The Wellcome Foundation Lecture, 1982 Opioid peptides and their receptors

No abstract is available for this paper.

• Publication year

  1985

• Venue

  Proceedings of the Royal Society of London. Series B. Biological Sciences

• Publication date

  1985-07-22

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1098/rspb.1985.0048PMID 2863824
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Types of opioid receptors: relation to antinociception.

  1985cited by this paper
• The use of [3H]‐[d‐Pen2,d‐Pen5]enkephalin as a highly selective ligand for the δ‐binding site

  1985influential reference
• Species differences in the concentrations and distributions of opioid binding sites.

  1985cited by this paper
• The use of [3H]-[D-Pen2,D-Pen5]enkephalin as a highly selective ligand for the delta-binding site.

  1985cited by this paper
• Opioid binding sites of the κ-type in guinea-pig cerebellum

  1984influential reference
• Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.

  1984cited by this paper
• Bremazocine induces antinociception, but prevents opioid-induced constipation and catatonia in rats and precipitates withdrawal in morphine-dependent rats.

  1984cited by this paper
• Site-directed alkylation of multiple opioid receptors. II. Pharmacological selectivity.

  1984cited by this paper
• Acute and persistent effects of β-funaltrexamine on the binding and agonist potencies of opioids in the myenteric plexus of the guinea-pig ileum

  1984cited by this paper
• Radioligands for probing opioid receptors.

  1984cited by this paper
• Opioid binding sites of the kappa-type in guinea-pig cerebellum.

  1984cited by this paper
• Hamster vas deferens contains delta-opioid receptors.

  1984cited by this paper
• Coexistence of neuroactive substances in neurons

  1984cited by this paper
• Hamster vas deferens contains δ-opioid receptors

  1984cited by this paper
• Chapter 5 – Opioid Receptors

  1984cited by this paper
• Site-directed alkylation of multiple opioid receptors. I. Binding selectivity.

  1984cited by this paper
• Selectivities of opioid peptide analogues as agonists and antagonists at the δ‐receptor

  1984influential reference
• Increase in potencies of opioid peptides after peptidase inhibition.

  1983cited by this paper
• Mixed opioid/nonopioid effects of dynorphin and dynorphin related peptides after their intrathecal injection in rats.

  1983cited by this paper
• Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

  1983influential reference
• Multiple opiate receptor in human brain: an autoradiographic investigation.

  1983cited by this paper
• Multiple opiate binding sites in the central nervous system of the rabbit. Large predominance of a mu subtype in the cerebellum and characterization of a kappa subtype in the thalamus.

  1983cited by this paper
• Different receptor sites mediate opioid agonism and antagonism.

  1983cited by this paper
• Dynorphin (1-17): lack of analgesia but evidence for non-opiate electrophysiological and motor effects.

  1982cited by this paper
• Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions

  1982influential reference
• Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate    receptor

  1982cited by this paper
• Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin

  1982cited by this paper
• Specific non-opiate binding sites for human β-endorphin on the terminal complex of human complement

  1982cited by this paper
• Cloning and sequence analysis of cDNA for porcine β-neo-endorphin/dynorphin precursor

  1982cited by this paper
• Improved assays for the assessment of kappa- and delta-properties of opioid ligands.

  1982cited by this paper
• Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary.

  1982cited by this paper
• Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides

  1982cited by this paper
• U-50488H, a pure kappa receptor agonist with spinal analgesic loci in the mouse.

  1982cited by this paper
• beta-Endorphin enhances lymphocyte proliferative responses.

  1982cited by this paper
• Dynorphin and dynorphin are ligands for the kappa-subtype of opiate receptor.

  1982cited by this paper
• Unexpected opioid activity in a known class of drug.

  1982influential reference
• Rimorphin, a unique, naturally occurring [Leu]enkephalin-containing peptide found in association with dynorphin and alpha-neo-endorphin.

  1982cited by this paper
• Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects.

