Hypothesis about mechanisms through which nicotine might exert its effect on the interdependence of inflammation and gut barrier function in ulcerative colitis

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Inflammatory Bowel Diseases

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/ibd.20020PMID 17206646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sensitivity and tolerance to nicotine in smokers and nonsmokers

  2006cited by this paper
• Mechanisms of Disease: the hygiene hypothesis revisited

  2006cited by this paper
• New genes in inflammatory bowel disease: lessons for complex diseases?

  2006cited by this paper
• Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution.

  2005cited by this paper
• Mechanisms of Disease: nicotine—a review of its actions in the context of gastrointestinal disease

  2005cited by this paper
• Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation?

  2005cited by this paper
• Defects in mucosal immunity leading to ulcerative colitis

  2005cited by this paper
• Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway

  2005cited by this paper
• Psychological stress in IBD: new insights into pathogenic and therapeutic implications

  2005cited by this paper
• Preliminary Observations of Oral Nicotine Therapy for Inflammatory Bowel Disease: An Open‐Label Phase I‐Ii Study of Tolerance

  2005cited by this paper
• Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease

  2005cited by this paper
• A randomized trial of nicotine enemas for active ulcerative colitis.

  2005cited by this paper
• A porous defense: the leaky epithelial barrier in intestinal disease

  2004cited by this paper
• Carbon Monoxide Produced by Heme Oxygenase-1 Suppresses T Cell Proliferation via Inhibition of IL-2 Production1

  2004cited by this paper
• TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.

  2004cited by this paper
• Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation.

  2004cited by this paper
• Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis.

  2004cited by this paper
• TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

  2004cited by this paper
• Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function.

  2004cited by this paper
• Inflammatory bowel disease: the role of environmental factors.

  2004cited by this paper
• Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

  2004cited by this paper
• Effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis.

  2003cited by this paper
• In vivo Influence of Nicotine on Human Basal and NSAID-induced Gut Barrier Function

  2003cited by this paper
• Divergent effects of nicotine administration on cytokine levels in rat small bowel mucosa, colonic mucosa, and blood.

  2003cited by this paper
• Nicotinic acetylcholine receptor subunits and receptor activity in the epithelial cell line HT29.

  2003cited by this paper
• Altered Anxiety-Related Responses in Mutant Mice Lacking the β4 Subunit of the Nicotinic Receptor

  2003cited by this paper
• Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms 1

  2003cited by this paper
• Increased expression of interleukin 17 in inflammatory bowel disease

  2003cited by this paper
• Interleukin-6 changes tight junction permeability and intracellular phospholipid content in a human enterocyte cell culture model

  2003cited by this paper
• MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

  2003cited by this paper
• Gut flora in health and disease.

  2003cited by this paper
• Over‐expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis

  2003cited by this paper
• p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease.

  2002cited by this paper
• p38 Mitogen-Activated Protein Kinase Is Activated and Linked to TNF-α Signaling in Inflammatory Bowel Disease1

  2002cited by this paper
• The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease.

  2002cited by this paper
• Transport Mechanisms of Nicotine across the Human Intestinal Epithelial Cell Line Caco-2

  2002cited by this paper
• Mechanisms of diarrhea in collagenous colitis.

  2002cited by this paper
• Effect of nicotine and nicotinic receptors on anxiety and depression

  2002cited by this paper
• Megacystis-microcolon-intestinal hypoperistalsis syndrome and the absence of the alpha3 nicotinic acetylcholine receptor subunit.

  2001cited by this paper
• Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10).

  2001cited by this paper
• Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

  2001cited by this paper
• Ulcerative colitis and Crohn's disease: molecular genetics and clinical implications

  2001cited by this paper
• Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site.

  2001cited by this paper
• Interleukin-2 Receptor β Subunit-dependent and -independent Regulation of Intestinal Epithelial Tight Junctions*

  2001cited by this paper
• Impact of cessation of smoking on the course of ulcerative colitis

  2001cited by this paper
• Megacystis-microcolon-intestinal hypoperistalsis syndrome and the absence of the α3 nicotinic acetylcholine receptor subunit

  2001cited by this paper
• Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging.

