Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy

Wen-jie Dong,Yongsheng Li,Dechao Niu,Zhi Ma,Jinlou Gu,Yi Chen,Wenru Zhao,Xiaohan Liu,Changsheng Liu,Jianlin Shi

Published 2011 in Advances in Materials

ABSTRACT

A simple seed-mediated growth route is developed to fabricate monodisperse, uniform superparamagnetic Fe(3)O(4) core/gold shell structured nanocomposites with tunable sizes and optical properties, in which gold seed formation and attachment onto the core surface via S-Au covalent bonding proceeds almost simultaneously in the one-pot synthesis. The as-prepared nanocomposite is demonstrated to have a great potential for magnetic resonance imaging (MRI)-guided, focused photothermal tumor therapy under near-IR laser radiation.

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