  1982cited by this paper
• Improved assays for the assessment of ϰ- and δ-properties of opioid ligands

  1982cited by this paper
• Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists

  1981influential reference
• Rabbit vas deferens: a specific bioassay for opioid kappa-receptor agonists.

  1981cited by this paper
• UNEXPECTED ANTAGONISM IN THE RAT VAS DEFERENS BY BENZOMORPHANS WHICH ARE AGONISTS IN OTHER PHARMACOLOGICAL TESTS

  1981cited by this paper
• Opioid Peptides and Sensory Function

  1981cited by this paper
• Tetraethylammonium facilitates the stimulation-evoked loss of the enkephalins from the myenteric plexus of guinea-pig ileum

  1981cited by this paper
• The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.

  1981cited by this paper
• Specificity of opioids towards the mu-, delta- and epsilon-opiate receptors.

  1979cited by this paper
• Specific protection of the binding sites of D-Ala2-D-Leu5- enkephalin (δ-receptors) and dihydromorphine (μ-receptors)

  1979cited by this paper
• Cerebellar opiate receptors in lagomorphs. Demonstration, characterization and regional distribution.

  1979cited by this paper
• Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor

  1979cited by this paper
• The opiate receptors.

  1978cited by this paper
• Opiate Receptors and Their Endogenous Ligands (Endorphins)

  1978cited by this paper

• Challenges and new opportunities for detecting endogenous opioid peptides in reward

  2022cites this paper
• Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions

  2020cites this paper
• Evidence for a Dynorphin-Mediated Inner Ear Immune/Inflammatory Response and Glutamate-Induced Neural Excitotoxicity: An Updated Analysis.

  2019influential citation
• Usefulness of knockout mice to clarify the role of the opioid system in chronic pain

  2018influential citation
• Stress-induced modulation of pain: Role of the endogenous opioid system.

  2018cites this paper
• Enkephalin and neuropeptide-Y interaction in the intergeniculate leaflet network, a part of the mammalian biological clock.

  2017cites this paper
• [Amphibian skin as a source of therapeutic peptides].

  2016cites this paper
• Endogenous dynorphins, glutamate and N-methyl-d-aspartate (NMDA) receptors may participate in a stress-mediated Type-I auditory neural exacerbation of tinnitus.

  2013cites this paper
• Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review.

  2012cites this paper
• Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus.

  2008cites this paper
• Morphine modulation of excitatory transmission in the rat spinal cord.

  2007cites this paper
• Detection of kappa and delta opioid receptors in skin--outside the nervous system.

  2005cites this paper
• Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens.

  2005cites this paper
• Naltrexone potentiates 4-aminopyridine seizures in the rat

  2005cites this paper
• Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms.

  2004cites this paper
• Immunohistochemical evidence for the presence of peptides derived from proenkephalin, prodynorphin and proopiomelanocortin in the guinea pig pineal gland

  2004cites this paper
• Placenta ingestion by rats enhances delta- and kappa-opioid antinociception, but suppresses mu-opioid antinociception.

  2004cites this paper
• The probability distribution of side-chain conformations in [Leu] and [Met]enkephalin determines the potency and selectivity to mu and delta opiate receptors.

  2003cites this paper
• Energetics, structures, vibrational frequencies, vibrational absorption, vibrational circular dichroism and Raman intensities of Leu-enkephalin

  2003cites this paper
• The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy.

  2003cites this paper
• Delta opioid receptors in the gastrointestinal tract

  2003cites this paper
• Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study.

  2002cites this paper
• Delta opioid inhibition of light-induced phase advances in hamster circadian activity rhythms.

  2002cites this paper
• Opioid and GABA receptors involved in mediation and modulation of tonic and stimulus-evoked inhibition of a spinal reflex in the decerebrated and spinalized rabbit.

  2001cites this paper
• Spinal and supraspinal changes in opioid mRNA expression are related to the onset of pain behaviors following excitotoxic spinal cord injury

  2001cites this paper
• Discriminative disulfide-bonding affinity labeling of opioid receptor subtypes.

