Epilepsy and Inflammation in the Brain: Overview and Pathophysiology

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Epilepsy Currents

• Publication date

  2014-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.5698/1535-7511-14.s2.3PMID 24955068PMCID PMC3966641
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

  2011cited by this paper
• Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

  2011cited by this paper
• The role of inflammation in epilepsy

  2011cited by this paper
• Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias

  2010cited by this paper
• Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability.

  2010cited by this paper
• c‐Jun N‐terminal kinase signaling pathway in excitotoxic cell death following kainic acid‐induced status epilepticus

  2010cited by this paper
• Epileptogenesis Provoked by Prolonged Experimental Febrile Seizures: Mechanisms and Biomarkers

  2010cited by this paper
• Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

  2010cited by this paper
• Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis

  2009cited by this paper
• Cyclooxygenase in epilepsy: from perception to application.

  2009cited by this paper
• Significantly higher serologic responses of Chlamydia trachomatis B group serovars versus C and I serogroups.

  2009cited by this paper
• Antagonism of peripheral inflammation reduces the severity of status epilepticus.

  2009cited by this paper
• Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy.

  2009cited by this paper
• Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors.

  2008cited by this paper
• A role for leukocyte-endothelial adhesion mechanisms in epilepsy

  2008cited by this paper
• yclooxygenase-2 / PGE 2 pathway facilitates entylenetetrazol-induced seizures

  2008cited by this paper
• A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta.

  2008cited by this paper
• Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy.

  2008cited by this paper
• Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex.

  2008cited by this paper
• Complement activation in experimental and human temporal lobe epilepsy.

  2007cited by this paper
• New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy

  2007cited by this paper
• TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis.

  2007cited by this paper
• High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

  2007cited by this paper
• Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy.

  2007cited by this paper
• Cytokines and neuronal ion channels in health and disease.

  2007cited by this paper
• Potential New Antiepileptogenic Targets Indicated by Microarray Analysis in a Rat Model for Temporal Lobe Epilepsy

  2006cited by this paper
• Astrocytic Glutamate Is Not Necessary for the Generation of Epileptiform Neuronal Activity in Hippocampal Slices

  2006cited by this paper
• Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy

  2006cited by this paper
• Inflammation and neurodegenerative diseases.

  2006cited by this paper
• The Blood–Brain Barrier and Epilepsy

  2006cited by this paper
• Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system.

  2006cited by this paper
• The IL-1β system in epilepsy-associated malformations of cortical development

  2006cited by this paper
• Interleukin-1 and neuronal injury

  2005cited by this paper
• An astrocytic basis of epilepsy

  2005cited by this paper
• Interleukin‐1β contributes to the generation of experimental febrile seizures

  2005cited by this paper
• Brain Inflammation in Epilepsy: Experimental and Clinical Evidence

  2005cited by this paper
• Causal Links between Brain Cytokines and Experimental Febrile Convulsions in the Rat

  2005cited by this paper
• Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy.

  2004cited by this paper
• Lasting Blood-Brain Barrier Disruption Induces Epileptic Focus in the Rat Somatosensory Cortex

  2004cited by this paper
• Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

  2003cited by this paper
• Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal‐regulating kinase 1 during seizure‐induced neuronal death

  2003cited by this paper
• Formation of Complement Membrane Attack Complex in Mammalian Cerebral Cortex Evokes Seizures and Neurodegeneration

  2003cited by this paper
• Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

  2003cited by this paper
• Profound increase in sensitivity to glutamatergic‐ but not cholinergic agonist‐induced seizures in transgenic mice with astrocyte production of IL‐6

  2003cited by this paper
• Innate immunity: the missing link in neuroprotection and neurodegeneration?

  2002cited by this paper
• Functional Role of Inflammatory Cytokines and Antiinflammatory Molecules in Seizures and Epileptogenesis

  2002cited by this paper
• CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

  2001cited by this paper
• The role of cytokines and growth factors in seizures and their sequelae.

  2001cited by this paper
• Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus

  2000cited by this paper
• Interleukin-1beta inhibits gamma-aminobutyric acid type A (GABA(A)) receptor current in cultured hippocampal neurons.

  2000cited by this paper
• Cytokine Effects on Glutamate Uptake by Human Astrocytes

  2000cited by this paper
• Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice.

  2000cited by this paper
• Kindling modulates the IL-1beta system, TNF-alpha, TGF-beta1, and neuropeptide mRNAs in specific brain regions.

  2000cited by this paper
• Kindling modulates the IL-1β system, TNF-α, TGF-β1, and neuropeptide mRNAs in specific brain regions

  2000cited by this paper
• Interleukin-1β Immunoreactivity and Microglia Are Enhanced in the Rat Hippocampus by Focal Kainate Application: Functional Evidence for Enhancement of Electrographic Seizures

  1999cited by this paper
• Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid.

