Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing the tumor microenvironment and promoting cancer initiation and progression. Thus, it orchestrates immunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recent findings showed that this cytokine can be directly produced by tumor cells in a positive feedback loop and contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated.

• Publication year

  2020

• Venue

  International Journal of Molecular Sciences

• Publication date

  2020-08-20

• Fields of study

  Medicine

• Identifiers
  DOI 10.3390/ijms21176009PMID 32825489PMCID 7503335
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• IL-1 Signaling in Tumor Microenvironment.

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  2019cited by this paper
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  2018cited by this paper
• IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy

  2018influential reference
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  2018cited by this paper
• Overview of the IL‐1 family in innate inflammation and acquired immunity

  2018cited by this paper
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  2018cited by this paper
• Tumour growth and immune evasion as targets for a new strategy in advanced cancer.

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• Interleukin-1 Beta—A Friend or Foe in Malignancies?

  2018cited by this paper
• A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy

  2018influential reference
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  2018cited by this paper
• Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

  2018cited by this paper
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• Hypoxia/IL‐1α axis promotes gastric cancer progression and drug resistance

  2017cited by this paper
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  2017cited by this paper
• Senescence-associated reprogramming promotes cancer stemness

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• IL-1 drives breast cancer growth and bone metastasis in vivo

  2016cited by this paper
• Targeting inflammasome/IL-1 pathways for cancer immunotherapy

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  2016influential reference
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• The Consensus Molecular Subtypes of Colorectal Cancer

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  2015influential reference
• Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma

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• Emerging cytokine networks in colorectal cancer

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• The role IL-1 in tumor-mediated angiogenesis

  2014influential reference
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  2013influential reference
• The Role of IL-1β in the Early Tumor Cell–Induced Angiogenic Response

  2013cited by this paper
• The interleukin-1 family: back to the future.

  2013cited by this paper
• Cancer-related inflammation: common themes and therapeutic opportunities.

  2012cited by this paper
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  2012cited by this paper
• Inflammation and colorectal cancer: colitis-associated neoplasia

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Therapy-induced senescence in cancer.

  2010cited by this paper
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  2009cited by this paper
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  1994cited by this paper
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