Omega–3 Fatty Acids, Inflammation and Angiogenesis: Nutrigenomic Effects as an Explanation for Anti-Atherogenic and Anti-Inflammatory Effects of Fish and Fish Oils

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Lifestyle Genomics

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1159/000109871PMID 19918111
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The composition of food consumed by Greenland Eskimos.

  2009cited by this paper
• Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974.

  2009cited by this paper
• Endothelial Functions and Dysfunctions

  2007cited by this paper
• Sources of the very-long-chain unsaturated omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid

  2007cited by this paper
• The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition.

  2006cited by this paper
• Oxidized Phospholipids Stimulate Angiogenesis Via Autocrine Mechanisms, Implicating a Novel Role for Lipid Oxidation in the Evolution of Atherosclerotic Lesions

  2006cited by this paper
• Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.

  2006cited by this paper
• The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKCε inhibition

  2006cited by this paper
• Plaque angiogenesis versus compensatory arteriogenesis in atherosclerosis.

  2006cited by this paper
• Interleukin-1β Induction of NFκB Is Partially Regulated by H2O2-mediated Activation of NFκB-inducing Kinase*

  2006cited by this paper
• Targeting Prostaglandin E2 Receptors as an Alternative Strategy to Block Cyclooxygenase-2-dependent Extracellular Matrix-induced Matrix Metalloproteinase-9 Expression by Macrophages*

  2006cited by this paper
• Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.

  2006cited by this paper
• COX-2 and Atherosclerosis

  2006cited by this paper
• n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review.

  2006cited by this paper
• Nutritional mechanisms that influence cardiovascular disease.

  2006cited by this paper
• Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers.

  2006cited by this paper
• Cardiovascular Risks of Cyclooxygenase Inhibition

  2006cited by this paper
• Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.

  2005cited by this paper
• Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways.

  2005cited by this paper
• NADPH oxidase and endothelial cell function.

  2005cited by this paper
• Atherosclerotic Plaque Progression and Vulnerability to Rupture: Angiogenesis as a Source of Intraplaque Hemorrhage

  2005cited by this paper
• Docosahexaenoic acid affects cell signaling by altering lipid rafts.

  2005cited by this paper
• n-3 PUFA and membrane microdomains: a new frontier in bioactive lipid research.

  2004cited by this paper
• Interleukin-1β stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes

  2004cited by this paper
• Oxidized Omega-3 Fatty Acids Inhibit NF-&kgr;B Activation Via a PPAR&agr;-Dependent Pathway

  2004cited by this paper
• Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation?

  2004cited by this paper
• Nutrients and gene expression.

  2004cited by this paper
• n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.

  2004cited by this paper
• Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells.

  2004cited by this paper
• Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway.

  2004cited by this paper
• Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy.

  2004cited by this paper
• Signaling to NF-kappaB.

  2004cited by this paper
• Interleukin-1beta stimulates matrix metalloproteinase-2 expression via a prostaglandin E2-dependent mechanism in human chondrocytes.

  2004cited by this paper
• Alpha-linolenic acid metabolism in men and women: nutritional and biological implications.

  2004cited by this paper
• Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

  2003cited by this paper
• Vascular biology of atherosclerosis: overview and state of the art.

  2003cited by this paper
• Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association.

  2003cited by this paper
• Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor.

  2003cited by this paper
• An Essential Role of Th1 Responses and Interferon-gamma in Infection-Mediated Suppression of Neoplastic Growth

  2003cited by this paper
• Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.

  2003cited by this paper
• Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids.

  2003cited by this paper
• Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion.

  2003cited by this paper
• NADPH Oxidase in Endothelial Cells: Impact on Atherosclerosis

  2003cited by this paper
• Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids*

  2003cited by this paper
• Differential effects of prostaglandin derived from ω-6 and ω-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion

  2003cited by this paper
• Transcriptional regulation of cyclo-oxygenase expression: three pillars of control.

  2003cited by this paper
• Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis.

  2003cited by this paper
• Augmented Contractile Response of Vascular Smooth Muscle in a Diabetic Mouse Model

  2003cited by this paper
• Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice.

  2003cited by this paper
• Cyclooxygenase isozymes and their gene structures and expression.