  1999cited by this paper
• Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

  1997cited by this paper
• Interleukin-1β does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in vitro

  1997cited by this paper
• Cytokine modulation of glial glutamate uptake: a possble involvement of nitric oxide

  1996cited by this paper
• Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

  1995cited by this paper
• Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

  1993cited by this paper

• ENHANCED ANTICONVULSANT EFFICACY OF INTERLEUKIN RECEPTOR BLOCKADE FOLLOWING LEVETIRACETAM USE

  2026cites this paper
• Influence of epilepsy syndrome on cancer comorbidity.

  2026cites this paper
• Phenobarbital-induced CD4+ upregulation predicts seizure reduction in epilepsy

  2025cites this paper
• Prednisolone attenuates seizure severity and neuroinflammation in a pentylenetetrazole-induced acute epilepsy model.

  2025cites this paper
• Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets

  2025cites this paper
• Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy

  2025influential citation
• Administering MSC‐Derived Exosomes After Hypoxia‐Induced Seizures in Neonatal Rats Improved Cognitive Function and Delayed the Onset of Epilepsy in Adulthood, Likely by Reducing Inflammation and Oxidative Stress

  2025cites this paper
• “Exosomal therapy: a promising approach to alleviate renal dysfunction induced by hypoxia in neonatal seizures”

  2025cites this paper
• Effects of Ghrelin on Brain and Serum Inflammatory Parameters in PTZ-Kindling Model in Rats

  2025cites this paper
• Mitochondria‐Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy

  2025cites this paper
• Efficacy and Safety of Pulse Intravenous Methylprednisolone in Pediatric Epileptic Encephalopathies: Timing and Networks Consideration

  2024cites this paper
• Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury

  2024cites this paper
• Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

  2024cites this paper
• Drug resistant epilepsies: A multicentre case series of steroid therapy.

  2024cites this paper
• High Translocation of High Mobility Group Box 1 in the Brain Tissue of Patients with Sturge-Weber Syndrome

  2024cites this paper
• The protective effect of DMI on hippocampus EEG, behavioral and biochemical parameters in hypoxia-induced seizure on neonatal period

  2024cites this paper
• Genetic association between epilepsy and gliomas: Insights from Mendelian randomization and single-cell transcriptomic analyses.

  2024cites this paper
• Saccharomyces Boulardii alleviates neuroinflammation and oxidative stress in PTZ-kindled seizure rat model

  2024cites this paper
• Candesartan restores blood-brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis.

  2024cites this paper
• Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation–mediated neuromodulation therapy and new technologies

  2024cites this paper
• A Systematic Review of the Predictive and Diagnostic Uses of Neuroinflammation Biomarkers for Epileptogenesis

  2024cites this paper
• Microglia and infiltrating macrophages in ictogenesis and epileptogenesis

  2024cites this paper
• Linking weed control techniques to anti-inflammatory potential: Comparative analysis of Angelica archangelica L. root essential oil profiles

  2024cites this paper
• Reduction of seizures and inflammatory markers by betamethasone in a kindling seizure model.

  2023cites this paper
• Investigation of Correlation between Resistance to Diazepam and Expression of Inflammatory Markers in The Peripheral Blood of Patients with Status Epilepticus

  2023cites this paper
• Highly dynamic inflammatory and excitability transcriptional profiles in hippocampal CA1 following status epilepticus

  2023cites this paper
• Microglia as a Game Changer in Epilepsy Comorbid Depression

  2023cites this paper
• Biomolecular mechanisms of epileptic seizures and epilepsy: a review

  2023cites this paper
• (-)-α-bisabolol exerts neuroprotective effects against pentylenetetrazole-induced seizures in rats by targeting inflammation and oxidative stress.

  2023cites this paper
• Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication

  2023cites this paper
• Microglial TRPV1 in epilepsy: Is it druggable for new antiepileptic treatment?

  2023cites this paper
• Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats.

  2023cites this paper
• The role of neuroinflammation in canine epilepsy.

  2023cites this paper
• The effect of quercetin on absence epilepsy in WAG/Rij rats

  2023cites this paper
• Microglia play beneficial roles in multiple experimental seizure models

  2023cites this paper
• Corticosteroids in childhood epilepsies: A systematic review

  2023cites this paper
• Inhibition of Microglial GSK3β Activity Is Common to Different Kinds of Antidepressants: A Proposal for an In Vitro Screen to Detect Novel Antidepressant Principles

  2023cites this paper
• Microglia play beneficial roles in multiple experimental seizure models

  2023cites this paper
• TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis

  2023cites this paper
• Role of Gut Microbiota in Neurological Disorders and Its Therapeutic Significance

  2023cites this paper
• Role of Short Chain Fatty Acids in Epilepsy and Potential Benefits of Probiotics and Prebiotics: Targeting “Health” of Epileptic Patients

  2022cites this paper
• Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.