  2001cited by this paper
• Increased expression of IL-16 in inflammatory bowel disease

  2001cited by this paper
• Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics.

  2001cited by this paper
• Mechanism of diarrhea in collagenous colitis.

  2001cited by this paper
• Molecular Cloning and Mapping of the Human Nicotinic Acetylcholine Receptor α10 (CHRNA10)

  2001cited by this paper
• A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

  2001cited by this paper
• An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease

  2000cited by this paper
• Analytical Determination of Nicotine and related Compounds and their Metabolites,: Edited by J. W. Gorrod and P. Jacob, III. ISBN 0-444-50095-2, 772 pages, Hardbound, $279 plus value added tax, Elsevier, Amsterdam: 1999

  2000cited by this paper
• Acetylcholine receptors and myasthenia

  2000cited by this paper
• Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

  2000cited by this paper
• Claudins regulate the intestinal barrier in response to immune mediators.

  2000cited by this paper
• The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease.

  2000cited by this paper
• The effects of smoking and indomethacin on small intestinal permeability

  2000cited by this paper
• Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis.

  1999cited by this paper
• Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6.

  1999cited by this paper
• A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.

  1999cited by this paper
• Interferon-γ decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin.

  1999cited by this paper
• Outcome of ulcerative colitis after treatment with transdermal nicotine

  1998cited by this paper
• Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis.

  1998cited by this paper
• Immunomodulatory effects of cigarette smoke.

  1998cited by this paper
• Effects of smoking on the urine excretion of oral51Cr EDTA in ulcerative colitis

  1998cited by this paper
• Increased colonic permeability in patients with ulcerative colitis: an in vitro study.

  1998cited by this paper
• Nicotine safety and toxicity

  1998cited by this paper
• Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis

  1997cited by this paper
• Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion.

  1997cited by this paper
• Nicotine enemas for active ulcerative colitis—a pilot study

  1997cited by this paper
• The Effect of Mesalamine and Nicotine in the Treatment of Inflammatory Bowel Disease

  1997cited by this paper
• Nicotine tartrate liquid enemas for mildly to moderately active left‐sided ulcerative colitis unresponsive to first‐line therapy: a pilot study

  1997cited by this paper
• Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

  1997cited by this paper
• Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis.

  1996cited by this paper
• Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-alpha by human mononuclear cells.

  1996cited by this paper
• Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits*

  1996cited by this paper
• Pilot trial of nicotine patches as an alternative to corticosteroids in ulcerative colitis

  1996cited by this paper
• Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

  1996cited by this paper
• Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.

  1996cited by this paper
• Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.

  1996cited by this paper
• The effect of nicotine on murine CD4 T cell responses.

  1996cited by this paper
• Transdermal nicotine as maintenance therapy for ulcerative colitis.

  1995cited by this paper
• Acetylcholine receptor channel imaged in the open state

  1995cited by this paper
• The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis.

  1995cited by this paper
• A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

  1995cited by this paper
• A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes.

  1995cited by this paper
• Nicotine inhibits cytokine synthesis by mouse colonic mucosa.

  1995cited by this paper
• Ulcerative colitis responsive to smoking and to nicotine chewing gum in a patient with alpha 1 anti-trypsin deficiency.

  1995cited by this paper
• Transdermal nicotine for active ulcerative colitis.

  1994cited by this paper
• IL-4 directly modulates function of a model human intestinal epithelium.

  1994cited by this paper
• Steroid-sparing effect of transdermal nicotine in ulcerative colitis.

  1994cited by this paper
• Intestinal permeability in patients with Crohn's disease and their first-degree relatives.

  1994cited by this paper
• Nicotinic acetylcholine receptor at 9 A resolution.

  1993cited by this paper
• Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.

  1993cited by this paper
• Intestinal permeability in patients with Crohn's disease and their first degree relatives.

  1992cited by this paper
• IL-1, IL-6, and PDGF mRNA expression in alveolar cells following stimulation with a tobacco-derived antigen.

  1992cited by this paper
• Colonic mucosal interleukin-6 in inflammatory bowel disease.

