Emerging Therapeutic Effects of Herbal Plants in Rheumatoid Arthritis.

OBJECTIVES Rheumatoid arthritis is a chronic inflammatory autoimmune disease characterized by failure of spontaneous resolution of inflammation with lifetime perseverance, becoming one of the major causes of disability in millions of people. It is mainly characterized with progressive erosion of cartilage in response to formation of pannus leading to chronic polyarthritis and joint distortion. Early diagnosis and advances in molecular biology undoubtedly revolutionized therapeutic interventions in the past decade for better disease management. Despite favorable prospects, many patients still fail to respond to the current therapies urging a burning need to develop newer and safer medications. KEY FINDINGS Herbal plants have been utilized since ancient era and provided base for massive bioactive compounds with flaunting therapeutic potential, many being advanced to drugs which are consumed worldwide for treating countless ailments. Scientific studies showed involvement of several cellular mechanisms like oxidative stress suppression, downregulated synthesis of proinflammatory cytokines namely interleukins (IL-1, IL-6), TNF-α, NF-κB, demoted metalloproteinases induced cartilage destruction and augmentation of free radical scavenging and antioxidant activity in treatment of rheumatoid arthritis. A plethora of active phytoconstituents like flavonoids, saponins, terpenes, alkaloids, lactones etc have been isolated from herbal plants with proven curative actions. SUMMARY The present review enlists some of the herbal drugs that can be used to amend the effects of rheumatoid arthritis and impart symptomatic relief to patients.

• Publication year

  2020

• Venue

  Endocrine, Metabolic & Immune Disorders - Drug Targets

• Publication date

  2020-06-20

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.2174/1871530320666200620232828PMID 32586262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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