  2001cites this paper
• The role of kainic acid/AMPA and metabotropic glutamate receptors in the regulation of opioid mRNA expression and the onset of pain-related behavior following excitotoxic spinal cord injury.

  2001cites this paper
• The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection.

  2000cites this paper
• Opioid peptide messenger RNA expression is increased at spinal and supraspinal levels following excitotoxic spinal cord injury.

  2000cites this paper
• Opioid induced non-photic phase shifts of hamster circadian activity rhythms.

  2000cites this paper
• Distribution of delta opioid receptor immunoreactivity in the hamster suprachiasmatic nucleus and intergeniculate leaflet.

  2000cites this paper
• Regulation of opioid peptides on the release of arginine vasotocin in the hen.

  2000cites this paper
• Solution structure of human β‐endorphin in helicogenic solvents: an NMR study

  1999cites this paper
• Opioid peptides as possible neuromodulators of the afferent synaptic transmission in the frog semicircular canal.

  1999cites this paper
• [In vitro investigations of the effect of morphine and its metabolites on the phagocytosis of peripheral mononuclear cells].

  1999cites this paper
• Solution structure of human beta-endorphin in helicogenic solvents: an NMR study.

  1999cites this paper
• Exploration of universal cysteines in the binding sites of three opioid receptor subtypes by disulfide-bonding affinity labeling with chemically activated thiol-containing dynorphin A analogs.

  1999cites this paper
• Opioidergic modulation of voltage-activated K+ currents in magnocellular neurons of the supraoptic nucleus in rat.

  1999cites this paper
• Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors.

  1999cites this paper
• Kinetics of homeostatic behavior of receptor-enzyme systems under the action of physiologically active compounds.

  1998cites this paper
• Naloxone-induced supersensitivity of oxytocin neurones to opioid antagonists.

  1998cites this paper
• Opioid peptides from frog skin.

  1998cites this paper
• Physiology of pain in labour.

  1998cites this paper
• Plasticity: Implications for opioid and other pharmacological interventions in specific pain states

  1997cites this paper
• Stimulation by enkephalins of D-glucose absorption in rabbit ileum

  1997cites this paper
• RB 101, A Purported Pro Drug Inhibitor of Enkephalin Metabolism, Is Antinociceptive in Pregnant Mice

  1997cites this paper
• Opioid systems and the newborn.

  1997cites this paper
• The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin.

  1997cites this paper
• Opioids in the brain: supraspinal mechanisms in pain control

  1997cites this paper
• Modulation by opioid peptides of mechanosensory pathways supplying the guinea‐pig inferior mesenteric ganglion.

  1996cites this paper
• Functional analysis of opioid receptor subtypes in the ventromedial hypothalamic nucleus of the rat.

  1996cites this paper
• Naloxone Blockade of (‐)Pentazocine‐Induced Changes in Auditory Function

  1996cites this paper
• Release of calcitonin gene-related peptide in guinea pig inferior mesenteric ganglion.

  1996cites this paper
• Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism?

  1995cites this paper
• Central endogenous opioid inhibition of supraoptic oxytocin neurons in pregnant rats

  1995cites this paper
• List of papers

  1995cites this paper
• Regulation ofL-valine absorption by opioids interacting withμ-receptors in rabbit ileum

  1995cites this paper
• Neuropeptide converting and processing enzymes in the spinal cord and cerebrospinal fluid.

  1995cites this paper
• Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat.

  1994cites this paper
• Improvement in Auditory Function Following Pentazocine Suggests a Role for Dynorphins in Auditory Sensitivity

  1994cites this paper
• Opioids and Coupling of the Anterior Peri‐Third Ventricular Input to Oxytocin Neurones in Anaesthetized Pregnant Rats

  1994cites this paper
• The efficacy of locally applied morphine in post-operative pain after bilateral third molar surgery.

