Omics technologies for kidney disease research

Omics‐based technologies in the areas of genomics, transcriptomics, and proteomics are revolutionizing research into many types of human and experimental disease. This review focuses on the potential of omics technologies to identify pathogenic mechanisms and biomarkers of disease in order to improve the diagnosis, prognosis, monitoring, and treatment of kidney disease.

• Publication year

  2020

• Venue

  The Anatomical Record

• Publication date

  2020-06-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ar.24413PMID 32592293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Whole Exome Sequencing

  2020cited by this paper
• Selected Reaction Monitoring

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• Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data.

  2020cited by this paper
• ncRNAs in Inflammatory and Infectious Diseases.

  2019cited by this paper
• Whole Genome Sequencing

  2019cited by this paper
• Proteomics and personalized medicine: a focus on kidney disease

  2019cited by this paper
• Genetic spectrum of renal disease for 1001 Chinese children based on a multicenter registration system

  2019cited by this paper
• Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways

  2019cited by this paper
• Big science and big data in nephrology.

  2019cited by this paper
• Reconstituting the transcriptome and DNA methylome landscapes of human implantation

  2019cited by this paper
• Opportunities and challenges for transcriptome-wide association studies

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• Multi-gene technical assessment of qPCR and NanoString n-Counter analysis platforms in cynomolgus monkey cardiac allograft recipients.

  2019cited by this paper
• Rolling Circle cDNA Synthesis Uncovers Circular RNA Splice Variants

  2019cited by this paper
• Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

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  2019cited by this paper
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  2019cited by this paper
• Long-Term Kinetics of Intragraft Gene Signatures in Renal Allograft Tolerance Induced by Transient Mixed Chimerism.

  2019cited by this paper
• Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases

  2019cited by this paper
• Controllability Methods for Identifying Associations Between Critical Control ncRNAs and Human Diseases.

  2019cited by this paper
• Multiple Reaction Monitoring (MRM)

  2019cited by this paper
• Workflow Development for the Functional Characterization of ncRNAs.

  2019cited by this paper
• Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.

  2019cited by this paper
• OP-NDTJ190063 1145..1206

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• Temporal Regulation of Glomerular and Cortical Tubulointerstitial Genes Involved in the Development of Nephrotoxic Serum Nephritis

  2018cited by this paper
• Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

  2018cited by this paper
• Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex–Associated Renal Cell Carcinoma

  2018cited by this paper
• Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis.

  2018cited by this paper
• A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes

  2018cited by this paper
• Determining mRNA Decay Rates Using RNA Approach to Equilibrium Sequencing (RATE-Seq).

  2018cited by this paper
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• Expanding the toolbox for 3D genomics

  2018cited by this paper
• JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial

  2018cited by this paper
• Evaluation of variability in human kidney organoids

  2018cited by this paper
• Whole Exome Sequencing of Patients with Steroid-Resistant Nephrotic Syndrome.

  2018cited by this paper
• Molecular Assessment of C4d-Positive Renal Transplant Biopsies Without Evidence of Rejection

  2018cited by this paper
• Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis.

  2018cited by this paper
• 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

  2018cited by this paper
• Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

  2018cited by this paper
• An integrated clinical and genomic information system for cancer precision medicine

  2018cited by this paper
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  2018cited by this paper
• Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics.

  2018cited by this paper
• PIWI-interacting RNAs: small RNAs with big functions

  2018cited by this paper
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  2018cited by this paper
• RNA motifs and combinatorial prediction of interactions, stability and localization of noncoding RNAs

  2018cited by this paper
• Kidney Response to Heart Failure: Proteomic Analysis of Cardiorenal Syndrome

  2018cited by this paper
• Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

  2018cited by this paper
• Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy

  2017cited by this paper
• Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

  2017cited by this paper
• Single-cell RNA sequencing to explore immune cell heterogeneity

  2017cited by this paper
• Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion

  2017cited by this paper
• Single-cell DNA methylome sequencing of human preimplantation embryos

