of androgen receptor signaling: implications for prostate cancer.

  2015cites this paper
• Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage

  2015cites this paper
• Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) Promotes Human Prostate Cancer Metastasis

  2014cites this paper
• MKK6 is Upregulated in Human Esophageal, Stomach, and Colon Cancers

  2014cites this paper
• Correction: A Fluorescence-Based Thermal Shift Assay Identifies Inhibitors of Mitogen Activated Protein Kinase Kinase 4

  2013cites this paper
• MKK3 Was Involved in Larval Settlement of the Barnacle Amphibalanus amphitrite through Activating the Kinase Activity of p38MAPK

  2013cites this paper
• A Fluorescence-Based Thermal Shift Assay Identifies Inhibitors of Mitogen Activated Protein Kinase Kinase 4

  2013cites this paper
• Disruption of Prostate Epithelial Differentiation Pathways and Prostate Cancer Development

  2013cites this paper
• Serum/glucocorticoid‐regulated kinase 1 expression in primary human prostate cancers

  2012cites this paper
• Control of Metastatic Colonization in Prostate Cancer: The Functional Mechanism of Metastasis Suppression by JNKK1/MKK4

  2012cites this paper
• JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate

  2012cites this paper
• MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression

  2012cites this paper
• Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies.

  2012cites this paper
• Role of the functional MKK4 promoter variant (−1304T>G) in a decreased risk of prostate cancer: case–control study and meta-analysis

  2012cites this paper
• Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents

  2012cites this paper
• How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal.

  2012cites this paper
• Human lactoferrin upregulates BCL-3 in the K562 erythroleukemia cell

  2011cites this paper
• Metastasis-suppressor genes in clinical practice: lost in translation?

  2011cites this paper
• Hematopoietic Progenitor Kinase 1, Mitogen-Activated Protein/Extracellular Signal-Related Protein Kinase Kinase Kinase 1, and phosphoMitogen-Activated Protein Kinase Kinase 4 are Overexpressed in Extramammary Paget Disease

  2011cites this paper
• Fyn Is Downstream of the HGF/MET Signaling Axis and Affects Cellular Shape and Tropism in PC3 Cells

  2011cites this paper
• Building on the foundation of daring hypotheses: Using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization

  2011cites this paper
• Metastasis suppressor genes at the interface between the environment and tumor cell growth.

  2011cites this paper
• ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6.

  2011cites this paper
• Gene expression profile in a glioma cell line resistant to cell death induced by the chimeric tumor suppressor-1 (CTS-1), a dominant-positive variant of p53--the role of NFkappaB.

  2010cites this paper
• The emerging importance of group II PAKs.

  2010cites this paper
• Inhibition of cancer cell invasion and metastasis by genistein

  2010cites this paper
• FYN is overexpressed in human prostate cancer

  2009cites this paper
• Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men.

  2009cites this paper
• MEK4 function, genistein treatment, and invasion of human prostate cancer cells.

  2009cites this paper
• The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras.

  2009cites this paper
• JNK1, a potential therapeutic target for hepatocellular carcinoma.

  2009cites this paper
• The association between −1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population

  2009cites this paper
• Meeting report: innovations in prostate cancer research.

  2008cites this paper
• New paradigms for the function of JNKK1/MKK4 in controlling growth of disseminated cancer cells.

  2008cites this paper
• Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer

  2007cites this paper
• Enhanced expression of SOS 1 is detected in prostate cancer epithelial cells from African-American men

  year unknowncites this paper
• Fyn Is Downstream of the Hgf/met Signaling Axis and Affects Cellular Shape and Tropism in Pc3 Cells Statement of Translational Relevance

  year unknowncites this paper