p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation: Heart Failure

• Publication date

  2012-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCHEARTFAILURE.111.961565PMID 22075967
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Telomere dysfunction induces metabolic and mitochondrial compromise

  2011cited by this paper
• Telomere dysfunction induces metabolic and mitochondrial compromise

  2011cited by this paper
• Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.

  2010cited by this paper
• Mitochondria in the diabetic heart.

  2010cited by this paper
• Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury.

  2009cited by this paper
• Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

  2009cited by this paper
• Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways

  2009cited by this paper
• Polo-like kinases mediate cell survival in mitochondrial dysfunction

  2009cited by this paper
• p53 and metabolism

  2009cited by this paper
• Cellular fatty acid uptake: a pathway under construction.

  2009cited by this paper
• Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis.

  2009cited by this paper
• Evaluating the glucose tolerance test in mice.

  2008cited by this paper
• Burst Emergence of Intracellular Ca2+ Waves Evokes Arrhythmogenic Oscillatory Depolarization via the Na+–Ca2+ Exchanger: Simultaneous Confocal Recording of Membrane Potential and Intracellular Ca2+ in the Heart

  2008cited by this paper
• Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes

  2008cited by this paper
• Role of mitochondria and reactive oxygen species in dendritic cell differentiation and functions.

  2008cited by this paper
• Diabetes, left ventricular systolic dysfunction, and chronic heart failure.

  2008cited by this paper
• Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease.

  2008cited by this paper
• Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America.

  2007cited by this paper
• p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

  2007cited by this paper
• Lipids in the heart: a source of fuel and a source of toxins

  2007cited by this paper
• Insulin-Resistant Heart Exhibits a Mitochondrial Biogenic Response Driven by the Peroxisome Proliferator-Activated Receptor-&agr;/PGC-1&agr; Gene Regulatory Pathway

  2007cited by this paper
• p53 Regulates Mitochondrial Respiration

  2006cited by this paper
• Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene

  2006cited by this paper
• Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice.

  2006cited by this paper
• PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

  2006cited by this paper
• Diabetes in heart failure: prevalence and impact on outcome in the population.

  2006cited by this paper
• Role of fatty acids in the transition from anaerobic to aerobic metabolism in skeletal muscle during exercise

  2006cited by this paper
• Fatty acid metabolism is enhanced in type 2 diabetic hearts.

  2005cited by this paper
• Role of mitochondria and reactive oxygen species in the differentiation process of human monocyte-derived dendritic cells

  2005cited by this paper
• Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity

  2005cited by this paper
• Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.

  2005cited by this paper
• Uncoupling Proteins 2 and 3 Function in Concert to Augment Tolerance to Cardiac Ischemia*

  2005cited by this paper
• Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice

  2005cited by this paper
• Effect of Obesity and Insulin Resistance on Myocardial Substrate Metabolism and Efficiency in Young Women

  2004cited by this paper
• Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

  2004cited by this paper
• Antioxidative treatment prevents activation of death-receptor- and mitochondrion-dependent apoptosis in the hearts of diabetic rats

  2004cited by this paper
• Aldosterone Directly Induces Myocyte Apoptosis Through Calcineurin-Dependent Pathways

  2004cited by this paper
• Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters

  2004cited by this paper
• Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes.

  2003cited by this paper
• Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

  2001cited by this paper
• Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene

  1999cited by this paper
• Triacylglycerol turnover in isolated working hearts of acutely diabetic rats.

  1994cited by this paper
• Molecular mapping of the mouse db mutation.

  1990cited by this paper

• Bulk and Single-Cell Transcriptomics Reveal That SCO2 Drives Psoriasis via Activating CCR7+ Dendritic Cell

  2026cites this paper
• High-intensity interval training (HIIT) ameliorates cardiac hypertrophy and fibrosis in diabetic rats: the role of P53 and SIRT1

  2025cites this paper
• Deciphering the Role of CD36 in Gestational Diabetes Mellitus: Linking Fatty Acid Metabolism and Inflammation in Disease Pathogenesis

  2025cites this paper
• Progress of heparanase in septic cardiomyopathy: A review

  2024cites this paper
• JinLiDa granules alleviates cardiac hypertrophy and inflammation in diabetic cardiomyopathy by regulating TP53.

