Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Genes & Development

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1101/GAD.12.19.3020PMID 9765204PMCID PMC317191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential use of CREB binding protein-coactivator complexes.

  1998cited by this paper
• p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation.

  1998cited by this paper
• Transcription factor-specific requirements for coactivators and their acetyltransferase functions.

  1998cited by this paper
• Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1

  1997cited by this paper
• Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

  1997cited by this paper
• Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.

  1997cited by this paper
• Mechanisms of transcriptional activation: differences and similarities between yeast, Drosophila, and man.

  1997cited by this paper
• Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

  1997cited by this paper
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997cited by this paper
• RNA helicase A mediates association of CBP with RNA polymerase II.

  1997cited by this paper
• Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.

  1997cited by this paper
• ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor.

  1997cited by this paper
• The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

  1997cited by this paper
• A signature motif in transcriptional co-activators mediates binding to nuclear receptors

  1997cited by this paper
• Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II

  1997cited by this paper
• A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

  1996cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• Role of CBP/P300 in nuclear receptor signalling

  1996cited by this paper
• The CBP co-activator is a histone acetyltransferase

  1996cited by this paper
• NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.

  1996cited by this paper
• RSC, an essential, abundant chromatin-remodeling complex.

  1996cited by this paper
• A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.

  1996cited by this paper
• Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator (*)

  1996cited by this paper
• SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.

  1996cited by this paper
• Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.

  1996cited by this paper
• Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

  1996cited by this paper
• p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.

  1995cited by this paper
• Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro.

  1995cited by this paper
• Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter.

  1995cited by this paper
• TAFs and TFIIA mediate differential utilization of the tandem Adh promoters.

  1995cited by this paper
• Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter.

  1995cited by this paper
• Purification and properties of an ATP-dependent nucleosome remodeling factor.

  1995cited by this paper
• Multiple TAFIIs Directing Synergistic Activation of Transcription

  1995cited by this paper
• Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF

  1995cited by this paper
• Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome.

  1995cited by this paper
• CBP‐induced stimulation of c‐Fos activity is abrogated by E1A.

  1995cited by this paper
• Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene (*)

  1995cited by this paper
• Stat1 Depends on Transcriptional Synergy with Sp1 (*)

  1995cited by this paper
• Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.

  1995cited by this paper
• Nuclear protein CBP is a coactivator for the transcription factor CREB

  1994cited by this paper
• SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.

  1994cited by this paper
• Facilitated binding of TATA-binding protein to nucleosomal DNA

  1994cited by this paper
• Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

  1994cited by this paper
• A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation.

  1994cited by this paper
• Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II.

  1994cited by this paper
• Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement.

  1994cited by this paper
• Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

  1994cited by this paper
• Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators.

  1994cited by this paper
• Transcriptional activation: a complex puzzle with few easy pieces.

  1994cited by this paper
• The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex.

  1994cited by this paper
• Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

  1994cited by this paper
• Molecular cloning of the small (gamma) subunit of human TFIIA reveals functions critical for activated transcription.

  1994cited by this paper
• Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators.

  1993cited by this paper
• Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.

  1993cited by this paper
• Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB.

  1993cited by this paper
• SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

  1993cited by this paper
• Phosphorylated CREB binds specifically to the nuclear protein CBP

  1993cited by this paper
• SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.

  1993cited by this paper
• Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly.

  1993influential reference
• Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.

  1993cited by this paper
• Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors.

  1992cited by this paper
• Yeast SNF2/SWI2, SNF5, and SNF6 proteins function coordinately with the gene-specific transcriptional activators GAL4 and Bicoid.

  1992cited by this paper
• Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

  1991cited by this paper
• Regulation of the mevalonate pathway

  1990cited by this paper
• Transcription activation by the adenovirus E1a protein

  1989cited by this paper
• Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

  1988cited by this paper
• Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

  1987cited by this paper

• SREBP1-Dependent Metabolism as a Potential Target for Breast Cancer Risk Reduction

  2025cites this paper
• Peak Scores Significantly Depend on the Relationships between Contextual Signals in ChIP-Seq Peaks

  2024cites this paper
• βIII-Tubulin Gene Regulation in Health and Disease

  2022cites this paper
• Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration.