  2002cited by this paper
• Blood levels of long-chain n-3 fatty acids and the risk of sudden death.

  2002cited by this paper
• Celecoxib Induces Apoptosis by Inhibiting 3-Phosphoinositide-dependent Protein Kinase-1 Activity in the Human Colon Cancer HT-29 Cell Line*

  2002cited by this paper
• Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice

  2002cited by this paper
• Cyclooxygenase 2-mediated suppression of macrophage interleukin-12 production after thermal injury.

  2002cited by this paper
• Plaque angiogenesis: its functions and regulation.

  2002cited by this paper
• Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men*

  2002cited by this paper
• Intracellular Localization and Preassembly of the NADPH Oxidase Complex in Cultured Endothelial Cells*

  2002cited by this paper
• Retinal capillary pericyte proliferation and c-Fos mRNA induction by prostaglandin D2 through the cAMP response element.

  2002cited by this paper
• Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha.

  2002cited by this paper
• Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

  2002cited by this paper
• Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.

  2002cited by this paper
• Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line*

  2002cited by this paper
• Quenching of Intracellular ROS Generation as a Mechanism for Oleate-Induced Reduction of Endothelial Activation and Early Atherogenesis

  2002cited by this paper
• Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling*

  2002cited by this paper
• Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E2-Dependent Plaque Instability

  2001cited by this paper
• The 3′-Untranslated Region of Murine Cyclooxygenase-2 Contains Multiple Regulatory Elements That Alter Message Stability and Translational Efficiency*

  2001cited by this paper
• Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production.

  2001cited by this paper
• Vascular endothelial growth factor enhances atherosclerotic plaque progression

  2001cited by this paper
• Adenylyl Cyclase 3 Mediates Prostaglandin E2-induced Growth Inhibition in Arterial Smooth Muscle Cells*

  2001cited by this paper
• Expression of cyclooxygenase‐2 promotes the release of matrix metalloproteinase‐2 and ‐9 in fetal rat hepatocytes

  2001cited by this paper
• Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.

  2001cited by this paper
• NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.

  2001cited by this paper
• Nutrients and gene expression.

  2001cited by this paper
• Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease

  2001cited by this paper
• Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice*

  2001cited by this paper
• A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.

  2001cited by this paper
• Effect of human recombinant vascular endothelial growth factor165 on progression of atherosclerotic plaque.

  2001cited by this paper
• Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice

  2001cited by this paper
• Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai, China.

  2001cited by this paper
• Akt takes center stage in angiogenesis signaling.

  2000cited by this paper
• Role of cyclooxygenases in angiogenesis.

  2000cited by this paper
• PKCε modulates NF-κB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes

  2000cited by this paper
• Endothelial dysfunctions: common denominators in vascular disease.

  2000cited by this paper
• PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes.

  2000cited by this paper
• Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries.

  2000cited by this paper
• Metabolism of highly unsaturated n-3 and n-6 fatty acids.

  2000cited by this paper
• Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions.

  2000cited by this paper
• Peroxisome proliferator-activated receptors: nuclear control of metabolism.

  1999cited by this paper
• Atherosclerosis--an inflammatory disease.

  1999cited by this paper
• Angiogenesis and the atherosclerotic carotid plaque: association between symptomatology and plaque morphology

  1999cited by this paper
• Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice.

  1999cited by this paper
• Comparative Study of Vanadate- and Phorbol Ester-induced Cyclo-oxygenase-2 Expression in Human Endothelial Cells

  1999cited by this paper
• Differential effects of long chain n-3 fatty acids on the expression of PGH synthase isoforms in bovine aortic endothelial cells.

  1999cited by this paper
• Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

  1999cited by this paper
• Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions.

  1999cited by this paper
• Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

  1999cited by this paper
• 25-hydroxycholesterol increases eicosanoids and alters morphology in cultured pulmonary artery smooth muscle and endothelial cells.

  1999cited by this paper
• PPARα Activators Inhibit Cytokine-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

  1999cited by this paper
• Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice.

  1999cited by this paper
• Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.

