Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. Clinical data indicate that severe COVID-19 most commonly manifests as viral pneumonia-induced acute respiratory distress syndrome (ARDS), a clinical entity mechanistically understood best in the context of influenza A virus-induced pneumonia. Similar to influenza, advanced age has emerged as the leading host risk factor for developing severe COVID-19. In this review we connect the current understanding of the SARS-CoV-2 replication cycle and host response to the clinical presentation of COVID-19, borrowing concepts from influenza A virus-induced ARDS pathogenesis and discussing how these ideas inform our evolving understanding of COVID-19-induced ARDS. We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. Finally, we explore hallmarks of ageing that could explain the association between advanced age and susceptibility to severe COVID-19. Review of viral ARDS pathogenesis, how it informs evolving models of COVID-19, and how hallmarks of ageing explain the age-related morbidity and mortality of severe COVID-19 https://bit.ly/39Ca0c0

• Publication year

  2020

• Venue

  European Respiratory Journal

• Publication date

  2020-08-03

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1183/13993003.02049-2020PMID 32747391PMCID 7397945
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Association of a Workplace Sales Ban on Sugar-Sweetened Beverages With Employee Consumption of Sugar-Sweetened Beverages and Health.

  2020cited by this paper
• Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

  2020cited by this paper
• Is a "Cytokine Storm" Relevant to COVID-19?

  2020cited by this paper
• Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

  2020cited by this paper
• Inhibition of SARS–CoV-2 by type I and type III interferons

  2020cited by this paper
• The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

  2020cited by this paper
• Genomewide Association Study of Severe Covid-19 with Respiratory Failure

  2020cited by this paper
• Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.

  2020cited by this paper
• Bronchoalveolar lavage findings in severe COVID-19 pneumonia

  2020cited by this paper
• Type III interferons disrupt the lung epithelial barrier upon viral recognition

  2020cited by this paper
• The molecular biology of intracellular events during Coronavirus infection cycle

  2020cited by this paper
• Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

  2020cited by this paper
• Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

  2020cited by this paper
• Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study

  2020cited by this paper
• Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

  2020influential reference
• Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

  2020cited by this paper
• Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

  2020cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System

  2020influential reference
• Endothelial cell infection and endotheliitis in COVID-19

  2020cited by this paper
• Recent apprise on coronavirus and its terrible insinuations

  2020cited by this paper
• High IL‐6/IFN‐γ ratio could be associated with severe disease in COVID‐19 patients

  2020cited by this paper
• Temporal dynamics in viral shedding and transmissibility of COVID-19

  2020cited by this paper
• COVID-19 pneumonia: different respiratory treatments for different phenotypes?

  2020cited by this paper
• Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1

  2020cited by this paper
• Clinical and immunologic features in severe and moderate Coronavirus Disease 2019.

  2020influential reference
• Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

  2020cited by this paper
• Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

  2020cited by this paper
• Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy.

  2020cited by this paper
• Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

  2020cited by this paper
• Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

  2020cited by this paper
• Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

  2020cited by this paper
• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

  2020cited by this paper
• Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China

  2020cited by this paper
• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

  2020cited by this paper
• The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

  2020cited by this paper
• Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

  2020influential reference
• SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

  2020cited by this paper
• A Novel Coronavirus from Patients with Pneumonia in China, 2019

  2020cited by this paper
• [Asymptomatic infection of COVID-19 and its challenge to epidemic prevention and control].

  2020cited by this paper
• Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

  2019cited by this paper
• DNA methylation as a transcriptional regulator of the immune system

  2019cited by this paper
• The Immunology of Macrophage Activation Syndrome

  2019cited by this paper
• Immunometabolism of pro-repair cells.

  2019cited by this paper
• Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

  2019cited by this paper
• Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

  2018cited by this paper
• Multidimensional assessment of alveolar T cells in critically ill patients.

  2018cited by this paper
• Mitochondrial complex III is essential for regulatory T cell suppressive function

  2018cited by this paper
• DNA methylation regulates the neonatal CD4+ T-cell response to pneumonia in mice

  2018cited by this paper
• Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

  2018cited by this paper
• Macrophage activation syndrome: early diagnosis is key

  2018cited by this paper
• A Role for Neutrophils in Viral Respiratory Disease

  2017cited by this paper
• Interferon‐&lgr; Mediates Non‐redundant Front‐Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

  2017cited by this paper
• Molecular and physiological manifestations and measurement of aging in humans

  2017cited by this paper
• Foxp3+ Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation

  2017cited by this paper
• Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

  2016influential reference
• Acute Respiratory Distress Syndrome

  2016cited by this paper
• Translational Research in Acute Lung Injury and Pulmonary Fibrosis Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming

  2016cited by this paper
• Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza.

  2016cited by this paper
• IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

  2016cited by this paper
• Influenza virus-induced lung injury: pathogenesis and implications for treatment

  2015cited by this paper
• Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.

  2015cited by this paper
• Relationship Between ICU Length of Stay and Long-Term Mortality for Elderly ICU Survivors*

  2015influential reference
• A Distinct Function of Regulatory T Cells in Tissue Protection.

  2015cited by this paper
• Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation

  2014cited by this paper
• Foxp3+ Regulatory T Cells Promote Lung Epithelial Proliferation

  2014cited by this paper
• Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

  2014cited by this paper
• Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

  2013cited by this paper
• Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis

  2013cited by this paper
• The hallmarks of aging.

  2013cited by this paper
• Interferon induction and function at the mucosal surface

  2013cited by this paper
• Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population

  2013cited by this paper
• Influenza Illness and Hospitalizations Averted by Influenza Vaccination in the United States, 2005–2011

  2013cited by this paper
• The Effect of Age on Thymic Function

  2013cited by this paper
• Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

  2012cited by this paper
• Macrophage plasticity and polarization: in vivo veritas.

