Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Nature Medicine

• Publication date

  2000-07-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/78654PMID 10932225
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection.

  1999cited by this paper
• Generation of Retroviral Vector for Clinical Studies Using Transient Transfection

  1999cited by this paper
• Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

  1999cited by this paper
• Markedly elevated levels of interferon (IFN)-γ, IFN-α, interleukin (IL)-2, IL-10, and tumor necrosis factor-α associated with fatal Ebola virus infection

  1999cited by this paper
• Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus

  1998cited by this paper
• Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins.

  1998cited by this paper
• Processing of the Ebola virus glycoprotein by the proprotein convertase furin.

  1998cited by this paper
• Immunization for Ebola virus infection

  1998cited by this paper
• The central structural feature of the membrane fusion protein subunit from the Ebola virus glycoprotein is a long triple-stranded coiled coil.

  1998cited by this paper
• Organ cultures of embryonic rat tongue support tongue and gustatory papilla morphogenesis in vitro without intact sensory ganglia

  1997cited by this paper
• Filovirus-induced endothelial leakage triggered by infected monocytes/macrophages

  1996cited by this paper
• Outbreak of Ebola viral hemorrhagic fever--Zaire, 1995.

  1995cited by this paper
• Gene therapy for vascular smooth muscle cell proliferation after arterial injury.

  1994cited by this paper
• Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein.

  1994cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• Ultrastructural pathology of experimental ebola haemorrhagic fever virus infection

  1985cited by this paper
• The pathology of experimental Ebola virus infection in monkeys

  1978cited by this paper
• VIRAL HÆMORRHAGIC FEVER IN SOUTHERN SUDAN AND NORTHERN ZAIRE: Preliminary Studies on the Aetiological Agent

  1977cited by this paper
• Letter: Lower oesophageal sphincter.

  1974cited by this paper

• Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Rousettus aegypticus)

  2025cites this paper
• Antiviral defense against filovirus infections: targets and evasion mechanisms

  2025cites this paper
• Pseudovirus-Based Neutralization Assays as Customizable and Scalable Tools for Serological Surveillance and Immune Profiling

  2025cites this paper
• Potential Mechanisms Underlying Bleeding During Infection With Hemorrhagic Fever Viruses.

  2025cites this paper
• The Antiviral Activity of Polyphenols

  2025cites this paper
• Investigation of the Status of Epidemiology, Pathophysiology, Virology, Clinical Symptoms, Diagnosis, Prevention, Treatment and Classification of Ebola Virus Disease (EVD): A Systematic Review.

  2025cites this paper
• Lassa virus protein–protein interactions as mediators of Lassa fever pathogenesis

  2025cites this paper
• Distinct immune properties of the N- and C-termini of the immunosuppressive domain of Ebola virus glycoprotein

  2025cites this paper
• Mucin-like protein of Crimean-Congo hemorrhagic fever virus is a key virulence factor and a potent target for developing novel attenuated vaccine

  2025cites this paper
• Prospects for the use of viral proteins for the construction of chimeric toxins

  2024cites this paper
• Novel filoviruses: indication of a global threat or cause to reassess our risk perception?

  2024cites this paper
• Use of in silico approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies.

  2024cites this paper
• Targeting host O-linked glycan biosynthesis affects Ebola virus replication efficiency and reveals differential GalNAc-T acceptor site preferences on the Ebola virus glycoprotein

  2024cites this paper
• Immunogenicity of various variants of Ebola and Marburg virus glycoprotein genes in recombinant adenoviral vectors

  2024cites this paper
• Ebola Virus–Specific Neutralizing Antibody Persists at High Levels in Survivors 2 Years After Resolution of Disease in a Sierra Leonean Cohort

  2024cites this paper
• Ebola virus–like particles reprogram cellular metabolism

  2023cites this paper
• Integrin-Dependent Cell–Matrix Adhesion in Endothelial Health and Disease

  2023cites this paper
• Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes

  2023cites this paper
• Crimean–Congo haemorrhagic fever virus

  2023cites this paper
• The Mucin-like Domain of the Ebola Glycoprotein Does Not Impact Virulence or Pathogenicity in Ferrets.

  2023cites this paper
• Viral interactions with host factors (TIM-1, TAM -receptors, Glut-1) are related to the disruption of glucose and ascorbate transport and homeostasis, causing the haemorrhagic manifestations of viral haemorrhagic fevers.

  2023cites this paper
• Structure and Role of O-Linked Glycans in Viral Envelope Proteins.

  2023cites this paper
• Differential symptomology of possible and confirmed Ebola virus disease infection in the Democratic Republic of the Congo: a retrospective cohort study.

  2022cites this paper
• RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy

  2022cites this paper
• Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway

  2022influential citation
• Predicting the combined effects of case isolation, safe funeral practices, and contact tracing during Ebola virus disease outbreaks

  2022cites this paper
• Isoform-specific O-glycosylation dictates Ebola virus infectivity

  2022cites this paper
• Ebola Virus GP Activates Endothelial Cells via Host Cytoskeletal Signaling Factors

  2022cites this paper
• Capillary leak syndrome: State of the art in 2021.

  2021cites this paper
• Immunotherapeutic strategies to target vulnerabilities in the Ebolavirus glycoprotein.

  2021cites this paper
• Development and Evaluation of an Ebola Virus Glycoprotein Mucin-Like Domain Replacement System as a New Dendritic Cell-Targeting Vaccine Approach against HIV-1

  2021cites this paper
• A Look into Bunyavirales Genomes: Functions of Non-Structural (NS) Proteins

  2021cites this paper
• Viren mit einzelsträngigem, kontinuierlichem RNA-Genom in Negativstrangorientierung

  2021cites this paper
• Cyanovirin-N Binds Viral Envelope Proteins at the Low-Affinity Carbohydrate Binding Site without Direct Virus Neutralization Ability

  2021cites this paper
• Mechanisms of Immune Evasion by Ebola Virus.