  2021cites this paper
• Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes

  2020cites this paper
• TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.

  2020influential citation
• Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

  2019cites this paper
• Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

  2019cites this paper
• SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait

  2019cites this paper
• Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation

  2019cites this paper
• TFIID Enables RNA Polymerase II Promoter-Proximal Pausing

  2019cites this paper
• Therapeutic potential of Mediator complex subunits in metabolic diseases.

  2018cites this paper
• Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy

  2018cites this paper
• Le médicament épigénétique 5-Azacytidine stabilise l’ARN messager du récepteur des lipoprotéines de basse densité (LDLR) via une voie IRE1α/EGFR/ERK1/2- dépendante

  2018cites this paper
• Combinatorial function of transcription factors and cofactors.

  2017cites this paper
• Identifying a TFIID interactome via integrated biochemical and high-throughput proteomic studies

  2017cites this paper
• New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis.

  2017cites this paper
• Regulation of metabolism by the Mediator complex

  2016cites this paper
• Regulatory divergence of homeologous Atlantic salmon elovl5 genes following the salmonid-specific whole-genome duplication.

  2016cites this paper
• Accepted refereed manuscript of: Carmona-Antonanzas G, Zheng X, Tocher DR & Leaver M (2016) Regulatory divergence of homeologous Atlantic salmon elovl5 genes

  2016cites this paper
• The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

  2015cites this paper
• Function of SREBP1 in the Milk Fat Synthesis of Dairy Cow Mammary Epithelial Cells

  2014cites this paper
• Evolutionary history and diversification of duplicated fatty-acyl elongase genes of Atlantic salmon (Salmo salar)

  2014cites this paper
• SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.

  2014cites this paper
• Alternative Splicing Targeting the hTAF4-TAFH Domain of TAF4 Represses Proliferation and Accelerates Chondrogenic Differentiation of Human Mesenchymal Stem Cells

  2013cites this paper
• Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis

  2013cites this paper
• Molecular recognition by the KIX domain and its role in gene regulation

  2013cites this paper
• Human TFIID binds to core promoter DNA in a reorganized structural state.

  2013cites this paper
• Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network

  2013cites this paper
• Activator-mediator binding stabilizes RNA polymerase II orientation within the human mediator-RNA polymerase II-TFIIF assembly.

  2012cites this paper
• Transcriptional regulation by coactivators in embryonic stem cells.

  2012cites this paper
• Transcription initiation by human RNA polymerase II visualized at single-molecule resolution.

  2012cites this paper
• Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

  2012cites this paper
• A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.

  2011influential citation
• Transcription Factor Sp1 Is Essential for the Regulation of the Porcine Caveolin-1 Gene

  2011cites this paper
• Mediator-dependent nuclear receptor function.

  2011cites this paper
• Regulation of mir-33 micro rna in the treatment of cholesterol-related disorders

  2010influential citation
• Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase

  2010cites this paper
• Transcriptional regulation of the mouse adrenal cyclase type 4 (Adcy4) in Y1 adrenocortical tumor cells.

  2010influential citation
• Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

  2010cites this paper
• The mRNA cap-binding complex stimulates the formation of pre-initiation complex at the promoter via its interaction with Mot1p in vivo

  2010cites this paper
• Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

  2009influential citation
• Expression and developmental requirement for transcription factor Sp2

  2009cites this paper
• p53 sumoylation: Mechanistic insights from reconstitution studies

  2009cites this paper
• In vitro activity of the EWS oncogene transcriptional activation domain.

  2009cites this paper
• Coordination of lipid metabolism in membrane biogenesis.

  2009cites this paper
• Investigation of the mechanisms of estrogen receptor activation by phosphorylation

  2009cites this paper
• SREBPs: protein interaction and SREBPs

  2009cites this paper
• Specificity protein-1 and -3 trans-activate the ovine placental lactogen gene promoter.

