Characterization of dendritic cells in human and experimental myocarditis

R. Pistulli,E. Andreas,S. König,S. Drobnik,D. Kretzschmar,I. Rohm,M. Lichtenauer,B. Heidecker,M. Franz,G. Mall,A. Yilmaz,P. C. Schulze

Published 2020 in ESC Heart Failure

ABSTRACT

Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence of their role in myocardial inflammatory disease. We hypothesized that plasmacytoid and myeloid DCs are involved in the mechanisms of myocarditis and analysed these two main subtypes in human myocarditis subjects, as well as in a murine model of experimental autoimmune myocarditis (EAM).

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