  1991cited by this paper
• Testing nicotine gum for ulcerative colitis patients. Experience with single-patient trials.

  1990cited by this paper

• Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates acetic acid-induced ulcerative colitis via modulating PI3K/Akt/VEGF signaling pathway.

  2025cites this paper
• Ethanol extract of Lactobacillus rhamnosus AC1-fermented soymilk alleviated DSS-induced colitis via LPS-TLR4-NF-κB signaling pathway

  2025cites this paper
• Fecal incontinence in hospitalized bipolar disorder patients: prevalence, gender disparities, and associations with demographic and pharmacological factors

  2025cites this paper
• Impact of substance use on intestinal permeability in patients with schizophrenia.

  2024cites this paper
• The Bidirectional Gut-Lung Axis in COPD.

  2023cites this paper
• Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function.

  2021cites this paper
• Cholinergic immunomodulation in inflammatory bowel diseases

  2021cites this paper
• Predicting doxorubicin drug delivery by single-walled carbon nanotube through cell membrane in the absence and presence of nicotine molecules: a molecular dynamics simulation study

  2020cites this paper
• Inflammatory bowel disease: A key role for microbiota?

  2020cites this paper
• Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation.

  2020cites this paper
• Review article: impact of cigarette smoking on intestinal inflammation—direct and indirect mechanisms

  2020cites this paper
• Can a gluten‐free diet be partly protective for COVID‐19 infection?

  2020cites this paper
• Epidemiologie der chronisch-entzündlichen Darmerkrankungen

  2020cites this paper
• Microscopic colitis: a narrative review with clinical approach.

  2019cites this paper
• Dose–response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study

  2019cites this paper
• Smoke and Autoimmunity

  2019cites this paper
• Chapter 1 Inflammatory Bowel Disease : Epidemiology

  2018cites this paper
• 3 Drug Therapy in Ulcerative Colitis

  2018cites this paper
• Chapter 10 Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

  2018cites this paper
• A comprehensive review and update on Crohn's disease.

  2017cites this paper
• Nectar and Pollen Phytochemicals Stimulate Honey Bee (Hymenoptera: Apidae) Immunity to Viral Infection

  2017cites this paper
• Investigating the role of aberrant gene regulation in inflammatory bowel disease to understand pathogenesis and help predict relapse

  2017cites this paper
• Systematic analysis of genomic copy number variations in inflammatory bowel diseases

  2017cites this paper
• Explorer Cigarette Smoke Extract ( CSE ) Delays NOD 2 Expression and Affects NOD 2 / RIPK 2 Interactions in Intestinal Epithelial Cells

  2017cites this paper
• Animal Inhalation Models to Investigate Modulation of Inflammatory Bowel Diseases

  2017cites this paper
• Inflammatory Bowel Disease: Epidemiology

  2016cites this paper
• Smoke and autoimmunity: The fire behind the disease.

  2016cites this paper
• Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors

  2015cites this paper
• Epidemiology and risk factors for IBD

  2015cites this paper
• Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro

  2015cites this paper
• Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production.

  2015cites this paper
• Gene-environment interactions in Inflammatory Bowel Disease

  2014cites this paper
• Literature-related discovery: common factors for Parkinson’s Disease and Crohn’s Disease

  2014cites this paper
• Smoking, use of moist snuff and risk of celiac disease: a prospective study

  2014cites this paper
• Gene-environment interactions in Inflammatory Bowel Disease

  2014cites this paper
• Chapter 3 ciGarette smoke enhances resistance to apoptosis ; relevance for its opposite effects in inflammatory Bowel Diseases

  2014cites this paper
• Le stress et les maladies inflammatoires cryptogénétiques de l'intestin (MICI) : rôle anti-inflammatoire de la neurostimulation vagale (NSV)

  2014cites this paper
• Nicotine alleviates colitis-induced damage in rats via its anti-oxidative activity Siçanlarda kolite bağli hasari nikotin antioksidatif aktivitesi ile hafifletir

  2014cites this paper
• Gene-environment interactions in Inflammatory Bowel Disease

  2014cites this paper
• Does Smoking Influence Crohn's Disease in the Biologic Era? The TABACROHN Study

  2013cites this paper
• Novel Insights on the Effect of Nicotine in a Murine Colitis Model

  2013cites this paper
• Osteoprotegerin Exerts Its Pro-inflammatory Effects Through Nuclear Factor-κB Activation

  2013cites this paper
• Cigarette smoking and inflammation revisited.