  1999cited by this paper

• Omega-3 Fatty Acids Weaken Lymphocyte Inflammatory Features and Improve Glycemic Control in Nonobese Diabetic Goto-Kakizaki Rats

  2024cites this paper
• Metabolites derived from radical oxidation of PUFA: NEO-PUFAs, promising molecules for health?

  2024cites this paper
• Preoperative Diet Therapy: The Right Choice of Components and Supplements Can Beneficially Impact Clinical Outcomes

  2023cites this paper
• Effect of Different Processing Methods (Roasting and Shade- Drying) on Fatty Acid Profile of Tumeric (Curcumin longa)

  2023cites this paper
• First Optimization of Tomato Pomace in Diets for Tenebrio molitor (L.) (Coleoptera: Tenebrionidae)

  2023cites this paper
• Improved skin regeneration with acellular fish skin grafts

  2020cites this paper
• Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn’s Disease Populations

  2020cites this paper
• Omega-3 polyunsaturated fatty acids: anti-inflammatory and anti-hypertriglyceridemia mechanisms in cardiovascular disease

  2020cites this paper
• The Mediterranean Diet And Cardioprotection: Historical Overview And Current Research

  2019cites this paper
• Chapter 88 – Antiinflammatory Diet

  2018cites this paper
• Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association

  2018cites this paper
• Short term omega-3 polyunsaturated fatty acid supplementation induces favorable changes in right ventricle function and diastolic filling pressure in patients with chronic heart failure; A randomized clinical trial.

  2016cites this paper
• The effects of different extraction methods on composition and storage stability of sturgeon oil.

  2015cites this paper
• Maternal fish consumption, fatty acid levels and angiogenic factors: The Generation R Study.

  2015cites this paper
• DIETARY PATTERNS AND LIFESTYLE OF PATIENTS AFTER MYOCARDIAL INFARCTION

  2015cites this paper
• Anti-Obesity and Anti-Hypertensive Action of Calanus Oil

  2015cites this paper
• Maternal dietary omega-3 fatty acids and placental function.

  2014cites this paper
• Genomics and Oral Health: An Overview

  2014cites this paper
• Beneficial effects of maternal dietary omega-3 fatty acids on placental growth and fuction

  2014cites this paper
• Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA

  2013cites this paper
• Fish consumption, omega-3 fatty acids, and environmental contaminants in relation to low-grade inflammation and early atherosclerosis.

  2013cites this paper
• The Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation on Biomarkers of Kidney Injury in Adults With Diabetes

  2013cites this paper
• Establishing the influence of dietary fatty acids on the colon through nutrigenomics

  2013cites this paper
• Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities

  2013influential citation
• The Effects of n-3 Long-Chain Polyunsaturated Fatty Acid Supplementation on Biomarkers of Kidney Injury in Adults With Diabetes Results of the GO-FISH trial

  2012cites this paper
• Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids.

  2012cites this paper
• Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids.

  2012cites this paper
• Análise da relação de qualidade da dieta com nível de atividade física e destes com perfil lipídico e estado inflamatório em indivíduos de risco cardiometabólico

  2011cites this paper
• Clinical Effects of n-3 PUFA Supplementation in Human Health and Inflammatory Diseases

  2011cites this paper
• Flax Seed (Linum usitatissimum) Fatty Acids

  2011cites this paper
• Toxicity of fatty acids on ECV-304 endothelial cells.

  2011cites this paper
• Focusing on Functionality How to get better results in nutritional therapy

  2011cites this paper
• Production of omega-3 polyunsaturated fatty acid concentrates: A review

  2010cites this paper
• Effect of dietary fat type on plasma lipid profile and leptin concentration in rats fed on high-sucrose diets

  2010cites this paper
• Efeitos dos ácidos graxos sobre a morte de células endoteliais.

  2010cites this paper
• Lipid lowering effect of policosanol and omega-3 fatty acids combined therapy in hypercholesterolemic patients

  2010cites this paper
• The negative effects of hydrogenated trans fats and what to do about them.

  2009cites this paper
• he negative effects of hydrogenated trans fats and what to do about them

  2009cites this paper
• 20 – Fish Oils

  2009cites this paper
• Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.

  2009cites this paper
• New Approaches in Atherothrombosis

  2008cites this paper