  2024cites this paper
• SWATH-MS insights on sodium butyrate effect on mAbs production and redox homeostasis in CHO cells

  2024cites this paper
• Tetra aniline-based polymers ameliorate BPA-induced cardiotoxicity in Sprague Dawley rats, in silico and in vivo analysis.

  2024cites this paper
• Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid

  2023cites this paper
• Role of Oxygen Starvation in Right Ventricular Decompensation and Failure in Pulmonary Arterial Hypertension.

  2023cites this paper
• p53 contributes to cardiovascular diseases via mitochondria dysfunction: A new paradigm.

  2023cites this paper
• Lipocalin-2 participates in sepsis-induced myocardial injury by mediating lipid accumulation and mitochondrial dysfunction

  2022cites this paper
• Mitochondrial quality control mechanisms as molecular targets in diabetic heart.

  2022cites this paper
• DNA damage response signaling: A common link between cancer and cardiovascular diseases

  2022cites this paper
• Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin

  2022cites this paper
• LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis

  2022cites this paper
• MicroRNA-34a: the bad guy in age-related vascular diseases

  2021cites this paper
• A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis

  2021cites this paper
• Cardioprotective effects of Fenugreek (Trigonella foenum-graceum) seed extract in streptozotocin induced diabetic rats

  2021cites this paper
• Cardiac transcriptomic remodeling in metabolic syndrome

  2021cites this paper
• Reactive Oxygen Species-Mediated Diabetic Heart Disease: Mechanisms and Therapies

  2021cites this paper
• CD36 Signaling in Diabetic Cardiomyopathy

  2021cites this paper
• Inhibition of mitochondrial reactive oxygen species improves coronary endothelial function after cardioplegic hypoxia/reoxygenation.

  2021cites this paper
• Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium

  2021cites this paper
• Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats.

  2021cites this paper
• Cardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice

  2021cites this paper
• Label-free and noninvasive method for assessing the metabolic status in type 2 diabetic rats with myocardium diastolic dysfunction.

  2020cites this paper
• Role of Sodium-Glucose Co-transporters on Cardiac Function in Metabolic Syndrome Mammalians

  2020cites this paper
• Bioenergetic functions in subpopulations of heart mitochondria are preserved in a non-obese type 2 diabetes rat model (Goto-Kakizaki)

  2020cites this paper
• Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy

  2020cites this paper
• TIGAR reduces smooth muscle cell autophagy to prevent pulmonary hypertension.

  2020cites this paper
• Effects of Anchomanes difformis on Inflammation, Apoptosis, and Organ Toxicity in STZ-Induced Diabetic Cardiomyopathy

  2020cites this paper
• Immunohistochemical, Histopathological and Biochemical Approaches on the Renoprotective Effect of Avicennia marina Extract in Streptozotocin-Induced Diabetic Rats

  2020cites this paper
• The regulatory roles of p53 in cardiovascular health and disease

  2020cites this paper
• Proteasome biology and therapeutics in cardiac diseases

  2019cites this paper
• Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis.

  2019cites this paper
• Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate.

  2019cites this paper
• Pathology Inhibition of long non-coding RNA Malat1 attenuates high glucose-induced 4 cardiomyocyte apoptosis via regulation of miR-181a-5p 5

  2019cites this paper
• Curcumin-loaded PEG-PDLLA nanoparticles for attenuating palmitate-induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway

  2019cites this paper
• Cardioprotective effect of vitamin D2 on isoproterenol-induced myocardial infarction in diabetic rats*

  2019cites this paper
• Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism

  2019cites this paper
• Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p

  2019cites this paper
• Cardioprotective effect of vitamin D2 on isoproterenol-induced myocardial infarction in diabetic rats.

  2019cites this paper
• Redox biology in retinal degeneration

  2019cites this paper
• Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

  2018cites this paper
• Does p53 Inhibition Suppress Myocardial Ischemia–Reperfusion Injury?

  2018cites this paper
• Evaluating the impact of diabetes and diabetic cardiomyopathy rat heart on the outcome of ischemia‐reperfusion associated oxidative stress

  2018cites this paper
• Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats

  2018cites this paper
• Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

  2018cites this paper
• Sodium Butyrate Protects ­Against High Fat Diet‐Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice

  2017cites this paper
• Is p53 Involved in Tissue-Specific Insulin Resistance Formation?

