Immunohistochemical, Histopathological and Biochemical Approaches on the Renoprotective Effect of Avicennia marina Extract in Streptozotocin-Induced Diabetic Rats

The present study examined the effect of aqueous extract (400 mg/kg body weight) of Avicennia marina leaves in streptozotocin (STZ)-induced diabetic rats. After 6 weeks of treatment, the biochemical, histological and immunohistochemical alterations were investigated in kidneys of normal and diabetic rats. Sixty rats were used in this study and were randomly distributed into four groups of 15 each. Rats of group 1 served as controls. Rats of group 2 were injected intraperitoneally (IP) by a single dose (60 mg/kg BW) of freshly prepared STZ. Rats of group 3 were exposed to STZ and supplemented with A.marina leaves extracts. Rats of group 4 were administered A.marina leaves extracts. The fasted animals with blood glucose levels =?250 mg/dl were considered diabetic and used for the experiment. The results showed that the levels of serum glucose, creatinine, urea and uric acid in STZ-induced diabetic rats revealed a significant increase compared to the normal control group. The histopathological and imunohistochemical investigations showed that A.marina leaves extracts protect the kidney tissues against the damaging effect of hyperglycemia. The results indicated that A.marina leaf extracts showed ameliorative effects on the histopathological and immunohistochemical parameters on kidney of treated diabetic rats and proves its potentials as hypoglycemic agent.

• Publication year

  2020

• Venue

  Biosciences Biotechnology Research Asia

• Publication date

  2020-06-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.13005/bbra/2831
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatorenal Protective Effects of Some Plant Extracts on Experimental Diabetes in Male Rats

  2019cited by this paper
• Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats

  2019cited by this paper
• Active caspase-3 upregulation is augmented in at-risk cerebellar Purkinje cells following inferior olive chemoablation in the shaker mutant rat: an immunofluorescence study

  2018cited by this paper
• Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes.

  2018cited by this paper
• Serum creatinine levels and risk of incident type 2 diabetes mellitus or dysglycemia in middle-aged Japanese men: a retrospective cohort study

  2018cited by this paper
• Influence of Diabetes and Gestation in Blood Biochemistry Variables in Wistar Rats

  2018cited by this paper
• Cytoprotective Effects of N-Acetylcysteine on Streptozotocin- Induced Oxidative Stress and Apoptosis in RIN-5F Pancreatic β-Cells

  2018cited by this paper
• The Study of Inhibitory Effect of Aqueous Extract Leaf of Avicennia marina (Hara) on Candida albicans , In Vitro

  2018cited by this paper
• Effect of the Administration of Solanum nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats

  2017cited by this paper
• Cerebellar Purkinje cells die by apoptosis in the shaker mutant rat.

  2017cited by this paper
• Correlation of serum creatinine and urea with glycemic index and duration of diabetes in Type 1 and Type 2 diabetes mellitus: A comparative study -

  2017cited by this paper
• Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?

  2016cited by this paper
• The protective effect of hydro-alcoholic extract of mangrove (Avicennia marina L.) leaves on kidney injury induced by carbon tetrachloride in male rats

  2016cited by this paper
• A review of recent evidence relating to sugars, insulin resistance and diabetes

  2016cited by this paper
• Antidiabetic potential of mangrove plants: a review

  2016cited by this paper
• Positive Regulation of Rhizophora mucronata Poir Extracts on Blood Glucose and Lipid Profile in Diabetic Rats

  2016cited by this paper
• Antibacterial potential of mangrove plant Avicennia marina against a clinical pathogen

  2016cited by this paper
• Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015

  2015cited by this paper
• Endothelin and the glomerulus in chronic kidney disease.

  2015cited by this paper
• Improvement in beta-islets of Langerhans in alloxan-induced diabetic rats by erythropoietin and spirulina

  2015cited by this paper
• β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes.

  2015cited by this paper
• Evaluation of Protective Efficacy of Avicennia marina (Forssk.) Vierh Leaves against Complete Freund᾽s Adjuvant-induced Arthritis in Wistar

  2014cited by this paper
• Role of Bioactive Food Components in Diabetes Prevention: Effects on Beta-Cell Function and Preservation

  2014cited by this paper
• The role of triterpenes in the management of diabetes mellitus and its complications

  2014cited by this paper
• [Diabetic nephropathy: new insights into diagnosis, prevention and treatment].

  2014cited by this paper
• AN OVERVIEW OF ANTIDIABETIC PROFILE OF MANGROVE PLANTS

  2014cited by this paper
• A Review on Herbs Used in the Treatment of Diabetes mellitus

  2014cited by this paper
• Vitamin D in plants: a review of occurrence, analysis, and biosynthesis

  2013cited by this paper
• Transforming Growth Factor-β–Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy

  2013cited by this paper
• Kidney Injury Biomarkers in Hypertensive, Diabetic, and Nephropathy Rat Models Treated with Contrast Media

  2013cited by this paper
• p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation

  2012cited by this paper
• An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats

  2012cited by this paper
• Antibacterial Activity of Mangrove Leaf Extracts against Human Pathogens

  2012cited by this paper
• Association of low serum creatinine, abnormal lipid profile, gender, age and ethnicity with type 2 diabetes mellitus in Trinidad and Tobago.

  2011cited by this paper
• Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes.

  2011cited by this paper
• [Pharmacological activation of tumor suppressor, wild-type p53 as a promising strategy to fight cancer].

  2010cited by this paper
• Altered Liver Morphology and Enzymes in Streptozotocin Induced Diabetic Rats

  2009cited by this paper
• Caspases and kinases in a death grip.

  2009cited by this paper
• Hyperglycemic Crises in Adult Patients With Diabetes

  2009cited by this paper
• Ethnobotanical survey of the Santal tribe residing in Thakurgaon district, Bangladesh.

  2009cited by this paper
• Apoptosis: controlled demolition at the cellular level

  2008cited by this paper
• A natural history of botanical therapeutics.

  2008cited by this paper
• A Conserved Physical and Functional Interaction between the Cell Cycle Checkpoint Clamp Loader and DNA Ligase I of Eukaryotes*

  2007cited by this paper
• Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats

  2007cited by this paper
• Involvement of both tumor necrosis factor-α-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin

  2007cited by this paper
• Coping with stress: multiple ways to activate p53

  2007cited by this paper
• The CASBAH: a searchable database of caspase substrates

  2007cited by this paper
• Management of Dyslipidemia in Diabetes

  2006cited by this paper
• Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.

  2006cited by this paper
• Standards of medical care in diabetes.

  2006cited by this paper
• Hyperuricemia induces endothelial dysfunction.

  2005cited by this paper
• Caspase family proteases and apoptosis.

  2005cited by this paper
• Oxygenated diterpenes and other constituents from Moroccan Juniperus phoenicea and Juniperus thurifera var. africana.

  2004cited by this paper
• Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy.

  2004cited by this paper
• Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

  2004cited by this paper
• Apoptosis of Tubular Epithelial Cells in Glycogen Nephrosis During Diabetes

  2003cited by this paper
• Literature abstracts

  2001cited by this paper
• CRC World Dictionary of Plant Names: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology

  1999cited by this paper
• Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria

  1999cited by this paper
• Diabetes mellitus.

  1993cited by this paper
• Effects of Preanalytical Variables on Clinical Laboratory Tests

  1993cited by this paper
• Clinical Laboratory Tests: Values and Implications

  1991cited by this paper

• In vitro antioxidant, antibacterial, and antihyperlipidemic potential of ethanolic Avicennia marina leaves extract supported by metabolic profiling

  2021cites this paper