Anabolic and destructive mediators in osteoarthritis.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Current opinion in clinical nutrition and metabolic care

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10871236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Detection of tumour necrosis factor alpha and interleukin-1 beta in the rheumatoid osteoarthritic cartilage-pannus junction by immunohistochemical methods

  2004cited by this paper
• Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.

  2000cited by this paper
• Signal transduction by beta1 integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor.

  1999cited by this paper
• Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes.

  1999cited by this paper
• Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.

  1999cited by this paper
• Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1.

  1999cited by this paper
• Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage.

  1999cited by this paper
• Preferential expression of tumor necrosis factor receptor 55 (TNF-R55) on human articular chondrocytes: selective transcriptional upregulation of TNF-R75 by proinflammatory cytokines interleukin 1beta, tumor necrosis factor-alpha, and basis fibroblast growth factor.

  1999cited by this paper
• Mitogen-activated protein kinase and nuclear factor kappaB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated proten kinase (MAPKAPK).

  1999cited by this paper
• Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints

  1999cited by this paper
• Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.

  1999cited by this paper
• The long‐term effect of a short course of transforming growth factor‐β1 on rat articular cartilage

  1999cited by this paper
• The Fibronectin Extra Domain A Activates Matrix Metalloproteinase Gene Expression by an Interleukin-1-dependent Mechanism*

  1999cited by this paper
• Induction of alpha1-antitrypsin synthesis in human articular chondrocytes by interleukin-6-type cytokines: evidence for a local acute-phase response in the joint.

  1999cited by this paper
• Integrin-regulated Secretion of Interleukin 4: A Novel Pathway of Mechanotransduction in Human Articular Chondrocytes

  1999cited by this paper
• Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone.

  1999cited by this paper
• Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium.

  1999cited by this paper
• Role of CDMP-1 in Skeletal Morphogenesis: Promotion of Mesenchymal Cell Recruitment and Chondrocyte Differentiation

  1999cited by this paper
• Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.

  1999cited by this paper
• Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.

  1999cited by this paper
• Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells.

  1999cited by this paper
• Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-β1 and BMP-2

  1999cited by this paper
• The Regulation of MMPs and TIMPs in Cartilage Turnover

  1999cited by this paper
• Nitric oxide in osteoarthritis.

  1999cited by this paper
• BMP‐6 Is an Autocrine Stimulator of Chondrocyte Differentiation

  1999cited by this paper
• IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses.

  1999cited by this paper
• Interleukin-1beta-converting enzyme/caspase-1 in human osteoarthritic tissues: localization and role in the maturation of interleukin-1beta and interleukin-18.

  1999cited by this paper
• Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.

  1999cited by this paper
• IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

  1998cited by this paper
• Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-beta into murine knee joints.

  1998cited by this paper
• Osteoarthritic synovial fluid and synovium supernatants up-regulate tumor necrosis factor receptors on human articular chondrocytes.

  1998cited by this paper
• Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation.

  1998cited by this paper
• Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States.

  1998cited by this paper
• Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro.

  1998cited by this paper
• Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis.

  1998cited by this paper
• Joint inflammation and cartilage destruction may occur uncoupled.

  1998cited by this paper
• Transforming growth factor-beta predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage.

  1997cited by this paper
• Osteoarthritic synovial fibroblasts possess an increased level of tumor necrosis factor-receptor 55 (TNF-R55) that mediates biological activation by TNF-alpha.

  1997cited by this paper
• Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage.

  1997cited by this paper
• Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines.

  1997cited by this paper
• Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

  1997cited by this paper
• Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content.

  1997cited by this paper
• Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis.

  1997cited by this paper
• Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta.

  1997cited by this paper
• Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex.

  1997cited by this paper
• Stimulation of Proteoglycan Synthesis in Explants of Porcine Articular Cartilage by Recombinant Osteogenic Protein-1 (Bone Morphogenetic Protein-7)*

  1997cited by this paper
• Gene expression of collagen types IIA and IX correlates with ultrastructural events in early osteoarthrosis: new applications of the rabbit meniscectomy model.

  1997cited by this paper
• Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines.

  1996cited by this paper
• Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies.

  1996cited by this paper
• Recombinant human bone morphogenetic protein‐2 maintains the articular chondrocyte phenotype in long‐term culture

  1996cited by this paper
• Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint.

  1994cited by this paper
• Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins.

  1994cited by this paper
• Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis.

  1993cited by this paper
• Osteoarthritic human cartilage is more sensitive to transforming growth factor beta than is normal cartilage.

  1993cited by this paper
• Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo.

  1993cited by this paper
• Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage.

  1992cited by this paper
• Insulin-like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid.

  1989cited by this paper
• Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines.