  2013cites this paper
• Association of Tobacco Exposure and Reduction of Radiographic Progression in Early Rheumatoid Arthritis: Results From a French Multicenter Cohort

  2013cites this paper
• Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.

  2012cites this paper
• The effect of aspirin and smoking on urinary excretion profiles of lactulose and mannitol in young women: toward a dynamic, aspirin augmented, test of gut mucosal permeability

  2012cites this paper
• The effect of smoking on intestinal inflammation: what can be learned from animal models?

  2012cites this paper
• Current and past cigarette smoking significantly increase risk for microscopic colitis

  2012cites this paper
• Review article: ulcerative colitis, smoking and nicotine therapy

  2012cites this paper
• Effect of oral hepatocyte growth factor gene mediated by attenuated salmonella on 2‐, 4‐, 6‐trinitro‐benzene‐sulfonic‐acid‐induced ulcerative colitis in rat

  2012cites this paper
• Targeting -7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System A Cholinergic Agonist Prevents Gut Barrier Failure after Severe Burn Injury

  2012cites this paper
• Pediatric Inflammatory Bowel Disease (IBD): Phenotypic, Genetic and Therapeutic Differences between Early-Onset and Adult-Onset IBD

  2011cites this paper
• Management of Crohn's disease in smokers: is an alternative approach necessary?

  2011cites this paper
• Cigarette Smoke Extract (CSE) Delays NOD2 Expression and Affects NOD2/RIPK2 Interactions in Intestinal Epithelial Cells

  2011cites this paper
• Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases

  2011cites this paper
• If the data contradict the theory, throw out the data: Nicotine addiction in the 2010 report of the Surgeon General

  2011cites this paper
• Variation Over Time in Preventable Hospitalization Rates Across Counties

  2011cites this paper
• Associazione tra malattia di Parkinson e rettocolite ulcerosa: un caso clinico Association between Parkinson's disease and ulcerative colitis: a case report

  2011cites this paper
• Smoking, use of moist snuff, and risk of chronic inflammatory diseases.

  2010cites this paper
• Selective 7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

  2010cites this paper
• Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

  2010cites this paper
• The impact of smoking in Crohn's disease: no smoke without fire

  2010cites this paper
• Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

  2010cites this paper
• [Smoking and Crohn's disease: cessation strategies].

  2009cites this paper
• Intestinal Dendritic Cells and Epithelial Barrier Dysfunction in Crohn's Disease

  2009cites this paper
• Influence of Smoking on Colonic Gene Expression Profile in Crohn's Disease

  2009cites this paper
• Nicotine-induced neurogenic relaxation in the mouse colon: changes with dextran sodium sulfate-induced colitis.

  2009cites this paper
• Tabaquismo y enfermedad de Crohn: estrategias de deshabituación

  2009cites this paper
• Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance

  2009cites this paper
• Does nicotine influence cytokine profile and subsequent cell cycling/apoptotic responses in inflammatory bowel disease?

  2008cites this paper
• Effets du tabagisme sur la thyroïde, le tube digestif, le rein et l’os

  2008cites this paper
• Enhancing concentration, mood and memory in healthy individuals: An empirical study of attitudes among general practitioners and the general population

  2008cites this paper
• MODIFIABLE CARDIOVASCULAR RISK FACTORS IN THE EARLY ADOLESCENT PERIOD

  2008cites this paper
• Pathophysiological mechanisms of stress-induced intestinal damage.

  2008cites this paper
• The Effect of the Cholinergic Anti‐Inflammatory Pathway on Experimental Colitis

  2007cites this paper
• Nicotinic receptors as targets for therapeutic discovery

  2007cites this paper
• [The significance of CARD15 mutations in Crohn's disease. The Spanish contribution].

  2007cites this paper