  2022cites this paper
• Epilepsy: GABRB3 Gene and Medical Treatment

  2022cites this paper
• Effects of vaccination, new SARS-CoV-2 variants and reinfections on post-COVID-19 complications

  2022cites this paper
• Effect of neurofeedback therapy on neurological post-COVID-19 complications (A pilot study)

  2022cites this paper
• Levetiracetam Suppresses the Infiltration of Neutrophils and Monocytes and Downregulates Many Inflammatory Cytokines during Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice

  2022cites this paper
• Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

  2022cites this paper
• Role of Dendritic Cells in Viral Brain Infections

  2022cites this paper
• Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy

  2022cites this paper
• A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

  2022cites this paper
• Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy

  2021cites this paper
• Protective effects of long-term probiotic mixture supplementation against pentylenetetrazole-induced seizures, inflammation and oxidative stress in rats.

  2021cites this paper
• Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats

  2021cites this paper
• Headache in people with epilepsy

  2021cites this paper
• Seizure control after late introduction of anakinra in a patient with adult onset Rasmussen’s encephalitis

  2021cites this paper
• Temporal lobe epilepsy associated with human herpes virus 6

  2021cites this paper
• Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

  2021cites this paper
• Pathophysiological Cascade of Events Leading to Epilepsy: Role of Inflammation

  2021cites this paper
• Cerebrospinal Fluid Pleocytosis Not Attributable to Status Epilepticus in First 24 Hours

  2021cites this paper
• Bidirectional communication between mast cells and the gut-brain axis in neurodegenerative disease: avenues for therapeutic intervention.

  2021cites this paper
• Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies.

  2021cites this paper
• Single-Nucleotide Variants in microRNAs Sequences or in their Target Genes Might Influence the Risk of Epilepsy: A Review

  2021cites this paper
• Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation.

  2021cites this paper
• Viral infections and their relationship to neurological disorders

  2021cites this paper
• Alleviation of prilocaine-induced epileptiform activity and cardiotoxicity by thymoquinone

  2021cites this paper
• Protective effects of forced exercise against topiramate-induced cognition impairment and enhancement of its antiepileptic activity: molecular and behavioral evidences

  2021cites this paper
• The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats

  2021cites this paper
• DDDT_A_314076 3163..3180

  2021cites this paper
• The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models

  2021cites this paper
• Beneficial and detrimental functions of microglia during viral encephalitis.

  2021cites this paper
• The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats

  2021cites this paper
• Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis

  2021cites this paper
• Dendritic Cell–Targeted Therapies to Treat Neurological Disorders

  2021cites this paper
• Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy.

  2021cites this paper
• The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic activity against pentylenetetrazol kindling in male Wistar rats

  2021cites this paper
• Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration

  2020cites this paper
• Role of Inflammation and Serum Creatine Phospho Kinase in Seizures

  2020cites this paper
• Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

  2020cites this paper
• Series of patients with febrile status epilepticus: clinical manifestations and long-term follow-up

  2020cites this paper
• Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.

  2020cites this paper
• Immunogenetic protective factors in Genetic Generalized Epilepsy.

  2020cites this paper
• Daily Low Dose of Erythropoietin and Neuroinflammation

  2020cites this paper
• Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling

  2020cites this paper
• Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole.

  2020cites this paper
• Determination of levels of oxidative stress and nitrosative stress in patients with epilepsy.

  2020cites this paper
• Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders.

  2020cites this paper
• Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis

  2020cites this paper
• Therapeutic Effects of Oleuropein in Improving Seizure, Oxidative Stress and Cognitive Disorder in Pentylenetetrazole Kindling Model of Epilepsy in Mice

  2020cites this paper
• Daily Low Dose of Erythropoietin in Neuroinflammation; EPO Might Be Hazardous in COVID-19

  2020cites this paper
• Gut Microbiota and Epilepsy: A Systematic Review on Their Relationship and Possible Therapeutics.

  2020cites this paper
• Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders.

  2020cites this paper
• The Effects of G2013 (α-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy.

  2020cites this paper
• IL-1β-31/IL1-RA genetic markers association with idiopathic generalized epilepsy and treatment response in a cohort of Egyptian population

  2019cites this paper
• Transient Cognitive Impairment in Epilepsy

  2019cites this paper
• Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

  2019cites this paper
• An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy

  2019cites this paper
• Anticonvulsant and antiepileptogenic effects of system xc− inactivation in chronic epilepsy models

  2019cites this paper
• Signal Transduction Pathways of Acupuncture for Treating Some Nervous System Diseases

  2019cites this paper
• Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

  2019cites this paper
• Neuroinflammation impact in epileptogenesis and new treatment strategy.

  2019cites this paper