  2017cited by this paper
• iTRAQ-Based Proteomic Analysis of Neonatal Kidney from Offspring of Protein Restricted Rats Reveals Abnormalities in Intraflagellar Transport Proteins

  2017cited by this paper
• Genetic advances in systemic lupus erythematosus: an update

  2017cited by this paper
• Whole Transcriptome Profiling: An RNA‐Seq Primer and Implications for Pharmacogenomics Research

  2017cited by this paper
• Comparative RNA‐Seq transcriptome analyses reveal distinct metabolic pathways in diabetic nerve and kidney disease

  2017cited by this paper
• Translational contributions to tissue specificity in rhythmic and constitutive gene expression

  2017cited by this paper
• Single-Cell Multiomics: Multiple Measurements from Single Cells

  2017cited by this paper
• Proteomic analysis of AQP11-null kidney: Proximal tubular type polycystic kidney disease

  2017cited by this paper
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  2017cited by this paper
• Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

  2017cited by this paper
• Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury

  2017cited by this paper
• Role of

  2017cited by this paper
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  2017cited by this paper
• Association Analysis of the MHC in Lupus Nephritis.

  2017cited by this paper
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  2016cited by this paper
• Measurement of mRNA Decay in Mouse Embryonic Fibroblasts.

  2016cited by this paper
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  2016cited by this paper
• Novel Biomarkers for Renal Diseases? None for the Moment (but One)

  2016influential reference
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  2016cited by this paper
• Urinary proteomics predict onset of microalbuminuria in normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2 study

  2016cited by this paper
• Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

  2016cited by this paper
• A urinary proteome‐based classifier for the early detection of decline in glomerular filtration

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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• The frequency and outcome of lupus nephritis: results from an international inception cohort study.

  2016cited by this paper
• On the Dependency of Cellular Protein Levels on mRNA Abundance.

  2016cited by this paper
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  2015cited by this paper
• Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.

  2015cited by this paper
• The human transcriptome across tissues and individuals

  2015cited by this paper
• LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.

  2015cited by this paper
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  2015cited by this paper
• A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury

  2015cited by this paper
• Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.

  2015cited by this paper
• Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

  2015cited by this paper
• A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

  2014cited by this paper
• Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants

  2014cited by this paper
• Assessment of Metabolomic and Proteomic Biomarkers in Detection and Prognosis of Progression of Renal Function in Chronic Kidney Disease

  2014cited by this paper
• Cell-specific translational profiling in acute kidney injury.

  2014cited by this paper
• End‐Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1

  2014cited by this paper
• Determination of in vivo RNA kinetics using RATE-seq

  2014cited by this paper
• Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Regulation of microRNA biogenesis

  2014cited by this paper
• Single-cell sequencing-based technologies will revolutionize whole-organism science

  2013cited by this paper
• Circular RNAs are a large class of animal RNAs with regulatory potency

  2013cited by this paper
• CKD273, a New Proteomics Classifier Assessing CKD and Its Prognosis

  2013cited by this paper

• Biomarker research for Henoch-Schönlein purpura nephritis based on “omics” techniques

  2025cites this paper
• Metabolomics for the Identification of Biomarkers in Kidney Diseases

  2025influential citation
• Potential Effects of Low-Level Toluene Exposure on the Nervous System of Mothers and Infants

  2024cites this paper
• Omics-based biomarkers for diagnosis and prediction of kidney allograft rejection

  2022cites this paper
• New Insights from Metabolomics in Pediatric Renal Diseases

  2022cites this paper
• Microfluidic Techniques for Next‐Generation Organoid Systems

  2022cites this paper
• Deciphering the genetic links between NAFLD and co-occurring conditions using a liver gene regulatory network

  2021cites this paper
• Multi-Omics Approach in the Identification of Potential Therapeutic Biomolecule for COVID-19

  2021cites this paper
• Introduction to a special issue on kidney development and disease

  2020cites this paper