  1989cited by this paper
• Active and latent forms of transforming growth factor beta activity in synovial effusions

  1989cited by this paper

• Molecular and Immunomodulatory Mechanisms of Statins in Inflammation and Cancer Therapeutics with Emphasis on the NF-κB, NLRP3 Inflammasome, and Cytokine Regulatory Axes

  2025cites this paper
• Effects of Pomegranate (Punica granatum L.) Peel Extract Supplementation on Markers of Inflammation and Serum Matrix Metalloproteinase 1 in Women With Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Study

  2024cites this paper
• Therapeutic Controlled Release Strategies for Human Osteoarthritis

  2024cites this paper
• ICAM‐1‐mediated osteoblast‐T lymphocyte direct interaction increases mineralization through TGF‐β1 suppression

  2023cites this paper
• Engineering Closed-Loop, Autoregulatory Gene Circuits for Osteoarthritis Cell-Based Therapies

  2022cites this paper
• The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies

  2022cites this paper
• Sodium Tanshinone IIA Sulfonate Ameliorates Injury-Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway

  2021cites this paper
• Bovine Milk‐Derived Extracellular Vesicles Inhibit Catabolic and Inflammatory Processes in Cartilage from Osteoarthritis Patients

  2021cites this paper
• Systematic review of the effects of pomegranate (Punica granatum) on osteoarthritis

  2021cites this paper
• LncRNA ANCR is positively correlated with transforming growth factor‐β1 in patients with osteoarthritis

  2019cites this paper
• TGF-β dampens IL-6 signaling in articular chondrocytes by decreasing IL-6 receptor expression.

  2019cites this paper
• Technology Open Access book

  2017cites this paper
• Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis

  2017cites this paper
• miRNA-146a, miRNA-155 and JNK expression levels in peripheral blood mononuclear cells according to grade of knee osteoarthritis.

  2017cites this paper
• Modern aspects on etiopathogenesis of canine osteoarthritis

  2017cites this paper
• PDK1 promotes apoptosis of chondrocytes via modulating MAPK pathway in osteoarthritis.

  2017cites this paper
• PROSPECTIVE EFFECT OF RED ALGAE, ACTINOTRICHIA FRAGILIS, AGAINST SOME OSTEOARTHRITIS AETIOLOGY

  2016cites this paper
• Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-κB

  2016cites this paper
• IL37 dampens the IL1&bgr;-induced catabolic status of human OA chondrocytes

  2016cites this paper
• DİZ OSTEOARTRİT HASTALARININ EVRELERİNE GÖRE NÜKLEAR FAKTÖR KAPPA B (NF-ΚB) AKTİVİTESİ / NUCLEAR FACTOR KAPPA B (NF-κB) ACTIVITY ACCORDING TO GRADE OF KNEE OSTEOARTHRITIS PATIENTS

  2016cites this paper
• Secretome analysis of human articular chondrocytes unravels catabolic effects of nicotine on the joint

  2016cites this paper
• Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis

  2015cites this paper
• sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair.

  2015cites this paper
• Integrin α1β1 differentially regulates cytokine-mediated responses in chondrocytes.

  2014cites this paper
• AAV-mediated dual-axis gene therapy to enhance cartilage repair

  2014cites this paper
• The Efficacy of Diacerein with and Without Diclofenac Sodium on Knee Pain Severity and Walking Time in Patients with Knee Osteoarthritis

  2014cites this paper
• The role of platelet gel in osteoarticular injuries of young and old patients

  2014cites this paper
• Inflammation in Equine Articular Cartilage The Effect of Cytokines in Chondrocyte Pellets and Explants: Two in vitro Models

  2014cites this paper
• Edible Bird’s nest extract as a chondro-protective agent for human chondrocytes isolated from osteoarthritic knee: in vitro study

  2013influential citation
• Yeast Hydrolysate Protects Cartilage via Stimulation of Type II Collagen Synthesis and Suppression of MMP‐13 Production

  2013cites this paper
• Hass Avocado Composition and Potential Health Effects

  2013cites this paper
• Cinnamophilin Isolated from Cinnamomum philippinense Protects against Collagen Degradation in Human Chondrocytes

  2013cites this paper
• Bovine lactoferricin is anti‐inflammatory and anti‐catabolic in human articular cartilage and synovium

  2013cites this paper
• EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee

  2013cites this paper
• Current nutraceuticals in the management of osteoarthritis: a review

  2012cites this paper
• Stem Cells and Cancer Stem Cells, Volume 7

  2012cites this paper
• Concentrace Trace Mineral Drops A Natural Food Supplement Provides Early Relief From Osteoarthritis of Knee Symptoms: A Randomized, Placebo Controlled Clinical Trial

  2012cites this paper
• SNP-induced apoptosis may be mediated with caspase inhibitor by JNK signaling pathways in rabbit articular chondrocytes.

  2012cites this paper
• Cellular Physiology of Articular Cartilage in Health and Disease

  2012cites this paper
• Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes

  2012influential citation
• Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes

  2011cites this paper
• What about supplements for osteoarthritis? A critical and evidenced‐based review

  2011cites this paper
• Anti-inflammatory effects of Cynanchum taiwanianum rhizome aqueous extract in IL-1β-induced NRK-52E cells

  2011cites this paper
• Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes

  2011cites this paper
• Medicinal and Pharmaceutical Potentialities of Tea ( Camellia sinensis L.)