  2021cites this paper
• Activating Natural Killer Cell Receptors, Selectins, and Inhibitory Siglecs Recognize Ebolavirus Glycoprotein

  2021cites this paper
• Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments

  2021cites this paper
• Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections

  2021cites this paper
• A Possible Inhibitory Role of Sialic Acid on MUC1 in Peritoneal Dissemination of Clear Cell-Type Ovarian Cancer Cells

  2021cites this paper
• Ebola and Marburg Virus: A Brief Review

  2020cites this paper
• Bombyx mori nucleopolyhedrovirus F-like protein Bm14 is a factor for viral-induced cytopathic effects via regulating oxidative phosphorylation and cellular ROS levels.

  2020cites this paper
• Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

  2020cites this paper
• Photocatalytic Nanowires‐Based Air Filter: Towards Reusable Protective Masks

  2020cites this paper
• Responsive principles and applications of smart materials in biosensing

  2020cites this paper
• Immunological Perspective for Ebola Virus Infection and Various Treatment Measures Taken to Fight the Disease

  2020cites this paper
• Activating NK- receptors, homing selectins and inhibitory Siglecs recognize EBOLA-GP and HPV-L1NK

  2020cites this paper
• Production and Characterization of Monoclonal Antibodies Against Gp Protein of Ebola Virus.

  2020cites this paper
• Maintaining neglected tropical disease programmes during pandemics

  2020cites this paper
• Viral genomics in Ebola virus research

  2020cites this paper
• Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding

  2020cites this paper
• T cell responses in patients with COVID-19

  2020cites this paper
• Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein

  2019cites this paper
• Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines

  2019cites this paper
• Interaction of Ebola Virus with the Innate Immune System

  2019cites this paper
• Dendritic Cells/Macrophages-Targeting Feature of Ebola Glycoprotein and its Potential as Immunological Facilitator for Antiviral Vaccine Approach

  2019cites this paper
• Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

  2019cites this paper
• Distinct Immunogenicity and Efficacy of Poxvirus-Based Vaccine Candidates against Ebola Virus Expressing GP and VP40 Proteins

  2018cites this paper
• Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates

  2018cites this paper
• On revealing the gene targets of Ebola virus microRNAs involved in the human skin microbiome

  2018influential citation
• Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors

  2018cites this paper
• Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

  2018cites this paper
• A GXXXA Motif in the Transmembrane Domain of the Ebola Virus Glycoprotein Is Required for Tetherin Antagonism

  2018cites this paper
• Broad Neutralizing Activity Against Ebolaviruses Lacking the Mucin-Like Domain in Convalescent Plasma Specimens From Patients With Ebola Virus Disease

  2018cites this paper
• Virus Neutralizing Antibodies Detectable in Survivors of Outbreak 40 Years after

  2018cites this paper
• Generation of recombinant antibodies for Ebola diagnostics

  2018cites this paper
• Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity

  2018cites this paper
• The Ebola-Glycoprotein Modulates the Function of Natural Killer Cells

  2018cites this paper
• Studies on steric shielding of cell surface proteins by filovirus envelope glycoproteins

  2018influential citation
• Addicted to sugar: roles of glycans in the order Mononegavirales

  2018cites this paper
• Correlates of vaccine-induced protective immunity against Ebola virus disease.

  2018cites this paper
• Ebola Virus Neutralizing Antibodies Detectable in Survivors of the Yambuku, Zaire Outbreak 40 Years after Infection

  2018cites this paper
• Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects

  2018influential citation
• Immunogenicity of propagation-restricted vesicular stomatitis virus encoding Ebola virus glycoprotein in guinea pigs

  2018cites this paper
• Ebola virus, but not Marburg virus, replicates efficiently and without required adaptation in snake cells

  2018cites this paper
• A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity

  2018cites this paper
• Ebola’s Fatal Hemorrhagic Fever from Discovery to Vaccine

  2018cites this paper
• Ebolaviruses: New roles for old proteins

  2018cites this paper
• Transmission, Human Population, and Pathogenicity: the Ebola Case in Point

  2018cites this paper
• [The use of monoclonal antibodies for the treatment of Ebola virus disease.]

  2018cites this paper
• Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

  2017cites this paper
• Forty Years of Ebolavirus Molecular Biology: Understanding a Novel Disease Agent Through the Development and Application of New Technologies.

  2017cites this paper
• Review of computational methods for virus–host protein interaction prediction: a case study on novel Ebola–human interactions

  2017cites this paper
• Filovirus Strategies to Escape Antiviral Responses.

  2017cites this paper
• Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine.

  2017cites this paper
• Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets

  2017cites this paper
• The Pathogenesis of Ebola Virus Disease.

  2017cites this paper
• Title : Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein 1

  2017cites this paper
• RT-PCR using glycoprotein target is more sensitive for the detection of Ebola virus in clinical samples.

  2017cites this paper
• Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein

  2017cites this paper
• Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection

  2017cites this paper
• Ebola Virus Disease in Humans: Pathophysiology and Immunity

  2017cites this paper
• IP3 receptor signaling and endothelial barrier function

  2017cites this paper
• Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

  2017influential citation
• Ebola Vaccine: How Far are we?

  2017cites this paper
• Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection

  2017cites this paper
• Mechanisms of Filovirus Entry.

  2017cites this paper
• Bioinformatics approach reveals the gene targets of Ebola virus microRNAs involved in the human skin microbiome

  2017cites this paper
• Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus

  2017cites this paper
• Fighting Ebola: A Window for Vaccine Re-evaluation?

  2017cites this paper
• Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function

  2017cites this paper