  1994cites this paper
• Opioid receptors and their subtypes: focus on peripheral isolated tissue preparations.

  1994cites this paper
• Calcitonin and its antinociceptive activity: Animal and human investigations 1975–1992

  1994cites this paper
• Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea‐pig colon

  1994cites this paper
• Effects oftheic-opioid agonist U50,488 onparturition inrats

  1993cites this paper
• Neurotransmitters and neuromodulators of the mammalian cochlea.

  1993cites this paper
• Endogenous Opioid Regulation of Oxytocin Secretion Through Pregnancy in the Rat

  1993cites this paper
• Morphine tolerance and inhibition of oxytocin secretion by kappa‐opioids acting on the rat neurohypophysis.

  1993cites this paper
• Selectivity of ligands for opioid receptors

  1993cites this paper
• In vitro study of the interaction of salmon calcitonin with μ, δ and κ opioid agonists

  1993cites this paper
• Regional expression and chromosomal localization of the delta opiate receptor gene.

  1993cites this paper
• Effects of the κ‐opioid agonist U50,488 on parturition in rats

  1993cites this paper
• Effects of the kappa-opioid agonist U50,488 on parturition in rats.

  1993cites this paper
• Mechanism of mu‐opioid receptor‐mediated presynaptic inhibition in the rat hippocampus in vitro.

  1993cites this paper
• Kappa-/mu-receptor interactions in the opioid control of the in vivo release of substance P-like material from the rat spinal cord.

  1992cites this paper
• Analgesic effect of salmon-calcitonin administered by two routes. Effect on morphine analgesia.

  1992cites this paper
• Kappa opioid agonists inhibit transmitter release from guinea pig hippocampal mossy fiber synaptosomes

  1992cites this paper
• Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan‐induced inflammation

  1992cites this paper
• Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.

  1992cites this paper
• Dissociation of mu and delta opioid receptor-mediated reductions in evoked and spontaneous synaptic inhibition in the rat hippocampus in vitro.

  1992cites this paper
• Comparison of opioid properties between D-Arg-containing dipeptides and tetrapeptides.

  1992cites this paper
• Opioid activity of dermenkephalin analogues in the guinea‐pig myenteric plexus and the hamster vas deferens

  1991cites this paper
• Opioid Receptor Subtypes: Past, Present and Future

  1991cites this paper
• Isolation and Characterization of Opioid Peptides from Rabbit Cerebellum

  1991cites this paper
• Modulation of Catecholamine Release in the Central Nervous System by Multiple Opioid Receptors

  1991cites this paper
• Mechanisms of the analgesic actions of opiates and opioids.

  1991cites this paper
• Differential effects of mu‐ and delta‐receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices

  1991cites this paper
• Morphine actions on supraoptic oxytocin neurones in anaesthetized rats: tolerance after i.c.v. morphine infusion.

  1991cites this paper
• Kinetics of the dual-action mechanism of narcotic substances: conditions for conservative functioning of enzyme-receptor systems.

  1991cites this paper
• Structure, bioactivity, and cellular localization of myomodulin B: a novel Aplysia peptide.

  1991cites this paper
• Evolution in nervous systems.

  1991cites this paper
• Dextromethorphan and levorphanol on dorsal horn nociceptive neurones in the rat.

  1991cites this paper
• Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord.

  1991cites this paper
• In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at delta receptors.

  1991cites this paper
• Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy

  1991cites this paper
• Effect of opioid peptides on circular muscle of canine duodenum.

  1991cites this paper
• Subcutaneous formalin induces a segmental release of Met‐enkephalin‐like material from the rat spinal cord

  1990cites this paper
• Enkephalins modulate inhibitory neuromuscular transmission in circular muscle of human colon via delta‐opioid receptors.

  1990cites this paper
• Modulation by muscarine and opioid receptors of acetylcholine release in slices from striato-striatal grafts in the rat.

  1990cites this paper