  2011cites this paper
• Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL‐1β and p38 MAPK signal

  2011cites this paper
• High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

  2010cites this paper
• Effects of (−)-epigallocatechin-3-gallate on cyclooxygenase 2, PGE2, and IL-8 expression induced by IL-1β in human synovial fibroblasts

  2010cites this paper
• Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis.

  2010cites this paper
• Dehydroxymethylepoxyquinomicin Inhibits Expression and Production of Inflammatory Mediators in Interleukin-1β-induced Human Chondrocytes

  2010cites this paper
• Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor alpha and interleukin-1beta.

  2010cites this paper
• Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected].

  2010cites this paper
• High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1 b in osteoarthritic synoviocytes

  2010cites this paper
• A Potential Role for Avocado- and Soybean-Based Nutritional Supplements in the Management of Osteoarthritis: A Review

  2010cites this paper
• Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.

  2009cites this paper
• p38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells.

  2009cites this paper
• Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease.

  2009cites this paper
• In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA

  2009cites this paper
• TGF-β inhibits IL-1β-activated PAR-2 expression through multiple pathways in human primary synovial cells

  2009cites this paper
• The effects of p-hydroxycinnamaldehyde from Alpinia galanga extracts on human chondrocytes.

  2009cites this paper
• p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL‐1

  2008cites this paper
• Stress-induced signaling pathways in hyalin chondrocytes: inhibition by Avocado-Soybean Unsaponifiables (ASU).

  2008cites this paper
• The multicomponent phytopharmaceutical SKI306X inhibits in vitro cartilage degradation and the production of inflammatory mediators.

  2008cites this paper
• Gene therapy methods in bone and joint disorders

  2007cites this paper
• Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]

  2007cites this paper
• Toll-like receptors and chondrocytes: the lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7.

  2007cites this paper
• p38 MAPK Inhibition in Nucleus Pulposus Cells: A Potential Target for Treating Intervertebral Disc Degeneration

  2007cites this paper
• Haem oxygenase‐1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes

  2007cites this paper
• Bmc Complementary and Alternative Medicine Comparison of Glucosamine Sulfate and a Polyherbal Supplement for the Relief of Osteoarthritis of the Knee: a Randomized Controlled Trial [isrctn25438351]

  2007cites this paper
• Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF‐κB, p53 and caspase‐3 activation in rabbit articular chondrocytes

  2007cites this paper
• Cat's claw: an Amazonian vine decreases inflammation in osteoarthritis.

  2007cites this paper
• Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study

  2006cites this paper
• Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism

  2006cites this paper
• Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.

  2006cites this paper
• Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells

  2006cites this paper
• Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis

  2006cites this paper
• Mitochondrial activity is modulated by TNFalpha and IL-1beta in normal human chondrocyte cells.

  2006cites this paper
• Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.

  2005cites this paper
• Adeno-associated vector mediated gene transfer of transforming growth factor-beta1 to normal and osteoarthritic human chondrocytes stimulates cartilage anabolism.

  2005cites this paper
• Comparative effects of IL-1beta and hydrogen peroxide (H2O2) on catabolic and anabolic gene expression in juvenile bovine chondrocytes.

  2005cites this paper
• Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors

  2005influential citation
• Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages.

  2005cites this paper
• A Pilot trial evaluating meta050, a proprietary combination of reduced iso‐alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia

  2005cites this paper
• Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro.

  2005cites this paper
• Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]

  2005cites this paper
• p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF‐β

  2005cites this paper
• Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.

  2005cites this paper
• Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages.

  2005cites this paper
• Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.

  2004cites this paper
• Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes.

  2004cites this paper
• Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG) Differentially Inhibits Interleukin-1β-Induced Expression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes

  2004cites this paper
• Metabolic activity of chondrocytes in human osteoarthritis as a result of cell-extracellular matrix interactions.

  2004cites this paper
• Haemoglobin-derived iron-dependent hydroxyl radical formation in blood-induced joint damage: an in vitro study.

  2003cites this paper
• High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases: possible role as a proinflammatory mediator in arthritis.

  2003cites this paper
• Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system.

  2003cites this paper
• Effects of interleukin-1beta on chondroblast viability and extracellular matrix changes in bovine articular cartilage explants.

  2003cites this paper
• Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition

  2003cites this paper
• Phenyl N-tert-Butylnitrone Down-Regulates Interleukin-1β-Stimulated Matrix Metalloproteinase-13 Gene Expression in Human Chondrocytes: Suppression of c-Jun NH2-Terminal Kinase, p38-Mitogen-Activated Protein Kinase and Activating Protein-1

  2003cites this paper
• Immunologic intervention in the pathogenesis of osteoarthritis.

  2003cites this paper
• Phenyl N-tert-butylnitrone Down-regulates IL-1β-stimulated Matrix Metalloproteinase-13 Gene Expression In Human Chondrocytes: Suppression of c-Jun NH2-terminal Kinase, p38-MAP Kinase And Activating Protein-1

  2003cites this paper