  2009cites this paper
• Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the β-Globin Locus

  2008cites this paper
• Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

  2008cites this paper
• Structural changes in TAF4b-TFIID correlate with promoter selectivity.

  2008cites this paper
• Cooperative activity of cdk 8 and GCN 5 L within Mediator directs tandem phosphoacetylation of histone

  2008cites this paper
• A nuclear receptor-like pathway regulating multidrug resistance in fungi

  2008cites this paper
• Sp1: emerging roles--beyond constitutive activation of TATA-less housekeeping genes.

  2008cites this paper
• Protein Recognition in Biology

  2008cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 403 Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

  2008cites this paper
• Expression of the Rat Sterol Regulatory Element-binding Protein-1c Gene in Response to Insulin Is Mediated by Increased Transactivating Capacity of Specificity Protein 1 (Sp1)*

  2007cites this paper
• Polyunsaturated fatty acid suppression of fatty acid synthase ( FASN ) : evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1 c

  2007cites this paper
• Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c.

  2007cites this paper
• Estudio del factor de transcripción SREBP1 en estados de resistencia a insulina.

  2007cites this paper
• Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.

  2007cites this paper
• Cholesterol: from feeding to gene regulation

  2007cites this paper
• Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression.

  2006cites this paper
• Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes.

  2006cites this paper
• An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

  2006cites this paper
• Characterization of a new response to bacterial pore-forming toxin that promotes cell survival in a caspase-1 dependent activation of SREBPs

  2006cites this paper
• Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues.

  2006cites this paper
• Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus

  2006cites this paper
• Coactivator cross-talk specifies transcriptional output.

  2006cites this paper
• Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y.

  2006cites this paper
• Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression

  2006cites this paper
• Regulation of transcription by the viral activator VP16

  2006cites this paper
• Transcription: The Never Ending Story

  2006cites this paper
• Human Immunodeficiency Virus Type 1 Tat Prevents Dephosphorylation of Sp1 by Tcf-4 in Astrocytes

  2006cites this paper
• Factors That Control the Tissue-Specific Transcription of the Gene for Phosphoenolpyruvate Carboxykinase-C

  2005influential citation
• CHAPTER 14 – Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity

  2005cites this paper
• The Mediator of RNA polymerase II

  2005influential citation
• E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation.

  2005cites this paper
• A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein 1a (SREBP-1a).

  2005cites this paper
• Changes in blood flow that affect hepatic gene expression

  2005cites this paper
• KLF11-mediated Repression Antagonizes Sp1/Sterol-responsive Element-binding protein-induced Transcriptional Activation of Caveolin-1 in Response to Cholesterol Signaling*

  2005cites this paper
• Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

  2005cites this paper
• Regulation of Sp2 DNA-Binding Activity and trans-Activation

  2005cites this paper
• Mediator and the mechanism of transcriptional activation.

  2005cites this paper
• Transcription Factors

  2004cites this paper
• Structure and function of the TFIID complex.

  2004cites this paper
• Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis.

  2004cites this paper
• SREBP-1c and Sp1 Interact to Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP) in the Liver*

  2004cites this paper
• SREBP transcription factors: master regulators of lipid homeostasis.

  2004cites this paper
• Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependent manner Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.M400088-JLR200

  2004cites this paper
• Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins

  2004cites this paper
• Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.

  2004cites this paper
• The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.

  2004cites this paper
• Distinct conformational states of nuclear receptor–bound CRSP–Med complexes

  2004cites this paper
• Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.

  2004cites this paper
• SREBP-1a Polymorphism Influences the Risk of Alzheimer’s Disease in Carriers of the ApoE4 Allele

  2004cites this paper
• Hypoxia-induced Activation of the Retinoic Acid Receptor-related Orphan Receptor α4 Gene by an Interaction between Hypoxia-inducible Factor-1 and Sp1*

  2004cites this paper
• Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex.

  2004cites this paper
• Interplay between HIV-1 Vpr and Sp1 Modulates p21WAF1 Gene Expression in Human Astrocytes*

  2004cites this paper