  2012cited by this paper
• Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

  2012cited by this paper
• Acute Respiratory Distress Syndrome The Berlin Definition

  2012cited by this paper
• Critical role of natural killer cells in lung immunopathology during influenza infection in mice.

  2012cited by this paper
• Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

  2011cited by this paper
• T cell responses during influenza infection: getting and keeping control.

  2011cited by this paper
• The senescence-associated secretory phenotype: the dark side of tumor suppression.

  2010cited by this paper
• Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling

  2010cited by this paper
• The effect of ageing on human lymphocyte subsets: comparison of males and females

  2010cited by this paper
• 2009 Pandemic Influenza A (H1N1)

  2010cited by this paper
• TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

  2009cited by this paper
• CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.

  2009cited by this paper
• Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells

  2008cited by this paper
• Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients.

  2007cited by this paper
• Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

  2007cited by this paper
• Epidemiology of seasonal influenza: use of surveillance data and statistical models to estimate the burden of disease.

  2006cited by this paper
• CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs

  2006cited by this paper
• CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

  2006cited by this paper
• Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

  2004cited by this paper
• Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

  2001cited by this paper
• CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

  1997cited by this paper

• Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases

  2026cites this paper
• Nebulized Long-Acting Bronchodilators to Treat Acute Respiratory Failure in an Older Adult: A Case Report

  2025cites this paper
• Kidney Involvement in SARS-CoV-2 Infection: Peritoneal Dialysis as the Preferred Modality

  2025cites this paper
• Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases

  2025cites this paper
• SARS-CoV-2 Variant-Specific Antibodies in Vaccinated Inflammatory Bowel Disease Patients

  2025cites this paper
• Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies

  2025cites this paper
• Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease

  2025cites this paper
• Inhibition of Inflammatory Regulators for Chronic Obstructive Pulmonary Disease (COPD) Treatment from Indonesian Medicinal Plants: A Systematic Review

  2025cites this paper
• Isorhamnetin alleviates pathological damage in influenza A virus strain PR8-induced pneumonia by activating the Nrf2/HO-1 pathway and suppressing apoptosis

  2025cites this paper
• Pirfenidone in post-COVID-19 pulmonary fibrosis (FIBRO-COVID): a phase 2 randomised clinical trial

  2025cites this paper
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  2025cites this paper
• Eosinophils and COVID‐19: Insights into immune complexity and vaccine safety

  2025cites this paper
• Isogenic induced-pluripotent-stem-cell-derived airway- and alveolus-on-chip models reveal specific innate immune responses

  2025cites this paper
• Aging and Its Societal Impact: A Bibliometric Analysis

  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Legal Protection of Health Workers on the Installation of Mechanical Ventilation of Covid-19 Patients in Hospitals

  2024cites this paper
• Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report

  2024cites this paper
• Smoking and vaping alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity: a systematic review and meta-analysis

  2024cites this paper
• Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS

  2024cites this paper
• Protective Effect of Vitamin K2 (MK-7) on Acute Lung Injury Induced by Lipopolysaccharide in Mice

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
• Clinical characteristics, management, and prevention of coronavirus disease 2019

  2023cites this paper
• Isogenic iPSC-derived proximal and distal lung-on-chip models: Tissue- and virus-specific immune responses in human lungs

  2023cites this paper
• A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia

  2023cites this paper
• Excipient-Free Lyophilization of Block Copolymer Micelles for Potential Lung Surfactant Therapy Applications.

  2023cites this paper
• Differential roles of regulatory T cells in acute respiratory infections

  2023influential citation
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  2023cites this paper
• Multisystem Inflammatory Syndrome in an Adult on Hemodialysis with Markedly Elevated Procalcitonin and Ferritin Levels

  2023cites this paper
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  2023cites this paper
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  2023influential citation
• Lung mechanics in pediatric acute respiratory distress syndrome associated to acute COVID-19 and MIS-C: implications for therapies and outcomes.

  2023influential citation
• Comparing Clinical Outcomes of COVID-19 and Influenza-Induced Acute Respiratory Distress Syndrome: A Propensity-Matched Analysis

  2023cites this paper
• Is COVID-19 different from other causes of acute respiratory distress syndrome?

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Utility of neutrophil to lymphocyte ratio to predict acute respiratory distress syndrome in COVID-19: short communication

  2023cites this paper
• Cesarean Delivery Outcomes for Patients with Coronavirus Disease-2019 in the USA

  2023cites this paper
• The Potency of Camellia Sinensis L. to Reduce Proinflammatory Cytokine Levels in the Acute Respiratory Distress Syndrome Rat Model

  2023cites this paper
• Extracellular Vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis.

  2023cites this paper
• Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality

  2023cites this paper
• Prehospital emergency medical service utilization and associated factors among critically ill COVID-19 patients treated at centers in Addis Ababa, Ethiopia

  2023cites this paper
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  2022cites this paper
• Yoghurt (LAB) as preventive method against COVID-19

  2022cites this paper
• Efficacy and safety of corticosteroid regimens for the treatment of hospitalized COVID-19 patients: a meta-analysis.

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022influential citation
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  2022cites this paper
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  2022cites this paper
• Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation

  2022cites this paper
• Risk Factors of Severe Disease and Methods for Clinical Outcome Prediction in Patients with COVID-19 (Review)

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis

  2022cites this paper
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  2022influential citation
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• The role of extracellular histones in COVID‐19

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour.

  2022cites this paper
• Potential Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome

  2022influential citation
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  2022cites this paper
• Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

  2022cites this paper
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  2022cites this paper