  2017cites this paper
• Catalase ameliorates diabetes‐induced cardiac injury through reduced p65/RelA‐ mediated transcription of BECN1

  2017cites this paper
• Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes.

  2017cites this paper
• Cardiac-Specific Bdh1 Overexpression Ameliorates Oxidative Stress and Cardiac Remodeling in Pressure Overload–Induced Heart Failure

  2017cites this paper
• Expression of p53 in myocardium following coronary microembolization in rats and its significance

  2017cites this paper
• Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy

  2017cites this paper
• Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

  2017cites this paper
• Association of serum HMGB2 level with MACE at 1 mo of myocardial infarction: Aggravation of myocardial ischemic injury in rats by HMGB2 via ROS.

  2017cites this paper
• Emulsified isoflurane treatment inhibits the cell cycle and respiration of human bronchial epithelial 16HBE cells in a p53-independent manner.

  2016cites this paper
• Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

  2016cites this paper
• DIABETIC CARDIOMYOPATHY: A REVIEW

  2016cites this paper
• Phenylpyruvic Acid-2O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H 9 c 2 Cardiomyocytes

  2016cites this paper
• Tapping into Mitochondria to Find Novel Targets for Diabetes Complications.

  2016cites this paper
• Diabetic cardiomyopathy: role of the E3 ubiquitin ligase.

  2016cites this paper
• Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model.

  2015cites this paper
• Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

  2015cites this paper
• Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

  2015cites this paper
• Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart.

  2015cites this paper
• The Effects of Tempol on Cyclophosphamide-Induced Oxidative Stress in Rat Micturition Reflexes

  2015cites this paper
• Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy

  2015cites this paper
• Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome

  2015influential citation
• Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways

  2015cites this paper
• Heart specific scoX knockdown induces p53 dependent apoptosis and cardiomyopathy

  2014cites this paper
• Deficiency of a Lipid Droplet Protein, Perilipin 5, Suppresses Myocardial Lipid Accumulation, Thereby Preventing Type 1 Diabetes-Induced Heart Malfunction

  2014cites this paper
• Aging-Related Changes in Mitochondrial Function and Implication for Heart Failure Therapy

  2014cites this paper
• Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.

  2013cites this paper
• Lipidomic characterization of streptozotocin-induced heart mitochondrial dysfunction.

  2013cites this paper
• Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo

  2013cites this paper
• Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies.

  2013cites this paper
• Metformin limits ceramide-induced senescence in C2C12 myoblasts.

  2013cites this paper
• Cost-Effectiveness Analysis of Continuous-Flow Left Ventricular Assist Devices as Destination Therapy

  2013cites this paper
• Cost-Effectiveness Analysis of Continuous-Flow Left Ventricular Assist Devices as Destination Therapy

  2013cites this paper
• Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure

  2013cites this paper
• Diabetic cardiomyopathy and metabolic remodeling of the heart.

  2013cites this paper
• Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria

  2013cites this paper
• Z-disc Transcriptional Coupling, Sarcomeroptosis and Mechanopoptosis

  2012cites this paper
• Ca+2/Calmodulin-Dependent Protein Kinase Mediates Glucose Toxicity-Induced Cardiomyocyte Contractile Dysfunction

  2012cites this paper
• Cost-Effectiveness Analysis of Continuous-Flow Left Ventricular Assist Devices as Destination Therapy

  2012cites this paper
• Effect of Exercise Training on the Expression of p53 and iNOS in the Cardiac Muscle of Type I Diabetic Rats

  2012influential citation
• Mechanisms of Lipotoxicity in the Cardiovascular System

  2012cites this paper
• Circulation: Heart Failure Editors' Picks Most Important Papers in Pathophysiology and Genetics

  2012cites this paper
• O R I G I N a L I N V E S T I G a T I O N Open Access Cardiac Contractile Function and Mitochondrial Respiration in Diabetes-related Mouse Models

  year unknowncites this paper
• O R I G I N a L I N V E S T I G a T I O N Open Access

  year unknowncites this paper